Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)
The explosion of publications on race, gender, and minority cultures during recent decades was a natural reaction to the universalistic pretensions of Western philosophy, for which many of these issues were invisible. The theoretical articulation of these issues has substantially contributed to the transformation of philosophy. However, the side-effect of an overemphasis on difference is an underestimating of unity, which may lead to disintegration. The challenge to philosophical thought on race, gender, and culture is to reconcile the difference with commonality, (...) and diversity with unity. This essay explores the issues of cultural identity and intercultural relations and their interpretation in African-Caribbean thought. The first part of the essay surveys the current debate over multiculturalism, which promotes diversity but overlooks the interrelations of cultures, and the alternative ideas of interculturality or the dialogue of cultures. Thedissatisfaction with multiculturalism and postmodern relativism stimulated alternative approaches, such as “transculture” and “intercultural philosophy”. Mikhail Epstein criticizes relativism from the perspective of “critical universalism” and develops the concept of “transculture”. Raúl Fornet-Betancourt’s project of the intercultural transformation of philosophy asserts the cultural embedding of philosophical thinking and draws attention to the indigenous and African thought. The second half of the essay focuses on the ideas of identity and interculturality as they are expressed in African-Caribbean philosophy. This philosophy is viewed as a part of Africana philosophy. Various theoretical approaches to the issues of race and culture are examined: Charles Mills’ concept of “racial contract”, Lewis Gordon’s “Africana philosophy of existence”, and Paget Henry’s project of Africana philosophy, which combines the existentialphenomenological approach with analysis of the discursive formations in search for the identity of this philosophy. The analysis shows that in the evolution of African-Caribbean philosophy, as in Latin American and other “Third World philosophies”, the initial focus on the search for identity is followed by more interest in dialogical relationships with other philosophies as a condition for its own development. (shrink)
Between the later views of Wittgenstein and those of connectionism 1 on the subject of the mastery of language there is an impressively large number of similarities. The task of establishing this claim is carried out in the second section of this paper.
Liberalism is the political philosophy of equal persons, yet liberalism has denied equality to those it saw as black sub-persons. In Black Rights/White Wrongs: The Critique of Racial Liberalism, political philosopher Charles Mills challenges mainstream accounts that ignore this history and its current legacy in the United States today.
White supremacy is the unnamed political system that has made the modern world what it is today. You will not find this term in introductory, or even advanced, texts in political theory. A standard undergraduate philosophy course will start off with plato and Aristotle, perhaps say something about Augustine, Aquinas, and Machiavelli, move on to Hobbes, Locke, Mill, and Marx, and then wind up with Rawls and Nozick. It will introduce you to notions of aristocracy, democracy, absolutism, liberalism, representative government, (...) socialism, welfare capitalism, andlibertarianism. But though it covers more than two thousand years of Western political thought and runs the ostensible gamut of political systems, there will be no mention of the basic political system that has shaped the world for the past several hundred years. And this omission is not accidental. Rather, it reflects the fact that standard textbooks and courses have for the most part been written and designed by whites, who take their racial privilege so much for granted that they do not even see it as political, as a form of domination. Ironically, the most important political system of recent global history-the system of domination by which white people have historically ruled over and, in certain important ways, continue to rule over nonwhite people-is not seen as a political system at all. It is just taken for granted; it is the background against which other systems, which we are to see as political are highlighted. This book is an attempt to redirect your vision, to make you see what, in a sense, has been there all along. (shrink)
The Stance team spoke with Charles Mills, noted philosopher and John Evans Professor of Moral and Intellectual Philosophy at Northwestern University whose work focuses on issues of social class, gender, and race, on December 1, 2014. Dr. Mills reviewed Stance’s transcription of the interview and made slight corrections for grammar, style, and reduction of repetition. He also inserted a sentence or two to add clarity. We hope readers find the result illuminating.
