Next SectionThere has been considerable debate surrounding the ethics of sham-controlled trials of procedures and interventions. Critics argue that these trials are unethical because participants assigned to the control group have no prospect of benefit from the trial, yet they are exposed to all the risks of the sham intervention. However, the placebo effect associated with sham procedures can often be substantial and has been well documented in the scientific literature. We argue that, in light of the scientific evidence supporting (...) the benefits of sham interventions for pain and Parkinson's disease that stem from the placebo effect, these sham-controlled trials should be considered as offering potential direct benefit to participants. If scientific evidence demonstrates the positive effect of placebo from sham interventions on other conditions, sham-controlled trials of interventions for the treatment of these conditions should be considered to have prospects of benefit as well. This potential benefit should be taken into account by research ethics committees in risk-benefit analyses, and be included in informed consent documents. (shrink)

Where exactly should we place Adam Smith in the cannon of classical liberalism? Smith's advocacy of free market economics and defence of religious liberty in The Wealth of Nations suffice for including him somewhere in that tradition.1 The nature and extent of Smith's liberalism, however, remain up for debate. One recent trend has been to characterise Smith as a proponent of social liberalism. This includes those like Stephen Darwall, Samuel Fleischacker and Charles Griswold, who have drawn attention to a kind (...) of descriptive moral egalitarianism in Smith.2 Humans, Smith seems to hold, are naturally disposed to valuing one another under a conception of equality. But that is not all these scholars suggest. They have also hinted at something more contentious ? the idea that, according to Smith, we value one another in a way resonant with contemporary notions of human dignity, conceived as the inherent value of persons grounding certain rights to, or restrictions on, treatment by others.3 In saying so, these scholars have hit upon something remarkable. However, I also think their arguments in this respect are both indirect and incomplete. Consequently, the full import of Smith's view remains obscure. This essay aims to bring some clarity. 1I intend this historically. I grant there are good reasons to be sceptical about the ultimate fate of liberty in capitalist society (e.g. Marxist reasons and reasons based on various postmodern critiques of enlightenment ideology). Also, the designation ?free market? should be understood loosely, as most scholars now agree it is a mistake to identify Smith with thoroughgoing laissez-faire economics. 2Darwall, S., ?Sympathetic Liberalism: Recent Work on Adam Smith?, Philosophy Fleischacker, S., A Third Concept of Liberty (Princeton: Princeton University Press, 1999) and On Adam Smith's Wealth of Nations (Princeton: Princeton University Press, 2004); and Griswold, C., Adam Smith and the Virtues of Enlightenment (New York: Cambridge University Press, 1999). Other major commentators holding some version of this view might include Raphael, D. D. The Impartial Spectator (New York: Oxford University Press, 2007) and Vivienne Brown, Adam Smith's Discourse: Canonicity, Commerce and Conscience (London: Routledge, 1994). 3See e.g. Fleischacker (2004), 205; Darwall at 142, 156 and Griswold at 235?239. However, one must read Fleischacker carefully, for he also uses the adjectival ?dignified? to express Smith's concern with what is ?honourable? or ?respectable? about persons, which use does not obviously match up with the notion of inherent value (see e.g. p. 207). Darwall's argument includes by far the most explicit discussion of ?dignity? as I've defined it. But as Darwall's article is ostensibly a book review (albeit a substantive one that addresses three books at once, including Griswold's), it cannot be called a direct inquiry. Griswold never explicitly puts his interpretation in terms of ?dignity?, but that is clearly what he is after. Thus Darwall also reads him that way. (shrink)

