BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)

This collection of essays by leading sinologists, historians, and philosophers both challenges and extends the work of David Nivison, whose contributions range across moral philosophy, religious thought, intellectual history, and Chinese language. Nivison himself replies to each essay.

Clarke proposes a conception of philosophy that provides an alternative to the reductions of materialism and the search for normative principles. Philosophy's proper role is to describe similarities and differences among differing levels of language, specifically the familiar level of discourse within an ordinary language shared by all and the specialized discourses of social institutions such as science, law, and the arts. By constructing a logical framework in which these comparisons and contrasts can be made, philosophy performs the indispensable role (...) of promoting the integration of disparate elements of our culture. (shrink)

The first English-language collection devoted to Hegel’s Philosophy of Subjective Spirit.

Handbook of Mathematical Induction: Theory and Applications shows how to find and write proofs via mathematical induction. This comprehensive book covers the theory, the structure of the written proof, all standard exercises, and hundreds of application examples from nearly every area of mathematics. In the first part of the book, the author discusses different inductive techniques, including well-ordered sets, basic mathematical induction, strong induction, double induction, infinite descent, downward induction, and several variants. He then introduces ordinals and cardinals, transfinite induction, (...) the axiom of choice, Zorn’s lemma, empirical induction, and fallacies and induction. He also explains how to write inductive proofs. The next part contains more than 750 exercises that highlight the levels of difficulty of an inductive proof, the variety of inductive techniques available, and the scope of results provable by mathematical induction. Each self-contained chapter in this section includes the necessary definitions, theory, and notation and covers a range of theorems and problems, from fundamental to very specialized. The final part presents either solutions or hints to the exercises. Slightly longer than what is found in most texts, these solutions provide complete details for every step of the problem-solving process. (shrink)

In recent years, the discipline of archaeology has witnessed its scientific base challenged by new interpretive approaches, new kinds of data and proposals for new levels of social relevance. The Reader in Archaeological Theory comprises a summary perspective on these different trends, problems and currents in recent archaeological method and theory, how they are related, and how they differ. Remarkable in its emphasis on North American research, many of the papers in this volume focus on ancient Mesoameria and the native (...) peoples of our continent. The breadth of scholarship covered in the Reader demonstrates how a variety of disciplines--from cognitive neuroscience to poststructural semiotics--have influenced some newer approaches to archaeological theory. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

As machine learning has gradually entered into ever more sectors of public and private life, there has been a growing demand for algorithmic explainability. How can we make the predictions of complex statistical models more intelligible to end users? A subdiscipline of computer science known as interpretable machine learning (IML) has emerged to address this urgent question. Numerous influential methods have been proposed, from local linear approximations to rule lists and counterfactuals. In this article, I highlight three conceptual challenges that (...) are largely overlooked by authors in this area. I argue that the vast majority of IML algorithms are plagued by (1) ambiguity with respect to their true target; (2) a disregard for error rates and severe testing; and (3) an emphasis on product over process. Each point is developed at length, drawing on relevant debates in epistemology and philosophy of science. Examples and counterexamples from IML are considered, demonstrating how failure to acknowledge these problems can result in counterintuitive and potentially misleading explanations. Without greater care for the conceptual foundations of IML, future work in this area is doomed to repeat the same mistakes. (shrink)

Radical Philosophy of Law represents a cross section of contemporary critiques of the legal establishment—its theoretical foundations and its institutions and processes. Recognizing that proposals for alternatives to mainstream legal theory and practice do not belong to any single discipline, Caudill and Gold select essays by scholars in philosophy, sociology, criminology, and political theory, in addition to law professors and practitioners. Recognizing, as well, that no single perspective dominates radical legal theory, the essays exemplify the approaches associated with Marxian and (...) neo-Marxian analyses, American Critical Legal Studies and Critical Race Theory, radical feminism, semiotics, liberal theology, and psychoanalytic theory and criticism. (shrink)

