8 found
Order:
  1.  8
    Developmental Scaffolding.Franco Giorgi & Luis E. Bruni - 2015 - Biosemiotics 8 (2):173-189.
    The concept of scaffolding has wide resonance in several scientific fields. Here we attempt to adopt it for the study of development. In this perspective, the embryo is conceived as an integral whole, comprised of several hierarchical modules as in a recurrent circularity of emerging patterns. Within the developmental hierarchy, each module yields an inter-level relationship that makes it possible for the scaffolding to mediate the production of selectable variations. A wide range of genetic, cellular and morphological mechanisms allows the (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  2.  23
    Are Olfactory Receptors Really Olfactive?Franco Giorgi, Roberto Maggio & Luis Emilio Bruni - 2011 - Biosemiotics 4 (3):331-347.
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  3.  16
    Semiotic Tools For Multilevel Cell Communication.Franco Giorgi & Gennaro Auletta - 2016 - Biosemiotics 9 (3):365-382.
    Cell communication plays a key role in multicellular organisms. In developing embryos as in adult organisms, cells communicate by coordinating their differentiation through the establishment and/or renewal of a variety of cell communication channels. Under both these conditions, cells interact by either receptor signalling, surface recognition of specific cell adhesion molecules or transfer of cytoplasmic components through junctional coupling. In recent years, it has become apparent that cells may also communicate through the extracellular release of microvesicles. They may originate as (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  4.  8
    Multi-Level Semiosis: A Paradigm of Emergent Innovation.Luis Emilio Bruni & Franco Giorgi - 2016 - Biosemiotics 9 (3):307-318.
    In this introductory article to the special issue on Multi-level semiosis we attempt to stage the background for qualifying the notion of “multi-levelness” when considering communication processes and semiosis in all life forms, i.e. from the cellular to the organismic level. While structures are organized hierarchically, communication processes require a kind of processual organization that may be better described as being heterarchical. Theoretically, the challenge arises in the temporal domain, that is, in the developmental and evolutionary dimension of dynamic semiotic (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  5.  7
    Receptor Oligomerization as a Process Modulating Cellular Semiotics.Franco Giorgi, Luis Emilio Bruni & Roberto Maggio - 2010 - Biosemiotics 3 (2):157-176.
    The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...)
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  6.  15
    Semiotic Selection of Mutated or Misfolded Receptor Proteins.Franco Giorgi, Luis Emilio Bruni & Roberto Maggio - 2013 - Biosemiotics 6 (2):177-190.
    Receptor oligomerization plays a key role in maintaining genome stability and restricting protein mutagenesis. When properly folded, protein monomers assemble as oligomeric receptors and interact with environmental ligands. In a gene-centered view, the ligand specificity expressed by these receptors is assumed to be causally predetermined by the cell genome. However, this mechanism does not fully explain how differentiated cells have come to express specific receptor repertoires and which combinatorial codes have been explored to activate their associated signaling pathways. It is (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  7.  11
    Germ Cells Are Made Semiotically Competent During Evolution.Franco Giorgi & Luis Emilio Bruni - 2016 - Biosemiotics 9 (1):31-49.
    Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, due to the (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  8.  13
    The Egg as a Semiotic Gateway to Reproduction.Franco Giorgi, Luis Emilio Bruni & Louis J. Goldberg - 2013 - Biosemiotics 6 (3):489-496.
    The egg behaves as a prospective cell sustaining the developmental processes of the future embryo. In biosemiotic terms, this apparent teleonomic behaviour can be accounted for without referring to the exclusive causal role played by its genetic makeup. We envision two different processes that are uniquely found in the oocyte: (1) the first involves the mechanisms by which large amounts of mRNA accumulate in the ooplasm to establish the embryo axes prior to fertilization; (2) the second involves transfer of an (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark