Calcineurin is a Ca2+/calmodulin‐activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is the conserved target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibition by the cyclophilin A–CsA and FKBP12–FK506 complexes. Calcineurin also functions in fungi to control a myriad of physiological processes including cell cycle progression, cation homeostasis, and morphogenesis. Recent investigations into the molecular mechanisms of pathogenesis in Candida albicans and (...) Cryptococcus neoformans, two fungi that cause life‐threatening infections in humans, have revealed an essential role for calcineurin in morphogenesis, virulence, and antifungal drug action. Novel non‐immunosuppressive analogs of the calcineurin inhibitors CsA and FK506 that retain antifungal activity have been identified and hold promise as candidate antifungal drugs. In addition, comparisons of calcineurin function in both fungi and humans may identify fungal‐specific components of calcineurin‐signaling pathways that could be targeted for therapy, as well as conserved elements of calcium signaling events. BioEssays 24:894–903, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

A portrait of Australian flying fox life in the Anthropocene illuminates startlingly familiar stories. These animals are participants in most of the major catastrophic events, as well as contestations about rescue, of contemporary life on Earth: warfare, man-made mass death, famine, urbanisation, emerging diseases, climate change, biosecurity, conservation, and local/international NGO aid. They are endangered, and are involved in all four of the major factors causing extinctions: habitat loss, overexploitation, introduced species, and extinction cascades. My account of flying foxes in (...) Australia rests on the understanding of species articulated both vigorously and eloquently by Donna Haraway : we and others are entangled in knots of species who are co-shaping each other in layers of reciprocating complexity. I seek to engage both the living, warm-blooded beings whose lives are threatened, and the excruciatingly dynamic deathscape that is surrounding them/us. Positioned, like much of life on Earth today, in zones of increasing conflict and terror, the lives and deaths of flying foxes tell us that in the Anthropocene there is no way out of entanglements within multispecies communities. Rather than seeking to erect more impenetrable barriers against others, relational ethics for living and dying in the Anthropocene urge us to assume ever greater mutuality and accountability as intradependent members of the suffering family of life on Earth. (shrink)

I discuss six problems with Warwick Fox’s “The Deep Ecology–Ecofeminism Debate and Its Parallels” and conclude that until Fox and some other deep ecologists take the time to study feminism and ecofeminist analyses, only disputes—not genuine debate—will occur between these two parties. An understanding of the six issues that I discuss is a precondition for such a debate.

This article treats the figure of the fox that appears as one of the members of the embassy sent by the animal s to Zeus in Callimachus' second ¡ambo By exploring previous appearances of the fox in the poetic repertoire, I identify a series of Archaic and early Classical works that Callimachus uses by way of 'intertexts', and argue that the Hellenistic author draws on the animal's place within the interconnected iambic and fable traditions that inform his poem. Already visible (...) in these earlier texts, and anticipating Callimachus, is a concern with literary as well as ethical polemics. (shrink)

This guide leads readers systematically through the arguments of Mary Shepherd's two books. Chapters 1-4 cover the arguments in the Essay Upon the Relation of Cause and Effect (1824), where Shepherd argues that causal principles can be known by reason to be necessary truths and that causal inferences can be rationally justified. Shepherd's primary target in this work is Hume, but she also addresses the views of Thomas Brown and William Lawrence. Shepherd considered her second book, Essays on the Perception (...) of an External Universe, and Other Subjects Connected with the Doctrine of Causation (1827), to be an extension of the earlier project on causation; here she appeals to the causal principles established in the first book to argue that we can know through reason that an external world of continually-existing objects must exist independently of us, as the causes of our sensations. Chapter 5 of this Guide addresses Shepherd's accounts of sensation and reasoning; Chapters 6-9 lead the reader through the arguments of the Essays, as well laying out Shepherd's views on skepticism and Berkeleyan idealism, her accounts of mind and body, her philosophy of religion, and the solutions she offers to two puzzles about vision. (shrink)

Economists and other social scientists in this century have often supported economic arguments by referring to positions taken by philosophers of science. This important new book looks at the reliability of this practice and, in the process, provides economists, social scientists, and historians with the necessary background to discuss methodological matters with authority. Redman first presents an accurate, critical, yet neutral survey of the modern philosophy of science from the Vienna Circle to the present, focusing particularly on logical positivism, sociological (...) explanations of science (Polanyi, Fleck, Kuhn), the Popper family, and the history of science. She then deals with economic methodology in the twentieth century, looking at a wide range of methodological positions, especially those supported by positions from the philosophy of science. She considers the myth of the feasibility of falsification in economics and, within the context of its significance for economics, discusses the interpretation of Kuhn's philosophy of science as consensus and the danger such a view represents to science. Appendices review the history of the is-ought dispute and list economists whose first works deal with methodological topics. Comprehensive, readable, and accessible to those with little background knowledge, Redman's book will appeal to a wide range of social scientists and philosophers of science. (shrink)

