The issue of benefits in international clinical research is highly controversial. Against the background of wide recognition of the need to share benefits of research, the nature of benefits remains strongly contested. Little is known about the perspectives of research populations on this issue and the extent to which research ethics discourses and guidelines are salient to the expectations and aspirations existing on the ground. This exploratory study contributes to filling this void by examining perspectives of people in low-income South (...) African communities on benefits in international clinical research. Twenty-four individuals with and without experience of being involved in clinical research participated in in-depth interviews. Respondents felt that ancillary care should be provided to clinical research participants, while a clinical study conducted in particular community should bring better health to its members through post-trial benefits. Respondents' perspectives were grounded in the perception that the ultimate goal of international clinical research is to improve local health. We argue that perspectives and understandings of the respondents are shaped by local moral traditions rather than clinical research specificities and require attention as valid moral claims. It is necessary to acknowledge such claims and cultural worlds from which they emerge, thus building the foundation for equal and embracing dialogue to bridge different perspectives and handle contradicting expectations. (shrink)

Italian philosopher Giorgio Agamben—whose work has influenced intellectuals in political theory, political philosophy, legal theory, literature, and art—stands among the foremost intellectual figures of the modern era. Engaging with a range of thinkers from Carl Schmitt and Martin Heidegger to Jacques Rancière and Alain Badiou, Agamben considers some of the most pressing issues in recent history and politics. His work explores the relationship between the sovereign state and the politically marginalized _Homo Sacer_—exiles, refugees, prisoners of war, and others whom the (...) state actively excludes from political participation and full humanity. Further, his critique of the increasing deployment of a “state of exception”—the declaration of a state of emergency that legitimizes the sovereign state’s suspension of law for the public good—as a dominant paradigm for governing has particular power in today’s global political climate. Infused with the spirit of Agamben’s critical self-reflection, this special issue of _SAQ_ examines his seminal works _Homo Sacer_, _The Open_, and _State of Exception_. Some contributors use Agamben’s work to examine the history of abortion law in the West, the history of slavery, and women’s rights. Others analyze the connections between Agamben’s work and that of his contemporaries, including Jacques Derrida, Slavoj Žižek, and Jean-Luc Nancy. Still other essays identify new points of interdisciplinary communication between some of Agamben’s most provocative ideas and popular twentieth-century writing. _Contributors_. Andrew Benjamin, Claire Colebrook, Jean-Philippe Deranty, Penelope Deutscher, Eleanor Kaufman, Adrian Mackenzie, Catherine Mills, Alison Ross, Lee Spinks, Ewa Płonowska Ziarek, Krzysztof Ziarek. (shrink)

Patient visits are an important opportunity for general practitioners to discuss the risks of smoking and cessation strategies. In Australia, the guidelines on cessation published by the Royal Australian College of General Practitioners represent a key resource for GPs in this regard. The predominant message of the Guidelines is that pharmacotherapy should be recommended as first-line therapy for smokers expressing an interest in quitting. This, however, ignores established evidence about the success of unassisted quitting. Our analysis of the Guidelines identifies (...) a number of potential conflicts of interest which may have affected the advice provided. These include extensive funding by the pharmaceutical industry of sources cited to support the recommendations, and relations between members of the Guidelines Content Advisory Group and the pharmaceutical industry. Recommendations issued by professional bodies have enormous potential impact upon public health and there is a need for the highest levels of scrutiny and transparency in their development. Information about research cited in guidelines should include funding sources, and developers should be free of obvious conflicts of interest. Smoking remains the leading preventable cause of global mortality. Concerns related to pharmaceutical industry funding of research, scientific integrity and recommendations on smoking cessation by medical advisory groups clearly have implications beyond Australia. (shrink)

