Whole-genome analysis and whole-exome analysis generate many more clinically actionable findings than traditional targeted genetic analysis. These findings may be relevant to research participants themselves as well as for members of their families. Though researchers performing genomic analyses are likely to find medically significant genetic variations for nearly every research participant, what they will find for any given participant is unpredictable. The ubiquity and diversity of these findings complicate questions about disclosing individual genetic test results. We outline an approach for (...) disclosing a select range of genetic results to the relatives of research participants who have died, developed in response to relatives? requests during a pilot study of large-scale medical genetic sequencing. We also argue that studies that disclose individual research results to participants should, at a minimum, passively disclose individual results to deceased participants? relatives. (shrink)

Using as a springboard a three-way debate between theoretical physicist Lee Smolin, philosopher of science Nancy Cartwright and myself, I address in layman’s terms the issues of why we need a unified theory of the fundamental interactions and why, in my opinion, string and M-theory currently offer the best hope. The focus will be on responding more generally to the various criticisms. I also describe the diverse application of string/M-theory techniques to other branches of physics and mathematics which render the (...) whole enterprise worthwhile whether or not “a theory of everything” is forthcoming. (shrink)

[...] Rousseau bir yandan çağının yükselen değerlerinden yararlanırken diğer yandan bu değerlerin içeriden eleştirisini yapmayı başarabilen düşünürlerden biri olduğu için fikirleri ölümünden asırlar sonra bile önemini yitirmemiştir. Demokratik devletlerin meşruiyet krizinin giderek derinleştiği ve çoğunlukçu, majoritarian, ideolojilerin etraflıca sorgulanmaya başlandığı çağımızda, demokrasiyi çoğunluk kararına ek olarak “rıza”, “Yurttaşlık”, “sivil özgürlük”, “kamusal uzlaşı” ve “Genel İrade” kavramlarıyla birlikte ele alan Rousseau’yu yeniden okumak önemlidir [...] Rousseau-demokrasi ilişkisinin kazılıp ortaya çıkartılacağı bu metinde uğranılacak olan kavramsal duraklar sırasıyla: Eşitsizlik (doğal ve toplumsal), özgürlük (...) (doğal ve sivil), politik bütün (bodypolitic), Genel İrade, ortak iyi (common good) ve Egemen olmalıdır. Söz konusu kavramlar, Rousseau’nun onlara yüklediği özgün anlamları gözden kaçırılmadan sanki ilk defa karşılaşılıyormuşçasına bir zihin açıklığı ile okundukları zaman, onun demokrasi görüşü de gün ışığına çıkartılabilir. (shrink)

My aim in this paper is to attempt a philosophical reading of M. Karagatsis’ novel Kitrinos Fakelos (1956), focusing my analysis on the passions and the emotions of its fictional characters, aiming at demonstrating their independence as well as the presentation of their psychography in Karagatsis’ novel where the description of the emotions caused by love is a dominant feature. In particular, I will examine the expression of desire, love (erôs) and sympathy in this novel – passions and emotions that (...) play an important role to moral life and human existence in general. I will be approaching these issues from the point of view of moral philosophy, analyzing the passions and the emotions expressed by the fictional characters in Kitrinos Fakelos, and in particular of the fictional character of Manos Tasakos. At the same time, I will attempt to show the philosophical influences that M. Karagatsis has received in his literary work, and especially in his novel Kitrinos Fakelos, by the philosophical thought of Friedrich Nietzsche. In addition, I will try to demonstrate the contrast between the Nietzschean moral model and that of both ancient and contemporary virtue ethical theory, in relation to the traditional interpretation of the work of Nietzsche’s that Karagatsis adopts, along with many of his contemporaries in Greece from the beginning of the 20th century until the 70’s at least. (shrink)