This article explores the principles of interaction that shape grammatical practices of conversational speech cross-linguistically. Seven such principles are explored, and the grammatical practices they give rise to are illustrated. The role of these principles in shaping non-linguistic behavior is also touched on.

Germund Hesslow has argued recently [2] that a probabilistic theory of causality as advocated by Patrick Suppes [4] has two problems that a deterministic theory avoids. In this paper, I argue that Suppes' probabilistic causal calculus is free of each of these problems and, moreover, that several broader issues raised by Hesslow's discussion tend to support a probabilistic conception of causes.

The Well-Ordered Universe argues that Cavendish's natural philosophy, social and political philosophy, and medical theory share an underlying concern with order. This reveals interesting connections among Cavendish's natural philosophy and her views on gender, animals and the environment, and human health, and explains her commitment to monarchy and social hierarchy.

During the past decade there has been a very effective campaign against any explanation of remembering whose basic concept is that of a causally mediating trace. This paper attempts to provide such an explanation by presenting an explicit deductive argument for the existence of the memory trace. The conclusion is shown to follow from reasonable, empirical assumptions of which the most interesting is a spatiotemporal contiguity thesis. Set-theoretic techniques are used to provide a framework of analysis and probabilistic definitions of (...) some causal notions, as that of a causal chain, are presented. (shrink)

A comprehensive bibliography of economic methodological works since 1860, this volume includes 2,244 entries divided into two primary sections. The first section covers works on economic methodology while Part Two deals with works on the philosophy of science. Many of the entries are annotated, including the classics in economic methodology, almost all of the books, and general works in the philosophy of science section. All other sections include an introduction to the topic and the articles collected under that heading.

A view of inequality as a relationship between the advantaged and the disadvantaged has gained considerable currency in psychological research. However, the implications of this view for theories and interventions designed to reduce inequality remain largely unexplored. Drawing on the literature on close relationships, we identify several key features that a relational theory of social change should include.

This essay explores the relationships between labour and community formation in order to think through how, where, and when diasporic solidarities are imagined or refused. I draw on ethnographic research among Jamaican women contracted for seasonal work in US hotels to situate diasporic calls and responses in relation to specific contexts and a changing global political economy. I show how global geopolitical shifts not only shape the processes of identity formation and social reproduction, but also condition the perpetuation of notions (...) of nationalized racial hierarchies and ideologies of progress. I also show that hotel workers’ notions of ‘America’ and their commitment to the ‘American Dream’ shapes their subjectivities as migrant workers/consumers and, in their assessment, differentiates them from African-Americans, particularly those most immediately affected by Hurricane Katrina. In doing so, I demonstrate that one of the ideological hegemonies of diaspora is the idea that an individual's capacity to affect their own social mobility and that of their social network always outstrips the ‘locals’ in diasporic elsewheres. (shrink)

Drawing on everyday telephone and video interactions, this book surveys how English speakers use grammar to formulate responses in ordinary conversation. The authors show that speakers build their responses in a variety of ways: the responses can be longer or shorter, repetitive or not, and can be uttered with different intonational 'melodies'. Focusing on four sequence types: responses to questions, responses to informings, responses to assessments, and responses to requests, they argue that an interactional approach holds the key to explaining (...) why some types of utterances in English conversation seem to have something 'missing' and others seem overly wordy. (shrink)

The Zhuangzi is one of the richest early Chinese sources for exploring conceptualizations of the visceral human form. Zhuangzi presents the human frame as a corpus of flesh, organs, limbs, and bone; he dissects it before the reader's eyes, turning it inside out and joyfully displaying its fragmented joints, sundered limbs, and beautifully monstrous mutations. This body is a site of immolation and fragmentation that ultimately evokes a larger wholeness and completeness. Drawing and quartering the body, Zhuangzi paradoxically frees it (...) from ordinary mortality. -/- Sommer explores the fields of meaning of different terms for the human body found in the Zhuangzi: the body might appear there as a gong body 躬, a sanctimonious ritualized body; as a shen body 身, a site of familial and social personhood; or as a ti body 體, a complex, multilayered corpus of multiple parts, each of which is consubstantial with the whole. Most commonly, however, the body in the Zhuangzi is the xing 形, an elemental or structural form. Zhuangzi enlivens and develops the xing form in ways that are not seen in other early Chinese texts. He mutilates and mutates it such that boundaries between form and formlessness disappear, and the physical frame becomes incorporated into a larger common body that includes all of life and death. (shrink)

Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs that have suffered a loss or gain of nucleotide sequence information. In contrast, HDR achieves accurate repair of such DSBs by use of a sister chromatid as a DNA template, but is restricted to cell cycle phases (S/G2) (...) when such templates are available. In this scheme, G1 cells appear to lack a mechanism for the accurate repair of certain DSBs, and an ability to use alternative templates would be highly advantageous. Considered here, therefore, is the possibility that RNA transcripts are used as templates for HDR. Potential mechanisms for transcript‐templated HDR, and ways in which it might be detected, are presented. BioEssays 28:78–83, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

In response to a bacterial infection, insects launch an array of countermeasures. Among these are the antibacterial proteins, which effectively lyse bacteria or are bacteriostatic. These proteins were generally assumed to be restricted to insects, yet recent information has shown some homologous counterparts in verte brates, including humans. Recent data have revealed that at least some of these proteins can also act against eukaryotic cells, including human infectious Parasites The latter activities have opened up new possibilities for disease control.

This paper attempts to set up a probabilistic framework for understanding the notion of causal necessity. What results is a relaxed and relativized probabilistic theory of epsilon-Causal necessity and an explicit attempt to avoid deterministic assumptions. The theory developed emphasizes the notions of partial cause, Causal contribution, And the degree of contribution. Implications for causal overdetermination, Causal preemption, And causal discourse are discussed.

This volume includes nineteen articles by scholars from Asia, North America, and Europe on Chinese thinkers from the eleventh to the eighteenth centuries. Included here are intellectual biographies of literati such as Zhou Dunyi, the Cheng brothers, Zhu Xi, Zhang Shi, Hu Hong, Wang Yangming, and Dai Zhen. Essays are arranged chronologically, and most begin with a biographical sketch of their subject. They provide variety rather than uniformity of approach, but all in all these essays are remarkably rich and offer (...) much new material on both familiar and lesser-known thinkers. (shrink)

The ji 己self is a site, storehouse, or depot of individuated allotment associated with the possession of things and qualities: wholesome and unwholesome desires (yu 欲) and aversions, emotions such as anxiety, and positive values such as humaneness and reverence. Each person's allotment is unique, and its "contents" are collected, measured, reflected on, and then distributed to others. The Analects, Mencius, Xunzi, Daodejing, and Zhuangzi each have their own vision for negotiating the space between self and other. Works as seemingly (...) dissimilar as the Analects and Daodejing both agree that positive qualities located within the self should be shared with others, and that the self can be optimized rather than maximized through sharing, emptying, or clearing. Sommer compares the ji self with other terms for body and person current in classical times. This self is strongly individuated, but it exists primarily in relation to other human beings (ren 人 ). These "others" are almost never one's own kind and are usually people who fall outside one's ascribed familial and social relationships. Negotiations between self and other often reflect apprehension regarding degrees of distance, intimacy, worth, recognition, or understanding (zhi 知) between people. (shrink)

This article explores the meanings of nature, and examines how understandings of this term inform the field of psychology. In this period of high, late, or post-modernity, many of the "givens" become contested, and perhaps nothing has become more contested than nature itself. There is a threefold purpose to this paper. This first goal is to unravel two types of nature in psychology, to be distinguished as nature and Nature. The second aim is to discuss how these types of nature/Nature (...) have been distinguished epistemologically, ontologically and methodologically within the field. The final purpose is to suggest points of unity within nature and Nature in psychology. 2012 APA, all rights reserved). (shrink)

The concept of innateness is central to Descartes's epistemology; the Meditations display a new, non-Aristotelian method of acquiring knowledge by attending properly to our innate ideas. Yet understanding Descartes's conception of innate ideas is not an easy task, and some commentators have concluded that Descartes held several distinct and unrelated conceptions of innateness. In Descartes on Innate Ideas, Deborah Boyle argues that Descartes's remarks on innate ideas in fact form a unified account. Addressing the further question of how Descartes (...) thinks innate ideas are known, the author shows that, for Descartes, thinkers have implicit knowledge of their innate ideas. Thus she shows that the actual perception of these innate ideas is, for Descartes, a matter of making them explicit, turning the intellect away from sense-perceptions and toward pure thought. The author also provides a new interpretation of the Cartesian "natural light," an important mental faculty in Descartes's epistemology. (shrink)

