Results for 'Epigenetics'

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  1.  5
    Epigenetic Inheritance and Evolution: The Lamarckian Dimension.Eva Jablonka & Marion J. Lamb - 1995 - Oxford University Press UK.
    '...a challenging and useful book, both because it provokes a careful scrutiny of one's own basic ideas regarding evolutionary theory, and because it cuts across so many biological disciplines.' -The Quarterly Review of Biology 'In my view, this work exemplifies Theoretical Biology at its best...here is rampant speculation that is consistently based on cautious reasoning from the available data. Even more refreshing is the absence of sloganeering, grandstanding, and 'isms'.' -Biology and Philosophy 'Epigenetics is fundamental to understanding both development (...)
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  2.  80
    Epigenetic Responsibility.Maria Hedlund - 2012 - Medicine Studies 3 (3):171-183.
    The purpose of this article is to argue for a position holding that epigenetic responsibility primarily should be a political and not an individual responsibility. Epigenetic is a rapidly growing research field studying regulations of gene expression that do not change the DNA sequence. Knowledge about these mechanisms is still uncertain in many respects, but main presumptions are that they are triggered by environmental factors and life style and, to a certain extent, heritable to subsequent generations, thereby reminding of aspects (...)
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  3.  66
    Epigenetics and the Environment in Bioethics.Charles Dupras, Vardit Ravitsky & Bryn Williams-Jones - 2014 - Bioethics 28 (7):327-334.
    A rich literature in public health has demonstrated that health is strongly influenced by a host of environmental factors that can vary according to social, economic, geographic, cultural or physical contexts. Bioethicists should, we argue, recognize this and – where appropriate – work to integrate environmental concerns into their field of study and their ethical deliberations. In this article, we present an argument grounded in scientific research at the molecular level that will be familiar to – and so hopefully more (...)
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  4. Social Epigenetics and Equality of Opportunity.Michele Loi, Lorenzo Del Savio & Elia Stupka - 2013 - Public Health Ethics 6 (2):142-153.
    Recent epidemiological reports of associations between socioeconomic status and epigenetic markers that predict vulnerability to diseases are bringing to light substantial biological effects of social inequalities. Here, we start the discussion of the moral consequences of these findings. We firstly highlight their explanatory importance in the context of the research program on the Developmental Origins of Health and Disease (DOHaD) and the social determinants of health. In the second section, we review some theories of the moral status of health inequalities. (...)
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  5. The epigenetic landscape in the course of time: Conrad Hal Waddington’s methodological impact on the life sciences.Jan Baedke - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):756-773.
    It seems that the reception of Conrad Hal Waddington’s work never really gathered speed in mainstream biology. This paper, offering a transdisciplinary survey of approaches using his epigenetic landscape images, argues that (i) Waddington’s legacy is much broader than is usually recognized—it is widespread across the life sciences (e.g. stem cell biology, developmental psychology and cultural anthropology). In addition, I will show that (ii) there exist as yet unrecognized heuristic roles, especially in model building and theory formation, which Waddington’s images (...)
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  6.  27
    Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck & Dirk S. Paul - 2018 - Bioessays 40 (2):1700148.
    Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...)
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  7. Genetic, epigenetic and exogenetic information.Karola Stotz & Paul Edmund Griffiths - 2017 - In Richard Joyce (ed.), The Routledge Handbook of Evolution and Philosophy. London & New York: Routledge.
    We describe an approach to measuring biological information where ‘information’ is understood in the sense found in Francis Crick’s foundational contributions to molecular biology. Genes contain information in this sense, but so do epigenetic factors, as many biologists have recognized. The term ‘epigenetic’ is ambiguous, and we introduce a distinction between epigenetic and exogenetic inheritance to clarify one aspect of this ambiguity. These three heredity systems play complementary roles in supplying information for development. -/- We then consider the evolutionary significance (...)
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  8. Epigenetics, Harm, and Identity.Joona Räsänen & Anna Smajdor - 2022 - American Journal of Bioethics 22 (9):40-42.