Society Must Be Defended is a collection of Michel Foucault’s courses at the College de France in 1976. In this volume, Foucault discusses the emergence of a new technology of domination called biopower. It is a power that is not “individualizing”, but “massifying”, that is directed at man as a member of a “species”. Biopolitics exerts control over relations between the human races. Yet, some critics claim that Foucault’s biopower does not address colonial societies and problems. This paper argues that (...) Foucault’s theory of biopower could be applied to the postcolonial discourse, too. To trace Foucauldian biopower in postcolonial literature, the authors of this article have focused on E. M. Forster’s A Passage to India. In this paper, the plot and the dialogue of Forster’s novel is studied based on Foucault’s theory of biopower as discussed in his Society Must Be Defended. It is concluded that in Forster’s novel, it can be noticed that the English power, which dominated early twentieth century Indian society, employs biopower to subjugate the Indian population. The English officials control India not merely by means of disciplinary institutions, but by manufacturing norms for an entire race which are explainable in terms of Foucault’s theory of biopower. (shrink)

Since the beginning of the 20th Century to the present day, it has rarely been doubted that whenever formal aesthetic methods meet their iconological counterparts, the two approaches appear to be mutually exclusive. In reality, though, an ahistorical concept is challenging a historical analysis of art. It is especially Susanne K. Langer´s long-overlooked system of analogies between perceptions of the world and of artistic creations that are dependent on feelings which today allows a rapprochement of these positions. Krois’s insistence on (...) a similar point supports this analysis. - I - Unbestritten bis heute gilt, formwissenschaftliche und ikonologische Methoden scheinen sich grundsätzlich auszuschließen, da die ersteren auf ahistorischen und die letzteren auf historischen Grundlagen aufbauen. Dem entgegen soll mit diesem Beitrag gezeigt werden, wie insbesondere die Forschungen Susanne K. Langers und ergänzend diejenigen von John M. Krois eine Annäherung beider Positionen ermöglichen. (shrink)

Attitudes towards elder people in society depend on the pace of its technological and economical development. Fast changes not only encourage discrimination on the ground of age but also blur the perception of both individual and collective benefits from the extension of life length. This article emphasizes the necessity of finding new ideas of elders’ active social participation. Furthermore it points out the conceptions of creating city areas that favor development and integration of all age groups. It underlines the significance (...) of older generations in process of sustaining cultural continuity in information and knowledge societies by contrasting those ideas with the wisdom society project. ** Ocena obecności ludzi starych w społeczeństwie zależy od tempa rozwoju technologicznego i gospodarczego. Szybkie zmiany sprzyjaj¸a} dyskryminacji ze wzglȩdu na wiek oraz przyczyniaj¸a} siȩ do niedostrzegania jednostkowych i zbiorowych korzyści płyn¸a}cych ze wzrostu długości życia ludzkiego. Artykuł zwraca uwagȩ na niezbȩdność poszukiwania pomysłów aktywnego uczestnictwa seniorów w życiu społecznym, jak też przybliża koncepcjȩ kreowania przestrzeni miejskich sprzyjaj¸a}cych rozwojowi i integracji wszystkich grup wiekowych. Praca podkreśla znaczenie starszego pokolenia w procesie utrzymania ci¸agłości kulturowej w społeczeństwach informacyjnych i społeczeństwach wiedzy poprzez przeciwstawienie tych idei projektowi społeczeństwa m¸adrości. (shrink)

The “representation problem” in abstract algebraic logic is that of finding necessary and sufficient conditions for a structure, on a well defined abstract framework, to have the following property: that for every structural closure operator on it, every structural embedding of the expanded lattice of its closed sets into that of the closed sets of another structural closure operator on another similar structure is induced by a structural transformer between the base structures. This question arose from Blok and Jónsson abstract (...) analysis of one of Blok and Pigozzis’s characterizations of algebraizable logics. The problem, which was later on reformulated independently by Gil-Férez and by Galatos and Tsinakis, was solved by Galatos and Tsinakis in the more abstract framework of the category of modules over a complete residuated lattice, and by Galatos and Gil-Férez in the even more abstract setting of modules over a quantaloid. We solve the representation problem in Blok and Jónsson’s original context of M-sets, where M is a monoid, and characterise the corresponding M-sets both in categorical terms and in terms of their inner structure, using the notions of a graded M-set and a generalized variable introduced by Gil-Férez. (shrink)

