Randomized controlled trials are often considered the gold standard for estimating causal effect, but they may lack external validity when the population eligible to the RCT is substantially different from the target population. Having at hand a sample of the target population of interest allows us to generalize the causal effect. Identifying the treatment effect in the target population requires covariates to capture all treatment effect modifiers that are shifted between the two sets. Standard estimators then use either weighting, outcome (...) modeling, or combine the two in doubly robust approaches. However, such covariates are often not available in both sets. In this article, after proving L 1 {L}^{1} -consistency of these three estimators, we compute the expected bias induced by a missing covariate, assuming a Gaussian distribution, a continuous outcome, and a semi-parametric model. Under this setting, we perform a sensitivity analysis for each missing covariate pattern and compute the sign of the expected bias. We also show that there is no gain in linearly imputing a partially unobserved covariate. Finally, we study the substitution of a missing covariate by a proxy. We illustrate all these results on simulations, as well as semi-synthetic benchmarks using data from the Tennessee student/teacher achievement ratio, and a real-world example from critical care medicine. (shrink)

This paper builds on the critique that Renaud Filleule addresses in this issue to radical ecological economics – known also as socio-ecological economics (SEE) – and more specifically to the works of one of his most famous representatives, Clive Spash. Filleule builds his critique from Austrian economics. I adopt a broader perspective. Indeed, although Austrian economics identifies key caveats of SEE, one may challenge its whole scientific substance on more general grounds. True, Clive Spash’s works are keen on putting forth (...) methodological arguments to institute SEE not only as a scientific theory but also as the major paradigm in ecological economics. However, such arguments are unconvincing, amounting to activism-in-disguise of science, as reflected in Spash’s semantic ambiguity, his misconception of social science and overstated claims and pointless ordering of scientific knowledge. Moreover, Spash’s critique of economic growth is not only empirically wrong – as correctly noticed by Filleule – but also conceptually irrelevant. This is because defective theories necessarily lead to wrong or insignificant statements. (shrink)

So geschaftig die internationale Nietzsche-Forschung auch ist, bleibt doch weithin unklar, was eigentlich gemeint ist, wenn wir von Nietzsches Philosophie sprechen. Handelt es sich um ein Gefuge von Lehrsatzen Wille zur Macht, Ewige Wiederkunft des Gleichen, Ubermensch? Wie sollen philosophisch interessierte Leserinnen und Leser damit umgehen, dass Nietzsche sich offensichtlich unentwegt selbst ins Wort fallt und jede doktrinale Festlegung verweigert? Ist das nur eine billige literarische Strategie, um das eigene Gefuge von Lehrsatzen interessanter zu machen? Oder handelt es sich vielmehr (...) um den Versuch, den Glauben an Philosophie als Gefuge von Lehrsatzen grundsatzlich zu problematisieren? Vielleicht ist Nietzsches Philosophie etwas vollig Anderes: eine andere Praxis. Der bekannte Nietzsche-Forscher Andreas Urs Sommer stellt und beantwortet in diesem Band grundlegende Fragen zum Umgang mit Nietzsches Texten, die so ganz anders zu funktionieren scheinen als landlaufige philosophische Texte. Die dafur erforderliche philosophische Hermeneutik muss auf einem sicheren philologisch-historischen Fundament stehen. (shrink)

RésuméÀ plusieurs reprises et poursuivant des buts distincts, Ibn al-Haytham a déterminé les variations d'une fonction bien connue aujourd'hui. Le contexte de ces applications révèle certaines caractéristiques de la pensée mathématique et physique de ce savant. Une étude précise de ses démonstrations mathématiques de monotonie suggère combien il a pu approcher d'un concept élaboré du continu.

RésuméNous avons tenté de restituer ici les mathématiques qui président aux théories planétaires exposées par l'astronome syrien Ibn al-Šāṭir dans son ouvrage Nihāyat al-Sūl. Dans la lignée des astronomes de l’école de Marāgha, en composant des mouvements de rotation à vitesse angulaire constante, Ibn al-Šāṭir atteint deux objectifs. Non seulement il élimine tout recours aux excentriques et aux points équants; mais il décrit aussi longitudes et latitudes planétaires par une méthode unique, sans adjoindre aucun orbe en sus des orbes nécessaires (...) à la description des seuls mouvements en longitude. Une meilleure compréhension des rotations comme transformations spatiales lui permet cette grande économie de moyens. Dans notre commentaire, nous prenons pour exemple la planète Vénus dont les latitudes posent un problème intéressant. C'est aussi l'occasion d'offrir l’édition critique d'un chapitre de la Nihāyat al-Sūl consacré aux mouvements en latitude de Mercure et Vénus. (shrink)

The necessity of epistemological theorisation for management science is questionable. However, epistemology can be useful if the following distinction between three kinds of epistemology, usually overlooked, is taken into account: epistemology as a structured academic discipline, epistemology as an intellectual exercise produced outside academic epistemology, and finally the epistemology specific to each researcher. When this distinction is not made, epistemology can become counterproductive and impede scientific work.