    Robert Sparrow argues that genome editing is unlikely to be person-affecting for the foreseeable future and, as a result, will neither benefit nor harm edited individuals. We regard Sparrow’...
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  9. Genetic, epigenetic and exogenetic information in development and evolution.Paul Edmund Griffiths - 2017 - Interface Focus 7 (5).
    The idea that development is the expression of information accumulated during evolution and that heredity is the transmission of this information is surprisingly hard to cash out in strict, scientific terms. This paper seeks to do so using the sense of information introduced by Francis Crick in his sequence hypothesis and central dogma of molecular biology. It focuses on Crick's idea of precise determination. This is analysed using an information-theoretic measure of causal specificity. This allows us to reconstruct some of (...)
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  10.  42
    Epigenetics: ambiguities and implications.Karola Stotz & Paul Griffiths - 2016 - History and Philosophy of the Life Sciences 38 (4).
    Everyone has heard of ‘epigenetics’, but the term means different things to different researchers. Four important contemporary meanings are outlined in this paper. Epigenetics in its various senses has implications for development, heredity, and evolution, and also for medicine. Concerning development, it cements the vision of a reactive genome strongly coupled to its environment. Concerning heredity, both narrowly epigenetic and broader ‘exogenetic’ systems of inheritance play important roles in the construction of phenotypes. A thoroughly epigenetic model of development (...)
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  11. Epigenetic regulation of replication origin assembly: A role for histone H1 and chromatin remodeling factors.Lucia Falbo & Vincenzo Costanzo - 2021 - Bioessays 43 (1):2000181.
    During early embryonic development in several metazoans, accurate DNA replication is ensured by high number of replication origins. This guarantees rapid genome duplication coordinated with fast cell divisions. In Xenopus laevis embryos this program switches to one with a lower number of origins at a developmental stage known as mid-blastula transition (MBT) when cell cycle length increases and gene transcription starts. Consistent with this regulation, somatic nuclei replicate poorly when transferred to eggs, suggesting the existence of an epigenetic memory suppressing (...)
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  12. Epigenetic landscaping: Waddington's use of cell fate bifurcation diagrams. [REVIEW]Scott F. Gilbert - 1991 - Biology and Philosophy 6 (2):135-154.
    From the 1930s through the 1970s, C. H. Waddington attempted to reunite genetics, embryology, and evolution. One of the means to effect this synthesis was his model of the epigenetic landscape. This image originally recast genetic data in terms of embryological diagrams and was used to show the identity of genes and inducers and to suggest the similarities between embryological and genetic approaches to development. Later, the image became more complex and integrated gene activity and mutations. These revised epigenetic landscapes (...)
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  13.  64
    Epigenetics, representation, and society.Ilya Gadjev - 2017 - Zygon 52 (2):491-515.
    In recent decades, advances in the life sciences have created an unprecedentedly detailed picture of heredity and the formation of the phenotype where clusters of simplistic reductionist and deterministic views and interpretations have begun to lose ground to more complex and holistic notions. The developments in gene regulation and epigenetics have become a vivid emblem of the ongoing ‘softening’ of heredity. Despite this headway, the outlook and rhetoric widely popular in the twentieth century favoring the ‘gene’ in the ‘genegenetic (...)
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  14.  34
    Epigenetic Exceptionalism.Mark A. Rothstein - 2013 - Journal of Law, Medicine and Ethics 41 (3):733-736.
    This article considers the distinctive features of epigenetics and discusses whether, as a matter of ethics and law, epigenetics should be considered separate from genetics.
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  15.  35
    Epigenetics and Future Generations.Lorenzo del Savio, Michele Loi & Elia Stupka - 2015 - Bioethics 29 (8):580-587.
    Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic (...)
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  16.  38
    Epigenetics in the Neoliberal “Regime of Truth”.Charles Dupras & Vardit Ravitsky - 2016 - Hastings Center Report 46 (1):26-35.
