would like for them to know that I am in pain or this part of my body hurts or the other part hurts — that I am not lying about it. To examine me and to cut down on the pain….And help me out.Patient with Sickle Cell Disease, Focus Group ParticipantPain in the United States is widely recognized to be undertreated; however, the capacity to treat pain has never been greater. The causes of this undertreatment are varied. As we focus (...) on pain and why it is too often ineffectively treated, we also discover that this undertreatment afflicts some more than others. What divides the some from the others isn't limited to one factor, but one particularly disturbing factor is race and ethnicity. Racial and ethnic minority populations are at higher risk for oligoanalgesia, or the ineffective treatment of pain. Only through further study of the differences in pain treatment based on race and ethnicity can we develop strategies to reduce the disparities in care. (shrink)

There is a longstanding debate about genetics research into intelligence. Some scholars question the value of focusing on genetic contributions to intelligence in a society where social and environmental determinants powerfully influence cognitive ability and educational outcomes. Others warn that censoring certain research questions, such as inquiries about genetic differences in intellectual potential, compromises academic freedom. Still others view interest in this subject as a corollary to a long and troublesome history of eugenics research. The dawn of a new era (...) in genome sequencing as a commodity will sustain scientific interest in the genetics of intelligence for the foreseeable future, but deep‐rooted challenges threaten the scientific merit of the research. The use of imprecise definitions of study populations, the difficult nature of studying the environment, and the potential of researcher bias are inextricably linked with concerns about the trustworthiness and utility of research in this area. Leadership by the genetics community is essential to ensure the value and trustworthiness of these studies. (shrink)

Hastings Center Report, Volume 52, Issue S1, Page S83-S88, March‐April 2022.

Background Noninvasive prenatal testing (NIPT) designed to screen for fetal genetic conditions, is increasingly being implemented as a part of routine prenatal care screening in the United States (US). However, these advances in reproductive genetic technology necessitate empirical research on the ethical and social implications of NIPT among populations underrepresented in genetic research, particularly Black women with sickle cell disease (SCD).Methods Forty (N = 40) semi-structured interviews were conducted virtually with Black women in the US (19 participants with SCD; 21 (...) participants without SCD) from June 2021 to January 2022. We employed a qualitative approach to examine the study participants’ perceptions of the potential advancement of NIPT for screening SCD in the fetus. Data were analyzed using NVivo 12 qualitative software.Results The themes revealed the complexities involving the intersectional lived experiences of SCD, prenatal care, lack of synergy among health providers, and NIPT decision-making. The results further revealed that even when Black women have shared commonalities in their lived experiences while navigating SCD and motherhood, their perceptions of NIPT screening technologies are divergent.Conclusion Expanding the ethical discourse on the social implications of NIPT is critical to fully elucidate how Black women perceive NIPT’s utility, particularly as NIPT advances to screen for SCD in the fetus. Neglecting to include Black women with genetic conditions in empirical studies on NIPT may contribute to ongoing health inequities and limit and constrain reproductive choices among Black women with and without SCD. (shrink)

Genetic research aimed at understanding human health and disease is grounded in the study of genetic variation. The inclusion of research subjects with diverse ancestral backgrounds is essential for genetic and genomic research that fully explores human diversity. Large-scale cohort studies and biobanks in Europe and the United States often do not include the breadth of ethnic and racial diversity observed in their countries' citizens. This article explores the findings of a qualitative study of U.S. scientists' understanding and views of (...) the NIH Policy and Guidelines on the Inclusion of Minorities as Subjects in Clinical Research. The findings suggest that the policy restricts how scientists use racial and ethnic categories to define and report their study populations and does little to motivate their efforts to increase the inclusion of non-European ancestral populations in genetic and genomic research. (shrink)

As genetic and genomic research has progressed since the sequencing of the human genome, scientists have continued to struggle to understand the role of genetic and socio-cultural factors in racial and ethnic health disparities. Recognition that race and ethnicity correlate imperfectly with differences in allele frequency, environmental exposures, and significant health outcomes has made framing the relationship between genetic variation, race, ethnicity, and disease one of the most heated debates of the genome era. Because racial and ethnic identities reflect a (...) complicated mix of social and genetic factors, critics have argued that use of racial and ethnic categories as analytical variables in biomedical research lacks rigor, leads to potentially dangerous stereotyping in medical practice, and sends harmful messages of innate racial difference to the broader public.Concerns over the current lack of diversity in human genetic and genomic studies have developed in parallel to discussions of the appropriate use of racial and ethnic categories during the research process. (shrink)

Increasing complexity and specialisation of modern sciences has led to increasingly collaborative publications, as well as the involvement of commercial services. Modern integrative taxonomy likewise depends on many lines of evidence and is increasingly complex, but the trend of collaboration lags and various attempts at ‘turbo taxonomy’ have been unsatisfactory. We are developing a taxonomic service in the Senckenberg Ocean Species Alliance to provide fundamental data for new species descriptions. This will also function as a hub to connect a global (...) network of taxonomists, assembling an alliance of scientists working on potential new species to tackle both the extinction and inclusion crises we face today. The current rate of new species descriptions is simply too slow; the discipline is often dismissed as old fashioned, and there is a crisis level need for taxonomic descriptions to come to grips with the scale of Anthropocene biodiversity loss. Here, we envision how the process of describing and naming species would benefit from a service supporting the acquisition of descriptive data. Also see the video abstract here: https://youtu.be/E8q3KJor_F8. (shrink)

