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Profile: Frederic Gilbert (University of Tasmania)
Profile: Fred Gilbert (University of Tasmania)
  1.  47
    Deep Brain Stimulation for Treatment Resistant Depression: Postoperative Feelings of Self-Estrangement, Suicide Attempt and Impulsive–Aggressive Behaviours.Frederic Gilbert - 2013 - Neuroethics 6 (3):473-481.
    The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and excluding (...)
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  2.  25
    Involuntary & Voluntary Invasive Brain Surgery: Ethical Issues Related to Acquired Aggressiveness. [REVIEW]Frederic Gilbert, Andrej Vranic & Samia Hurst - 2013 - Neuroethics 6 (1):115-128.
    Clinical cases of frontal lobe lesions have been significantly associated with acquired aggressive behaviour. Restoring neuronal and cognitive faculties of aggressive individuals through invasive brain intervention raises ethical questions in general. However, more questions have to be addressed in cases where individuals refuse surgical treatment. The ethical desirability and permissibility of using intrusive surgical brain interventions for involuntary or voluntary treatment of acquired aggressiveness is highly questionable. This article engages with the description of acquired aggressiveness in general, and presents a (...)
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  3.  1
    Beyond Genomic Association: Ethical Implications of Elucidating Disease Mechanisms and Genotype-Influenced Treatment Response.John Noel M. Viaña, Roemel Jeusep Bueno & Frederic Gilbert - 2017 - American Journal of Bioethics 17 (4):24-26.
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  4.  37
    The Burden of Normality: From 'Chronically Ill' to 'Symptom Free'. New Ethical Challenges for Deep Brain Stimulation Postoperative Treatment.Frederic Gilbert - 2012 - Journal of Medical Ethics 8 (7):408-412.
    Although an invasive medical intervention, Deep Brain Stimulation (DBS) has been regarded as an efficient and safe treatment of Parkinson’s disease for the last 20 years. In terms of clinical ethics, it is worth asking whether the use of DBS may have unanticipated negative effects similar to those associated with other types of psychosurgery. Clinical studies of epileptic patients who have undergone an anterior temporal lobectomy have identified a range of side effects and complications in a number of domains: psychological, (...)
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  5.  10
    Deep Brain Stimulation in the Media: Over-Optimistic Media Portrayals Calls for a New Strategy Involving Journalists and Scientifics in the Ethical Debate.Frederic Gilbert & Ovadia Daniela - 2011 - Journal of Integrative in Neuroscience 5 (16).
    Deep brain stimulation (DBS) is optimistically portrayed in contemporary media. This already happened with psychosurgery during the first half of the twentieth century. The tendency of popular media to hype the benefits of DBS therapies, without equally highlighting risks, fosters public expectations also due to the lack of ethical analysis in the scientific literature. Media are not expected (and often not prepared) to raise the ethical issues which remain unaddressed by the scientific community. To obtain a more objective portrayal of (...)
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  6.  11
    The Need to Tackle Concussion in Australian Football Codes.Frederic Gilbert & Bradley J. Partridge - 2012 - Medical Journal of Australia 196 (9):561-563.
    Postmortem evidence of chronic traumatic encephalopathy (CTE) in the brains of American National Football League players who suffered concussions while playing have intensified concerns about the risks of concussion in sport.1 Concussions are frequently sustained by amateur and professional players of Australia’s three most popular football codes (Australian football, rugby league, and rugby union) and, to a lesser extent, other contact sports such as soccer. This raises major concerns about possible long-term neurological damage, cognitive impairment and mental health problems in (...)
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  7.  7
    Paedophilia, Invasive Brain Surgery, and Punishment.Frederic Gilbert & Andrej Vranič - 2015 - Journal of Bioethical Inquiry 12 (3):521-526.
  8.  30
    The Impact of American Tackle Football-Related Concussion in Youth Athletes.Frederic Gilbert & L. Syd M. Johnson - 2011 - AJOB Neuroscience 2 (4):48-59.
    Postmortem research on the brains of American tackle football players has revealed the presence of chronic traumatic encephalopathy (CTE), a degenerative brain disease caused by repeated head trauma. Repeated concussion is a risk factor for CTE, raising ethical concerns about the long-term effects of concussion on athletes at risk for football-related concussion. Of equal concern is that youth athletes are at increased risk for lasting neurocognitive and developmental deficits that can result in behavioral disturbances and diminished academic performance. In this (...)
