Opioid agonist treatment, including methadone, is the safest and most effective method for treating opioid use disorders and reduces opioid overdose deaths. While access to methadone is highly regulated by federal law, a substantial portion of states impose stricter barriers.

Cells and tissue within injured organs undergo a complicated healing process that still remains poorly understood. Interestingly, smaller organisms respond to injury with tissue regeneration and restoration of function, while humans and other large organisms respond to injury by forming dysfunctional, fibrotic scar tissue. Over the past few decades, allometric scaling principles have been well established to show that larger organisms experience exponentially higher tissue forces during movement and locomotion and throughout the organism's lifespan. How these evolutionary adaptations may affect (...) tissue injury has not been thoroughly investigated in humans. We discuss how these adapations may affect healing and demonstrate that blocking the most evolutionary conserved biologic force sensor enables large organisms to heal after injury with true tissue regeneration. Future strategies to disrupt tissue force sensors may unlock the key to regenerating after injury in a wide range of organ systems. (shrink)

Gilead et al. present a rich account of abstraction. Though the account describes several elements which influence mental representation, it is worth also delineating how feelings, such as fluency and emotion, influence mental simulation. Additionally, though past experience can sometimes make simulations more accurate and worthwhile, many systematic prediction errors persist despite substantial experience.

It is commonly thought that logic, whatever it may be, is normative. While accounting for the normativity of logic is a challenge for any view of logic, in this paper I argue that it is particularly problematic for certain types of logical pluralists, due to what I call the normative problem for logical pluralism. I introduce the NPLP, distinguish it from other problems that logical pluralists may face, and show that it is unsolvable for one prominent type of logical pluralism.

Suppose that two competing norms, N1 and N2, can be identified such that a given person’s response can be interpreted as correct according to N1 but incorrect according to N2. Which of these two norms, if any, should one use to interpret such a response? In this paper we seek to address this fundamental problem by studying individual variation in the interpretation of conditionals by establishing individual profiles of the participants based on their case judgments and reflective attitudes. To investigate (...) the participants’ reflective attitudes we introduce a new experimental paradigm called the Scorekeeping Task. As a case study, we identify the participants who follow the Suppositional Theory of conditionals (N1) versus Inferentialism (N2) and investigate to what extent internally consistent competence models can be reconstructed for the participants on this basis. After extensive empirical investigations, an apparent reasoning error with and-to-if inferences was found in one of these two groups. The implications of this case study for debates on the proper role of normative considerations in psychology are discussed. (shrink)

In this study we investigate the influence of reason-relation readings of indicative conditionals and ‘and’/‘but’/‘therefore’ sentences on various cognitive assessments. According to the Frege-Grice tradition, a dissociation is expected. Specifically, differences in the reason-relation reading of these sentences should affect participants’ evaluations of their acceptability but not of their truth value. In two experiments we tested this assumption by introducing a relevance manipulation into the truth-table task as well as in other tasks assessing the participants’ acceptability and probability evaluations. Across (...) the two experiments a strong dissociation was found. The reason-relation reading of all four sentences strongly affected their probability and acceptability evaluations, but hardly affected their respective truth evaluations. Implications of this result for recent work on indicative conditionals are discussed. (shrink)

In this paper I argue that contemporary truth pluralists have undersold the connection between their views and the semantic realism/anti-realism debate. I argue that pluralist theories of truth are essentially a combination of accepting both realist and anti-realist intuitions, and that we should take this lesson to heart. I show how we can categorize pluralist views by how realist or anti-realist they are, and introduce two notions to do so: methodological fundamentality and theoretical fundamentality. I show how viewing the pluralist (...) literature in this way reveals the core principles behind rival pluralist accounts and cuts across another influential way to divide up the truth pluralist literature. I conclude by introducing a new version of truth pluralism: methodological pluralism about truth. Methodological pluralism about truth stays methodologically neutral between its realist and anti-realist poles, and thus better accounts for both of its key theoretical motivations. (shrink)

Residency selection is a challenging process for medical students, one further complicated in the USA by the recentDobbs v Jackson Women’s Health Organization(Dobbs) decision over-ruling the federal right to abortion. We surveyed medical students to examine howDobbsis influencing the ideological, personal and professional factors they must reconcile when choosing where and how to complete residency.Between 6 August and 22 October 2022, third-year and fourth-year US medical students applying to US residency programmes were surveyed through social media and direct outreach to (...) medical schools. Analysis of quantitative and qualitative data from 494 responses was performed to assess downstream effects ofDobbson residency applicants’ family, health and career choices.Most respondents said changes in abortion access would likely or very likely influence their decision regarding location of considered residency programme (76.9%), where to start a family (72.2%) and contraceptive planning for them or their partner (57.9%). Cis-gender females were more influenced byDobbsregarding where (5 (4, 5) p<0.001) and when (3 (3, 5) p<0.001) to start a family. In qualitative responses, medical trainees highlighted the importance of abortion access for their patients, themselves and their loved ones.Medical trainees are incorporating state abortion access into their residency programme choices. Future physicians care about both the quality of care they will be able to provide and their own health. For personal and professional reasons, reproductive healthcare access is now a key factor in residency match decisions. (shrink)

This commentary argues against the indictment of current experimental practices such as piecemeal testing, and the proposed integrated experiment design (IED) approach, which we see as yet another attempt at automating scientific thinking. We identify a number of undesirable features of IED that lead us to believe that its broad application will hinder scientific progress.