Ethics of Richard M. Hare is widely considered as a classical example of the strong internalistic theory of motivation: he is thought to believe that having a moral motive is a sufficient condition to act accordingly. However, strong internalism has difficulties with explaining the phenomenon of acrasia and amoralism. For this reason some critics charge him with developing a false theory of moral motivation. In the article I present Hare's answer to these questions by dividing the discussion about motivation into (...) three levels: semantical, epistemological, and ontological. I also explain his concept of internal motivation and argue that his theory, contrary to what his critics assume, may be called a weak motivational internalism. (shrink)

This is a review (in French) of the French translation and edition of D.M. Armstrong's Universals: An Opiniated Introduction.

The opening argument in the Metaphysics M.2 series targeting separate mathematical objects has been dismissed as flawed and half-hearted. Yet it makes a strong case for a point that is central to Aristotle’s broader critique of Platonist views: if we posit distinct substances to explain the properties of sensible objects, we become committed to an embarrassingly prodigious ontology. There is also something to be learned from the argument about Aristotle’s own criteria for a theory of mathematical objects. I hope to (...) persuade readers of Metaphysics M.2 that Aristotle is a more thoughtful critic than he is often taken to be. (shrink)

Artykuł przedstawia sformułowaną przez M.A. Krąpca propozycję filozoficznego wyjaśnienia bytu społecznego na podstawie rozumienia człowieka jako spotencjalizowanej osoby. Kluczowe dla zaprezentowanej w artykule koncepcji M.A. Krąpca jest filozoficzne ujęcie dobra wspólnego rozumianego personalistycznie, jako analogicznie wspólny wszystkim ludziom cel: aktualizacja potencjalności osobowych człowieka, a więc rozwój moralny, wolitywny i twórczy każdego człowieka. Zapewnienie środków realizacji tak rozumianego dobra wspólnego stanowi zasadniczą rację bytu społeczeństwa i państwa. Wszelki byt społeczny jest bowiem — jako rzeczywistość relacyjna — ontycznie „słabszy” niż istniejąca w (...) sposób podmiotowy osoba ludzka. Dobro wspólne rozumiane personalistycznie stanowi jedyne dobro w pełni nieantagonistyczne: rozwój osobowy poszczególnych ludzi nikogo nie uszczupla, a wszystkich ubogaca. Zatem nie stanowi ono podporządkowania jednostki dobru całości rozumianej w sposób kolektywny. Jednocześnie pozwala na wskazanie racjonalnych podstaw dla konieczności istnienia rozmaitych społeczności, bez których rozwój osobowy nie mógłby się dokonać. Zaproponowana w artykule koncepcja M.A. Krąpca, akcentując prymat osoby względem bytu społecznego, jednocześnie wskazuje na fakt konieczności istnienia różnorakich społeczności jako ugruntowanych w ludzkiej spotencjalizowanej naturze środowisk umożliwiających rozwój osobowy człowieka. Tym samym pozwala na przekroczenie dychotomii indywidualizm — kolektywizm. (shrink)

Von 1925 bis 1928 wurden im Berliner J. M. Spaeth-Verlag unter der Leitung von Hans Rosenkranz eine Reihe von Werken seinerzeit eher unbekannter, in der Retrospektive jedoch signifikanter Autoren der Zwischenkriegszeit publiziert. Der Beitrag thematisiert Rosenkranz als jungen Verleger und Bewunderer Stefan Zweigs. Er entwirft auf Grundlage der Archivüberlieferung einen neuen Blick auf die Geschichte des Unternehmens und kommentiert das damit verbundene literarische Programm: Welche wichtigen verlegerischen Projekte wurden in jener kurzen Zeit unternommen? Welche Rolle hatte Stefan Zweig für das (...) Zustandekommen einiger Titel und besonders in den letzten Wochen der Verlagsexistenz? Inwiefern lässt sich Programmgestaltung und ökonomische Entwicklung von J. M. Spaeth als paradigmatisch für jüdische Verlage in der Weimarer Republik verstehen? Dazu wird erstmals das Scheitern des Unternehmens während der „Bücherkrise“ Ende der 1920er Jahre aus den Quellen rekonstruiert. (shrink)