The world of science was stunned, and the hopes of many people dashed, when Professor Hwang Woo Suk of Seoul National University was recently found guilty of massive scientific fraud. Until January 2006 he was considered one of the world’s leading experts in cloning and stem cell research. Yet he was found by his own university to have fabricated all of the cell lines he claimed, in articles published in Science in 2004 and 2005, to have derived from cloned human (...) embryos. By the time he was exposed, Hwang had been given the title of leading scientist in Korea by his government. A postage stamp had been issued in his honour, showing a paralysed man leaping out of a wheelchair to embrace his lady love. Schoolchildren read specially produced stories of the indefatigable scientist who supposedly worked 365 days a year for the sake of saving humanity from disease and disability. When I spoke on the ethical wrongness of human embryonic stem cell research at a major conference in San Francisco in 2005, I overheard scientists — professors of high repute and excited graduate students alike — speaking in awed tones of the incredible technical skill that Hwang and his team were thought to have displayed. He told N din re Medicine that his dexterity was a cultural inheritance: "This work can be done much better in Oriental hands. We can pick up very slippery corn or rice with steel chopsticks.'. (shrink)

This introduction to the basic forms of deductive inference as evaluated by methods of modern symbolic logic is de­signed for sophomore-junior-level stu­dents ready to specialize in the study of deductive logic. It can be used also for an introductory logic course. The inde­pendence of many sections allows the instructor utmost flexibility. The text consists of eight chapters, the first six of which are designed to intro­duce the student to basic topics of sen­tence and predicate logic. The last two chapters extend (...) the procedures of the first six to alethic modal logic, the logic of imperatives, and deontic logic. Throughout the text there is an attempt to relate symbolic techniques to issues in the philosophy of logic. (shrink)

Over the course of a career that has spanned more than fifty years, philosopher Fred Sommers has taken on the monumental task of reviving the development of Aristotelian (syllogistic) logic after it was supplanted by the predicate logic of Gottlob Frege and Bertrand Russell. The enormousness of Sommers's undertaking can be gauged by the fact that most philosophers had come to believe - as David S. Oderberg writes in his preface - that "Aristotelian logic was good but is now (...) as good as dead." A revival of traditional syllogistic logic would involve not only its restatement but its refashioning into a system that could rival the elegance and deductive power of predicate logic. Building on work by medieval scholastic logicians, Leibniz, and nineteenth-century algebraic logicians, Sommers accomplished this renovation and rehabilitation of syllogistic logic with his magnum opus The Logic of Natural Language, published in 1982. In The Old New Logic, essays by a diverse group of contributors show how widely influential Sommers's work has been-not only in logic, but in category theory and other areas. Scholars in psychology, linguistics, and computer science join philosophers and logicians in discussing aspects of Sommers's contributions to philosophy. Sommers himself provides an intellectual autobiography at the beginning and in the final chapter offers comments on the contributions. This collection should help bring to Sommers's work the attention it deserves from the wider philosophical and intellectual community. (shrink)

Unsupervised learning algorithms are widely used for many important statistical tasks with numerous applications in science and industry. Yet despite their prevalence, they have attracted remarkably little philosophical scrutiny to date. This stands in stark contrast to supervised and reinforcement learning algorithms, which have been widely studied and critically evaluated, often with an emphasis on ethical concerns. In this article, I analyze three canonical unsupervised learning problems: clustering, abstraction, and generative modeling. I argue that these methods raise unique epistemological and (...) ontological questions, providing data-driven tools for discovering natural kinds and distinguishing essence from contingency. This analysis goes some way toward filling the lacuna in contemporary philosophical discourse on unsupervised learning, as well as bringing conceptual unity to a heterogeneous field more often described by what it isnot(i.e., supervised or reinforcement learning) than by what itis. I submit that unsupervised learning is not just a legitimate subject of philosophical inquiry but perhaps the most fundamental branch of all AI. However, an uncritical overreliance on unsupervised methods poses major epistemic and ethical risks. I conclude by advocating for a pragmatic, error-statistical approach that embraces the opportunities and mitigates the challenges posed by this powerful class of algorithms. (shrink)