Jonathan Quong Ethics, 119, 507–537 has recently argued that the permissibility of killing innocent threats turns on a distinction between eliminative and opportunistic agency. When we kill bystanders we view them under the guise of opportunism by using them as mere survival tools, but when we kill threats we simply eliminate them. According to Quong, the distinction between opportunistic and eliminative agency reveals that there are two different ways of killing someone as a means to save your own life. Call (...) this the Means Distinction. In this note, I argue that although the Means Distinction seems prima facie plausible it is not a sufficient explanation for the permissibility of killing threats. My argument against the Means Distinction is two-fold. Most non-consequentialists accept that the Means Distinction carries some moral significance, but I argue that this is a mistake: we do not have any reason to believe that opportunistic killings are, in general, worse than eliminative killings. Following this, I argue that even if we accept the Means Distinction, there are threat-type scenarios in which there is no intuitive difference between killing a threat opportunistically and killing a threat eliminatively. (shrink)

Academic integrity policies at 200 institutions of higher education were examined for the presence of academic prohibitions against the nonmedical use of prescription stimulants or any other cognitive enhancing drug. Researchers used online search tools to locate policy handbooks in a stratified random sample of IHE’s drawn from the Integrated Postsecondary Education Data System database, searching for NMUPS/CED use as violations of either academic integrity or alcohol and other drug policies. Of 191 academic integrity policies found online, NMUPS/CED prohibitions were (...) present in only one. However, NMUPS was addressed in all but two of the 200 IHE AOD policies, often with language referencing IHE adherence to federal or state law. NMUPS/CED prohibitions are predominantly absent in IHE academic integrity policies, raising questions about whether colleges and universities are concerned about the use of enhancement drugs as a form of cheating. Implications for fairness, health promotion, and future research are discussed. (shrink)

Ted Honderich, Philosopher: A Kind of Life, London: Routledge, 2001, 472 pp., ?30, ISBN 0415236975 .Colin McGinn, The Making of a Philosopher: My Journey Through Twentieth-Century Philosophy, New York: HarperCollins, 2002, 256 pp., $25.95, ISBN 0060197927.

To avoid the deadends, I redeploy[52] the idea that integral human freedom (and understanding) has two modes. One is "natural" and the other "supernatural," though dividing the matter that way supposes the "natural" is the residue after the integrated whole is lost, because the supernatural[53] contains the natural "eminently" the way olympic winning routines envelop the qualifying skills.[54] In my account, humans were never "merely" objects in nature at all-- that is, objects, alongside stones and tigers and dinosaurs, that are (...) entirely consequences of matter and biotic life, or explicable the way trees and volcanos are. Humans never had a "completion"-- a fulfilment-- that can be defined by conditions of earthly life or attained by "flourishing," as other living things do.[55]. (shrink)

Mitochondrial genomes represent relict bacterial genomes derived from a progenitor α‐proteobacterium that gave rise to all mitochondria through an ancient endosymbiosis. Evolution has massively reduced these genomes, yet despite relative simplicity their organization and expression has developed considerable novelty throughout eukaryotic evolution. Few organisms have reengineered their mitochondrial genomes as thoroughly as the protist lineage of dinoflagellates. Recent work reveals dinoflagellate mitochondrial genomes as likely the most gene‐impoverished of any free‐living eukaryote, encoding only two to three proteins. The organization and (...) expression of these genomes, however, is far from the simplicity their gene content would suggest. Gene duplication, fragmentation, and scrambling have resulted in an inflated and complex genome organization. Extensive RNA editing then recodes gene transcripts, and trans‐splicing is required to assemble full‐length transcripts for at least one fragmented gene. Even after these processes, messenger RNAs (mRNAs) lack canonical start codons and most transcripts have abandoned stop codons altogether. (shrink)