Idealist philosopher Georg Hegel defied the traditional epistemological distinction of objective from subjective and developed his own dialectical alternative. Remarkable for its breadth and profundity, this work combines aspects of psychology, logic, moral philosophy, and history to form a comprehensive view that encompasses all forms of civilization. Its three divisions consist of the subjective mind (dealing with anthropology and psychology), the objective mind (concerning philosophical issues of law and morals), and the absolute mind (covering fine arts, religion, and philosophy). Wide-ranging (...) in its influence, this survey of the evolution of consciousness is essential reading for all students of philosophy and history. (shrink)

The topic of a priori knowledge is approached through the theory of evidence. A shortcoming in traditional formulations of moderate rationalism and moderate empiricism is that they fail to explain why rational intuition and phenomenal experience count as basic sources of evidence. This explanatory gap is filled by modal reliabilism -- the theory that there is a qualified modal tie between basic sources of evidence and the truth. This tie to the truth is then explained by the theory of concept (...) possession: this tie is a consequence of what, by definition, it is to possess (i.e., to understand) one’s concepts. A corollary of the overall account is that the a priori disciplines (logic, mathematics, philosophy) can be largely autonomous from the empirical sciences. (shrink)

This chapter examines the nature of deception and lying by attempting to find an understanding of lying which can make sense of the Earth Kingdom citizens' behavior. It deals with analyzing the concepts of deception and lying, and briefly discusses what makes them such a dangerous and problematic phenomenon. Bald‐faced lies are lies where the liar has no intention of deceiving their audience. Sorensen introduces the idea of bald‐faced lies by giving examples of various statements which citizens of oppressive and (...) totalitarian states are forced to make. Bald‐faced lies are the norm within totalitarian states. These lies undermine the trust which serves as the foundation of the communities, and thus split them further apart. In addition, the more falsehoods there are, the harder it becomes to recognize and believe the truth. In communities in which lying is expected, the truth fails to have meaning. (shrink)

This important new work surveys the source and ramifications of the famed Nuremburg Code -- recognized around the world as one of the cornerstones of modern bioethics.

TRANSLATORS PREFACE THE PRESENT TRANSLATION OF GEORG SIMMEL'S Schopen- hauer und Nietzsche: Ein Vortragszyklus (1907), ...

"This book is a sorely needed corrective. Animal Spirits is an important--maybe even a decisive--contribution at a difficult juncture in macroeconomic theory.

touch 27 Thirrdly, the straining of the eye 28 The occasions which suggest distance have in their own nature no relation to it 29 A difficult case proposed by Dr. Barrow as repugnant to all the known theories 30 This case contradicts a ...

Functionalism would be mistaken if there existed a system of deviant relations (an “anti-mind”) that had the same functional roles as the standard mental relations. In this paper such a system is constructed, using “Quinean transformations” of the sort associated with Quine’s thesis of the indeterminacy of translation. For example, a mapping m from particularistic propositions (e.g., that there exists a rabbit) to universalistic propositions (that rabbithood is manifested). Using m, a deviant relation thinking* is defined: x thinks* p iff (...) x thinks m(p). Such deviant relations satisfy the commonly discussed functionalist psychological principles. Finally, a more complicated system of deviant relations is constructed, one satisfying sophisticated principles dealing with the self-conscious rational mind. (shrink)

Marketing Ethics addresses head-on the ethical questions, misunderstandings and challenges that marketing raises while defining marketing as a moral activity. A substantial introduction to the ethics of marketing, exploring the integral relations of marketing and morality Identifies and discusses a series of ethical tools and the marketing framework they constitute that are required for moral marketing Considers broader meanings and background assumptions of marketing infrequently included in other marketing literature Adds direction and meaning to problems in marketing ethics through reflection (...) on concepts such as individual choice, freedom and responsibility, desire satisfaction, noncoercive exchanges, and instrumental efficiency. (shrink)

The description for this book, Desert, will be forthcoming.

George Berkeley (1685-1753) is the superstar of Irish Philosophy. He entered Trinity College, Dublin, in 1700 and became a fellow in 1707. In 1724 he resigned his Fellowship to become Dean of Derry, and in 1734 he was made Bishop of Cloyne. He settled in Oxford in 1752 and died the following year. The work of George Berkeley is marked by its diversity and range. His writings take in such topics as mathematics, psychology, politics, health, economics, deism and education, as (...) well as that with which he is most associated - philosophy. Whatever topic he dealt with, his grasp of the subject matter was always impressive and his criticisms of his contemporaries often acute. Among the most noteable of the British Empiricists, he took his starting point from Locke's new 'way of ideas', but he rejected abstract ideas and the possibility of real existence outside perception. It is for this doctrine that he is most known - that there is no such thing as matter, and that things are collections of ideas which can exist only in our minds and only for so long as they are perceived. This philosophy, summed up in his phrase 'to be is to be perceived', he termed 'immaterialism'. A.C. Fraser's collection includes a series of what were previously unpublished notes by Berkeley on all the main topics of his philosophy. This, the 1901 edition, was the first complete edition of his works. (shrink)