    Recent findings in epigenetics have been attracting much attention from social scientists and bioethicists because they reveal the molecular mechanisms by which exposure to socioenvironmental factors, such as pollutants and social adversity, can influence the expression of genes throughout life. Most surprisingly, some epigenetic modifications may also be heritable via germ cells across generations. Epigenetics may be the missing molecular evidence of the importance of using preventive strategies at the policy level to reduce the incidence and prevalence of (...)
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  17.  11
    Epigenetic Responsibility.Maria Hedlund - 2012 - Medicine Studies 3 (3):171-183.
    The purpose of this article is to argue for a position holding that epigenetic responsibility primarily should be a political and not an individual responsibility. Epigenetic is a rapidly growing research field studying regulations of gene expression that do not change the DNA sequence. Knowledge about these mechanisms is still uncertain in many respects, but main presumptions are that they are triggered by environmental factors and life style and, to a certain extent, heritable to subsequent generations, thereby reminding of aspects (...)
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  18. Thinking embodiment with genetics: epigenetics and postgenomic biology in embodied cognition and enactivism.Maurizio Meloni & Jack Reynolds - 2020 - Synthese 198 (11):10685-10708.
    The role of the body in cognition is acknowledged across a variety of disciplines, even if the precise nature and scope of that contribution remain contentious. As a result, most philosophers working on embodiment—e.g. those in embodied cognition, enactivism, and ‘4e’ cognition—interact with the life sciences as part of their interdisciplinary agenda. Despite this, a detailed engagement with emerging findings in epigenetics and post-genomic biology has been missing from proponents of this embodied turn. Surveying this research provides an opportunity (...)
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  19. Epigenetics across the evolutionary tree: New paradigms from non‐model animals.Kirsten C. Sadler - 2023 - Bioessays 45 (1):2200036.
    All animals have evolved solutions to manage their genomes, enabling the efficient organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of gene expression while keeping transposable elements suppressed. Epigenetic modifications are central to accomplishing all these. Recent advances in sequencing technologies and the development of techniques that profile epigenetic marks and chromatin accessibility using reagents that can be used in any species has catapulted epigenomic studies in diverse animal species, shedding light on the multitude (...)
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  20. Epigenetics, Responsiveness and Embodiment.Maria Kronfeldner - 2020 - In Dana Mahr & Martina von Arx (eds.), De-Sequencing: Identity Work With Genes.
    This short paper comments on the connections between epigenetics, responsiveness and embodiment. Epigenetics has solidified a new conception of DNA as “responsive,” and rightfully so. Yet, the discussion too easily falls back to metaphors of agency and can show a tendency to see responsiveness and embodiment as based on epigenetics, which is shown to be wrong.
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  21.  29
    Is Epigenetic Inheritance a Counterexample to the Central Dogma?Alex Rosenberg - 2006 - History and Philosophy of the Life Sciences 28 (4):549 - 565.
    This paper argues that nothing that has been discovered in the increasingly complex delails of gene regulation has provided any grounds to retract or qualify Crick's version of the central dogma. In particular it defends the role of the genes as the sole bearers of information, and argues that the mechanism of epigenetic modification of the DNA is but another vindication of Crick's version of the central dogma. The paper shows that arguments of C.K. Waters for the distinctive causual role (...)
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  22.  3
    Epigenetics and Obesity: The Reproduction of Habitus through Intracellular and Social Environments.Stanley Ulijaszek, Michael Davies, Vivienne Moore & Megan Warin - 2016 - Body and Society 22 (4):53-78.
    Bourdieu suggested that the habitus contains the ‘genetic information’ which both allows and disposes successive generations to reproduce the world they inherit from their parents’ generation. While his writings on habitus are concerned with embodied dispositions, biological processes are not a feature of the practical reason of habitus. Recent critiques of the separate worlds of biology and culture, and the rise in epigenetics, provide new opportunities for expanding theoretical concepts like habitus. Using obesity science as a case study we (...)
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  23.  4
    Conducting epigenetics research with refugees and asylum seekers: attending to the ethical challenges.Faten Taki & Inmaculada de Melo-Martin - 2021 - Clinical Epigenetics 13 (1):105-.
