FraukeAlbersmeier | : In Zoopolis, Donaldson and Kymlicka dismiss the abolitionist, or extinctionist approach in animal rights theory as insufficient in its theoretical foundation and disproportional regarding the means it promotes to prevent domesticated animals from suffering abuse by humans. Among the consequences of their counterproposal—granting domesticated animals citizenship—is an increased pressure to justify any interference with domesticated animals’ reproductive activities. This paper attempts to give such justification with reference to domesticated animals’ specific state of vulnerability, but (...) also takes into account the interest of the mixed society to prevent overly demanding obligations. Even while recognizing existing domesticated animals as citizens, humans might be unable to fully meet their obligation to protect the most dependent of them, and therefore might be justified in conditionally subscribing to “extinctionism” and limiting these animals’ reproduction to the point of their ultimate extinction. Therefore, rather than upholding a strict opposition between extinctionism in any form and a political framework for animal rights, out of reasonable concern for the well-being of domesticated animals in the societies they have been placed in, a qualified extinctionist approach should be incorporated into the political framework developed in Zoopolis. | : Dans Zoopolis, Donaldson et Kymlicka rejettent l’approche abolitionniste, ou extinctionniste, de la théorie du droit des animaux. Ils estiment que ses fondements théoriques sont insuffisants et que les mesures qu’elle promeut pour protéger les animaux domestiques des abus des humains sont disproportionnées. Leur contre-proposition – qui accorde la citoyenneté aux animaux domestiques – a plusieurs conséquences, parmi lesquelles un renforcement de la justification de toutes les formes d’ingérence dans la reproduction des animaux domestiques. Cet article tente de justifier pareille ingérence en raison de l’état particulier de vulnérabilité des animaux domestiques, mais tient également compte du fait que la société mixte a intérêt à éviter l’établissement d’obligations trop exigeantes. Cependant, les humains peuvent accorder aux animaux domestiques existant un statut de citoyen tout en s’avérant incapables de remplir pleinement leur obligation de protéger les plus dépendants d’entre eux. Ils pourraient par conséquent être justifiés de souscrire de manière conditionnelle à « l’extinctionnisme » et limiter la reproduction de ces animaux jusqu’à leur extinction. C’est pourquoi, au lieu de maintenir une opposition stricte entre l’extinctionnisme sous toutes ses formes et l’élaboration d’un cadre politique pour le droit des animaux, l’on devrait, par souci du bien-être des animaux domestiques dans les sociétés dans lesquelles ils vivent, insérer une approche extinctionniste conditionnelle dans le cadre politique élaboré dans Zoopolis. (shrink)
We present here the hypothesis that the unique microenvironmental pH landscape of acid‐base transporting epithelia is an important factor in development of epithelial cancers, by rendering the epithelial and stromal cells pre‐adapted to the heterogeneous extracellular pH (pHe) in the tumor microenvironment. Cells residing in organs with net acid‐base transporting epithelia such as the pancreatic ductal and gastric epithelia are exposed to very different, temporally highly variable pHe values apically and basolaterally. This translates into spatially and temporally non‐uniform intracellular pH (...) (pHi) patterns. Disturbed pHe‐ and pHi‐homeostasis contributes to essentially all hallmarks of cancer. Our hypothesis, that the physiological pHe microenvironment in acid‐base secreting epithelia shapes cancers arising in these tissues, can be tested using novel imaging tools. The acidic tumor pHe in turn might be exploited therapeutically. Pancreatic cancers are used as our prime example, but we propose that this concept is also relevant for other cancers of acid‐base transporting epithelia. (shrink)
Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, (...) we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. (shrink)
This paper presents a proof of concept for a graphical models approach to assessing the moral coherence and moral robustness of systems of social interactions. “Moral coherence” refers to the degree to which the rights and duties of agents within a system are effectively respected when agents in the system comply with the rights and duties that are recognized as in force for the relevant context of interaction. “Moral robustness” refers to the degree to which a system of social interaction (...) is configured to ensure that the interests of agents are effectively respected even in the face of noncompliance. Using the case of conscientious objection of pharmacists to filling prescriptions for emergency contraception as an example, we illustrate how a graphical models approach can help stakeholders identify structural weaknesses in systems of social interaction and evaluate the relative merits of alternate organizational structures. By illustrating the merits of a graphical models approach we hope to spur further developments in this area. (shrink)
Many Europeans are concerned about the living conditions of farm animals because they view animals as beings that possess interests of their own. Against this background the introduction of an animal welfare label is being intensively discussed in Europe. In choosing a market-based instrument to take these concerns into account, normative judgments are made about the formation of preferences, the value system that is implicitly assumed, and the distribution of property rights. From the perspective of classical institutional economics it can (...) be shown that the introduction of a label as an institutional change does not redefine institutions in a way that allows them to consider the interests of animals for their own sake. Rather, the label only redefines the property rights that humans have over animals. The market segregation into privileged and normal animals conflicts with the idea of equality between sentient animals. Within the group of humans only the interests of those who act on markets count. The commodification of their moral concerns assumes that people always decide based on their own interests, which can be traded off. The lexicographical ordering of preferences, which occurs when humans view animals as entities with rights, is not compatible with the normative assumptions of markets. Furthermore, interpreting animal suffering as market failure that can be corrected by labeling impedes a reasoned dialog within the society about the values and beliefs that serve as a basis for preference formation. Thus, an animal welfare label cannot replace a fundamental societal debate about legal standards on animal well-being. (shrink)
The article deals with the role of companies in the social market economy. An example of a successful international self-regulatory initiative and its implementation in German chemical industry is discussed.
I wish to acknowledge my gratitude to Professor James Morrison of the University of Toronto for his encouragement and aid in the preparation of this work. His generosity is an example of the genuine philosophic spirit. I should also like to thank Ernie and Frauke Hankamer as well as Hugo and Ruth Jakusch whose kindness sustained us in Munich and Dieben. Finally, mention must be made of the Canada Council without whose financial aid this book would not have been (...) possible. (shrink)