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Denis Noble [25]Denise Noble [1]
  1.  30
    The Music of Life: Biology Beyond the Genome.Denis Noble - 2006 - Oxford University Press.
    What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that (...)
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  2.  38
    The Illusions of the Modern Synthesis.Denis Noble - forthcoming - Biosemiotics:1-20.
    The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of (...)
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  3.  44
    The Music of Life: Biology Beyond Genes.Denis Noble - 2008 - Oxford University Press.
    What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.
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  4.  54
    The Evolution of Consciousness and Agency.Denis Noble - 2022 - Biosemiotics 15 (3):439-446.
    Conscious Agency is a major driver of evolution. Artificial Selection (i.e. Conscious Selection by human breeders) was the foil against which Charles Darwin defined Natural Selection. In later work, he extended Artificial Selection to other species. That ability for social (e.g. sexual) selection must have evolved. Jablonka and Ginsburg identify markers of conscious agency, such as Unlimited Associative Learning (UAL), and show that it must have existed at the time of the Cambrian Explosion. To their insights, my commentary argues that (...)
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  5.  26
    What Future for Evolutionary Biology? Response to Commentaries on “The Illusions of the Modern Synthesis”.Denis Noble - forthcoming - Biosemiotics:1-13.
    The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...)
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  6.  36
    Can Reasons and Values Influence Action: How Might Intentional Agency Work Physiologically?Raymond Noble & Denis Noble - 2020 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 52 (2):277-295.
    In this paper, we demonstrate (1) how harnessing stochasticity can be the basis of creative agency; (2) that such harnessing can resolve the apparent conflict between reductionist (micro-level) accounts of behaviour and behaviour as the outcome of rational and value-driven (macro-level) decisions; (3) how neurophysiological processes can instantiate such behaviour; (4) The processes involved depend on three features of living organisms: (a) they are necessarily open systems; (b) micro-level systems therefore nest within higher-level systems; (c) causal interactions must occur across (...)
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  7.  68
    Charles Taylor on Teleological Explanation.Denis Noble - 1967 - Analysis 27 (3):96 - 103.
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  8. Editorial. Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy.Plamen L. Simeonov, Arran Gare, Seven M. Rosen & Denis Noble - 2015 - Progress in Biophysics and Molecular Biology 119 (3):208-218.
    The is the Editorial of the 2015 JPBMB Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy.
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  9. The Western and Eastern thought traditions for exploring the nature of mind and life.Plamen L. Simeonov, Arran Gare, Koichiro Matsuno, Abir U. Igamberdiev & Denis Noble - 2017 - Progress in Biophysics and Molecular Biology 131:1-11.
    This is the editorial to the special edition of Progress in Biophysics and Molecular Biology on the role engagement with Eastern traditions of thought could play in the advancement of science generally and biology and the science of mind in particular.
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  10.  16
    Modelling the heart: insights, failures and progress.Denis Noble - 2002 - Bioessays 24 (12):1155-1163.
    Mathematical models of the heart have developed over a period of about 40 years. Cell types in all regions of the heart have been modelled and they are now being incorporated into anatomically detailed models of the whole organ. This combination is leading to the creation of the first ‘virtual organ,’ which is being used in drug discovery and testing, and in simulating the action of devices, such as cardiac defibrillators. Simulation is a necessary tool of analysis in attempting to (...)
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  11.  48
    The Conceptualist View of Teleology.Denis Noble - 1967 - Analysis 28 (2):62 - 63.
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  12.  14
    Kathy Wilkes, Teleology, and the Explanation of Behaviour.Denis Noble - 2022 - Croatian Journal of Philosophy 22 (66):313-325.
    Kathy Wilkes contributed to two books on Goal-directed Behaviour and Modelling the Mind based on interdisciplinary graduate classes at Oxford during the 1980s. In this article, I assess her contributions to those discussions. She championed the school of philosophers who prefer problem dissolution to problem-solution. She also addressed the problem of realism in psychology. But the contribution that has turned out to be most relevant to subsequent work was her idea that in modelling the mind, we might need to “use (...)
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  13.  25
    The Principle of Biological Relativity: Origins and Current Status.Denis Noble - 2021 - In Jan Voosholz & Markus Gabriel (eds.), Top-Down Causation and Emergence. Cham: Springer Verlag. pp. 117-133.
    This chapter describes the origin of the principle of biological relativity and its development since 2012. It was first formulated by distinguishing between the causal properties of initial and boundary conditions, regarded as a formal cause, compared to the dynamics of the differential functions themselves, regarded as an efficient cause. The concept of organisational level, and of boundaries between levels and environmental factors are also central to the principle. Work on the properties of boundaries reveals two important features: the nature (...)
