New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
In this paper I utilize anthropological insights to illuminate how health professionals and patients navigate and negotiate what for them is social about tuberculosis in order to improve treatment outcomes and support patients as human beings. I draw on ethnographic research about the implementation of the DOTS approach in Georgia’s National Tuberculosis Program in the wake of the Soviet healthcare system. Georgia is a particularly unique context for exploring these issues given the country’s rich history of medical professionalism (...) and the insistence that the practice of medicine is a moral commitment to society. I argue for critical attention to the ways in which treatment recipients and providers navigate what, for them, is “social” about therapeutic practices and their significance for avoiding biological and social reductionism. (shrink)
This article reports the findings from a study that investigates the relationship between ethical climates and police whistle-blowing on five forms of misconduct in the State of Georgia. The results indicate that a friendship or team climate generally explains willingness to blow the whistle, but not the actual frequency of blowing the whistle. Instead, supervisory status, a control variable investigated in previous studies, is the most consistent predictor of both willingness to blow the whistle and frequency of blowing the (...) whistle. Contrary to popular belief, the results also generally indicate that police are more inclined than civilian employees to blow the whistle in Georgia - in other words, they are less inclined to maintain a code of silence. (shrink)
Currently, all 50 states and the District of Columbia have youth concussion laws based on the core principals of the 2009 Lystedt Law of Washington State. On April 23, 2013, the state of Georgia signed into law House Bill 284, “The Return to Play Act of 2013” and became one of the last states to pass youth concussion legislation. This Act became effective on January 1, 2014. The purpose of this report is to highlight the legislative process of enacting (...)Georgia House Bill 284 and compare it to the legislation of other states. (shrink)
This article argues that the equality versus difference dispute in feminism is not essentially a dispute about the basis of public policy as Georgia Warnke implies. Furthermore, rarely can public policy issues concerning women be resolved by direct appeal to interpretation. Interpretation should be understood as offering a model of cultural transformation rather than public policy adjudication. Key Words: deliberation democracy difference equality feminism interpretation.
(2010). Betwixt and Between: Working Through the Aesthetic in Philosophy of Education: George F. Kneller Lecture, Conference of the American Educational Studies Association Savannah, Georgia, October 30, 2008. Educational Studies: Vol. 46, No. 3, pp. 291-316.
We examine the applicability of the concept of Social Licence to Operate (SLO) for international humanitarian and development cooperation organizations. We review the relevant literature on SLO and derive criteria that can be applicable to the work of development agencies. We also examine the case of the international NGO, Mercy Corps, in the region of Samtskhe-Javakheti, Georgia, specifically its Market Alliances against Poverty project. Using focus groups and key informant interviews, we sought to understand what would constitute an SLO (...) for the local community in the context of a development intervention. Themes that emerged included: transparency and accountability; access to information; the potential benefits and dangers of innovations; the inspirational effect of the presence of an external organization; risks associated with loans and grants; and the reliability of intermediaries. Our results can be utilized by development practitioners and humanitarian organizations as well as academics who want t.. (shrink)