Democracy is not self‐executing. We have to make it work, and to make it work we have to understand it…Not only external vigilance, but unending self‐examination must be the perennial price of liberty, because the work of self‐government never ceases.
The Cambridge Companion to Socrates is a collection of essays providing a comprehensive guide to Socrates, the most famous Greek philosopher. Because Socrates himself wrote nothing, our evidence comes from the writings of his friends , his enemies, and later writers. Socrates is thus a literary figure as well as a historical person. Both aspects of Socrates' legacy are covered in this volume. Socrates' character is full of paradox, and so are his philosophical views. These paradoxes have led to deep (...) differences in scholars' interpretations of Socrates and his thought. Mirroring this wide range of thought about Socrates, this volume's contributors are unusually diverse in their background and perspective. The essays in this volume were authored by classical philologists, philosophers and historians from Germany, Francophone Canada, Britain and the United States, and they represent a range of interpretive and philosophical traditions. (shrink)
Finally, in four chapters greatly expanded for this edition, Griffin considers the latest scientific research on animal consciousness, pro and con, and...
A biological explanation for the dependence of genome-wide mutation-rate variation on local base context is now becoming clearer. The proportions of G + C relative to A + T—expressed as GC%—is a species-specific DNA character. The frequencies of these single bases correlate with frequencies of corresponding oligonucleotides that are more-sensitive indicators of species specificity. Thus, when k = 3 there are 64 possible trinucleotide sequences and a GC%-rich species has a high frequency of GC-rich 3-mers. Closely related species have similar (...) k-mer patterns. For distantly related species, even if happening to have the same GC% values, k-mer patterns are widely discordant. Conventionally, a base substitution mutation is viewed as a chemical 1-mer phenomenon. However, the selective difference by which the corresponding mutation is scored usually relates to context. Thus, an A to U codon mutation in sickle cell anemia, rather than attracting an anticodon in a structural loop of glutamate tRNA, pairs with the more complementary anticodon loop of valine tRNA. Likewise, a recent statistical analysis of genome-wide mutation-rate variation supports the view that a failure of discordant DNA loops to pair at meiosis can initiate and/or sustain the speciation process. Such disharmony among base patterns may have unknowingly been hinted at by geneticist William Bateson who invoked a music metaphor when considering speciation mechanisms. (shrink)
The Cambridge Companion to Socrates is a collection of essays providing a comprehensive guide to Socrates, the most famous Greek philosopher. Because Socrates himself wrote nothing, our evidence comes from the writings of his friends (above all Plato), his enemies, and later writers. Socrates is thus a literary figure as well as a historical person. Both aspects of Socrates' legacy are covered in this volume. Socrates' character is full of paradox, and so are his philosophical views. These paradoxes have led (...) to deep differences in scholars' interpretations of Socrates and his thought. Mirroring this wide range of thought about Socrates, this volume's contributors are unusually diverse in their background and perspective. The essays in this volume were authored by classical philologists, philosophers and historians from Germany, Francophone Canada, Britain and the United States, and they represent a range of interpretive and philosophical traditions. (shrink)
I argue that consciousness is an aspect of an agent's intelligence, hence of its ability to deal adaptively with the world. In particular, it allows for the possibility of noting and correcting the agent's errors, as actions performed by itself. This in turn requires a robust self-concept as part of the agent's world model; the appropriate notion of self here is a special one, allowing for a very strong kind of self-reference. It also requires the capability to come to see (...) that world model as residing in its belief base , while then representing the actual world as possibly different, i.e., forming a new world-model. This suggests particular computational mechanisms by which consciousness occurs, ones that conceivably could be discovered by neuroscientists, as well as built into artificial systems that may need such capabilities. Consciousness, then, is not an epiphenomenon at all, but rather a key part of the functional architecture of suitably intelligent agents, hence amenable to study as much as any other architectural feature. I also argue that ignorance of how subjective states could be essentially functional does not itself lend credibility to the view that such states are not essentially functional; the strong self-reference proposal here is one possible functional explanation of consciousness. (shrink)