    An increase in global violence has forced the displacement of more than 70 million people, including 26 million refugees and 3.5 asylum seekers. Refugees and asylum seekers face serious socioeconomic and healthcare barriers and are therefore particularly vulnerable to physical and mental health risks, which are sometimes exacerbated by immigration policies and local social discriminations. Calls for a strong evidence base for humanitarian action have encouraged conducting research to address the barriers and needs of refugees and asylum seekers. Given the (...)
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  24.  75
    Three epigenetic information channels and their different roles in evolution.Nicholas Shea, Ido Pen & Tobias Uller - 2011 - Journal of Evolutionary Biology 24:1178-87.
    There is increasing evidence for epigenetically mediated transgenerational inheritance across taxa. However, the evolutionary implications of such alternative mechanisms of inheritance remain unclear. Herein, we show that epigenetic mechanisms can serve two fundamentally different functions in transgenerational inheritance: (i) selection-based effects, which carry adaptive information in virtue of selection over many generations of reliable transmission; and (ii) detection-based effects, which are a transgenerational form of adaptive phenotypic plasticity. The two functions interact differently with a third form of epigenetic information transmission, (...)
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  25. Epigenetic regulation of mirror neuron development, and related evolutionary hypotheses.Antonella Tramacere - 2015 - In Pier Francesco Ferrari & Giacomo Rizzolatti (eds.), New Frontiers in Mirror Neurons Research.
    This chapter offers a brief review of theories on mirror neuron development, highlighting different models. These models focus on either the role of genetic mechanisms or the contributions of experience and of learning processes in shaping the brain circuits involved in action–perception coupling. As an alternative, the chapter proposes an epigenetic model for mirror neuron development, explaining how such a model can help to elucidate, within a unifying explanatory framework, the emergence, diversity, and functional reuse of mirror neurons. Lastly, a (...)
     
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  26.  5
    Epigenetics and Bruxism: from Hyper-Narrative Neural Networks to Hyper-Function.Aleksandra Čalić & Eva Vrtačič - 2020 - Biosemiotics 13 (2):241-259.
    This article develops a biosemiotic ´hyper-narrative model´ for the purposes of investigating emergent motor behaviors. It proposes to understand such behaviors in terms of the following associations: the organization of information acquired from the environment, focusing on narrative; the organizational dynamics of epigenetic mechanisms that underly the neural processes facilitating the processing of information; and the evolution of emergent motor behaviors that enable the informational acquisition. The article describes and explains these associations as part of a multi-ordered and multi-causal generative (...)
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  27.  29
    Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.Jack S. Hardwick, Andrew N. Lane & Tom Brown - 2018 - Bioessays 40 (3):1700199.
    To decode the function and molecular recognition of several recently discovered cytosine derivatives in the human genome – 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine – a detailed understanding of their effects on the structural, chemical, and biophysical properties of DNA is essential. Here, we review recent literature in this area, with particular emphasis on features that have been proposed to enable the specific recognition of modified cytosine bases by DNA-binding proteins. These include electronic factors, modulation of base-pair stability, flexibility, and radical changes (...)
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  28.  16
    Epigenetics and metaphor: Language of limits.Sofia Falomir - 2018 - Technoetic Arts 16 (3):295-302.
    Because the term ‘epigenetics’ has been used in a wide array of inquires within the life-sciences, it has come to bear a significant number of meanings. And just as biologists cannot come to an univocal understanding on what epigenetics connotes, the effect that its study has had in challenging contemporary neo-Darwinian, genecentred paradigms is also unclear. Some scientists and philosophers go as far as to say epigenetics has eroded dichotomies central to modern western thought, such as nature (...)
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  29.  25
    How epigenetic mutations can affect genetic evolution: Model and mechanism.Filippos D. Klironomos, Johannes Berg & Sinéad Collins - 2013 - Bioessays 35 (6):571-578.
  30.  28
    Epigenetic Theories: Caspar Friedrich Wolff and Immanuel Kant.Ina Goy - 2014 - In Eric Watkins & Ina Goy (eds.), Kant's Theory of Biology. De Gruyter. pp. 43-60.
    In this paper, I investigate the relation of Kant's theory of biology to epigenetic accounts of organic generation and development. In the literature, a dispute about similarities between Blumenbach's epigenetic account and Kant dominated the debate for many years (see Lenoir 1980, 1981, and 1982, 17–34, Richards 2000; 2002, 207–37; Look 2006, and van den Berg 2009). Some more recent interpreters claim that Wolff's, more than Blumenbach's account plays the pivotal role in the development of a vitalistic conception of epigenesis (...)
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  31.  31
    Epigenetic Exceptionalism.Mark A. Rothstein - 2013 - Journal of Law, Medicine and Ethics 41 (3):733-736.
    Emerging fields of science often create new challenges for ethics and law. In assessing the broader societal implications of scientific discoveries, a reasonable analytical starting point is determining how the discoveries compare with existing science. If the new field is substantially similar to an established one, then the ethical and legal analyses are likely to be comparable. On the other hand, if the new scientific developments are extraordinary in kind or degree, then a new analytical framework and new approaches to (...)
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  32. Epigenetics, Evolution, and Us.W. Malcolm Byrnes - 2003 - The National Catholic Bioethics Quarterly 3 (3):489-500.
    This essay moves along broad lines from molecular biology to evolutionary biology and ecology to theology. Its objectives are to: 1) present some recent scientific findings in the emerging field of epigenetics that indicate that it is “the genome in context,” not genes per se, that are important in biological development and evolution; 2) show that this weakens the gene-centric neo-Darwinist explanation of evolution which, in fact, shares a certain preformationist orientation with intelligent design theory; 3) argue that the (...)
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  33.  32
    Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology.Philipp A. Steffen, João P. Fonseca & Leonie Ringrose - 2012 - Bioessays 34 (10):901-913.
  34.  31
    Epigenetics as a Driver of Developmental Origins of Health and Disease: Did We Forget the Fathers?Adelheid Soubry - 2018 - Bioessays 40 (1):1700113.
    What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this (...)
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  35.  19
    An Epigenetic Approach to Semantic Categories.Peter Gardenfors - forthcoming - IEEE Transactions on Cognitive and Developmental Systems.
    It is argued that early language learning in children emerges from five primary knowledge structures: Space, objects, actions, number and events. These structures constitute the basis for the semantic domains that are used to form categories that represent the meanings of early words. The domains are naturally modeled in conceptual spaces that are based on geometric notions rather than on symbolic representations. It is shown how these semantics domains can be used to generate an epigenetic model of language acquisition. The (...)
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  36.  39
    Epigenetics Changes Nothing: What a New Scientific Field Does and Does Not Mean for Ethics and Social Justice.Jonathan Y. Huang & Nicholas B. King - 2018 - Public Health Ethics 11 (1):69-81.
    Recently, ethicists have posited that consideration of epigenetic mechanisms presents novel challenges to concepts of justice and equality of opportunity, such as elevating the importance of environments in bioethics and providing a counterpoint to gross genetic determinism. We argue that new findings in epigenetic sciences, including those regarding intergenerational health effects, do not necessitate reconceptualization of theories of justice or the environment. To the contrary, such claims reflect a flawed understanding of epigenetics and its relation to genetics that may (...)
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  37.  28
    Why epigenetics is not a vindication of Lamarckism – and why that matters.Ute Deichmann - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 57:80-82.
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  38.  32
    Epigenetics: A way to bridge the gap between biological fields.Antonine Nicoglou & Francesca Merlin - 2017 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 66:73-82.
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  39.  25
    The epigenetic turn: Some notes about the epistemological change of perspective in biosciences.Guido Nicolosi & Guido Ruivenkamp - 2012 - Medicine, Health Care and Philosophy 15 (3):309-319.
