Recently opposing effects of cysteine protease inhibitors, the human cystatins, on neurodegeneration have been reported. Human cystatin C is a risk factor for late‐onset Alzheimer's disease (AD), whereas human stefin B (cystatin B) has no direct involvement in AD. Conflicting data show that their target protease, cathepsin B, might be anti‐amyloidogenic, helping in amyloid‐beta (Aβ) clearance or, instead, might be involved in Aβ production. Some reports claim that cystatin C binds soluble Aβ, making transgenic animals healthier, others, in contrast, that (...) deleting cystatins genes may contribute to amyloid pathology in animal models of AD. (shrink)

Modern science is so much specialised that it seems utopic to try to follow it all at once. This new book is aimed at crossing the gap between specialists and a common understanding of 'modern science'. It would seem desirable that all educated people would know something from the humanities, literature, art but also the newest developments of natural sciences. One aim of this book is to point out the main messages of certain scientific fields, and what is really new (...) and beyond the average educational level, in order to broaden our horizons. Therefore, at the end of the chapters each scientific field possible future contributions and and ethical concerns, if any, are elaborated. (shrink)