Replication forks inevitably stall at damaged DNA in every cell cycle. The ability to overcome DNA lesions is an essential feature of the replication machinery. A variety of specialized polymerases have recently been discovered, which enable cells to replicate past various forms of damage by a process termed translesion synthesis. Alternatively, homologous recombination can be used to restart DNA replication across the lesion. Genetic and biochemical studies have shed light on the impact of these two post‐replication repair pathways in bacteria (...) and yeast. In vertebrates, however, a genetic approach to study post‐replication repair has been compromised because many of the genes involved appear to be essential for embryonic development. We have taken advantage of the chicken cell line DT40 to perform a genetic analysis of translesion synthesis and homologous recombination and to characterize genetic interactions between these two pathways in vertebrates. In this article, we aim to summarize our current understanding of post‐replication repair in DT40 in the perspective of bacterial, yeast and mammalian genetics. BioEssays 26:151–158, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Most previous research has demonstrated that receiving ability-focused praise negatively affects intrinsic motivation following failure. Surprisingly, a recent study showed that ability-focused praise affects not only the praisee but also the person offering praise, that is, the praiser. However, evidence of the effects on the praiser is quite limited, despite the utility of praise in education. Therefore, the present study employed face-to-face interaction to advance the knowledge of the effects of praise on the praiser. Two experiments were conducted in which (...) undergraduate participants praised a research confederate. We measured attentional engagement using an eye-tracker as a behavioral indicator of intrinsic motivation, as well as self-reported task enjoyment. To estimate the effect of praise, we combined the results of two experiments and conducted a Bayes factor meta-analysis. The results showed that in the ability praise group, participants’ attentional engagement in a task was significantly lower than in the control group. The present finding indicates that ability-focused praise negatively affects the praiser’s intrinsic motivation and suggests that praise should be used with caution in social and educational contexts. (shrink)

Friedrich Nietzsche's work has had a significant impact on the intellectual life of non-Western cultures and elicited responses from important thinkers outside of the Anglo-American philosophical traditions as well. Bringing together thirteen internationally renowned scholars, this is the first collection of essays to address the connection between Nietzsche's ideas and philosphies in India, China, and Japan. The contributors are Roger T. Ames, Johann Figl, Chen Guying, Michel Hulin, Arifuku Kogaku, David A. Kelly, Glen T. Martin, Sonoda Muneto, Graham Parkes, (...) okochi Ryogi, Eberhard Scheiffele, Mervyn Sprung, and Joan Stambaugh. "Exemplary. Its comparative approach is incisive yet accessible. I consider it a 'must read'"—Kathleen Marie Higgins, _Philosophy East and West_ "An excellent introduction to the broad ranging reception of Nietzsche among Asian thinkers."—James R. Watson, _Canadian Philosophical Review_ "The essays in this welcome collection are invariably thought-provoking and genuinely cross-disciplinary."—Kenneth Surin, _Religious Studies Review_ "A worthy and undogmatic introduction to several fascinating questions concerning the relations between Nietzschean thought and certain traditions of thought in India, China, and Japan."—Don Miller, _Asian Studies Review_. (shrink)