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  9.  14
    Self-Estrangement & Deep Brain Stimulation: Ethical Issues Related to Forced Explantation.Frederic Gilbert - 2015 - Neuroethics 8 (2):107-114.
    Although being generally safe, the use of Deep Brain Stimulation has been associated with a significant number of patients experiencing postoperative psychological and neurological harm within experimental trials. A proportion of these postoperative severe adverse effects have lead to the decision to medically prescribe device deactivation or removal. However, there is little debate in the literature as to what is in the patient’s best interest when device removal has been prescribed; in particular, what should be the conceptual approach to ethically (...)
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  10.  9
    State of the Concussion Debate: From Sceptical to Alarmist Claims.Frédéric Gilbert - 2015 - Neuroethics 8 (1):47-53.
    Current discussions about concussion in sport are based on a crucial epistemological question: whether or not we should believe that repetitive mild Traumatic Brain Injury causes Chronic Traumatic Encephalopathy. This epistemological question is essential to understanding the ethics at stake in treating these cases: indeed, certain moral obligations turn on whether or not we believe that mTBI causes CTE. After discussing the main schools of thought, namely the CTE-sceptic position and the CTE-orthodox position, this article examines the concussion debate in (...)
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  11.  21
    Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury.Frederic Bretzner, Frederic Gilbert, Françoise Baylis & Robert M. Brownstone - 2011 - Cell Stem Cell 8 (5):468-475.
    Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute (...)
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  12.  15
    Neuroenhancement: Much Ado About Nothing?Frederic Gilbert & Bernard Baertschi - 2011 - American Journal of Bioethics Neuroscience 2 (4):45-47.
    In their paper “Deflating the neuroenhancement bubble”, more precisely in their section entitled “How New is Neuroenhancement?”, Lucke and colleagues argue that neuroenhancement is nothing new to our epoch by demonstrating that the use of psychoactive stimulants in the 19th and 20th centuries was already common. The purpose of our comment is to show that the current bubble surrounding neuroenhancement in particular, and enhancement in general, is a recasting of an even older speculative engagement that can be traced back from (...)
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  13.  6
    Print Me an Organ? Ethical and Regulatory Issues Emerging From 3D Bioprinting in Medicine.Frederic Gilbert, Cathal D. O’Connell, Tajanka Mladenovska & Susan Dodds - forthcoming - Science and Engineering Ethics:1-19.
    Recent developments of three-dimensional printing of biomaterials in medicine have been portrayed as demonstrating the potential to transform some medical treatments, including providing new responses to organ damage or organ failure. However, beyond the hype and before 3D bioprinted organs are ready to be transplanted into humans, several important ethical concerns and regulatory questions need to be addressed. This article starts by raising general ethical concerns associated with the use of bioprinting in medicine, then it focuses on more particular ethical (...)
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  14.  24
    Is There a Moral Obligation to Develop Brain Implants Involving NanoBionic Technologies? Ethical Issues for Clinical Trials.Frédéric Gilbert & Susan Dodds - 2014 - NanoEthics 8 (1):49-56.
    In their article published in Nanoethics, “Ethical, Legal and Social Aspects of Brain-Implants Using Nano-Scale Materials and Techniques”, Berger et al. suggest that there may be a prima facie moral obligation to improve neuro implants with nanotechnology given their possible therapeutic advantages for patients [Nanoethics, 2:241–249]. Although we agree with Berger et al. that developments in nanomedicine hold the potential to render brain implant technologies less invasive and to better target neural stimulation to respond to brain impairments in the near (...)
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  15.  12
    Framing the Debate: Concussion and Mild Traumatic Brain Injury.L. Syd M. Johnson, Brad Partridge & Frédéric Gilbert - 2015 - Neuroethics 8 (1):1-4.
    Concussion and Mild Traumatic Brain Injury affect millions of people worldwide. mTBI has been called the “signature injury” of the recent conflicts in Iraq and Afghanistan, affecting thousands of active duty service men and women, and veterans. Sport-related concussion represents a significant public health problem, with elite and professional athletes, and millions of youth and amateur athletes worldwide suffering concussions annually. These brain injuries have received scant attention from neuroethicists, and the focus of this special issue is on defining the (...)