Where Men Hide is a spirited tour of the dark and often dirty places men go to find comfort, camaraderie, relaxation, and escape. Ken Ross's striking photographs and James B. Twitchell's lively analysis trace the evolution of these virtual caves, and question why they are rapidly disappearing. They find that for centuries men have met with each other in underground lairs and clubhouses to conduct business or to bond and indulge in shady entertainments. In these secret dens, certain rules (...) are abandoned while others are obeyed. Twitchell connects the places men hide with figures like Hemingway and Huck Finn, Frederick Jackson Turner's theory of the American frontier, and the mythological interpretations of Joseph Campbell and Robert Bly. Documenting both traditional and contemporary male haunts, Twitchell and Ross examine the provenance, purpose, and appeal of this little-discussed and controversial phenomenon. (shrink)

This book discusses the complexities of love and the nature of erotic passion as these appear in the great love stories of the world. Starting with the story of Romeo and Juliet and its roots in European Christianity, the authors uncover hidden depths of cultural and universal significance in famous romantic tales of the Middle East and the Indian Subcontinent-'Layla and Majnun', 'Heer and Ranjha', 'Sohni and Mahinwal', 'Vis and Ramin', and 'Radha and Krishna'. Moving westward again, Kakar and (...) class='Hi'>Ross look at the Greek myth of Oedipus, the Celtic saga of Tristan and Isolde, the tragic drama of Hamlet, the legend of Phaedra and Hippolytus, and a contemporary handling of the love theme in the writings of Vladimir Nabokov. This new edition, published after 25 years of the first edition, includes an Epilogue which re-evaluates the authors' assertions about romantic and erotic love in the context of contemporary psychoanalysis and modern literary theory. (shrink)

This article argues thatPanegyricus LatinusXII(9), a speech performed before Constantine in Trier in 313c.e.following his defeat of Maxentius the previous year, acted as a crucial localized act of communication to the emperor. Through a series of allusions and the careful presentation of his narrative, the orator made a case for the continued political and cultural importance of Trier within the newly expanded Constantinian empire.

Evidence for an EEA-derived domain-specific inference system must point to an active, latent representational structure. Otherwise we need to hypothesize only passive, virtual belief not over-ridden on the basis of the individual's experience. The folk economic beliefs identified by Boyer & Petersen (B&P), being with one exception about macroeconomics, might be virtual beliefs that people extrapolate across the micro–macro scale shift based on their experiences with markets.

This paper critically discusses Amartya Sen’s case for broadening the basket of wellbeing indicators in development policy beyond income and consumption expenditure. I first argue that, contrary to what Sen has suggested, the theoretical and practical motivations that he gives for this do not form a mutually complementary set. In the second, policy-focused, part of the paper I present problems Sen’s approach to measurement raises in the context of a case study from rural South Africa. I conclude by suggesting that (...) development indicators should be regarded as narrower – in particular, that we should give privileged attention to women’s incomes – rather than broader. Keywords: development policy; well-being proxies; welfare; Amartya Sen Word count: 11,315.. (shrink)

Michael Murrin’s work on allegory provides an instructive contrast to Stephen Greenblatt’s Aristotelian conception of art as representation. This essay argues that Christian Platonism created the allegorical mode in which Spenser wrote, allowing a different perspective of the self than the one Greenblatt describes in Renaissance Self-Fashioning. The essay then suggests that those Christian thinkers (cited by Greenblatt in The Swerve) who rejected Lucretius and Epicureanism did so for philosophical reasons deeply grounded in Plato’s thought–reasons that in the twentieth century (...) found a home in the work of C. S. Lewis. (shrink)

Traces Western ideas of corporeal bodies from Plato to contemporary feminist and postructuralist writings, with the purpose of reexamining the good, identified in Plato as that which gives authority to knowledge and truth.

Explores themes of dispossession, shattering, and fragmentation that arise in contemporary writings from the point of view of the selves whose subjectivities and practices are said to be fragmented, shattered, and dispossessed.