This chapter opens with a discussion on the mechanics of canon in the Star Wars universe. The practice of dividing a fiction into canonical and noncanonical parts is not merely an exercise in fanboy/girl esoterica. Once a fiction is massive enough, and the Star Wars fiction is certainly quite massive, the canon/noncanon divide can play a practical role in pointing to which portions of the story are required knowledge for understanding and interpreting the overall universe. Canon/noncanon distinctions make massive fictions (...) like Star Wars accessible. A particular work will not be eternally canonical or eternally noncanonical. The canon/noncanon divide does not merely tell us that some stories count as genuine parts of the Star Wars fiction while others do not. It also dictates which version of a particular story counts as genuine when there are multiple versions from which to choose. (shrink)

The idea of nature in medical theory and practice -- Diseases -- Health: popular concept and philosophical question -- Is a pedagogy of healing possible? -- The problem of regulation in the organism and in society.

Berkeley's Idealism both advances Berkeley scholarship and serves as a useful guide for teachers and students.

Few Star Wars characters are more beloved than Luke Skywalker, Jedi Knight, son of Darth Vader, and mentor to Rey. Fictional characters like Luke are wholly defined by how people understand, interpret, and evaluate their depictions within the fictions in which they appear. This chapter explores various ways to provide identity conditions for fictional characters. It examines a more sophisticated, but again ultimately incorrect, account of fictional character identity: the Say‐So Account, in which authors determine whether two characters, from two (...) fictional works, are identical. The Perspectival Account avoids the problems seen in the earlier accounts and provides the authors with an adequate account of identity conditions for fictional characters. Further, the Perspectival Account allows the authors to explain how the truth‐value of fictional character identity claims can change over time. (shrink)

Wonder Woman wields a number of magical Amazonian devices: her bulletproof bracelets, her invisible plane, and most importantly for this chapter, her golden lasso of truth. The first thing to notice about the golden lasso is that evildoers bound by it are not only compelled to tell the truth if and when they answer questions, but also compelled to answer Wonder Woman's questions in the first place. The second thing to notice is that answering truthfully does not, in this context, (...) necessarily mean uttering a true sentence. Rather, if a person is tied up with the golden lasso, then they are compelled to answer questions with what they believe is the truth. The chapter shows the examples that contemplating Wonder Woman's golden lasso, and Bizarra's golden lasso, can provide us with a wealth of interesting and entertaining paradoxes and puzzles. (shrink)

Georges Sorel's Study on Vico is a revelatory document of the depths and stakes of French social thought at the end of the 19th century. What brought Sorel to the 18th century Neapolitan theorist of history? Acute awareness of the limitations of Marxist thought in his day, a profound concern with the material underpinnings of language, law, and culture, and the imperative to understand the possibilities of revolutionary change. We find here a different Sorel, one who speaks in surprising (...) ways to the 21st century. The translation is accompanied by an introduction and by a set of notes which situate the text both in Sorel's overall intellectual trajectory and in the fin de siècle debates from which it emerged. (shrink)

What drives much of the current philosophical interest in the idea of group cognition is its appeal to the manifestation of psychological properties—understood broadly to include states, processes, and dispositions—that are in some important yet elusive sense emergent with respect to the minds of individual group members. Our goal in this paper is to address a set of related, conditional questions: If human mentality is real yet emergent in a modest metaphysical sense only, then: (i) What would it mean for (...) a group to have emergent cognitive states? (ii) Is this even a metaphysically coherent view? (iii) Relative to which notion of emergence do we have reason to believe that certain groups in fact have emergent cognitive states? We shall argue that evidence from a wide variety of social science domains makes it plausible that there are group cognitive states and processes no less metaphysically emergent than human cognitive (and other special science) states and processes. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Darwin the writer -- Learning to see : Darwin's prophetic apprenticeship on the Beagle voyage -- The prose of On the origin of species -- Surprise and paradox : Darwin's artful legacy -- Darwinian mind and Wildean paradox -- Hardy's Woodlanders and the Darwinian grotesque -- Coda : the comic Darwin.

In the light of two unpublished letters from Carnap to Kuhn, this essay examines the relationship between Kuhn's The Structure of Scientific Revolutions and Carnap's philosophical views. Contrary to the common wisdom that Kuhn's book refuted logical empiricism, it argues that Carnap's views of revolutionary scientific change are rather similar to those detailed by Kuhn. This serves both to explain Carnap's appreciation of The Structure of Scientific Revolutions and to suggest that logical empiricism, insofar as that program rested on Carnap's (...) shoulders, was not substantially upstaged by Kuhn's book. (shrink)

Many epistemologists have been interested in justification because of its presumed close relationship to knowledge. This relationship is intended to be ...