Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome soon after birth. Recent data demonstrates that nearly every 15 min a baby is born in the United States suffering from NOWS. The primary treatment for NOWS is opioid replacement therapy, commonly oral morphine, which has neurotoxic effects on the developing brain. There is an urgent need for non-opioid treatments for NOWS. Transcutaneous auricular neurostimulation, a novel and non-invasive form of (...) electrostimulation, may serve as a promising alternative to morphine. tAN is delivered via a multichannel earpiece electrode worn on and around the left ear, targeting two cranial nerves—the vagus and trigeminal nerves. Prior research suggests that auricular neurostimulation exerts an anxiolytic effect on the body by releasing endogenous opioids and reduces withdrawal symptoms in adults actively withdrawing from opioids. In this first-in-human prospective, open-label trial, we investigated tAN as an adjuvant to morphine therapy in eight infants >33 weeks gestational age suffering from NOWS and receiving oral morphine treatment. Infants received tAN for 30 min 1 h before receiving a morphine dose. tAN was delivered at 0.1 mA below perception intensity at two different nerve targets on the ear: Region 1, the auricular branch of the vagus nerve; and Region 2, the auriculotemporal nerve. tAN was delivered up to four times daily for a maximum of 12 days. The primary outcome measures were safety [heart rate monitoring, Neonatal Infant Pain Scale, and skin irritation] and morphine length of treatment. tAN was well-tolerated and resulted in no unanticipated adverse events. Comparing to the national average of 23 days, the average oral morphine LOT was 13.3 days and the average LOT after tAN initiation was 7 days. These preliminary data suggest that tAN is safe and may serve as a promising alternative adjuvant for treating NOWS and reducing the amount of time an infant receives oral morphine. (shrink)

Nishida Kitaro's reformulation of the major issues of Western philosophy from a Zen standpoint of "absolute nothingness" and "absolutely contradictory self-identity" represents the boldest speculative enterprise of modern Japan, continued today by his successors in the "Kyoto School" of philosophy. This English translation of Intuition and Reflection in Self-Consciousness evokes the movement and flavor of the original, clarifies its obscurities, and eliminates the repetitions. It sheds new light on the philosopher's career, revealing a long struggle with such thinkers as Cohen, (...) Natorp, Husserl, Fichte, and Bergson, that ended with Nishida's break from the basic ontological assumptions of the West. Throughout labyrinthine arguments, Nishida never loses sight of his theme: the irreducibility and unobjectifiability of the act of self-consciousness which constitutes the self. Extensive annotation is provided for the first time in any edition of Nishida's work. Historians of Japanese philosophy and culture, and all those interested in the interaction of Eastern and Western thought-forms, now have a document which highlights many of the cultural, psychological, and intellectual dynamics that have shaped Japanese intellectual life in one of its most fascinating and ambitious manifestations. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Do the rich descriptions and narrative shapings of literature provide a valuable resource for readers, writers, philosophers, and everyday people to imagine and confront the ultimate questions of life? Do the human activities of storytelling and complex moral decision-making have a deep connection? What are the moral responsibilities of the artist, critic, and reader? What can religious perspectives—from Catholic to Protestant to Mormon—contribute to literary criticism? Thirty well known contributors reflect on these questions, including iterary theorists Marshall Gregory, James Phelan, (...) and Wayne Booth; philosophers Martha Nussbaum, Richard Hart, and Nina Rosenstand; and authors John Updike, Charles Johnson, Flannery O'Connor, and Bernard Malamud. Divided into four sections, with introductory matter and questions for discussion, this accessible anthology represents the most crucial work today exploring the interdisciplinary connections between literature, religion and philosophy. (shrink)

Apocalyptic expectations of Armageddon and a New Age have been a fixture of the American cultural landscape for centuries. With the approach of the year 2000, such millennial visions seem once again to be increasing in popularity. Stephen O'Leary sheds new light on the age-old phenomenon of the End of the Age by proposing a rhetorical explanation for the appeal of millennialism. Using examples of apocalyptic argument from ancient to modern times, O'Leary identifies the recurring patterns in apocalyptic (...) texts and movements and shows how and why the Christian Apocalypse has been used to support a variety of political stances and programs. The book concludes with a critical review of the recent appearances of doomsday scenarios in our politics and culture, and a meditation on the significance of the Apocalypse in the nuclear age. Arguing the Apocalypse is the most thorough examination of its subject to date: a study of a neglected chapter of our religious and cultural history, a guide to the politics of Armageddon, and a map of millennial consciousness. (shrink)

Tout s’est passé très vite, prenant l’Église au dépourvu. Le mouvement pour la reconnaissance des mariages et des unions civiles entre personnes du même sexe a connu un succès extraordinaire. La hiérarchie de l’Église catholique oppose une fin de non-recevoir à toute reconnaissance positive des couples homosexuels, en invoquant une morale sexuelle qu’on dit ancienne et invariable,..

Examining the ways in which two representatives of the “theological turn in French phenomenology” speak of the interrelationship between philosophy and theology, one may detect a number of tendencies which are deleterious both to philosophy and theology. The idea of an autonomous philosophy, pursued as an end in itself, needs to be defended against claims that philosophy can only flourish under theological tutelage. Again, the integrity of theology as a science of faith excludes any identification of theology as a kind (...) of philosophy. Interaction between the two disciplines, especially in the border areas of apologetics, fundamental theology, religious philosophy, and philosophy of religion, can be fruitful only if a keen sense of their radical difference of orientation is sustained. Behind the swamping of phenomenology by theological concerns lies a series of misunderstandings of metaphysics and its overcoming as well as a misguided notion that phenomenology allows revealed theology to re-enter the French university under the rubric of philosophy. (shrink)

The final book of O'Leary's trilogy, Conventional and Ultimate Truth deals with the nature of theological rationality today, drawing on Buddhist ideology.