There are approximately one million cases oftype 1 diabetes in the US, and the incidenceis increasing worldwide. Given that two-thirdsof cases present in childhood, it is criticalthat prediction and prevention research involvechildren. In this article, I examine whethercurrent research methodologies conform to theethical guidelines enumerated by the NationalCommission for the Protection of Human Subjectsof Biomedical and Behavioral Research, andadopted into the federal regulations thatprotect research subjects. I then offer twopolicy recommendations to help researchersdesign studies that conform to these ethicalrequirements.

This paper considers the particular ways in which the familiar letter and twenty-first century technologies like the Internet differingly shaped and shape our experience of distance and presence. It follows Heidegger, Dreyfus, and Borgmann in critiquing the kinds of experience and action the Internet makes possible, and—by way of Benjamin’s concept of “aura”—argues that while mediated communication over distance might have never been easier, faster, or cheaper, this increase in our effective power comes at the cost of a diminution of (...) the affective power of the messages carried. (shrink)

There are many general economic policies I favour such that I would feel significantly ashamed were I to succumb to bribery, or to institutional pressure short of physical threat, to publicly support their opposites. Here are a few of these policies: (1) Rich countries should not impose trade barriers, including subsidies for their own producers, against imports from poor countries. (2) Leaders of poor countries should be regarded as irresponsible when they imply to their people that their economic difficulties arise (...) principally from wickedness and exploitative behavior on the part of rich countries – the moral urgency of (1) notwithstanding. (3) Much freer movement of people across national borders for purposes of labour should be allowed everywhere. (4) Destitution is an unduly severe penalty for laziness, lack of talent or intelligence, or bad luck. More productive people should provide the lazy, the unskilled and the unlucky with as large a basic income grant as is compatible with maximizing net social productivity (which no present society comes very close to doing, partly due to confused social morality and partly due to incentive-distorting tax systems). (shrink)

Beauty pageants are ubiquitous around the world, and their importance in many cultures is indisputable. This paper empirically examines those factors that contribute to beauty pageant success in a cross-national setting. Our analysis pays particular attention to the role of market liberalism, i.e., economic freedom, in the process. The results indicate that nations with higher economic freedom scores are underrepresented among Miss Universe semifinalists after controlling for other relevant determinants.

A clinical scenario is described where an anaesthetist is concerned about the seemingly high risk/benefit ratio relating to laparoscopic versus standard inguinal hernia operations. Some options for further action by the anaesthetist are introduced. The remainder of the paper explores the question of who can legitimately assess the acceptability of risk/benefit ratios, and defends the use of practice guidelines at the expense of so called clinical freedom. It is argued that respect for persons is not breached by limiting the treatment (...) options offered to patients to those therapies which have a ‘reasonable’ risk/benefit ratio. This ‘reasonableness’ is context dependent, and should be properly decided by those with expertise in the field. (shrink)

Memory is, therefore, neither perception nor conception, but a state or affection of one of these, conditioned by lapse of time. As already observed, there is no such thing as memory of the present while present; for the present is object only of perception, and the future, of expectation, but the object of memory is the past. All memory, therefore, implies a time elapsed; consequently only those animals which perceive time remember, and the organ whereby they perceive time is also (...) that whereby they remember. (Aristotle, OM, 449b24–30). (shrink)

Man, in the analytic of finitude, is a strange empirico-transcendental doublet, since he is a being such that knowledge will be attained in him of what renders all knowledge possible. (Foucault, OT, 318)Man is a mode of being which accommodates that dimension-always open, never finally delimited, yet constantly traversed-which extends from a part of himself not reflected in a cogito to the act of thought by which he apprehends that part; and which, in the inverse direction, extends from that pure (...) apprehension to ... the whole silent horizon of what is posited in the sandy stretches of non-thought .... The question is no longer: How can experience of nature give rise to necessary judgements? But rather: How can man think what he does not think, inhabit as though by a mute occupation something that eludes him, animate with a kind of frozen movement that figure of himself that takes the form of a stubborn exteriority? (pp. 322-3). (shrink)