Eminent scientists are well-placed to bring the novel works of others, even if not in their own areas of expertise, to general attention. In so doing, they may be able to extend original accounts or introduce new terminologies, but they are basically messengers, not innovators. In the 1940s an evolutionary theory of biological aging was explained by Peter Medawar, and informational concepts relating to DNA were explained by Erwin Schrödinger. Both explanations were eventually traced back to the Victorian polymath Samuel (...) Butler—one by Medawar’s research associate Alex Comfort, and the other, albeit indirectly, by Schrödinger himself. In his time Butler’s works were too erudite for general readers and too laden with populist jargon for contemporary experts to take seriously. However, today it appears counterfactually plausible that an early acceptance of his ideas would have greatly quickened the pace of research. (shrink)
Four years after the death of Charles Darwin, his research associate, George Romanes, invoked a mysterious process—“physiological selection”—that could often have secured reproductive isolation independently of, and prior to, natural selection, so leading to an origin of species. This postulate of two sequential selection modes can now be regarded as leading to modern “chromosomal,” as opposed to “genic,” speciation theories. Romanes’ abstractions—which confounded many, but not all, of his contemporaries—equate with divergences in parental DNA sequences that impede meiotic pairing in (...) their hybrid offspring, so rendering that offspring sterile. Unlike Darwin, Romanes saw hybrid sterility as a parental, rather than offspring, phenotype that would, within a species, reproductively isolate certain parents from each other while not impeding their crossing with other parents. This group selection would have empowered natural selection to act more advantageously than in its absence. Given suitable conditions, there could then be divergence from one species into two. The present essay introduces Romanes’ “Physiological Selection; an Additional Suggestion on the Origin of Species” 19:337–411; available as supplementary material in the online version of this essay) for the journal’s “Classics in Biological Theory” collection. (shrink)
Sightings of the revolutionary comet that appeared in the skies of evolutionary biology in 1976—the selfish gene—date back to the 19th and early 20th centuries. It became generally recognized that genes were located on chromosomes and compete with each other in a manner consistent with the later appellation “selfish.” Chromosomes were seen as disruptable by the apparently random “cut and paste” process known as recombination. However, each gene was only a small part of its chromosome. On a statistical basis a (...) gene should escape disruption for many generations. This led George Williams and Richard Dawkins to a new definition of the gene, differing from conventional biochemical definitions in that there were no consistent genic boundaries. There had been no previous sightings of another revolutionary, albeit less verbally spectacular, comet that appeared in 1975—the homostability principle of Akiyoshi Wada. Each gene has a base composition “accent” that distinguishes it from its neighbors. We now see that recombination can be triggered by the shift in base composition at genic boundaries. Hence, the Williams-Dawkins definition approaches the conventional definitions. (shrink)
My purpose is to offer an assessment of the scientific legacy of Converse's ?Belief Systems? by reviewing five productive lines of research stimulated by his authoritative analysis and unsettling conclusions. First I recount the later life history of Converse's notion of ?nonattitudes,? and suggest that as important as nonattitudes are, we should be paying at least as much attention to their opposite: attitudes held with conviction. Second, I argue that the problem of insufficient information that resides at the center of (...) Converse's analysis has not gone away, and that newly fashioned models of information processing offer only partial remedies. Third, I suggest that the concept of the ?average voter? is a malicious fiction, as it blinds us to the enormous variation in political attention, interest, and knowledge that characterizes mass publics, in Converse's time as in our own. Fourth, I develop an affirmative aspect of Converse's analysis that has mostly been overlooked: namely, that if ideological reasoning is beyond most citizens? capacity and interest, they might fall back on a simple and reasonable alternative, which I will call ?group?centrism.? And fifth, I consider the possibility that while the majority of individual citizens falls short of democratic standards, the public as a whole might do rather well. (shrink)
