Erythropoietin (EPO), long appreciated as the chief endocrine regulator of red blood cell formation, is now recognized to exert many additional functions outside the bone marrow. Thus, the quest is on to define the full range of EPO functions in the physiology and pathology of non‐hematopoietic tissues. Two recent studies in man and mice have highlighted the importance of the mammalian skin as one peripheral tissue with a previously unsuspected role in EPO biology; both, as a target and as a (...) source of EPO. In addition, the skin has been proposed to function as an oxygen sensor. The present hypothesis essay critically reviews the currently available evidence for this and provides a unifying theoretical scenario for intracutaneous EPO functions and for a potential role of the skin in the control of EPO production. Mainly, we propose that the skin itself directly contributes to the up‐regulation of EPO plasma levels in response to hypoxia. (shrink)

In the context of mainstream feminism, Eastern-European women, coming from a post-Communist context are overwhelmed. As they have been unable to access the newest developments of feminist thought, feminist theology, they cannot find their own place and voice. In order to overcome this state of mind, this article puts forward an approach and a strategy. Drawing from the main ideas of contemporary Romanian and Transylvanian feminists – Mihaela Mudure, Mihaela Miroiu, Réka Geambasu, Enikő Magyari-Vincze and others – the article aims (...) to start the quest for a fitting Eastern European-type of feminism. Post-Communist countries are the so-called ‘second world’. They need to find their own way, their own voice, similar to the ‘third world’, which has already started to do so. The knowledge and reception of the international feminist movement and its main oeuvre can help Central and Eastern European women theologians find those aspects that have supported others. Stating the specific situation of ‘second world’ women and seeking the theological aspects that describe their position and problems adequately, they can contribute to finding their one and only special voice. (shrink)

Faced with an ever-growing number of ethical marketing issues and uncertainty about the impact of specialized ethics journals, researchers are struggling to keep abreast of developments in the field. In order to address these challenges, our paper provides a comprehensive review of the literature on marketing ethics over almost 50 years, offers a citation analysis and develops a unique marketing ethics impact factor (MEIF). We contribute to the field in three important ways. First, we present a state-of-the-art picture of marketing (...) ethics research. This provides an account of the research focus in each decade, assesses the importance of specific topics in the debate and identifies existing research gaps. Second, we identify the most influential papers and researchers in the marketing ethics area. Third, we evaluate the most important journals in terms of their impact on marketing ethics. To this end, we have developed an MEIF. This improves our ability to judge a journal's influence on this particular sub-discipline. (shrink)

pt. I. Fundamentals of marketing ethics -- pt. II. Ethics in international marketing practice : cases -- pt. III. Readings in international marketing ethics -- pt. IV. Business ethics resources.

Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles (...) and behavioural variables might be breed-specific. In the current study, we found that Siberian huskies with the A allele approached a friendly unfamiliar woman less frequently in a greeting test, which indicates that certain polymorphisms are related to human directed behaviour, but that the relationship patterns between polymorphisms and behavioural phenotypes differ between populations. This finding was further supported by our next investigation. According to primate studies, endogenous opioid peptide (e.g. endorphins) receptor genes have also been implicated in social relationships. Therefore, we examined the rs21912990 of the OPRM1 gene. Firstly, we found that the allele frequencies of Siberian huskies and gray wolves were similar, but differed from that of Border collies and German shepherd dogs, which might reflect their genetic relationship. Secondly, we detected significant associations between the OPRM1 SNP and greeting behaviour among German shepherd dogs and a trend in Border collies, but we could not detect an association in Siberian huskies. Although our results with OXTR and OPRM1 gene variants should be regarded as preliminary due to the relatively low sample size, they suggest that (1) OXTR and OPRM1 gene variants in dogs affect human-directed social behaviour and (2) their effects differ between breeds. (shrink)