How can we make businesspeople more concerned about the truth of the information they spread or allow to circulate? In this age of ‘fake news’, ‘business bullshit’ and ‘post-truth,’ the issue is of the utmost importance, especially for business trustworthiness in the internet economy. The issue is related to a kind of epistemic responsibility, that consists in accounting for one’s own epistemic wrongdoings, such as making a third party believe something false. Despite growing interest in epistemic misbehavior in the literature (...) of business ethics, the question of epistemic responsibility has been neglected. The aim of this paper is therefore to address this gap, by proposing a notion of epistemic responsibility for business, that may help regulate undesirable epistemic behavior, such as the spreading of false information. To define this notion of epistemic responsibility, I have introduced the concept of epistemic fault. Being epistemically responsible consists in being disposed to account for alleged epistemic faults. This notion of epistemic fault relies on a theoretical framework which combines a typology of eight ‘epistemic values’, a normative stance regarding these values, and a dispositional approach to epistemic virtues and vices. I use this theoretical framework to integrate the various accounts of epistemic virtues and vices found in the literature into a single explanatory scheme. Combined with the notion of epistemic responsibility itself, such an integrative framework should facilitate the practical application of an operational epistemic ethics in business, i.e., the development of virtuous epistemic practices. (shrink)

This article serves as an introduction to the special issue discussing the usefulness of philosophy in managerial practice. We present the papers included in this special issue and identify keynote directions for further research. The initial intention of the call for papers was to promote this topic on research agendas by offering a platform for discussing if, why, and how philosophy can complement and enhance management practice. Now that this special issue has been published, we see a broader significance: the (...) arguments explored here are a starting point for more in-depth studies of the connections that can occur between specific philosophical concepts, theories, methods on the one hand, and concrete managerial practices on the other. (shrink)

In his book, Andreas Urs Sommer reflects on the question of what it really means when everybody’s appealing to values, all the time – the question, fundamentally, of what values actually are. Values explores both of these points, arriving at two intriguing suggestions: Maybe what we call values are just a set of elaborate fictions. And maybe those fictions serve some very important purposes.

This chapter contains sections titled: Introduction Nihilism Skepticism Nihilism and Skepticism.

Although the promyelocytic leukemia (PML) protein is renowned for regulating a wide range of cellular processes and as an essential component of PML nuclear bodies (PML‐NBs), the mechanisms through which it exerts its broad physiological impact are far from fully elucidated. Here, we review recent studies supporting an emerging view that PML's pleiotropic effects derive, at least partially, from its role in regulating histone H3.3 chromatin assembly, a critical epigenetic mechanism. These studies suggest that PML maintains heterochromatin organization by restraining (...) H3.3 incorporation. Examination of PML's contribution to H3.3 chromatin assembly in the context of the cell cycle and PML‐NB assembly suggests that PML represses heterochromatic H3.3 deposition during S phase and that transcription and SUMOylation regulate PML's recruitment to heterochromatin. Elucidating PML’ s contributions to H3.3‐mediated epigenetic regulation will provide insight into PML's expansive influence on cellular physiology and open new avenues for studying oncogenesis linked to PML malfunction. (shrink)

La "cause de la phénoménologie" s'est trouvée défendue et illustrée en France par de multiples oeuvres, qui, au-delà même de la réception des pensées de Husserl et de Heidegger, ont aujourd'hui des effets en retour sur les pays germaniques d'où la phénoménologie est originaire. Organisées par Christian Sommer et Jean-Claude Monod, deux journées d'étude ont réuni aux Archives Husserl de Paris les principaux représentants de la "nouvelle phénoménologie" en France. Les textes du présent volume évoquent et réévaluent les évolutions, les (...) thèmes et les débats qui ont marqué le champ phénoménologique français depuis le début des années 1980. (shrink)