Sightings of the revolutionary comet that appeared in the skies of evolutionary biology in 1976—the selfish gene—date back to the 19th and early 20th centuries. It became generally recognized that genes were located on chromosomes and compete with each other in a manner consistent with the later appellation “selfish.” Chromosomes were seen as disruptable by the apparently random “cut and paste” process known as recombination. However, each gene was only a small part of its chromosome. On a statistical basis a (...) gene should escape disruption for many generations. This led George Williams and Richard Dawkins to a new definition of the gene, differing from conventional biochemical definitions in that there were no consistent genic boundaries. There had been no previous sightings of another revolutionary, albeit less verbally spectacular, comet that appeared in 1975—the homostability principle of Akiyoshi Wada. Each gene has a base composition “accent” that distinguishes it from its neighbors. We now see that recombination can be triggered by the shift in base composition at genic boundaries. Hence, the Williams-Dawkins definition approaches the conventional definitions. (shrink)
The philosopher Ludwig Wittgenstein chose as his prime exemplar of certainty the fact that the skulls of normal people are filled with neural tissue, not sawdust. In 1980 the British pediatrician John Lorber reported that some normal adults, apparently cured of childhood hydrocephaly, had no more than 5 % of the volume of normal brain tissue. While initially disbelieved, Lorber’s observations have since been independently confirmed by clinicians in France and Brazil. Thus Wittgenstein’s certainty has become uncertain. Furthermore, the paradox (...) that the human brain’s information content appears to exceed the storage capacity of even normal-sized brains, requires resolution. This article is one of a series on disparities between brain size and its assumed information content, as seen in cases of savant syndrome, microcephaly, and hydrocephaly, and with special reference to the Victorian era views of Conan Doyle, Samuel Butler, and Darwin’s research associate, George Romanes. The articles argue that, albeit unlikely, the scope of explanations must not exclude extracorporeal information storage. (shrink)
In this book, one of the world's leading intellectual historians offers a critical survey of Western historical thought and writing from the pre-classical era to the late eighteenth century. Donald R. Kelley focuses on persistent themes and methodology, including questions of myth, national origins, chronology, language, literary forms, rhetoric, translation, historical method and criticism, theory and practice of interpretation, cultural studies, philosophy of history, and "historicism." Kelley begins by analyzing the dual tradition established by the foundational works of Greek (...) historiography--Herodotus's broad cultural and antiquarian inquiry and the contrasting model of Thucydides' contemporary political and analytical narrative. He then examines the many variations on and departures from these themes produced in writings from Greek, Roman, Jewish, and Christian antiquity, in medieval chronicles, in national histories and revisions of history during the Renaissance and Reformation, and in the rise of erudite and enlightened history in the seventeenth and eighteenth centuries. Throughout, Kelley discusses how later historians viewed their predecessors, including both supporters and detractors of the authors in question. The book, which is a companion volume to Kelley's highly praised anthology Versions of History from Antiquity to the Enlightenment, will be a valuable resource for scholars and students interested in interpretations of the past. (shrink)
The problems, purposes, and methods of history writing have been the subject of debate for almost three millennia. Should history be political or philosophical? Is the writing of history an art or a science? What are the limitations of history? This book is an intriguing collection of views on these and other aspects of history writing by eminent Western historians from early Greece to the end of the eighteenth century. The book contains major texts from 112 historians, both well-known and (...) neglected, ranging from the “mythistories” of Homer and Hesiod to the “reasoned” and “philosophical” accounts of Vico and Voltaire. These texts discuss, for example, theories of historical change, problems of anachronism, narrative, and gender, questions of origins, causation, and historical patterns, and historical criticism. Donald R. Kelley, who selected and arranged the writings, also provides essays and commentary that give background material on the themes of historiography and on the authors included in the book. (shrink)
In Fortunes of History Donald R. Kelley offers an authoritative examination of historical writing during the “long nineteenth century”—the years from the French Revolution to those just after the First World War. He provides a comprehensive analysis of the theories and practices of British, French, German, Italian, and American schools of historical thought, their principal figures, and their distinctive methods and self-understandings. Kelley treats the modern traditions of European world and national historiography from the Enlightenment to the “new histories” (...) of the twentieth century, attending not only to major authors and schools but also to methods, scholarship, criticisms, controversies, ideological questions, and relations to other disciplines. (shrink)
