The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)
Beauty challenges conventional approaches to the subject through an interdisciplinary approach that forges connections between the arts, sciences and mathematics. Classical, conventional aspects of beauty are addressed in subtle, unexpected ways: symmetry in mathematics, attraction in the animal world and beauty in the cosmos. This collection arises from the Darwin College Lecture Series of 2011 and includes essays from eight distinguished scholars, all of whom are held in esteem not only for their research but also for their ability to communicate (...) their subject to popular audiences. Each essay is entertaining, accessible and thought-provoking and is accompanied by images illustrating beauty in practice. Contributors include the artist José Hernández, Nobel Prize Laureate Frank Wilczek, Lord May of Oxford and Jeanne Altmann. (shrink)
El presente artículo aborda los engranajes entre escritura y ciudadanía que plantea el poemario de Elvira Hernández, Estado de sitio. Para ello, considera los factores de orden sociocultural que acompañaron su producción, circulación y recepción crítica, en el contexto del estallido social de octubre 2019 en Chile, la coyuntura feminista y el actual proceso constituyente. Hitos de nuestra historia reciente frente a los cuales la poeta se posiciona ética y estéticamente desde una concepción política de la palabra como litigio, esto (...) es, una disputa –discursiva y social– por la enunciación de (en) lo común. (shrink)
A book that pulls together the results of research by several scholars to provide a fresh look at the rich heritage of ideas that Wright contributed to the theory and practice of architecture, with special emphasis on the ordering of structuring of architectural experience. An attempt is made to convey an understanding of Wright's contributions through a direct analysis of his designs as they exist or existed in reality. The authors take a different look at Wright's work in a search (...) for clarity and understanding. (shrink)
At the most general level I am interested in how we come to make sense of the world around us. Much of this research involves asking how intuitive explanations and understandings emerge in development and how they are related to notions of cause, mechanism and agency. These relations are linked to broader questions of what concepts are, how they change with development and increasing expertise and how they are structured in adults.
Wind, water, and molten rock constantly tear apart and resculpt the natural world we live in, and people have always struggled to create structures that will permanently establish their existence on the land. Frank Golhke has committed his camera lens to documenting that fraught relationship between people and place, and this retrospective collection of his work by John Rohrbach reveals how people carve out their living spaces in the face of constant natural disruption. An acclaimed master of landscape photography, (...) Golhke explores in _Accommodating Nature_ how people configure the places where they live, work, and commune, both on an everyday level and in the aftermath of catastrophic destruction. Whether a ranch house anchored fast on an endless Texas plain, the shattered buildings and whipped trees left by a category 5 tornado, or the jagged cliffs of ash and rock created by the volcanic eruption of Mount St. Helens, the photographs unearth the ways in which new homes and lives emerge from the fragments of the old. Thought-provoking essays by Rebecca Solnit, Frank Gohlke, and John Rohrbach expand upon the issues raised by the images, contemplating the complexities of human and cultural geography and the relationships we have with our respective place. An arresting and vibrant visual essay combining magnificent vistas with intimate emotional detail, _Accommodating Nature_ exposes the intricate threads that bind our lives to the land surrounding us. (shrink)
Wind, water, and molten rock constantly tear apart and resculpt the natural world we live in, and people have always struggled to create structures that will permanently establish their existence on the land. Frank Golhke has committed his camera lens to documenting that fraught relationship between people and place, and this retrospective collection of his work by John Rohrbach reveals how people carve out their living spaces in the face of constant natural disruption. An acclaimed master of landscape photography, (...) Golhke explores in Accommodating Nature how people configure the places where they live, work, and commune, both on an everyday level and in the aftermath of catastrophic destruction. Whether a ranch house anchored fast on an endless Texas plain, the shattered buildings and whipped trees left by a category 5 tornado, or the jagged cliffs of ash and rock created by the volcanic eruption of Mount St. Helens, the photographs unearth the ways in which new homes and lives emerge from the fragments of the old. Thought-provoking essays by Rebecca Solnit, Frank Gohlke, and John Rohrbach expand upon the issues raised by the images, contemplating the complexities of human and cultural geography and the relationships we have with our respective place. An arresting and vibrant visual essay combining magnificent vistas with intimate emotional detail, Accommodating Nature exposes the intricate threads that bind our lives to the land surrounding us. (shrink)