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  16.  33
    How Do Research Duties Conflict with Aboriginal Rights? Genetics Research and Biobank Problem in Taiwan.Mark Munsterhjelm & Frederic Gilbert - 2010 - Dilemata 2 (4):33-56.
    Taiwan has a population of 23 million, of which some 500,000 are Aborigines. Recent conflicts over a national biobank as part of Taiwan's biotechnological industrial development, genetic research on Aboriginal origins, and commercialization of research findings involving Aborigines have raised a number of important ethical conflicts. These ethical conflicts involve on one hand, the importance of researchers' duties, and on the other hand, Aboriginal rights. This paper will go in three steps. First, this paper describes the three cases of ethical (...)
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  17.  1
    Deep Brain Stimulation: Inducing Self-Estrangement.Frederic Gilbert - forthcoming - Neuroethics:1-9.
    Despite growing evidence that a significant number of patients living with Parkison’s disease experience neuropsychiatric changes following Deep Brain Stimulation treatment, the phenomenon remains poorly understood and largely unexplored in the literature. To shed new light on this phenomenon, we used qualitative methods grounded in phenomenology to conduct in-depth, semi-structured interviews with 17 patients living with Parkinson’s Disease who had undergone DBS. Our study found that patients appear to experience postoperative DBS-induced changes in the form of self-estrangement. Using the insights (...)
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  18.  31
    The Inheritance, Power and Predicaments of the “Brain-Reading” Metaphor.Frederic Gilbert, Lawrence Burns & Timothy Krahn - 2011 - Medicine Studies 2 (4):229-244.
    Purpose With the increasing sophistication of neuroimaging technologies in medicine, new language is being sought to make sense of the findings. The aim of this paper is to explore whether the brain-reading metaphor used to convey current medical or neurobiological findings imports unintended significations that do not necessarily reflect the genuine findings made by physicians and neuroscientists. Methods First, the paper surveys the ambiguities of the readability metaphor, drawing from the history of science and medicine, paying special attention to the (...)
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  19.  24
    On the Use of Animals in Emergent Embryonic Stem Cell Research for Spinal Cord Injuries.Andrew Fenton & Frederic Gilbert - 2011 - Journal of Animal Ethics 1 (1):37-45.
    In early 2009, President Obama overturned the ban on federal funding for research involving the derivation of human embryonic stem cells (hESC). The Food and Drug Administration (FDA) also approved Geron’s first-in-human hESC trial for spinal cord injury (SCI) patients. We anticipate an increase in both research in the United States to derive hESC and applications to the FDA for approval of clinical trials involving transplantation of hESCs. An increase of such clinical trials will require a concomitant increase in the (...)
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  20.  22
    Working While Under the Influence of Performance-Enhancing Drugs: Is One “More Responsible”?Frederic Gilbert - 2011 - American Journal of Bioethics Neuroscience 2 (3):57-59.
    The purpose of this commentary is to address an ethical issue introduced by Walter Glannon regarding whether responsibility can be affected by the use of performance enhancing drugs. Glannon uses the example of a surgeon taking drugs to enhance her capacities. I explore whether conducting surgeries while under the influence of performance enhancing drugs will affect the surgeon’s responsibility for performing more surgeries ‘and’ the surgeon’s responsibility for assuming the consequences of performing these surgeries. Here, the ‘and’ is cumulative: one (...)
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  21.  5
    Efficacy Testing as a Primary Purpose of Phase 1 Clinical Trials: Is It Applicable to First-in-Human Bionics and Optogenetics Trials?Frederic Gilbert, Alexander R. Harris & Robert M. I. Kapsa - 2012 - AJOB Neuroscience 3 (2):20-22.
    In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...)
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  22. ¿Cómo Entran En Conflicto Las Responsabilidades de Un Investigador Con Los Derechos de Los Aborígenes? Problemas En Investigación Genética y Biobancos En Taiwán.Mark Munsterhjelm & Frederic Gilbert - 2010 - Dilemata 4.
    Taiwan has a population of 23 million, of which some 500,000 are Aborigines. Recent conflicts over a national biobank as part of Taiwan's biotechnological industrial development, genetic research on Aboriginal origins, and commercialization of research findings involving Aborigines have raised a number of important ethical conflicts. These ethical conflicts involve on one hand, the importance of researchers' duties, and on the other hand, Aboriginal rights. This paper will go in three steps. First, this paper describes the three cases of ethical (...)
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