Cet essai se situe sur le terrain de la théologie pour relever l’usage qu’elle en fait comme clef du langage sur Dieu. A ce titre, l’analogie déborde et dépasse le domaine de la logique et de l’épistémologie pour servir une pensée non seulement spéculative, mais encore spirituelle et mystique. Son emploi en théologie traduit l’aspect intellectuel d’une attitude d’abord existentielle et croyante où l’homme se reconnaît comme créature distante de son Créateur, mais surtout en tant que nature raisonnable, comme fait (...) à l’image de Dieu et appelé à la dignité de fils du Dieu Père. La réflexion sur l’analogie nous introduit ainsi inévitablement dans le domaine de l’image dont l’homme ne porte la marque qu’en raison de sa participation à l’image parfaite de Dieu qu’est son Verbe. Si l’analogie suggère la distance entre les termes transcendant et immanent qu’elle relie, ne reviendrait-il pas à l’image d’effectuer leur rapprochement ? S’appuyant sur la théologie de S. Thomas, l’enquête de G. Rémy traite de l’analogie comme outil conceptuel indispensable au discours sur Dieu et le mystère trinitaire ; le relais sera pris par la notion d’image appliquée à l’homme mais dont l’archétype est le Christ.This essay is situated in the area of theology to note how analogy is used as a key to language about God. As such, analogy goes beyond and transcends the domain of logic and epistemology to serve not only speculative but even spiritual and mystical reflection. Its use in theology translates the intellectual aspect of an attitude at first existential and believing, in which man recognizes himself as a creature distant from his Creator, but, above all, as a reasonable nature made in the image of God and called to dignity as the son of God the Father. This reflection on analogy inevitably leads us into the domain of the image, of which man carries only the mark by reason of his participation to the perfect image of God who is his Word. If analogy suggests the distance between the transcendent and immanent terms that it connects, is it not the role of the image to bring them close to each other? Relying on the theology of St. Thomas, the inquiry of G. Remy treats analogy as a conceptual tool that is indispensable to the discourse on God and the Trinitarian mystery. It is relayed by the notion of image applied to man, of which the archetype is Christ. (shrink)

The French school of theoretical biology has been mainly initiated in Poitiers during the sixties by scientists like J. Besson, G. Bouligand, P. Gavaudan, M. P. Schützenberger and R. Thom, launching many new research domains on the fractal dimension, the combinatorial properties of the genetic code and related amino-acids as well as on the genetic regulation of the biological processes. Presently, the biological science knows that RNA molecules are often involved in the regulation of complex genetic networks as effectors, e.g., (...) activators, inhibitors or hybrids. Examples of such networks will be given showing that there exist RNA “relics” that have played an important role during evolution and have survived in many genomes, whose probability distribution of their sub-sequences is quantified by the Shannon entropy, and the robustness of the dynamics of the networks they regulate can be characterized by the Kolmogorov–Sinaï dynamic entropy and attractor entropy. (shrink)

ABSTRACTThis study investigates the effects of emotion on the integration mechanism which binds together the components of an event and the relations between these components and encodes them within a memory trace [Versace, R., Vallet, G. T., Riou, B., Lesourd, M., Labeye, É, & Brunel, L.. Act-In: An integrated view of memory mechanisms. Journal of Cognitive Psychology, 26, 280–306. doi:10.1080/20445911.2014.892113]. Based on the literature, the authors argue that, in a memory task, contextual emotion could strengthen the integration mechanism and, more (...) specifically, the relations between a target item and its contextual features. To test this hypothesis, the authors used two odorants to compare the effects of a negative context with those of a neutral one on three different types of recall: item recall, source recall and recall of the association between an item and its location. The results show... (shrink)

This volume presents a penetrating interview and sixteen essays that explore key intersections of medieval religion and philosophy. With characteristic erudition and insight, Rémi_ _Brague focuses less on individual Christian, Jewish, and Muslim thinkers than on their relationships with one another. Their disparate philosophical worlds, Brague shows, were grounded in different models of revelation that engendered divergent interpretations of the ancient Greek sources they held in common. So, despite striking similarities in their solutions for the philosophical problems they all faced, (...) intellectuals in each theological tradition often viewed the others’ ideas with skepticism, if not disdain. Brague’s portrayal of this misunderstood age brings to life not only its philosophical and theological nuances, but also lessons for our own time. (shrink)