This paper compares the results of large-scale U.S. and U.K. surveys designed to identify managers' major ethical concerns and to investigate how firms are formulating and communicating ethics policies responsive to these concerns.Our findings indicate some important differences between U.S. and U.K. firms in perceptions of what are important ethical issues, in the means used to communicate ethics policies, and in the issues addressed in ethics policies and employee training. U.K. companies tend to be more likely to communicate ethics policies (...) through senior executives, whereas U.S. companies tend to rely more on their Human Resources and Legal Departments. U.S. firms consider most ethical issues to be more important than do their U.K. counterparts, and are especially concerned with employee behavior which may harm the firm. In contrast, the issues which U.K. managers consider more important tend to be concerned with external corporate stakeholders rather than employees. (shrink)

Some spoken words are iconic, exhibiting a resemblance between form and meaning. We used native speaker ratings to assess the iconicity of 3001 English words, analyzing their iconicity in relation to part-of-speech differences and differences between the sensory domain they relate to. First, we replicated previous findings showing that onomatopoeia and interjections were highest in iconicity, followed by verbs and adjectives, and then nouns and grammatical words. We further show that words with meanings related to the senses are more iconic (...) than words with abstract meanings. Moreover, iconicity is not distributed equally across sensory modalities: Auditory and tactile words tend to be more iconic than words denoting concepts related to taste, smell and sight. Last, we examined the relationship between iconicity and systematicity. We find that iconicity in English words is more strongly related to sensory meanings than systematicity. Altogether, our results shed light on the extent and distribution of iconicity in modern English. (shrink)

Some spoken words are iconic, exhibiting a resemblance between form and meaning. We used native speaker ratings to assess the iconicity of 3001 English words, analyzing their iconicity in relation to part-of-speech differences and differences between the sensory domain they relate to. First, we replicated previous findings showing that onomatopoeia and interjections were highest in iconicity, followed by verbs and adjectives, and then nouns and grammatical words. We further show that words with meanings related to the senses are more iconic (...) than words with abstract meanings. Moreover, iconicity is not distributed equally across sensory modalities: Auditory and tactile words tend to be more iconic than words denoting concepts related to taste, smell and sight. Last, we examined the relationship between iconicity and systematicity. We find that iconicity in English words is more strongly related to sensory meanings than systematicity. Altogether, our results shed light on the extent and distribution of iconicity in modern English. (shrink)

We have evolved to become who we are, at least in part, due to our general drive to create new things and ideas. When seeking to improve our creations, ideas, or situations, we systematically overlook opportunities to perform subtractive changes. For example, when tasked with giving feedback on an academic paper, reviewers will tend to suggest additional explanations and analyses rather than delete existing ones. Here, we show that this addition bias is systematically reflected in English language statistics along several (...) distinct dimensions. First, we show that words associated with an increase in quantity or number (e.g., add, addition, more, most) are more frequent than words associated with a decrease in quantity or number (e.g., subtract, subtraction, less, least). Second, we show that in binomial expressions, addition-related words are mentioned first, that is, add and subtract rather than subtract and add. Third, we show that the distributional semantics of verbs of change, such as to improve and to transform, overlap more with the distributional semantics of add/increase than subtract/decrease, which suggests that change verbs are implicitly biased toward addition. Fourth, addition-related words have more positive connotations than subtraction-related words. Fifth, we demonstrate that state-of-the-art large language models, such as the Generative Pre-trained Transformer (GPT-3), are also biased toward addition. We discuss the implications of our results for research on cognitive biases and decision-making. (shrink)

The sound system of a language must be able to support a perceptual contrast between different words in order to signal communicatively relevant meaning distinctions. In this paper, we use a simple agent-based exemplar model in which the evolution of sound-category systems is understood as a co-evolutionary process, where the range of variation within sound categories is constrained by functional pressure to keep different words perceptually distinct. We show that this model can reproduce several observed effects on the range of (...) sound variation. We argue that phonological systems can be seen as finding a relative optimum of variation: Efficient communication is sustained while at the same time, hidden category variation provides pathways for future evolution. (shrink)

The distinction between abstract and concrete concepts is fundamental to cognitive linguistics and cognitive science. This distinction is commonly operationalized through concreteness ratings based on the aggregated judgments of many people. What is often overlooked in experimental studies using this operationalization is that ratings are attributed to words, not to concepts directly. In this paper we explore the relationship between the linguistic properties of English words and conceptual abstractness/concreteness. Based on hypotheses stated in the existing linguistic literature we select a (...) set of variables and verify whether they are statistically associated with concreteness ratings. We show that English nouns are rated as more concrete compared to other parts of speech, but mass nouns are rated as less concrete than count nouns. Furthermore, a more complex morphological structure is associated with abstractness, and as for etymology, French- and Latin-derived words are more abstract than words of other origin. This shows that linguistic properties of words are indeed associated with the degree of concreteness that we attribute to the underlying concepts, and we discuss the implications that these findings have for linguistic theory and for empirical investigations in the cognitive sciences. (shrink)

The main features of the tetron model of elementary particles are discussed in the light of recent developments, in particular the formation of strong and electroweak vector bosons and a microscopic understanding of how the observed tetrahedral symmetry of the fermion spectrum may arise.

Wie Heine in den Memoiren bemerkt hat, sind ihm »alle Systeme der freyen Denker« seit seiner Schulzeit vertraut gewesen. Sie haben dauerhaft seinen »Unglauben« begründet. Der Aufsatz untersucht, welche Bedeutung das Denken und die Strategie der radikalen Aufklärung für den Dichter gehabt hat. Das betrifft erstens das Prinzip der zweifachen Lehre, zweitens die Methode des ›syllogismus practicus‹ und drittens die Glücksphilosophie.

Horror movies consistently reflect metaphorical associations between verticality and affect, as well as between brightness and affect. For example, bad events happen when movie characters are going downwards, or when lights go off. Monsters and villains emerge from below and from the darkness. And protagonists get lost and stuck in dark underground caves, dungeons, tunnels, mines, bunkers or sewers. Even movies that are primarily set above ground or in bright light have the most suspenseful scenes happening beneath the ground and (...) in the dark. An analysis of several horror movies highlights the striking consistency with which the two metaphors “EVIL IS DOWN” and “EVIL IS DARK” are used within this genre. I will argue that these metaphors help in creating fear. Moreover, I will outline how cinematic manifestations of metaphor elaborate and extend metaphorical concepts and ultimately may have a formative role in keeping metaphors alive within a culture. (shrink)

As with biological systems, spoken languages are strikingly robust against perturbations. This paper shows that languages achieve robustness in a way that is highly similar to many biological systems. For example, speech sounds are encoded via multiple acoustically diverse, temporally distributed and functionally redundant cues, characteristics that bear similarities to what biologists call “degeneracy”. Speech is furthermore adequately characterized by neutrality, with many different tongue configurations leading to similar acoustic outputs, and different acoustic variants understood as the same by recipients. (...) This highlights the presence of a large neutral network of acoustic neighbors for every speech sound. Such neutrality ensures that a steady backdrop of variation can be maintained without impeding communication, assuring that there is “fodder” for subsequent evolution. Thus, studying linguistic robustness is not only important for understanding how linguistic systems maintain their functioning upon the background of noise, but also for understanding the preconditions for language evolution. (shrink)

Metaphors and other tropes are commonly thought to reflect asymmetries in concreteness, with concrete sources being used to talk about relatively more abstract targets. Similarly, originating sense...