Resumen Nuestro trabajo presenta una nueva propuesta de lectura de una inscripción hallada en Emporiae en honor de un M. Iuṇ[ius] cuya identidad tratamos de determinar, planteando la posibilidad de que se trate del pretor M. Iunius citado por Cicerón en su discurso Pro Cluentio y de que, por lo tanto, la inscripción corresponda a su posible proconsulado en Hispania Citerior hacia el año 68 a. C. Dicho supuesto nos permite al mismo tiempo poner al personaje en relación con las (...) circunstancias fundacionales de la ciudad romana de Emporiae, cuyo nacimiento sitúan hoy ciertos arqueólogos en las primeras décadas del siglo I a. C. (shrink)

Zusammenfassung Ellen M. Wood hat mit ihrer Studie „Retreat from Class. A ‚new true socialism“ bereits 1986 eine überzeugende Kritik des Postmarxismus vorgelegt. Der Artikel zeichnet deren zentrale Punkte nach und zeigt, dass diese auf einer innovativen Interpretation des historischen Materialismus beruhen, die als ‚politischer Marxismus‘ bezeichnet wird. Gleichwohl bleibt zu fragen, ob Woods Kritik nicht zugleich Annahmen des klassischen Marxismus reproduziert, die historisch wie systematisch zweifelhaft sind.

This paper gives an account of the debate between F.A. Hayek and J.M. Keynes in the 1930s written for the general public. The purpose of this is twofold. First, to provide the general reader with a narrative of what happened, … More ›.

This paper aims to present a critique of naturalistic theories of violence. The context of this critique concerns the naturalization of violence, which induces the assimilation power as a form of violence. Therefore, we resumed the theses of Hannah Arendt and Michel Foucault on power and violence. The goal is not to list the differences between these authors on the subject, which are explicit in the development of the test, but show their concordance regarding the critique of power as something (...) synonymous with violence. (shrink)

Kinetic models using enzyme kinetics are developed for the three ways that Louie proved that Rosen’s minimal (M-R)-System can be closed to efficient cause; i.e., how the “replication” component can itself be entailed from within the system. The kinetic models are developed using the techniques of network thermodynamics. As a demonstration, each model is simulated using a SPICE circuit simulator using arbitrarily chosen rate constants. The models are built from SPICE sub-circuits representing the key terms in the chemical rate equations. (...) The models include the addition of an ad hoc semi-permeable membrane so the system can achieve steady state fluxes and also to illustrate the need for all the efficient cause agents to be continually replaced. Comments are made about exactly what is being simulated. (shrink)

In this note we develop a method for constructing finite totally-ordered m-zeroids and prove that there exists a categorical equivalence between the category of finite, totally-ordered m-zeroids and the category of pseudo Łukasiewicz-like implicators.

In this paper we pursue the study of the variety of m -generalized Łukasiewicz algebras of order n which was initiated in [1]. This variety contains the variety of Łukasiewicz algebras of order n . Given , we establish an isomorphism from its congruence lattice to the lattice of Stone filters of a certain Łukasiewicz algebra of order n and for each congruence on A we find a description via the corresponding Stone filter. We characterize the principal congruences on A (...) via Stone filters. In doing so, we obtain a polynomial equation which defines the principal congruences on the algebras of . After showing that for m > 1 and n > 2, the variety of Łukasiewicz algebras of order n is a proper subvariety of , we prove that is a finitely generated discriminator variety and point out some consequences of this strong property, one of which is congruence permutability. (shrink)