I'm pleased to have been offered the chance of replying to Joseph Frank's criticisms . He is a courteous opponent, though capable of a certain asperity. . . . Frank complains that his critics appear incapable of attending to what he really said in his original essay. It is the blight critics are born for; and it is undoubtedly sometimes caused by the venal haste of reviewers, and sometimes by native dullness, and sometimes by malice. But there are (...) other reasons why an author may sometimes feel himself to be misrepresented. One is that a genuinely patient and intelligent reader may be more interested in what the piece under consideration does not quite say than in what is expressly stated. Another is the consequence of fame. Frank's original article is over thirty years old; it crystallised what had been for the most part vague notions, ideas that were in the air, and gave them a memorable name. "Spatial form" entered the jargon of the graduate school and began an almost independent existence. The term might well be used by people who had never read the essay at all; or they might casually attribute to him loose inferences made by others from the general proposition—inferences he had already disallowed and now once more contests. It must be difficult, particularly for an exasperated author, to distinguish between these causes of apparent misrepresentation. But sometimes it can be done; and then it will appear that the effect of the first is far more interesting than that of the second cause. For the suggestion then must be that the author has repressed a desire to take a position which, in his manifest argument, he differentiates from his own. This, as it happens, is what he advances as an explanation of certain ambiguities in my Sense of an Ending; the least one can say is that it is perfectly possible. Frank Kermode is the author of The Sense of an Ending: Studies in the Theory of Fiction, Continuities, and Shakespeare, Spenser, Donne: Renaissance Essays; his works also include The Classic and The Genesis of Secrecy. His contributions to Critical Inquiry are "Novels: Recognition and Deception" , "A Reply to Denis Donoghue" , and "Secrets and Narrative Sequence". (shrink)
Prescriptive political and moral theories contain ideas about what human beings are like and about what, correspondingly, is good for them. Conceptions of human “nature” and corresponding human good enter into normative argument by way of support and justification. Of course, it is logically open for the ratiocinative traffic to run the other way. Strongly held convictions about the rightness or wrongness, goodness or badness, of certain social institutions or practices may help condition and shape one's responses to one or (...) another set of propositions about what people are like and what, in consequence, they have reason to value. (shrink)
In what follows I argue for two interrelated theses: that early Buddhism is not a form of empiricism, and that consequently there is no basis for an early Buddhist apologetic which contrasts an empirical early Buddhism with either a metaphysical Hinduism on the one hand, or with a baseless Christianity on the other.
This paper argues that God may create and exist in any possible world, no matter how much suffering of any sort that world includes. It combines the traditional free will defence with the notion of an ‘occasion’ for good or evil action and limits God's responsibility to the creation of these occasions. Since no possible world contains occasions for more evil than good action, God is morally permitted to create any possible world. With regard to suffering that is not due (...) to free will, namely the suffering of beings who are not moral agents, the paper questions the idea that the relief of such suffering is a moral perfection. (shrink)
We make a huge variety of claims framed in vocabularies drawn from physics and chemistry, everyday talk, neuroscience, ethics, mathematics, semantics, folk and professional psychology, and so on and so forth. We say, for example, that Jones feels cold, that Carlton might win, that there are quarks, that murder is wrong, that there are four fundamental forces, and that a certain level of neurological activity is necessary for thought. If we follow Huw Price's Carnapian lead, we can put this by (...) saying that we make many claims in many different frameworks. (shrink)
Recently Steven E. Boër gave another turn to the discussion of the free will defence by claiming that the free will defence is irrelevant to the justification of moral evil. Conceding that free will may be of real value, Boër claims that free will could have been allowed creatures without that leading to any moral evil at all. What I shall hereafter refer to as the ‘Boër reform’ is the suggestion that God could have allowed creatures to exercise free choices (...) but have intervened with ‘coincidence miracles’ to prevent all the intended evil from actually occurring. What is important to the free will defence, according to Boër, is the ability to choose freely and not the ability to succeed in effecting what we have intended to accomplish. It is no intrusion on the freedom of our wills for God to prevent us from accomplishing what we tried to do with our free wills as long as we were free to try. (shrink)
I submit as a good rule of thumb that if a discussion of any major philosophical position or proposition ends with the conclusion that that position or proposition is ‘absurd’ or ‘meaningless’ then a mistake has been made in the discussion. The mistake often turns out to be the accuser's failure to appreciate precisely what the position being attacked really is.