    This article compares two different bodies of theories concerning the role of the genome in life processes. The first group of theories can be indicated as referring to the gene-centric paradigm. Dominated by an informational myth and a mechanistic Cartesian body/mind and form/substance dualism, this considers the genome as an ensemble of discrete units of information governing human body and behavior, and remains hegemonic in life sciences and in the public imagination. The second body of theories employs the principle of (...)
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  40.  20
    Epigenetics and the brain: Transcriptome sequencing reveals new depths to genomic imprinting.Gavin Kelsey - 2011 - Bioessays 33 (5):362-367.
  41.  18
    Epigenetics and parental effects.Laurent Kappeler & Michael J. Meaney - 2010 - Bioessays 32 (9):818-827.
  42.  10
    Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior.Benjamin D. Schanker - 2012 - Behavioral and Brain Sciences 35 (5):377-378.
    Several recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.
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  43. Epigenetic is back!Massimo Pigliucci - 2003 - Cell Cycle 2 (1):34-35.
    Back in 1942, C.H. Waddington proposed a new mechanism of evolutionary change, which he termed “genetic assimilation”.1,2 The idea was that certain environmental or genetic factors can disrupt the normally canalized (i.e., stable) course of development of living organisms. This disruption may then generate phenotypic variation that could allow a population to persist in a novel or stressful environment until new mutations would eventually let natural selection fix (“assimilate”) the advantageous phenotypic variants.
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  44.  9
    Epigenetic cancer therapy: Proof of concept and remaining challenges.Cora Mund & Frank Lyko - 2010 - Bioessays 32 (11):949-957.
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  45.  10
    Epigenetic-induced alterations in sex-ratios in response to climate change: An epigenetic trap?Sofia Consuegra & Carlos M. Rodríguez López - 2016 - Bioessays 38 (10):950-958.
  46.  2
    Maternal epigenetic responsibility: what can we learn from the pandemic?Ilke Turkmendag & Ying-Qi Liaw - 2022 - Medicine, Health Care and Philosophy 25 (3):483-494.
    This paper examines the construction of maternal responsibility in transgenerational epigenetics and its implications for pregnant women. Transgenerational epigenetics is suggesting a link between maternal behaviour and lifestyle during pregnancy and the subsequent well-being of their children. For example, poor prenatal diet and exposure to maternal distress during pregnancy are linked to epigenetic changes, which may cause health problems in the offspring. In this field, the uterus is seen as a micro-environment in which new generations can take shape. (...)
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  47.  3
    Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder.Yamil Quevedo, Linda Booij, Luisa Herrera, Cristobal Hernández & Juan Pablo Jiménez - 2022 - Frontiers in Human Neuroscience 16.
    Genetic and early environmental factors are interwoven in the etiology of Borderline Personality Disorder. Epigenetic mechanisms offer the molecular machinery to adapt to environmental conditions. There are gaps in the knowledge about how epigenetic mechanisms are involved in the effects of early affective environment, development of BPD, and psychotherapy response. We reviewed the available evidence of the effects of psychotherapy on changes in DNA methylation and conducted a pilot study in a sample of 11 female adolescents diagnosed with BPD, exploring (...)
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  48.  6
    Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information.Antony M. Jose - 2020 - Bioessays 42 (7):1900254.
    Our view of heredity can potentially be distorted by the ease of introducing heritable changes in the replicating gene sequences but not in the cycling assembly of regulators around gene sequences. Here, key experiments that have informed the understanding of heredity are reinterpreted to highlight this distortion and the possible variety of heritable changes are considered. Unlike heritable genetic changes, which are always associated with mutations in gene sequence, heritable epigenetic changes can be associated with physical or chemical changes in (...)
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  49.  8
    Epigenetic Regulation of Secondary Metabolite Biosynthetic Genes in Fungi.Robert Cichewicz - 2012 - In Witzany (ed.), Biocommunication of Fungi. Springer. pp. 57--69.
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  50.  10
    The epigenetic character of development.Gilbert Gottlieb - 1978 - Behavioral and Brain Sciences 1 (3):446-447.
1 — 50 / 567