Descartes is often accused of lacking a coherent conception of innate ideas. I argue that Descartes' remarks on innate ideas actually form a unified account. "Innate idea" is triply ambiguous, but its three meanings are interdependent. "Innate idea" can mean an act of perceiving; that which is perceived; or a faculty, capacity, or disposition to have certain ideas. An innate idea qua object of thought is some thing existing objectively , which we have a capacity to perceive, but which we (...) can only actually perceive through meditation. ;Descartes thinks that some innate ideas, such as the idea of thought itself, are implicit in the very process of thinking. Because they are relied on in thinking itself, we have implicit awareness of them. We also have implicit knowledge of other ideas contained in them. The actual perception of these innate ideas is, for Descartes, a matter of making them explicit, turning the intellect away from sense-perceptions and towards pure thought. ;Some innate truths, Descartes says, are perceived by the "natural light." I argue that such truths are made explicit through attending to how the concepts which those truths are about have been relied on in the process of thinking. I discuss the relationship between the natural light and the will, arguing that other accounts of Descartes' "natural light" in the secondary literature are unsatisfactory. I also explore how Descartes' use of the metaphor of light might have been informed by his scientific views about light. ;The innate ideas of corporeal nature and mathematics are also made explicit through attention and reflection, according to Descartes. Though many commentators read Descartes as holding that the innate idea of extension can be known without any use of the senses, I argue that it is discovered through reflection on our sense-perceptions. Once this idea is explicit, Descartes thinks, we can use it to generate explicit awareness of further innate ideas, such as ideas of shapes. Reflection on those further innate ideas, in turn, makes explicit various innate truths about those shapes. (shrink)

This article considers the advice found on six internet sites written for people who are considering coming out. The article uses Edwards’ script formulation theory to examine how the grammatical choices by the writers formulate the dispositions of the main actors in the texts: the advice seeker, LGB individuals, and the people to whom they come out. The writers’ formulations are shaped by a view of coming out as the act of a reasonable, emotionally healthy, moral and loving lesbian, gay (...) or bisexual individual. It is argued that one of the purposes of these texts is to normalize coming out as a routine event and as a rational course of action for an LGB individual. Furthermore, the use of script formulation is seen to be characteristic of written texts and a strategy by which advice writers can legitimize themselves as qualified to give advice. (shrink)

In this article we assess the extant literature on women’s careers appearing in selected career, management and psychology journals from 1990 to the present to determine what is currently known about the state of women’s careers at the dawn of the 21st century. Based on this review, we identify four patterns that cumulatively contribute to the current state of the literature on women’s careers: women’s careers are embedded in women’s larger-life contexts, families and careers are central to women’s lives, women’s (...) career paths reflect a wide range and variety of patterns, and human and social capital are critical factors for women’s careers. We also identify paradoxes that highlight the disconnection between organizational practice and scholarly research associated with each of the identified patterns. Our overall conclusion is that male-defined constructions of work and career success continue to dominate organizational research and practice.We provide direction for a research agenda on women’s careers that addresses the development of integrative career theories relevant for women’s contemporary lives in hopes of providing fresh avenues for conceptualizing career success for women. Propositions are identified for more strongly connecting career scholarship to organizational practice in support of women’s continued career advancement. (shrink)

We have found that the left side of faces displayed in Rembrandt's portraits capture how humans rank male dominance, helping to coordinate avoidance behaviors among asymmetric individuals. Moreover, the left side of faces may also coordinate approach responses, like attractiveness, in human females. Therefore, adding sexual selection to dominance paints a more realistic picture of what the contralateral right hemisphere is doing.

Extrait de la couverture : ""Here, for the first time, is a book that brings women's writings out of exile to rethink anthropology's purpose at the end of the century.... As a historical resource, the collection undertakes fresh readings of the work of well-known women anthropologists and also reclaims the writings of women of color for anthropology. As a critical account, it bravely interrogates the politics of authorship. As a creative endeavor, it embraces new Feminist voices of ethnography that challenge (...) prevailing definitions of theory and experimental writing.". (shrink)