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  1.  6
    Ethical Issues Surrounding Controlled Human Infection Challenge Studies in Endemic Low‐and Middle‐Income Countries.Euzebiusz Jamrozik & Michael J. Selgelid - 2020 - Bioethics 34 (8):797-808.
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  2. Victims, Vectors and Villains: Are Those Who Opt Out of Vaccination Morally Responsible for the Deaths of Others?Euzebiusz Jamrozik, Toby Handfield & Michael J. Selgelid - 2016 - Journal of Medical Ethics (12):762-768.
    Mass vaccination has been a successful public health strategy for many contagious diseases. The immunity of the vaccinated also protects others who cannot be safely or effectively vaccinated—including infants and the immunosuppressed. When vaccination rates fall, diseases like measles can rapidly resurge in a population. Those who cannot be vaccinated for medical reasons are at the highest risk of severe disease and death. They thus may bear the burden of others' freedom to opt out of vaccination. It is often asked (...)
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  3.  69
    Against COVID‐19 Vaccination of Healthy Children.Steven R. Kraaijeveld, Rachel Gur-Arie & Euzebiusz Jamrozik - forthcoming - Bioethics.
    COVID-19 vaccination of children has begun in a number of countries with provisional regulatory approval and public support. This article provides an ethical analysis of COVID-19 vaccination of healthy children. Specifically, we present three of the strongest arguments that might justify COVID-19 vaccination of children: (a) an argument from paternalism, (b) an argument from indirect protection and altruism, and (c) an argument from global eradication. We offer a series of objections to each of these arguments to show that none of (...)
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  4.  8
    Human Infection Challenge Studies in Endemic Settings and/or Low-Income and Middle-Income Countries: Key Points of Ethical Consensus and Controversy.Euzebiusz Jamrozik & Michael J. Selgelid - 2020 - Journal of Medical Ethics 46 (9):601-609.
    Human infection challenge studies involve intentionally infecting research participants with pathogens. There have been recent calls for more HCS to be conducted in low-income and middle-income countries, where many relevant diseases are endemic. HCS in general, and HCS in LMICs in particular, raise numerous ethical issues. This paper summarises the findings of a project that explored ethical and regulatory issues related to LMIC HCS via a review of relevant literature and 45 qualitative interviews with scientists and ethicists. Among other areas (...)
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  5.  15
    Coronavirus Human Infection Challenge Studies: Assessing Potential Benefits and Risks.Euzebiusz Jamrozik, George S. Heriot & Michael J. Selgelid - 2020 - Journal of Bioethical Inquiry 17 (4):709-715.
    Human infection challenge studies have been proposed as a means to accelerate SARS-CoV2 vaccine development and thereby help to mitigate a prolonged global public health crisis. A key criterion for the ethical acceptability of SARS-CoV2 HCS is that potential benefits outweigh risks. Although the assessment of risks and benefits is meant to be a standard part of research ethics review, systematic comparisons are particularly important in the context of SARS-CoV2 HCS in light of the significant potential benefits and harms at (...)
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  6.  51
    An Ethical Analysis of Vaccinating Children Against COVID-19: Benefits, Risks, and Issues of Global Health Equity [Version 2; Peer Review: 1 Approved, 1 Approved with Reservations].Rachel Gur-Arie, Steven R. Kraaijeveld & Euzebiusz Jamrozik - forthcoming - Wellcome Open Research.
    COVID-19 vaccination of children has begun in various high-income countries with regulatory approval and general public support, but largely without careful ethical consideration. This trend is expected to extend to other COVID-19 vaccines and lower ages as clinical trials progress. This paper provides an ethical analysis of COVID-19 vaccination of healthy children. Specifically, we argue that it is currently unclear whether routine COVID-19 vaccination of healthy children is ethically justified in most contexts, given the minimal direct benefit that COVID-19 vaccination (...)
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  7.  8
    Should Practice and Policy Be Revised to Allow for Risk-Proportional Payment to Human Challenge Study Participants?Euzebiusz Jamrozik & Michael J. Selgelid - 2020 - Journal of Medical Ethics 46 (12):835-836.