Nous sommes une seule et même espèce humaine, mais nous avons parfois différentes manières de nous manifester. Les diverses expressions de l’humain sont les signifiants d’un même signifié : l’homme. Ce dernier a donc une marge de manœuvre plus ou moins grande qui lui permet de mener la vie digne qui convient. Pour ce faire, il doit travailler son image du monde afin de la rendre adéquate au concept du meilleur des mondes possibles. Il a besoin de faire en sorte (...) que le monde dans lequel il vit ne soit pas ce qu’il est, c’est-a-dire littéralement insensé. Le retour aux valeurs africaines est un ressourcement nécessaire. Il nous permet d’apporter notre pierre à l’édifice humain. D’où l’avènement des différents mouvements de réaction tels que la négritude, l’ethnophilosophie, etc. (shrink)

Nous sommes une seule et même espèce humaine, mais nous avons parfois différentes manières de nous manifester. Les diverses expressions de l’humain sont les signifiants d’un même signifié : l’homme. Ce dernier a donc une marge de manœuvre plus ou moins grande qui lui permet de mener la vie digne qui convient. Pour ce faire, il doit travailler son image du monde afin de la rendre adéquate au concept du meilleur des mondes possibles. Il a besoin de faire en sorte (...) que le monde dans lequel il vit ne soit pas ce qu’il est, c’est-a-dire littéralement insensé. Le retour aux valeurs africaines est un ressourcement nécessaire. Il nous permet d’apporter notre pierre à l’édifice humain. D’où l’avènement des différents mouvements de réaction tels que la négritude, l’ethnophilosophie, etc. (shrink)

Embodied approaches to cognition see abstract thought and language as grounded in interactions between mind, body, and world. A particularly important challenge for embodied approaches to cognition is mathematics, perhaps the most abstract domain of human knowledge. Conceptual metaphor theory, a branch of cognitive linguistics, describes how abstract mathematical concepts are grounded in concrete physical representations. In this paper, we consider the implications of this research for the metaphysics and epistemology of mathematics. In the case of metaphysics, we argue that (...) embodied mathematics is neutral in the sense of being compatible with all existing accounts of what mathematical entities really are. However, embodied mathematics may be able to revive an older position known as psychologism and overcome the difficulties it faces. In the case of epistemology, we argue that the evidence collected in the embodied mathematics literature is inconclusive: It does not show that abstract mathematical thinking is constituted by metaphor; it may simply show that abstract thinking is facilitated by metaphor. Our arguments suggest that closer interaction between the philosophy and cognitive science of mathematics could yield a more precise, empirically informed account of what mathematics is and how we come to have knowledge of it. (shrink)

Welcome precision is brought to the idea, history, types and motives of ethical investment in what will become an authoritative review of the subject. Marc Cooper is a postgraduate researcher at the European Business Management School, University of Wales, and Bodo Schlegelmilch, recently British Rail Professor of Marketing there, has recently been appointed Professor of Marketing at the American Graduate School of International Management (Thunderbird), Phoenix, Arizona.

Welcome precision is brought to the idea, history, types and motives of ethical investment in what will become an authoritative review of the subject. Marc Cooper is a postgraduate researcher at the European Business Management School, University of Wales, and Bodo Schlegelmilch, recently British Rail Professor of Marketing there, has recently been appointed Professor of Marketing at the American Graduate School of International Management (Thunderbird), Phoenix, Arizona.

This volume examines mystical experiences as portrayed in various ways by "authors" such as philosophers, mystics, psychoanalysts, writers, and peasant women. These "mystical authors" have, throughout the ages, attempted to convey the unsayable through writings, paintings, or oral stories. The immediate experience of God is the primary source and ultimate goal of these mystical expressions. This experience is essentially ineffable, yet all mystical authors, either consciously or unconsciously, feel an urge to convey what they have undergone in the moments of (...) rapture. At the same time they are in the role of intermediaries: the goal of their self-expression - either written, painted or oral - is to make others somehow understand or feel what they have experienced, and to lead others toward the spiritual goal of human life. This volume studies the mystical experiences and the way they have been described or portrayed in West-European culture, from Antiquity to the present, from an interdisciplinary perspective, and approaches the concept of "immediate experience" in various ways. (shrink)

English speakers use vertical language to talk about power, such as when speaking of people being “at the bottom of the social hierarchy” or “rising to the top.” Experimental research has shown tha...