In a regressive tax system, lower-income taxpayers pay larger percentages of their incomes in taxes compared to higher-income taxpayers. Although most policymakers and citizens view regressive taxation as generally unfair and unethical, the U.S. tax system taxes wage, salary, and self-employment income in a manner that deliberately subjects lower-income taxpayers to marginal tax rates that are greater than those imposed on higher-income taxpayers. As a result, some lower-income taxpayers pay a larger percentage of their income in taxes than higher-income taxpayers. (...) In this essay, we argue that this regressiveness in the taxation of salaried income is unfair and unethical. We then evaluate President Obama’s social security plan, which would retain most of the current tax system’s regressive structure. Finally, we offer two simple alternative proposals that are non-regressive, and thus more fair and ethical approaches to the taxation of salaried income. (shrink)
Arthur O. Lovejoy conceived of the history of ideas as an interdisciplinary study, encompassing a variety of fields, including literary history, comparative literature, the history of folklore and ethnography, the history of language and the history of religious beliefs. This volume gathers together some of the most significant articles concerning the theory and practice of intellectual history, by Lovejoy himself and other scholars. Contributors: DONALD R. KELLEY, ARTHUR O. LOVEJOY, FREDERICK J. TEGGART, LEO SPITZER, THEODORE SPENCER, ABRAHAM EDEL, PAUL (...) O. KRISTELLER, PHILIP P. WIENER, JOSEPH A. MAZZEO, LEONARD KRIEGER, DANIEL J. WILSON, EDWARD P. MAHONEY, FRANCIS OAKLEY,JOHANN HUIZINGA, JOSEPH KATZ, CALVIN G. RAND, NILS B. KVASTAD, LESTER G. CROCKER and PATRICK H. HUTTON. (shrink)
Knowing how introns originated should greatly enhance our understanding of the information we carry in our DNA. Gilbert’s suggestion that introns initially arose to facilitate recombination still stands, though not for the reason he gave. Reanney’s alternative, that evolution, from the early “RNA world” to today’s DNA-based world, would require the ability to detect and correct errors by recombination, now seems more likely. Consistent with this, introns are richer than exons in the potential to extrude the stem-loop structures needed for (...) the homology search that can lead to heteroduplex formation and the recognition of base mismatches. In nucleic acid sequences that were unable concomitantly to encode sufficient stem-loop potential, protein-encoding potential was constrained to arise as segments (exons) interrupted by segments rich in stem-loop potential (introns). Thus, sequences with properties that we now deem intronic are likely to have preceded the emergence of exons. (shrink)
Observations suggesting the existence of natural antibody prior to exposure of an organism to the corresponding antigen, led to the natural selection theory of antibody formation of Jerne in 1955, and to the two signal hypothesis of Forsdyke in 1968. Aspects of these were not only first discoveries but also foundational discoveries in that they influenced contemporaries in a manner that, from our present vantage point, appears to have been constructive. Jerne’s later hypothesis (1971, European Journal of Immunology 1: 1–9), (...) that antibody-like receptors on lymphocytes were selected over evolutionary time for reactivity with the major histocompatibility complex (MHC) antigens of the species, was a first, but it was incorrect, and was foundational only to the extent that it emphasized the need to explain the Simonsen phenomenon. Although easily construed as derivative of Jerne (1971), the affinity/avidity model of Forsdyke (1975, Journal of Theoretical Biology 52: 187–198), which predicted that cell-surface components, including MHC antigens, would restrict antigen-reactivity by somatically shaping lymphocyte repertoires, was actually an extension of the two signal hypothesis. While presenting a mechanism for the positive selection of lymphocyte repertoires, and explaining the Simonsen phenomenon, the affinity/avidity model was not foundational in that it had to be independently rediscovered. For science to advance optimally we must seek to close temporal gaps so that first discoveries are also foundational. Listening to young scientists may be part of the solution. (shrink)
What is the relationship between intellectual and cultural history? An answer to this question may be found in the area between the two poles of inquiry commonly known as internalist and externalist methods. The first of these deals with old-fashioned `ideas' (in Lovejoy's sense) and the second with social and political context and the sociology and anthropology of knowledge. This article reviews this question in the light of the earlier historiography of philosophy, literature and science, and debates over the role (...) of context in determining historical meaning. Within the horizon-structure of experience and interpretation the short answer is that cultural history is the outside of intellectual history and intellectual history the inside of cultural history. Ideally, historians ought to work both sides of the historical street. (shrink)