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  14.  22
    Goals, No-Goals and Own Goals.J. B. C., Alan Montefiore & Denis Noble - 1992 - Philosophical Quarterly 42 (167):264.
  15.  15
    Science between convictions and responsability.Gilbert Hottois, Denis Noble & Jean Vincentelli - 1997 - In Denis Noble, Jean Didier Vincent & György Ádám (eds.), The Ethics of Life. UNESCO.
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  16.  10
    Goals, no-goals, and own goals: a debate on goal-directed and intentional behaviour.Alan Montefiore & Denis Noble (eds.) - 1989 - Boston: Unwin Hyman.
    Athlete after athlete in this book found discipline, hope, and inspiration on the playing field, rising above their circumstances. Filled with first-hand accounts from stars who exemplify the idea of enduring at all costs, Rising Above will serve as a must-read source of inspiration for kids and sports fans of all ages.
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  17. Academic integrity.Denis Noble - 1999 - In Alan Montefiore & David Vines (eds.), Integrity in the Public and Private Domains. Routledge. pp. 166.
  18.  16
    Correction to: Neither Dogmas nor Barriers are Absolute.Denis Noble - 2022 - Biosemiotics 15 (2):391-391.
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  19.  7
    L'éthique du vivant.Denis Noble, Jean Didier Vincent & Union Internationale des Sciences Physiologiques - 1998 - UNESCO.
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  20.  12
    Neither Dogmas nor Barriers are Absolute.Denis Noble - 2022 - Biosemiotics 15 (1):57-60.
    The Weismann Barrier and the Central Dogma do not protect the assumptions of The Modern Synthesis.
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  21.  5
    Postcolonial Criticism, Transnational Identifications and the Hegemonies of Dancehall's Academic and Popular Performativities.Denise Noble - 2008 - Feminist Review 90 (1):106-127.
    Despite the unprecedented freedoms that decolonization has brought for many Black1 people – especially in specific regions of the African Diaspora – freedom and its fulfilment, adequate signs and contested meanings remain a preoccupation within Black cultural discourses and practices. At the same time, while political and cultural nationalisms have led to greater political and civil rights, racism has not been eradicated. Furthermore, the new postcolonial globalizations of capital, people and cultures have destabilized the collective identities that framed twentieth-century struggles (...)
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  22.  8
    The ethics of life.Denis Noble, Jean Didier Vincent & György Ádám (eds.) - 1997 - Paris: UNESCO.
    Papers from a seminar held in Paris, Sept. 1995, organized by the International Union of Physiological Sciences and UNESCO.
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  23.  9
    The language of symmetry.Denis Noble (ed.) - 2023 - Boca Raton, FL: C&H/CRC Press.
    The Language of Symmetry is a re-assessment of the structure and reach of symmetry, by an interdisciplinary group of specialists from the arts, humanities, and sciences at Oxford University. It explores, amongst other topics order and chaos in the formation of planetary systems entropy and symmetry in particle physics group theory, fractals and self-similarity symmetrical structures in western classical music, and how biological systems harness disorder to create order. This book aims to open up the scope of interdisciplinary work in (...)
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  24. The 3rd World Conference on Buddhism and Science (WCBS).Denis Noble - unknown
    Systems Biology is the study of the interactions between the elements (genes, proteins and other molecules) of living systems. Genes do not act in isolation either from each other or from the environment, and so I replace the metaphor of the selfish gene with metaphors that emphasise the processes involved rather than the molecular biological components. This may seem a simple shift of viewpoint. In fact it is revolutionary. Nothing remains the same. There is no 'book of life', nor are (...)
     
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  25.  24
    Modelling of ca2+-activated chloride current in tracheal smooth muscle cells.Etienne Roux, Penelope J. Noble, Jean-Marc Hyvelin & Denis Noble - 2001 - Acta Biotheoretica 49 (4):291-300.
    Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl– current (IClCa) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model IClCa in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple binding site activation by calcium. In order to (...)
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  26.  62
    Scale Relativity: an Extended Paradigm for Physics and Biology? [REVIEW]Charles Auffray & Denis Noble - 2011 - Foundations of Science 16 (4):303-305.
    With scale relativity theory, Laurent Nottale has provided a powerful conceptual and mathematical framework with numerous validated predictions that has fundamental implications and applications for all sciences. We discuss how this extended framework reviewed in Nottale (Found Sci 152 (3):101–152, 2010a ) may help facilitating integration across multiple size and time frames in systems biology, and the development of a scale relative biology with increased explanatory power.
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