The law of God: these words conjure an image of Moses breaking the tablets at Mount Sinai, but the history of the alliance between law and divinity is so much longer, and its scope so much broader, than a single Judeo-Christian scene can possibly suggest. In his stunningly ambitious new history, Rémi Brague goes back three thousand years to trace this idea of divine law in the West from prehistoric religions to modern times—giving new depth to today’s discussions about the (...) role of God in worldly affairs. Brague masterfully describes the differing conceptions of divine law in Judaic, Islamic, and Christian traditions and illuminates these ideas with a wide range of philosophical, political, and religious sources. In conclusion, he addresses the recent break in the alliance between law and divinity—when modern societies, far from connecting the two, started to think of law simply as the rule human community gives itself. Exploring what this disconnection means for the contemporary world, Brague—powerfully expanding on the project he began with _The Wisdom of the World_—re-engages readers in a millennia-long intellectual tradition, ultimately arriving at a better comprehension of our own modernity. “Brague’s sense of intellectual adventure is what makes his work genuinely exciting to read. _The Law of God_ offers a challenge that anyone concerned with today’s religious struggles ought to take up.”—Adam Kirsch, _New York__ Sun_ __ “Scholars and students of contemporary world events, to the extent that these may be viewed as a clash of rival fundamentalisms, will have much to gain from Brague’s study. Ideally, in that case, the book seems to be both an obvious primer and launching pad for further scholarship.”—_Times Higher Education Supplement_. (shrink)

This volume presents a penetrating interview and sixteen essays that explore key intersections of medieval religion and philosophy. With characteristic erudition and insight, Rémi_ _Brague focuses less on individual Christian, Jewish, and Muslim thinkers than on their relationships with one another. Their disparate philosophical worlds, Brague shows, were grounded in different models of revelation that engendered divergent interpretations of the ancient Greek sources they held in common. So, despite striking similarities in their solutions for the philosophical problems they all faced, (...) intellectuals in each theological tradition often viewed the others’ ideas with skepticism, if not disdain. Brague’s portrayal of this misunderstood age brings to life not only its philosophical and theological nuances, but also lessons for our own time. (shrink)

The law of God: these words conjure an image of Moses breaking the tablets at Mount Sinai, but the history of the alliance between law and divinity is so much longer, and its scope so much broader, than a single Judeo-Christian scene can possibly suggest. In his stunningly ambitious new history, Rémi Brague goes back three thousand years to trace this idea of divine law in the West from prehistoric religions to modern times—giving new depth to today’s discussions about the (...) role of God in worldly affairs. Brague masterfully describes the differing conceptions of divine law in Judaic, Islamic, and Christian traditions and illuminates these ideas with a wide range of philosophical, political, and religious sources. In conclusion, he addresses the recent break in the alliance between law and divinity—when modern societies, far from connecting the two, started to think of law simply as the rule human community gives itself. Exploring what this disconnection means for the contemporary world, Brague—powerfully expanding on the project he began with _The Wisdom of the World_—re-engages readers in a millennia-long intellectual tradition, ultimately arriving at a better comprehension of our own modernity. “Brague’s sense of intellectual adventure is what makes his work genuinely exciting to read. _The Law of God_ offers a challenge that anyone concerned with today’s religious struggles ought to take up.”—Adam Kirsch, _New York__ Sun_ __ “Scholars and students of contemporary world events, to the extent that these may be viewed as a clash of rival fundamentalisms, will have much to gain from Brague’s study. Ideally, in that case, the book seems to be both an obvious primer and launching pad for further scholarship.”—_Times Higher Education Supplement_. (shrink)

« Pourquoi y a-t-il plusieurs arts, et non pas un seul ? Cette question paraît trop simple : on pensera même qu’elle ne fait pas question. Et cependant, pour peu qu’on se dérobe à une idée romantique de l’Art majuscule, elle est de nature à déplacer toute notre manière de considérer ce qu’on appelle les arts, et avec eux d’une part les sens (et le sens de “sens”), d’autre part la technique (dont l’“art” n’est jamais que la traduction). Avec les (...) arts, c’est le sens du monde qui se trouve, à nouveau, remis en jeu. ». (shrink)