Social entrepreneurship is a precarious activity that must always strike a delicate balance between commercial principles and social concerns. There is no shortage of discussion concerning the possible solutions that could help to maintain this balance, and social entrepreneurs are striving to reconcile conflicting aims on a daily basis, but the economic roots of this precariousness remain. Based on an analysis of these root causes, we propose a new radical approach to this precariousness, “radical” in the etymological sense of the (...) term “root”. We start by identifying what determines the dilemma that lies at the heart of the precariousness of social entrepreneurship in present-day economic institutions. This enables us to identify the institutional conditions that might allow us to overcome it. The first condition is linked to the conservation of money in individual trade, which might be alleviated. To determine the second condition, we introduce the notion of the endogeneity of the institutional solutions to the dilemma. The lesser the involvement of the actors concerned by its formulation, the less endogenous is the solution. On this basis, we suggest institutional reforms that could prompt entrepreneurs to organize themselves in support of the actions of the most socially oriented entrepreneurs, thus safeguarding their sustainability. (shrink)

Cette étude formule l'hypothèse critique d'une opération de remythologisation par une réactualisation théologico-politique de la tragédie chez Heidegger. Cette opération ne saurait simplement coïncider avec une revalorisation " irrationnelle " du mythe, car elle procède d'abord d'une mise en question, non moins problématique, de la dualité supposée entre muthos et logos pour culminer dans ce qu'une note des années 1950 appellera la " mytho-logie de l'événement ". La réélaboration de la notion de mythe s'accomplit à partir du poème de Hölderlin (...) qui doit préfigurer les dieux de l'" autre commencement " post-judéo-chrétien, selon le projet spéculatif d'une " religion " censée relier le peuple à ses dieux nouveaux via l'être comme événement. L'hypothèse d'une remythologisation théologico-politique doit ainsi permettre d'éclairer non seulement le rôle matriciel de Hölderlin pour la pensée de l'être, mais aussi le surinvestissement illusoire du national-socialisme censé donner lieu au " peuple de Hölderlin ". Pour interroger cette réactualisation théologico-politique du mythe, l'étude se concentre sur les cours que Heidegger consacra à Hölderlin, tout en sollicitant l'intégralité du corpus des années 1933-1945, c'est-à-dire les cours fribourgeois, les traités inédits rédigés dans le sillage des Contributions (Beiträge) et les Cahiers noirs (Schwarze Hefte). (shrink)

Les sciences de gestion ne sont pas dans la science, mais dans le désir de faire science, le désir d’une science fantasmée. Cela apparaît dans leur obsession pathologique pour une « méthode scientifique » chimérique. Rien ne doit dépasser, tout doit être propre et lisse, alors que c’est l’approximation qui est au cœur du travail scientifique. Les sciences de gestion ratent ainsi quelque chose de fondamental dans la démarche scientifique en état incapable de saisir son imperfection. Comme les sciences médiévales, (...) elles sont au contraire habitées par une mystique de la perfection. Il n’est pas possible de s’en extraire individuellement. Mais une philosophie des sciences de gestion pourrait aider à collectivement sortir de cet état. (shrink)

In the second half of the nineteenth century, France was the main site of the controversy around the so-called eoliths, supposedly human-made tools of Tertiary Europe. In contrast to the more common situation where scientists have to make sure that an object stabilized in a laboratory is not an artifact of the lab but a natural object, in the eoliths debates the opposite was the case. The eolith proponents tried to render plausible the object's artificial, that is human, origin. In (...) their case, the objects would only be of scientific interest if they were artifacts not geofacts (naturally flaked stones). The paper ties in with existing literature on the French eoliths movement and investigates the successive eoliths debates in Britain. In Bruno Latour's terms, eoliths as archaeological evidence for Tertiary Man in Europe could gain in reality through a successful enlisting of the collaboration of human and non-human actors such as scientists, theories, publications, taxonomies, technologies, institutions, etc. Indeed, networks were established among scientists, preferably of powerful institutions, the 'tools' were integrated or denied a place in existing taxonomies of prehistoric artifacts, experiments were carried out to demonstrate their chance or designed origin, and their convergence or incompatibility with a certain theoretical framework was discussed. Arguments often revolved around questions of negative evidence, since both proponents and opponents of eoliths as tools were aware of the fact that the eoliths' strongest tie to reality would be evidence of the toolmakers themselves. Several known hominid fossils, among them those of doubtful age, were thus proposed as Tertiary shapers of the 'tools'. These hypothetical 'Englishmen' and their supposed artifacts were enmeshed in particular theories of human evolution, marked as they were by the racism and nationalism widespread at the time. (shrink)