    Human infection challenge studies provide illuminating case studies for several ongoing debates in research ethics, including those related to research risks and payment of participants. Grimwade et al 1 add to previous public engagement, qualitative evidence and philosophical literature on these topics.1–8 The authors advocate revision of research payment policy and practice based on their main finding that members of the public endorse ex ante payment of participants proportional to research-related risk exposure, in addition to post hoc compensation for any (...)
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  8.  7
    SARS-CoV-2 Challenge Studies: Ethics and Risk Minimisation.Susan Bull, Euzebiusz Jamrozik, Ariella Binik & Michael J. Parker - 2021 - Journal of Medical Ethics 47 (12):79-79.
    COVID-19 poses an exceptional threat to global public health and well-being. Recognition of the need to develop effective vaccines at unprecedented speed has led to calls to accelerate research pathways ethically, including by conducting challenge studies ) with SARS-CoV-2. Such research is controversial, with concerns being raised about the social, legal, ethical and clinical implications of infecting healthy volunteers with SARS-CoV-2 for research purposes. Systematic risk evaluations are critical to inform assessments of the ethics of any proposed SARS-CoV-2 CHIs. Such (...)
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  9.  7
    Surveillance and Control of Asymptomatic Carriers of Drug‐Resistant Bacteria.Euzebiusz Jamrozik & Michael J. Selgelid - 2019 - Bioethics 33 (7):766-775.
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  10.  14
    Ethics, Health Policy, and Zika: From Emergency to Global Epidemic?Euzebiusz Jamrozik & Michael J. Selgelid - 2018 - Journal of Medical Ethics 44 (5):343-348.
    Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation, with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting the PAHO ethics (...)
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  11.  12
    How to Hold an Ethical Pox Party.Euzebiusz Jamrozik - 2017 - Journal of Medical Ethics:medethics-2017-104336.
    Pox parties are a controversial alternative to vaccination for diseases such as chickenpox. Such parties involve parents infecting non-immune children by exposing them to a contagious child. If successful, infection will usually lead to immunity, thus preventing infection later in life, which, for several vaccine-preventable diseases, is more severe than childhood infection. Some may consider pox parties more morally objectionable than opting out of vaccination through non-medical exemptions. In this paper, I argue that this is not the case. Pox parties (...)
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  12.  6
    Imagination and Remembrance: What Role Should Historical Epidemiology Play in a World Bewitched by Mathematical Modelling of COVID-19 and Other Epidemics?Euzebiusz Jamrozik & George S. Heriot - 2021 - History and Philosophy of the Life Sciences 43 (2):1-5.
    Although every emerging infectious disease occurs in a unique context, the behaviour of previous pandemics offers an insight into the medium- and long-term outcomes of the current threat. Where an informative historical analogue exists, epidemiologists and policymakers should consider how the insights of the past can inform current forecasts and responses.
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  13. Ethics and Drug Resistance: Collective Responsibility for Global Public Health.Euzebiusz Jamrozik & Michael Selgelid (eds.) - 2020 - Springer.
    This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data (...)
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  14.  6
    Invisible Epidemics: Ethics and Asymptomatic Infection. [REVIEW]Michael J. Selgelid & Euzebiusz Jamrozik - 2020 - Monash Bioethics Review 38 (Suppl 1):1-16.
    Interactions between microbes and human hosts can lead to a wide variety of possible outcomes including benefits to the host, asymptomatic infection, disease, and/or death. Whether or not they themselves eventually develop disease, asymptomatic carriers can often transmit disease-causing pathogens to others. This phenomenon has a range of ethical implications for clinical medicine, public health, and infectious disease research. The implications of asymptomatic infection are especially significant in situations where, and/or to the extent that, the microbe in question is transmissible, (...)
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  15.  1
    Infections with Benefits.Euzebiusz Jamrozik - 2020 - The Philosophers' Magazine 90:64-70.
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