To our knowledge, this is one of the first studies to test different theoretical models of working memory in childhood based on a computerized assessment. We tested this across several countries: Argentina, Brazil, Canada, Italy, and UK. The present study addressed the wider macro-cultural context and how this impacts working memory. We used two economic indices to characterize the participating countries and ranked the countries based on the Global Index of Cognitive Skills and Educational Attainment. Children between 5 and 10 (...) years completed the same set of short-term and working memory tests. There were two main findings. First, there was a similar pattern in verbal working memory across countries, which suggests that this skill may be relatively consistent across different cultural groups. In contrast, the pattern for visuo-spatial working memory was different across countries, which may explained by cultural differences and educational rankings of the countries. The second main finding was that both a domain-general model and a domain-specific model provided a reasonably good fit with the data, there was the high relationship between the verbal and visuo-spatial working memory constructs across the countries in the latter model. Thus, it may be a more parsimonious choice to rely on a three-factor model. The data also suggest culture-similar patterns in a computerized assessment of working memory. (shrink)

El presente artículo presenta los nuevos e importantes descubrimientos en la terraza litoral al pie del oasis de niebla, a partir de Noviembre de 2003, que junto a estudios anteriores conforman un cuadro general bastante completo de los patrones de asentamiento, modus vivendi, costumbres y actividades económicas de los antiguos pobladores costeros del norte de Chile, que reafirman la enorme importancia que adquirió el ecosistema de oasis de niebla costero en el género de vida, tipos de asentamiento y desplazamientos de (...) los cazadores-recolectores marinos del litoral norte. (shrink)

The present paper proposes to analyse the role of the practical syllogism in G.E.M. Anscombe’s theory of action. To this end, I have rst of all chosen to examine, even if in broad terms, the conception of practical syllogism as it is present in the Aristotelian doctrine, and to reveal/delineate some critical points found within it. The following section is the central part of the paper, where, starting from § 33 of Intention, a re ection is carried out on the (...) practical syllogism, which is among Aristotle’s most signi cant discoveries, chie y bringing into focus its teleological prospective. Action, in Anscombe’s thought, almost seems be the cornerstone of a profound, and in a certain sense “contextual”, comprehension of the subject. (shrink)

l. There is an antinomy in Hare's thought between Ought-Implies-Can and No-Indicatives-from-Imperatives. It cannot be resolved by drawing a distinction between implication and entailment. 2. Luther resolved this antinomy in the l6th century, but to understand his solution, we need to understand his problem. He thought the necessity of Divine foreknowledge removed contingency from human acts, thus making it impossible for sinners to do otherwise than sin. 3. Erasmus objected (on behalf of Free Will) that this violates Ought-Implies-Can which he (...) supported with Hare-style ordinary language arguments. 4. Luther a) pointed out the antinomy and b) resolved it by undermining the prescriptivist arguments for Ought-Implies-Can. 5. We can reinforce Luther's argument with an example due to David Lewis. 6. Whatever its merits as a moral principle, Ought-Implies-Can is not a logical truth and should not be included in deontic logics. Most deontic logics, and maybe the discipline itself, should therefore be abandoned. 7. Could it be that Ought-Conversationally-Implies-Can? Yes - in some contexts. But a) even if these contexts are central to the evolution of Ought, the implication is not built into the semantics of the word; b) nor is the parallel implication built into the semantics of orders; and c) in some cases Ought conversationally implies Can, only because Ought-Implies-Can is a background moral belief. d) Points a) and b) suggest a criticism of prescriptivism - that Oughts do not entail imperatives but that the relation is one of conversational implicature. 8. If Ought-Implies-Can is treated as a moral principle, Erasmus' argument for Free Will can be revived (given his Christian assumptions). But it does not 'prove' Pelagianism as Luther supposed. A semi-Pelagian alternative is available. (shrink)

This article compares James M. Buchanan's and John Rawls's theories of democratic governance. In particular it compares their positions on the characteristics of a legitimate social contract. Where Buchanan argues that additional police force can be used to quell political demonstrations, Rawls argues for a social contract that meets the difference principle.