The concept of "fitness" is a notion of central importance to evolutionary theory. Yet the interpretation of this concept and its role in explanations of evolutionary phenomena have remained obscure. We provide a propensity interpretation of fitness, which we argue captures the intended reference of this term as it is used by evolutionary theorists. Using the propensity interpretation of fitness, we provide a Hempelian reconstruction of explanations of evolutionary phenomena, and we show why charges of circularity which have been levelled (...) against explanations in evolutionary theory are mistaken. Finally, we provide a definition of natural selection which follows from the propensity interpretation of fitness, and which handles all the types of selection discussed by biologists, thus improving on extant definitions. (shrink)
In Morals By Agreement, David Gauthier concludes that under certain conditions it is rational for an agent to be disposed to choose in accordance with a fair cooperative scheme rather than to choose the course of action that maximizes his utility. This is only one of a number of important claims advanced in that book. In particular, he also propounds a distinctive view concerning what counts as a fair cooperative arrangement. The thesis concerning the rationality of adopting a cooperative disposition (...) is, however, logically independent of his substantive view of a fair cooperative scheme and is itself central to the project as a whole. Gauthier's concern is to establish that certain moral principles are those that fully rational, self-interested persons would agree to take as regulative of their dealings with one another – that a contractarian approach, in this sense, can provide an adequate basis for a theory of morality. (shrink)
Butler refused to be satisfied with just one leading principle, or rational basis for human action, but in the end settled for three: self-love, to provide for our ‘own private good’; benevolence, to consider ‘the good of our fellow creatures’ ; and conscience, ‘to preside and govern’ over our lives as a whole . By so doing he hoped to ensure a completeness to our ethical scheme, so that nothing would be omitted from our moral deliberations. Yet by so doing (...) he also exposed himself to severe criticism. For any such appeal to a plurality of principles, as Green remarked, is ‘repugnant both to the philosophic craving for unity, and to that ideal of “singleness of heart” which we have been accustomed to associate with the highest virtue’. More specifically, by appealing to a plurality of principles Butler faced the charges of circularity, where the principles come to define and defend each other; inconsistency, where the principles ‘take turns’ at being primary and hence render each other superfluous; and incompleteness, where the ‘primary principle’ is itself undefined or undefended. As the tale has been told Butler stands accused of all three of these errors. (shrink)
This book argues that the philosophical history of India contains a tradition of skepticism about philosophy represented most clearly by three figures: Nāgārjuna, Jayarāśi, and Śrī Harṣa. Furthermore, understanding this tradition ought to be an important part of our contemporary metaphilosophical reflections on the purposes and limits of philosophy.
I articulate and discuss a geometrical interpretation of Yang–Mills theory. Analogies and disanalogies between Yang–Mills theory and general relativity are also considered.
Issues in reproductive ethics, such as the capacity of parents to ‘choose children’, present challenges to philosophical ideas of freedom, responsibility and harm. This book responds to these challenges by proposing a new framework for thinking about the ethics of reproduction that emphasizes the ways that social norms affect decisions about who is born. The book provides clear and thorough discussions of some of the dominant problems in reproductive ethics - human enhancement and the notion of the normal, reproductive liberty (...) and procreative beneficence, the principle of harm and discrimination against disability - while also proposing new ways of addressing these. The author draws upon the work of Michel Foucault, especially his discussions of biopolitics and norms, and later work on ethics, alongside feminist theorists of embodiment to argue for a new bioethics that is responsive to social norms, human vulnerability and the relational context of freedom and responsibility. This is done through compelling discussions of new technologies and practices, including the debate on liberal eugenics and human enhancement, the deliberate selection of disabilities, PGD and obstetric ultrasound. (shrink)
This volume examines the role and influence of multiculturalism in general theories of international law; in the composition and functioning of international ...
Mills argues for a new critical theory that develops the insights of the black radical political tradition. While challenging conventional interpretations of key Marxist concepts and claims, the author contends that Marxism has been 'white' insofar as it has failed to recognize the centrality of race and white supremacy to the making of the modern world.
It is impossible to imagine contemporary critical theory without the work of Michel Foucault. His radical reworkings of the concepts of power, knowledge, discourse and identity have influenced the widest possible range of theories and impacted upon disciplinary fields from literary studies to anthropology. Aimed at students approaching Foucault's texts for the first time, this volume offers: * an examination of Foucault's contexts * a guide to his key ideas * an overview of responses to his work * practical hints (...) on 'using Foucault' * an annotated guide to his most influential works * suggestions for further reading. Challenging not just what we think but how we think, Foucault's work remains the subject of heated debate. Sara Mills' Michel Foucault offers an introduction to both the ideas and the debate, fully equipping student readers for an encounter with this most influential of thinkers. (shrink)
Giorgio Agamben has gained widespread popularity in recent years for his rethinking of radical politics and his approach to metaphysics and language. However, the extraordinary breadth of historical, legal and philosophical sources which contribute to the complexity and depth of Agamben's thinking can also make his work intimidating. Covering the full range of Agamben's work, this critical introduction outlines Agamben's key concerns: metaphysics, language and potentiality, aesthetics and poetics, sovereignty, law and biopolitics, ethics and testimony, and his powerful vision of (...) post-historical humanity. Highlighting the novelty of Agamben's approach while also situating it in relation to the work of other continental thinkers, "The Philosophy of Agamben" presents a clear and engaging introduction to the work of this original and influential thinker. (shrink)
This essay tries to develop a “black radical Kantianism”—that is, a Kantianism informed by the black experience in modernity. After looking briefly at socialist and feminist appropriations of Kant, I argue that an analogous black radical appropriation should draw on the distinctive social ontology and view of the state associated with the black radical tradition. In ethics, this would mean working with a social ontology of white persons and black sub-persons and then asking what respect for oneself and others would (...) require under those circumstances. In political philosophy, it would mean framing the state as a Rassenstaat and then asking what measures of corrective justice would be necessary to bring about the ideal Rechtsstaat. (shrink)
