Alexander Herzen was the most outstanding figure in the early period of the Russian revolutionary movement. Lenin claimed him as a forerunner of the Bolsheviks, and Soviet scholars have sought to establish his latent sympathy with Marxism. In the west on the other hand, he has been seen as a precursor of Solzhenitsyn, the personification of protest against all forms of oppression. Dr Acton provides a compelling intellectual biography. The focus is on the years between 1847 and 1863. Herzen's ideas (...) are set in the context of those political developments and dramatic private experiences that affected his outlook. His profound faith in human nature and in the inevitable triumph of socialism was undermined not only by the failure of the revolutions of 1848, but even more deeply by personal catastrophe - the discovery of the infidelity of his beautiful wife Natalie. This dual blow, Dr Acton shows, had a decisive impact upon Herzen's approach to Russian problems. It lay at the root of the ambivalent attitude he adopted towards peasant revolution in the critical period of Emancipation. (shrink)

The discovery, made in Oxford, that crude penicillin could cure systemic and life‐threatening bacterial infections was followed by attempts to purify penicillin, to determine its structure and then to produce it by total chemical synthesis. The β‐lactam structure of the molecule, first proposed in October 1943, was a source of controversy until 1945. However, no useful chemical synthesis was achieved and fermentation became the commercial source of the antibiotic.In 1953, one of the products of a Cephalosporium sp. from Sardinia was (...) shown to be a new and hydrophilic penicillin (penicillin N). This was contaminated with a substance having the same side‐chain but a characteristic absorption spectrum. The latter, cephalosporin C, showed antibacterial activity but was not inactivated by a penicillinase. The determination of its β‐lactam structure and isolation of its nucleus enabled pharmaceutical companies to produce many semisynthetic cephalosporins.A new tripeptide was later found to be an intermediate in the biosynthesis of both penicillin N and cephalosporin C, and this was followed by the complete elucidation of the biosynthetic pathways leading to these compounds and to benzylpenicillin. (shrink)

Spence develops and applies a normative model based on rationalist and virtue ethics as well as stoic philosophy to assess the impact of technology on wellbeing. Through developing this model, Spence offers a novel and important examination of the benefit of technology to our society as a whole.

This paper grapples with Bernard Williams’s prima vista enigmatic assertion that ‘[w]hether it is a matter of good philosophical sense to treat a practice as a violation of human rights, and whether it is politically good sense, cannot ultimately constitute two separate questions’. Though Williams’s approach to thinking about human rights has a number of affinities with other ‘political’ and ‘minimalist’ understandings, we highlight its distinctive features and argue that it has significant implications for our understanding of human rights along (...) a number of key dimensions. We then proceed to explain how Williams’s way of thinking about human rights coheres with certain aspects of the reasoning of one of the most important international human rights courts, to wit, the European Court of Human Rights. This lends further plausibility to the view that a politically realistic understanding of human rights, of the kind urged by Williams, should be taken seriously, since it is a plausible candidate for the explanation of important aspects of human rights practices. We close by examining the suggestion that thinking in these terms is worryingly conservative. (shrink)

oes anything exist outside culture? Is there anything that we do that is free of the distortions of our tastes and customs? That isn't irrevocably shaped by the languages we speak or our material interests? Is there anything out there that we can assume to be noncultural or transcultural or even universal?

Mutuality, the defining relationship of personal life, provides a meaningful context for unifying and clarifying three facets of personal existence: self-identity, rationality, and freedom.

While reports of sensory encounters with the divine come from a variety of religious traditions, philosophers as diverse as Thomas Aquinas and Robert Oakes have argued that such experiences of incorporeal divine beings are impossible. Nevertheless, by clarifying various relations among acts of perception, perceptual detections of presence and kinds of perceptual recognition, the sensory perception of imperceptible things emerges as a coherent possibility. So, even if they are essentially unobservable, incorporeal divine beings still fall well within the range of (...) normal human sense perception. (shrink)

The main goal of the paper is to indicate some misunderstandings in Ingarden's criticism of vob Bertalanffy's conception of open system.

This article presents a skeleton of a potential paradigm of human flourishing and happiness in a free society. It is an exploratory attempt to construct an understanding from various disciplines and to integrate them into a clear, consistent, coherent, and systematic whole. Holding that there are essential interconnections among objective ideas, the article specifically emphasizes the compatibility of Aristotelianism, Austrian Economics, Positive Psychology, and Ayn Rand’s Objectivism arguing that particular ideas from these areas can be integrated into a paradigm of (...) human flourishing and happiness based on the nature of man and the world. Such a paradigm will help people to understand the world and to survive and flourish in it. It is hoped that the paradigm will grow and evolve as scholars engage, question, critique, interpret, and extend its ideas. Our goal is to have a paradigm that accords with reality and there is always more to learn from reality. (shrink)