BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

I present the current experimental and theoretical work on interference in complementary spaces. These ideas are applicable to both light and matter waves. I give a detailed treatment for classical light beams in frequency and time domains. I also present a description which gives the totality of interferences.

The essays in this book offer an in-depth exploration of value theory. Portions examine the theoretical foundations of values and valuation exploring the rational groundwork for judgments. Other aspects, appealing to value distinctions of inherent, intrinsic, and instrumental, bring to light matters of aesthetic, social political, ethical, and ontological issues.

_The Ethics of Homelessness_ is a compilation of essays analysing the philosophical, legal and social implications of the seemingly intractable condition that people endure without a home, where their fundamental human rights, autonomy and privacy are compromised. Authors use literature and arguments to demonstrate the failings of public policy.

The empirical investigations over the past fifteen years of evolutionary biologists and cognitive scientists have demonstrated the accessibility and power of the human brain. Whatever moral concepts used to acknowledge the normative appraisals of human conduct are now explained through neurological hardwiring. This essay outlines some of the main views of proponents, but especially Marc Hauser, and I argue that it does not render the end of morals. It does provide an opportunity to view the facts of how the brain (...) functions but this essay finds a large domain of valuing unable to be justified by these new scientific challenges. (shrink)

ABSTRACT This essay argues for the emergence of a cultural and epistemological divide between amateur savants and members of the Royal Academy of the Sciences in late Old Regime and revolutionary France and suggests that the amateur ideal rose in significance even as intellectual activity came to be increasingly centralized in the postrevolutionary era. At the crux of the tensions between the amateur ideal and the professionalizing reality in the immediate postrevolutionary period stood Aubin-Louis Millin and his journal, the Magasin (...) Encyclopédique. The essay examines, in particular, the revival in the pages of the Magasin Encyclopédique of interest in Nicolas-Claude Fabri de Peiresc, the seventeenth-century icon of an amateur ideal in which investigations in the natural sciences and scholarship were private, decentralized, often provincial activities. Although the sciences in the revolutionary and Napoleonic eras were often perceived as forward looking and dismissive of the past, this essay finds that a sentimental and nostalgic attachment to the past—to a myth of Peiresc—continued to play an important role in the identity of postrevolutionary men of letters. (shrink)