Resurrection has been used as the conceptual basis for attempted solutions to two problems that occur in the context of western theism, the problem of cognitive meaning and the problem of theodicy. Because John Hick has proposed resurrection as a solution to both problems so extensively, and because Antony Flew and Terence Penelhum have examined those solutions so strenuously, I will use their writings to lay out the problem. My aim is to improve upon Hick by overcoming a weakness in (...) his defence of resurrection. My narrower focus will be on resurrection and the ‘replica objection’, rather than the wider use of resurrection to solve problems of evil or the meaningfulness of theistic discourse, but some brief remarks on the wider problems will be necessary to set the stage. (shrink)
How important is luck in economic success? No question more reliably divides conservatives from liberals. As conservatives correctly observe, people who amass great fortunes are almost always talented and hardworking. But liberals are also correct to note that countless others have those same qualities yet never earn much. In recent years, social scientists have discovered that chance plays a much larger role in important life outcomes than most people imagine. In Success and Luck, bestselling author and New York Times economics (...) columnist Robert Frank explores the surprising implications of those findings to show why the rich underestimate the importance of luck in success--and why that hurts everyone, even the wealthy. Frank describes how, in a world increasingly dominated by winner-take-all markets, chance opportunities and trivial initial advantages often translate into much larger ones--and enormous income differences--over time; how false beliefs about luck persist, despite compelling evidence against them; and how myths about personal success and luck shape individual and political choices in harmful ways. But, Frank argues, we could decrease the inequality driven by sheer luck by adopting simple, unintrusive policies that would free up trillions of dollars each year--more than enough to fix our crumbling infrastructure, expand healthcare coverage, fight global warming, and reduce poverty, all without requiring painful sacrifices from anyone. If this sounds implausible, you'll be surprised to discover that the solution requires only a few, uncontroversial steps. Compellingly readable, Success and Luck shows how a more accurate understanding of the role of chance in life could lead to better, richer, and fairer economies and societies. (shrink)
Am Wiener Kreis scheiden sich die Geister, trat er doch mit dem dezidierten Anspruch auf, mit den Mitteln der modernen Logik den metaphysischen Schutt von Jahrtausenden aus dem Weg zu räumen. Statt einer homogenen Bewegung, die sich empiristischen Dogmen verschrieb, erscheint der Wiener Kreis in der philosophischen Forschung jedoch heute als eine heterogene Gruppe von eigenständigen Denkern, die gemeinsam die Grundlagen der modernen Wissenschaftstheorie legten. In jeweils spezifischer Weise setzten sie sich von der philosophischen Tradition ab oder versuchten, einzelne Teile (...) davon in die wissenschaftliche Weltauffassung zu integrieren. Der Band enthält eine repräsentative Auswahl von Aufsätzen der Mitglieder des Wiener Kreises. Sie beschränkt sich mit Ausnahme dreier Frühschriften der Gründer bewußt auf die Jahre des historischen Kreises vom Beginn der Treffen 1924 bis zur Ermordung Schlicks 1936, obwohl einige der Hauptideen erst in den USA ihre volle Wirkung entfalteten und von dort Ende der sechziger Jahre wieder in die deutschsprachige Philosophie zurückwirkten. In ihrer Einleitung skizzieren die Herausgeber die historische Entwicklung des Kreises und erläutern die zentralen thematischen Fragestellungen. Die Anmerkungen identifizieren die internen wie externen Opponenten und erklären den Kontext der zeitgenössischen Wissenschaft. (shrink)