Risk–benefit assessment is a routine requirement for research ethics committees that review and oversee biomedical research with human subjects. Nevertheless, it remains unclear how to weigh and balance risks to research participants against the social benefits that flow from generating biomedical knowledge. In this article, we address the question of whether there are any reasonable criteria for defining the limit of permissible risks to individuals who provide informed consent for research participation. We argue against any a priori limit to permissible (...) research risks. However, attention to the uncertainty of potential social benefit that can be derived from any particular study warrants caution in exposing prospective research participants to a substantial likelihood of serious harm. (shrink)

Does action always arise out of desire? G. F. Schueler examines this hotly debated topic in philosophy of action and moral philosophy, arguing that once two senses of "desire" are distinguished - roughly, genuine desires and pro attitudes - apparently plausible explanations of action in terms of the agent's desires can be seen to be mistaken. Desire probes a fundamental issue in philosophy of mind, the nature of desires and how, if at all, they motivate and justify our actions. At (...) least since Hume argued that reason "is and of right ought to be the slave of the passions," many philosophers have held that desires play an essential role both in practical reason and in the explanation of intentional action. G. F. Schueler looks at contemporary accounts of both roles in various belief-desire models of reasons and explanation and argues that the usual belief-desire accounts need to be replaced. Schueler contends that the plausibility of the standard belief-desire accounts rests largely on a failure to distinguish "desires proper," like a craving for sushi, from so-called "pro attitudes," which may take the form of beliefs and other cognitive states as well as desires proper. Schueler's "deliberative model" of practical reasoning suggests a different view of the place of desire in practical reason and the explanation of action. He holds that we can arrive at an intention to act by weighing the relevant considerations and that these may not include desires proper at all. (shrink)

`Folk Psychology' - our everyday talk of beliefs, desires and mental events - has long been compared with the technical language of `Cognitive Science'. Does folk psychology provide a correct account of the mental causes of our behaviour, or must our everyday terms ultimately be replaced by a language developed from computational models and neurobiology? This broad-ranging book addresses these questions, which lie at the heart of psychology and philosophy. Providing a critical overview of the key literature in the field, (...) including the seminal work of Fodor and Churchland, the author explores the classic `Frame Problem' and assesses the future prospects of cognitive science. The scope of the frame problem, touching on connec. (shrink)

Transplantation of vital organs has been premised ethically and legally on "the dead donor rule" (DDR)—the requirement that donors are determined to be dead before these organs are procured. Nevertheless, scholars have argued cogently that donors of vital organs, including those diagnosed as "brain dead" and those declared dead according to cardiopulmonary criteria, are not in fact dead at the time that vital organs are being procured. In this article, we challenge the normative rationale for the DDR by rejecting the (...) underlying premise that it is necessarily wrong for physicians to cause the death of patients and the claim that abandoning this rule would exploit vulnerable patients. We contend that it is ethical to procure vital organs from living patients sustained on life support prior to treatment withdrawal, provided that there is valid consent for both withdrawing treatment and organ donation. However, the conservatism of medical ethics and practical concerns make it doubtful that the DDR will be abandoned in the near future. This leaves the current practice of organ transplantation based on the "moral fiction" that donors are dead when vital organs are procured. (shrink)

Participants are often not informed by investigators who conduct randomised, placebo-controlled acupuncture trials that they may receive a sham acupuncture intervention. Instead, they are told that one or more forms of acupuncture are being compared in the study. This deceptive disclosure practice lacks a compelling methodological rationale and violates the ethical requirement to obtain informed consent. Participants in placebo-controlled acupuncture trials should be provided an accurate disclosure regarding the use of sham acupuncture, consistent with the practice of placebo-controlled drug trials.

Despite strong growth in scientific investigation of the placebo effect, understanding of this phenomenon remains deeply confused. We investigate critically seven common conceptual distinctions that impede clear understanding of the placebo effect: (1) verum/placebo, (2) active/inactive, (3) signal/noise, (4) specific/nonspecific, (5) objective/subjective, (6) disease/illness, and (7) intervention/context. We argue that some of these should be eliminated entirely, whereas others must be used with caution to avoid bias. Clearing away the conceptual underbrush is needed to lay down a path to understanding (...) and harnessing placebo effects in clinical medicine. (shrink)