A large body of literature agrees that persons with schizophrenia suffer from a Theory of Mind deficit. However, most empirical studies have focused on third-person, egocentric ToM, underestimating other facets of this complex cognitive skill. Aim of this research is to examine the ToM of schizophrenic persons considering its various aspects, to determine whether some components are more impaired than others. We developed a Theory of Mind Assessment Scale and administered it to 22 persons with a DSM-IV diagnosis of schizophrenia (...) and a matching control group. Th.o.m.a.s. is a semi-structured interview which allows a multi-component measurement of ToM. Both groups were also administered a few existing ToM tasks and the schizophrenic subjects were administered the Positive and Negative Symptoms Scale and the WAIS-R. The schizophrenic persons performed worse than control at all the ToM measurements; however, these deficits appeared to be differently distributed among different components of ToM. Our conclusion is that ToM deficits are not unitary in schizophrenia, which also testifies to the importance of a complete and articulated investigation of ToM. (shrink)

This paper examines the complexity and fluidity of maternal identity through an examination of narratives about "real motherhood" found in children's literature. Focusing on the multiplicity of mothers in adoption, I question standard views of maternity in which gestational, genetic and social mothering all coincide in a single person. The shortcomings of traditional notions of motherhood are overcome by developing a fluid and inclusive conception of maternal reality as authored by a child's own perceptions.

This response offers an interpretation of James Gustafson's “Participation: A Religious Worldview,” which thinks with Gustafson on the theme of “participation,” while highlighting points where my own thoughts diverge from his. The essay begins by drawing the reader's attention to Gustafson's style, arguing that the simple elegance of his writing constitutes part of his larger claim about the need to remove ourselves from the center of our thought. Next, the essay analyzes Gustafson's use of “participation” by putting it in context (...) and connecting it with his broader methodology. Finally, I draw the reader's attention to important loci in the text in order to show how Gustafson's essay helps address various extant misinterpretations of his thought but also to point to ways in which my “thinking with” Gustafson leads me to think otherwise than he does. (shrink)

In his Ph.D. thesis [7], L. van den Dries studied the model theory of fields with finitely many orderings and valuations where all open sets according to the topology defined by an order or a valuation is globally dense according with all other orderings and valuations. Van den Dries proved that the theory of these fields is companionable and that the theory of the companion is decidable .In this paper we study the case where the fields are expanded with finitely (...) many orderings and an independent derivation. We show that the theory of these fields still admits a model companion in the language Lequation image = {+, –, ·, D, <1, …, shrink)

J.M. Coetzee’s book, 'Elizabeth Costello' is one of the stranger works to appear in recent years. Yet if we focus our attention on the book’s two chapters dealing with animals, two preoccupations emerge. The first sees Coetzee use animals to evoke a particular conception of ethics, one similar to that of the philosopher Mary Midgley. Coetzee’s second theme connects animals to the phenomena of scapegoating, as it has been characterized by the philosophical anthropologist René Girard. While both themes involve human (...) interactions with animals, each transcends application to that particular issue and raises deeper questions, respectively concerning the foundations of morality and the therapeutic allure of political violence. Making explicit these two preoccupations enhances our understanding of Coetzee’s fiction, particularly Disgrace. However, when Coetzee’s two philosophical strands are analyzed in their own terms, the ethics of sympathy is shown to be a more coherent notion than the understanding of politics he takes over from Girard. (shrink)

R. M. Adams’s essay, “Must God Create the Best?” can be interpreted as offering a theodicy for God’s creating morally less perfect beings than he could have created. By creating these morally less perfect beings, God is bestowing grace upon them, which is an unmerited or undeserved benefit. He does so, however, in advance of the free moral misdeeds that render them undeserving. This requires that God have middle knowledge, pace Adams’s version of the Free Will Theodicy, of what would (...) result from his actualization of possible free persons. It is argued that God’s possession of such middle knowledge negates the freedom of created beings, since God completely determines every action of every created person. And since they are not free, they cannot qualify as morally unmeritorious or undeserving. And, with that, Adams’s theodicy of grace-in-advance collapses. (shrink)