In lieu of an abstract, here is a brief excerpt of the content:Religious Pluralism and Christian TruthJoseph S. O’Leary has been named recipient of the 1998 Frederick J. Streng Book Award for his 1996 volume, Religious Pluralism and Christian Truth. Dr. O’Leary was born in Cork, Ireland, in 1949. He studied literature, theology, and philosophy in Maynooth, Rome, and Paris. After teaching briefly in the United States (University of Notre Dame and Duquesne University), he moved to Japan in 1983. He (...) has worked in association with the Nanzan Institute for Religion and Culture and currently teaches English literature at Sophia University (with special emphasis on Joyce and the modernist period) and a course on Japanese values at International Christian University.He has been working on a trilogy in fundamental theology that has taken on an increasingly interreligious character. The first volume is Questioning Back: The Overcoming of Metaphysics in Christian Tradition (Minneapolis: Winston/Seabury, 1985), reviewed in Buddhist-Christian Studies in 1987; a French version is in preparation. The second volume appeared first as La verite chretienne a l’age du pluralisme religieux (Paris: Cerf, 1994) and then as Religious Pluralism and Christian Truth (Edinburgh University Press, 1996). Joseph O’Leary is also coeditor of Heidegger et la question de Dieu (Paris: Grasset, 1980) and Buddhist Spirituality (vols. 8 and 9 of World Spirituality, New York: Crossroad, 1993 and 1999).Terry Muck: Why did you write this book?Joseph O’Leary: My earlier book, Questioning Back: The Overcoming of Metaphysics in Christian Tradition, advocated deconstruction of the Greek and Hebrew elements in Christian theology—the need for a radical retrieval of the tradition in the spirit of Heidegger’s “step back” from metaphysical systems to the original phenomena. In Religious Pluralism and Christian Truth, I broadened the horizon to see all religion as historical, cultural constructs growing and changing through mutual interaction. Living in Japan brought me a liberating sense of historical and cultural relativity and with it the sense that the Christian tradition should be thought of as an essentially incomplete project, always reaching out to other traditions in search of a fuller vision.But that discovery did not mean giving up on the Christian tradition.No. Rather than sitting back and enjoying the pluralism, I found myself more and more concerned with the question of truth. Followers of Jacques Derrida assured me that “truth” has been exposed as a historical myth. Struggling with Derrida I found rather a recontextualization of the value of truth. Moreover, the “situated truth” (always relative to a given context in culture and praxis) of historically formulated dogmatic propositions turned out to be quite defensible despite Derrida’s demolition [End Page 239] of notions of truth as totality (Hegel) or truth as presence (Heidegger). Christianity has nothing to fear from opening itself up to its historical relativity. Buddhism has long accepted the provisionality of all religious expressions. I focused especially on the notion of skillful means and on the theory of the two truths (conventional and ultimate) in Madhyamaka Buddhism.What does this “opening up” do to traditional Christian doctrines?The notion of God is not only compatible with such a relativized view of the status of religious language, but demands it. The biblical discourse about God consists in a constant deconstruction of old images of God by new ones. As for the role of Jesus Christ, Incarnation is an ongoing event in that the historical significance of Jesus is still unfolding. The uniqueness of Jesus resides not in some ontological amalgamation of divinity and humanity but in the specifics of his historical role. God’s Word is spoken in other ways elsewhere, indeed is spoken in all things, and its specifically “fleshly” (human and historical) and “eschatological” manifestation in the unfolding of the Jesus story should not be divorced from these wider contexts.How have these ideas been received?The most flattering response has come from the Society for Buddhist-Christian Studies in granting me the Frederick J. Streng Book Award. Streng’s book, Emptiness, which I read in Pittsburgh in 1982, opened my eyes to the world of Madhyamaka thought.Any criticisms?Predictably, the book has come under fire from two opposing camps. The Revue Thomiste reviewer claimed that I could... (shrink)

This book is of interest to those working at the intersection of contemporary debates in philosophy, ethics, politics and cultural studies.

Towards the end of Analyze This , during a shoot-out, the psychotherapistplayed by Billy Crystal falls in front of the mobster played by Robert de Niro andtakes a bullet in his shoulder. De Niro thanks him for taking the bullet, but Crystalprotests that he just tripped up. De Niro replies, ‘No Doc, you tripped on yourunconscious!’ In this observation, the mobster not only provides the key to thisfilm, he also opens up a way of understanding something essential about TheGodfather . (...) One of the central and, for me, unexplained problems in TheGodfather is the motivation for Michael Corleone’s transformation from modelcitizen and war-hero into the ruthless Don who takes his father’s place at thehead of one of New York’s mafia families. In this paper, I will use Analyze This –and Freud – to explain this transformation as a form of ‘tripping over theunconscious’. My suggestion is that Analyze This, in its self-consciously popFreudian fashion, actually gives us the basis for a more serious Freudianinterpretation of Michael’s transformation. If we approach Coppola’s film as atragedy in which the ostensible rise to power of Michael is, in effect, hisdownfall, then we are faced with the question of how to understand the natureof the forces that bring him to that end. Against the idea that Michael is simply destined to take over his father’s position, I will give an account of the underlying psychological forces that bring him to that culmination. (shrink)

I have decided to focus this discussion on the famous article by Milton Friedman, “The Social Responsibility of Business is to Increase Its Profits.” This article was originally published in 1970 and has been reproduced in many sources since then. So the article is over 30 years old. However, the perspective that Friedman promotes in this article is one that is still very much a part of discussions about business, business ethics, and ethics and economics. It seems legitimate to me (...) to try to get an insight into some of Friedman’s insights and oversights. (shrink)