In the present paper, I argue against a naturalistic conception of epistemology. I do this by showing, among other things, that conceptual intuition, which constitutes the proper method of the analytic conception of epistemology, is methodologically superior to the best method available to naturalistic epistemology.Resumo: Nós argumentamos aqui contra uma concepção naturalista de epistemologia. Nós o fazemos mostrando, entre outras coisas, que a intuição conceitual, que é o método próprio da concepção analítica de epistemologia, é superior metodologicamente ao melhor método (...) disponível à epistemologia naturalista. (shrink)

Sumário - Introdução; Ética e política; Jornada de seis horas; As utopias do século XXI; Dois mil e cinquenta; Política e ética; Política e ética II; Política e ética III; Desenvolvimento moral; O programa de direitos humanos; A verdade e o futuro da nação; Restaurando a ética; Moral e interesse; A eficácia sempre vence; A volta da política; O policial Beltrame; O amor cidadão.

El estudio de la akrasía o incontinencia que Aristóteles abre en el libro VII de Ética a Nicómaco es una de las primeras aproximaciones filosóficas al problema de la maldad específicamente humana. Este artículo comienza identificando el tipo humano que revela la akrasía, señalando su importancia filosófica y exponiendo brevemente la explicación aristotélica del fenómeno. Después categoriza las diferentes formas que puede asumir la transgresión de los propios principios morales, según dos criterios independientes. Por un lado, el tipo de deseo (...) que vence a la razón. Por otro lado, el momento del razonamiento práctico en el que tiene lugar la akrasía. Cruzando ambos criterios, encontramos una tipología rica y matizada de la akrasía, así como de la enkráteia. Asimismo, se ofrece una interpretación del valor moral de esta tipología, en el que cada uno de los tipos akrásicos merece una determinada calificación ética. Finalmente, esta evaluación ilumina la propia concepción ética y antropológica de Aristóteles. (shrink)

En el presente trabajo analizamos el tratamiento que hace Isidoro de Sevilla, la más ilustre figura de la cultura hispanovisigoda, que ejerció un notabilísimo influjo durante todo el medievo a lo largo y ancho de la cristiandad, del problema de la pobreza y la injusticia social. En los dos primeros epígrafes estudiamos sus consideraciones teóricas para entender y concebir el problema, y en el tercero nos detenemos en sus tres propuestas prácticas para afrontar –y, quizá, vencer– el mal que representan (...) la pobreza y la injusticia social: justicia, comunidad y, sobre todo, caridad. En un cuarto apartado recogemos las principales conclusiones y, como refuerzo y complemento a lo estudiado, ofrecemos al lector unos breves himnos de la liturgia hispana altomedieval –testigos del mismo espíritu que movió al obispo de Sevilla– que ahondan en la idea central de la propuesta isidoriana: que solo el aumento y ejercicio de la caridad, amor Dei et proximi, puede vencer el mal de la pobreza y la injusticia social, porque solo el amor vence siempre. (shrink)

¿Qué es un héroe de la emancipación? Rousseau comparaba el héroe antiguo, un guerrero triunfante que vence a los enemigos de su país, con el verdadero héroe, aquel que es capaz de posponer su singularidad en vistas a promover la acción común del pueblo soberano. De acuerdo con Miguel Abensour, la Revolución francesa redefine el heroísmo político como la capacidad de iniciar algo cuyo resultado es aún imprevisible, estableciendo así una nueva sociedad en la cual las figuras del héroe (...) y del legislador coinciden, anudando una enigmática relación entre esclavitud y libertad, y estableciendo un orden que sobrepasa las divisiones generadas por los intereses injustos. Pero si "el héroe es el verdadero sujeto de la modernidad" , ¿no es la posibilidad del heroísmo en la prosaica sociedad moderna y postrevolucionaria la llave de salida del siglo XIX? ¿Qué pensar de una figura heroica como la de Simón Bolívar, el usurpador del título de Libertador, según Benjamin Constant; el Napoleón de las retiradas, según Marx? ¿El partero de la emancipación, según escriben Pierre Leroux y Jean Reynaud en la Nueva Enciclopedia? ¿La luminaria de la emancipación del pueblo americano caído en la esclavitud, como dirá Juan Montalvo? Who is a hero of emancipation? Rousseau contrasted the ancient hero, a triumphant worrier who defeats the enemies of his country, with the true hero, the one who is able to surrender his singularity in order better to promote the collective agency of a sovereign people. The French revolution, according to Miguel Abensour, redefines political heroism as the ability to initiate something in the unpredictability of the result, establishing therefore a new society in which the figures of the hero and the legislator coincide, broaching an enigmatic relationship between bondage and freedom, and establishing an order that supersedes the divisions generated by unjust desires. But if "the hero is the true subject of modernity" is not the possibility of heroism in a prosaic modern post-revolutionary society the key issue of the nineteenth century? What to think of a heroic figure like Simon Bolivar, - the usurper of the title Libertador ? The Napoleon of the retreats ? The accoucheur of the emancipation, ? The emancipating luminary of the American people fallen in bondage ? (shrink)