Previous studies have identified the critical role of the left fusiform cortex in visual word form processing, learning, and memory. However, this so-called visual word form area's other functions are not clear. In this study, we used fMRI and the subsequent memory paradigm to examine whether the putative VWFA was involved in the processing and successful memory encoding of faces as well as words. Twenty-two native Chinese speakers were recruited to memorize the visual forms of faces and Chinese words. Episodic (...) memory for the studied material was tested 3. h after the scan with a recognition test. The fusiform face area and the VWFA were functionally defined using separate localizer tasks. We found that, both within and across subjects, stronger activity in the VWFA was associated with better recognition memory of both words and faces. Furthermore, activation in the VWFA did not differ significantly during the encoding of faces and words. Our results revealed the important role of the so-called VWFA in face processing and memory and supported the view that the left mid-fusiform cortex plays a general role in the successful processing and memory of different types of visual objects. © 2010 Elsevier Inc. (shrink)

This collection of Kant's writings on the philosophy of history includes, besides the well-known "What is Enlightenment?" and "Perpetual Peace," several other essays from his critical period. Most are newly translated. Together they give a reasonably complete picture of Kant's views on history, which he never presented in systematic form. The result is valuable in showing how widely Kant applied some of the central principles of the Critiques, as well as the close relationship of his ideas to other Enlightenment thinkers. (...) The editor provides a useful introduction.--A. F. G. (shrink)

This volume forms a part of the Great American Thinkers Series and is intended for the general reader. It is largely devoted to a highly readable biography of Jefferson in which main emphasis is placed on his political activities and ideas, and their influence upon the development of the United States. A separate essay at the end gives the outlines of Jefferson's thought, relating it to the contemporary ideas of the enlightenment, and tracing its sources to those thinkers whom Jefferson (...) most admired, Bacon, Newton, Locke, and Epicurus. In discussing these figures, the author exhibits an unfortunate tendency towards facile and occasionally incorrect generalizations.—A. F. G. (shrink)

Although established in the law and current practice, the determination of death according to neurological criteria continues to be controversial. Some scholars have advocated return to the traditional circulatory and respiratory criteria for determining death because individuals diagnosed as ‘brain dead’ display an extensive range of integrated biological functioning with the aid of mechanical ventilation. Others have attempted to refute this stance by appealing to the analogy between decapitation and brain death. Since a decapitated animal is obviously dead, and ‘brain (...) death’ represents physiological decapitation, brain dead individuals must be dead. In this article we refute this ‘decapitation gambit.’ We argue that decapitated animals are not necessarily dead, and that, moreover, the analogy between decapitation and the clinical syndrome of brain death is flawed. (shrink)

Friedman characterizes modern man as alienated and problematic, an exile and a rebel. The Modern Promethean and the Modern Job are the typical responses to this situation. These categories are central to Friedman's "depth-image" of modern man and he attempts to give them concrete meaning through intensive examination of the writings of Melville, Dostoievsky, Kafka and Camus. The analysis tends to be repetitious and often too detailed to have clear relevance to the author's main theme.—A. F. G.

Contains three lectures on vaguely related topics. John Cogley outlines the sources of religious conflict in the United States. Holding that the First Amendment was intended not to discourage religion but to promote religious liberty, he develops principles for the solution of problems of Church-State relations. Paul Weiss discusses the more theoretical problem of the relationship of natural and supernatural law. Natural law derives from a common good relative to a particular group, and is strictly utilitarian. Reference to a supernatural (...) or divinely given good is necessary to adjudicate between and order the differing and possibly conflicting common goods of different groups, and to provide for ethical laws that transcend utilitarian considerations. John Wu sees the main prerequisite of a future world democracy as a meeting of the insights and cultures of the East and West.--A. F. G. (shrink)

Cassirer rejects Burckhardt's thesis that there is a radical separation between the theory and practice of the Renaissance, and that Renaissance philosophy is merely a survival of the Middle Ages, containing none of the new tendencies of the period. Nor does he see a sharp break between Renaissance and medieval thought. Instead, Cassirer traces the "close interplay between religion, philosophy, and humanism" in Renaissance thought, and the gradual emergence of a new view of man. Underlying the astonishing variety of philosophies (...) in this period, he uncovers certain common tendencies. Starting with Cusanus, the key transition figure in the shift from medieval patterns of thought, Cassirer traces the rise of new conceptions of knowledge, science, freedom and humanity.--A. F. G. (shrink)