5 found
Order:
  1.  16
    Do solidarity and reciprocity obligations compel African researchers to feedback individual genetic results in genomics research?Dimpho Ralefala, Mary Kasule, Ambroise Wonkam, Mogomotsi Matshaba & Jantina de Vries - 2020 - BMC Medical Ethics 21 (1):1-11.
    BackgroundA key ethical question in genomics research relates to whether individual genetic research results should be disclosed to research participants and if so, which results are to be disclosed, by whom and when. Whilst this issue has received only scarce attention in African bioethics discourse, the extension of genomics research to the African continent has brought it into sharp focus.MethodsIn this qualitative study, we examined the views of adolescents, parents and caregivers participating in a paediatric and adolescent HIV-TB genomic study (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   8 citations  
  2.  4
    Understanding cultural values, norms and beliefs that may impact participation in genome‐editing related research: Perspectives of local communities in Botswana.Setlhomo Koloi-Keaikitse, Mary Kasule, Irene Kwape, Dudu Jankie, Dimpho Ralefala, Dolly Mogomotsi Ntseane & Gaonyadiwe George Mokone - forthcoming - Developing World Bioethics.
    Gene‐editing research is a complex science and foreign in most communities including Botswana. Adopting a qualitative deliberative framework with 109 participants from 7 selected ethnic communities in Botswana, we explored the perceptions of local communities on cultural values, norms, and beliefs that may motivate or deter likely participation in the use of gene‐editing related research. What emerged as the ethnic community's motivators for research participation include the potential for gene‐editing technologies to promote access to individualized medications, and the possibility of (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  3.  10
    A case study of researchers’ knowledge and opinions about the ethical review process for research in Botswana.Dimpho Ralefala, Joseph Ali, Nancy Kass & Adnan Hyder - 2018 - Research Ethics 14 (1):1-14.
    Most countries, including Botswana, have established Institutional Review Boards to provide oversight of research involving human beings. Although much has been published on the structure and function of IRBs around the world, there is less literature that empirically describes the perspectives of stakeholders in low- and middle-income country settings regarding IRB processes. In this study, we employed primarily quantitative methods to examine the perceptions of researchers at the University of Botswana about the review of research protocols by local IRBs. Data (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  4.  10
    Participant views on practical considerations for feedback of individual genetic research results: a case study from Botswana.Dimpho Ralefala, Mary Kasule, Olivia P. Matshabane, Ambroise Wonkam, Mogomotsi Matshaba & Jantina de Vries - 2023 - Global Bioethics 34 (1):1-14.
    Key to discussions around feedback of individual results from genomics research are practical questions on how such results should be fed back, by who and when. However, there has been virtually no work investigating these practical considerations for feedback of individual genetic results in the context of low-and middle-income countries (LMICs), especially in Africa. Consequently, we conducted deliberative focus group discussions with 6 groups of adolescents (n = 44) who previously participated in a genomics study in Botswana as well as (...)
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  5.  16
    Should Feedback of Individual Results be Integrated into the Consent Process in African Genomics? Participants’ Views from an HIV-TB Genomics Research Project in Botswana.Dimpho Ralefala, Mary Kasule, Ambroise Wonkam, Mogomotsi Matshaba & Jantina de Vries - 2022 - AJOB Empirical Bioethics 13 (1):48-56.