There can be no doubt that the public face of contemporary philosophy is the professional who goes by the name of “bioethicist.” Since the bioethics industry—which is what it is—sprang up in the 1970s, large numbers of professional philosophers have found it a congenial and remunerative way in which to make a reputation for themselves. A few general observations can be made about bioethicists. Some of them are well-meaning. For example, they are dedicated to the laudable notion that philosophy should (...) be heard in the public square and have an influence on the making of policy. Or they believe, rightly, that the bioethical problems of our day are of such grave moment that philosophers should try to grapple with them, at least, and provide solutions if possible. It is not only that the welfare of society depends on such solutions, but that if philosophers, who are supposed to be trained in rigorous thinking, do not do the hard conceptual work that needs to be done, the void will be filled by the looser and fuzzier moral thinking of others—especially lawyers, politicians, and economists. Some are simply committed to the idea, again admirable, that bioethics is a serious intellectual discipline that demands equally serious analytical application. Some find bioethics just interesting and worthy of philosophical pursuit in its own right. Again, this is true. On the other hand, it is all too evident that very many, perhaps the majority, of bioethicists are, to put it frankly, less than competent. I believe that this is a view a good number of philosophers share. The bioethics industry is, unfortunately, populated by many individuals whom one might even call second-rate philosophers. They have found themselves unable to grapple with the more technical or abstract areas of philosophy—or at least to make a name for themselves in such areas—but have found that it is relatively easy to forge a name for oneself in the bioethics business. For one, there is an insatiable demand by the media for comment upon the latest developments in biotechnology, medicine, genetics, and so on, or for comment upon someone else’s comment upon such developments.. (shrink)

Natural law theory says that humans can only live well if they recognise the goods that are natural for humans, and understand how those goods generate the system of practical guidance that we call morality. Natural law is a long-established and flourishing ethical tradition, with roots in Aristotle and Aquinas, which is increasingly recognised as a worthy competitor to Kantianism, utilitarianism and virtue ethics. The new essays in this collection represent the latest thinking - both constructive and critical - of (...) some of the most important thinkers in the field. And they reflect the growing influence, sophistication, and importance of natural law theory within contemporary ethical debate. (shrink)

Although the language of vocation was born in a religious context, the contributors in this volume demonstrate that it has now taken root within the broad framework of higher education and has become intertwined with a wide range of concerns. This volume makes a compelling case for vocational reflection and discernment in undergraduate education today, arguing that it will encourage faculty and students alike to venture out of their narrow disciplinary specializations and to reflect on larger questions of meaning and (...) purpose. In conversation with a growing range of scholarly resources, these essays advance the cause of vocational reflection and discernment well beyond its occasional mention in general education courses and career placement offices. The book's thirteen contributors all work in higher education, but they do so as biologists and musicians, sociologists and engineers, doctors and lawyers, college presidents and deans, and scholars of history, literature, and business administration. Together, they demonstrate that vocation has an important role to play across the entire range of traditional academic disciplines and applied fields. Regardless of major, all undergraduates need to consider their current and future responsibilities, determine the stories they will live by, and discover resources for addressing the tensions that will inevitably arise among their multiple callings. Vocation across the Academy will help to reframe current debates about the purpose of higher education. It underscores the important role that colleges and universities can play in encouraging students to reflect more deeply on life's most persistent questions and to consider how they might best contribute to the common good. (shrink)

The distinction between the essence of an object and its properties has been obscured in contemporary discussion of essentialism. Locke held that the properties of an object are exclusively those features that ‘flow’ from its essence. Here he follows the Aristotelian theory, leaving aside Locke’s own scepticism about the knowability of essence. I defend the need to distinguish sharply between essence and properties, arguing that essence must be given by form and that properties flow from form. I give a precise (...) definition of what the term of art ‘flow’ amounts to, and apply the distinction to various kinds of taxonomic issues. (shrink)

Ten years after over half a million Christians signed their names to a statement of conscience clarifying where they stood, the three issues dealt with in the Manhattan Declaration are of more cultural importance than ever. The main difference now, as opposed to then, is the state has since claimed authority, not only over life, but also over marriage and religious liberty." -- Amazon.com.

As an undergraduate at the University of Melbourne in the 1980s, I recall a story that used to circulate to the effect that Australian philosophers were realists (the term prefixed by the obligatory adjective "hard-headed") because we lived in a harsh, sunlit environment where no misty meadow or morning fog obscured the objective reality of a mind-independent physical universe.