The aim of this paper is to examine the philosophical sources of some of the criticisms made in the second half of the 20th century to the practices and the main assumptions of historiography. In particular, the influence of the writings by Nietzsche dedicated to European Historicism on the renewed concept of history which is imposed in the twentieth century from the thought of Heidegger and Foucault. The divergent concepts of historical time and existential temporality, as well as those of (...) narrative unity and continuity of historical events, are the concepts that mainly fall under the critical scrutiny of these thinkers. Archaeological investigations that Foucault devotes to institutions and procedures of the European past are mentioned as examples of the critical review of traditional historiography. (shrink)

Africa, along with Asia, is the continent with the highest number of ‘living’ indigenous languages. European languages, mainly English, French and Portuguese, have spread throughout all African nations during the last 200 years; however, until today, the use of these ‘foreign’ languages has been mostly restricted to certain domains, such as higher education, politics and business, and also to a relatively small number of people. According to Scotton (1982: 68) only 10 per cent or less of the rural African population (...) have a considerable competence in the imported languages, even though these are in many instances the official languages of their home countries. African vernaculars are generally not in danger of being replaced by European languages. However, we observe a diminishing use of African vernaculars, not only in an increasing number of domains, but also with regard to the absolute number of indigenous languages; that means, in short, that linguistic vitality and variety on the African continent is decreasing. (shrink)

Résumé C’est en faisant la nature que nous la connaissons et, en vivant, nous lui donnons forme. La nature n’est pas quelque chose d’extérieur. L’écologie n’est pas une science, c’est un mouvement social et politique.

RésuméDans l’Almageste, Ptolémée a proposé le concept du mouvement d'enroulement pour expliquer notamment les latitudes planétaires. Ibn al-Haytham a rédigé un traité intitulé Fī ḥarakat al-iltifāf, « Surle mouvement d'enroulement ». Un anonyme a écrit une critique de ce traité. Les deux mémoires sont perdus; mais heureusement a survécu la réponse d'Ibn al-Haytham, intitulée Fī ḥall šukūk ḥarakat al-iltifāf, « La résolution des doutes sur le mouvement d'enroulement ». Il y rappelle le modèle élaboré et en détaille encore l'explication. Nous (...) donnons ici édition critique, traduction et commentaire de cette réponse, ainsi qu'une édition et traduction de passages apparentés des Hypothèses planétaires de Ptolémée et de la Nihāyat al-idrāk de Quṭb al-Dīn al-Shīrāzī. (shrink)

Consent governs innumerable everyday social interactions, including sex, medical exams, the use of property, and economic transactions. Yet little is known about how ordinary people reason about the validity of consent. Across the domains of sex, medicine, and police entry, Study 1 showed that when agents lack autonomous decision-making capacities, participants are less likely to view their consent as valid; however, failing to exercise this capacity and deciding in a nonautonomous way did not reduce consent judgments. Study 2 found that (...) specific and concrete incapacities reduced judgments of valid consent, but failing to exercise these specific capacities did not, even when the consenter makes an irrational and inauthentic decision. Finally, Study 3 showed that the effect of autonomy on judgments of valid consent carries important downstream consequences for moral reasoning about the rights and obligations of third parties, even when the consented-to action is morally wrong. Overall, these findings suggest that laypeople embrace a normative, domain-general concept of valid consent that depends consistently on the possession of autonomous capacities, but not on the exercise of these capacities. Autonomous decisions and autonomous capacities thus play divergent roles in moral reasoning about consent interactions: while the former appears relevant for assessing the wrongfulness of consented-to acts, the latter plays a role in whether consent is regarded as authoritative and therefore as transforming moral rights. (shrink)

What does morality require of individuals in their dating and sex life? In this article I challenge recent outlines of antidiscrimination duties in the dating sphere and present a plausible alternative: the deliberative duty. This duty avoids the risks and limitations of earlier outlines: it is time-sensitive regarding the malleability of intimate preferences, it avoids being too demanding on the duty-bearer and minimizes the risk of generating mere dutiful attraction behavior towards right-holders. In addition, it is better suited for universal (...) action guidance in the dating sphere than earlier outlines of individual antidiscrimination duties. (shrink)