Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

[Graeme Forbes] In I, I summarize the semantics for the relational/notional distinction for intensional transitives developed in Forbes (2000b). In II-V I pursue issues about logical consequence which were either unsatisfactorily dealt with in that paper or, more often, not raised at all. I argue that weakening inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a gorgon', are valid, but that disjunction inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a mortal gorgon or (...) an immortal gorgon', are invalid. Since 'a gorgon' and 'a mortal gorgon or an immortal gorgon' are extensionally and intensionally the same quantifier, it is not completely trivial to arrange the semantics of intensional transitives so that this classification of the inferences is obtained. (This paper is an abridged version of Forbes (2001a); the latter will be incorporated into a forthcoming monograph, Attitude Problems.) /// [Jennifer Saul] This paper discusses the question of which verbs are intensional transitives. In particular, I ask which verbs Forbes should take to be intensional transitives. I argue that it is very difficult to arrive at a clear and plausible understanding of what an intensional transitive is-making it difficult to answer these questions. I end by briefly raising some questions about the usefulness of the category of intensional transitives. (shrink)

Marx did not approach the state in answer to some such broad and abstract philosophical question as: What is the state? Nor did he offer a full sociological or historical or analytic account of state institutions and functions, and there are hence clear and substantial dangers in extrapolating to all or most conditions an account which is, in large part, specific to bourgeois society. Failing a comprehensive and formal treatise on politics and the state, Marx's own discussion consists of a (...) number of scattered and not altogether consistent general observations and some detailed investigation of the role and character of the state in particular historical situations. It seems sensible, then, to begin an elucidation of his account of the state with a comment on the nature of his interest in the subject. Why did he need a theory of the state? At what points does it become important to his explanatory and his revolutionary doctrines? (shrink)

In this paper, I focus on the so-called "tacking by disjunction problem". Namely, the problem to the effect that, if a hypothesis H is confirmed by a statement E, H is confirmed by the disjunction E v F, for whatever statement F. I show that the attempt to settle this difficulty made by Grimes 1990, in a paper apparently forgotten by today methodologists, is irremediably faulty.

In this particularly well written volume Graeme Hirst presents a theoretically motivated foundation for semantic interpretation (conceptual analysis) by computer, and shows how this framework facilitates the resolution of both lexical and syntactic ambiguities.

In this article, we consider two independently appealing theories—the Growing-Block view and Humean Supervenience—and argue that at least one is false. The Growing-Block view is a theory about the nature of time. It says that past and present things exist, while future things do not, and the passage of time consists in new things coming into existence. Humean Supervenience is a theory about the nature of entities like laws, nomological possibility, counterfactuals, dispositions, causation, and chance. It says that none of (...) these entities are fundamental, since if they were, this would entail the existence of irreducible necessary connections between matters of fact. Instead, these entities supervene on a fundamental, non-nomological ‘Humean mosaic’ of property instances at spacetime points. We will further explain and motivate the Growing-Block view and Humean Supervenience in Sects. 2 and 3, but first, we turn to our master argument. (shrink)

We show that five important elements of the ‘nomological package’— laws, counterfactuals, chances, dispositions, and counterfactuals—needn’t be a problem for the Growing-Block view. We begin with the framework given in Briggs and Forbes (in The real truth about the unreal future. Oxford studies in metaphysics. Oxford University Press, Oxford, 2012 ), and, taking laws as primitive, we show that the Growing-Block view has the resources to provide an account of possibility, and a natural semantics for non-backtracking causal counterfactuals. We show (...) how objective chances might ground a more fine-grained concept of feasibility, and furnished a places in the structure where causation and dispositions might fit. The Growing-Block view, thus understood, provides the resources to explain the close link between modality and tense, so that it predicts modal change as time passes. This account lets us capture not only what the future might hold for us, and also what might have been. (shrink)

The phenomenon of the New Genetics raises complex social problems, particularly those of privacy. This book offers ethical and legal perspectives on the questions of a right to know and not to know genetic information from the standpoint of individuals, their relatives, employers, insurers and the state. Graeme Laurie provides a unique definition of privacy, including a concept of property rights in the person, and argues for stronger legal protection of privacy in the shadow of developments in human genetics. (...) He challenges the role and the limits of established principles in medical law and ethics, including respect for patient autonomy and confidentiality. This book will interest lawyers, philosophers and doctors concerned both with genetic information and issues of privacy; it will also interest genetic counsellors, researchers, and policy makers worldwide for its practical stance on dilemmas in modern genetic medicine. (shrink)

The COVID-19 pandemic has led to intense conversations about ventilator allocation and reallocation during a crisis standard of care. Multiple voices in the media and multiple state guidelines mention reallocation as a possibility. Drawing upon a range of neuroscientific, phenomenological, ethical, and sociopolitical considerations, the authors argue that taking away someone’s personal ventilator is a direct assault on their bodily and social integrity. They conclude that personal ventilators should not be part of reallocation pools and that triage protocols should be (...) immediately clarified to explicitly state that personal ventilators will be protected in all cases. (shrink)

Over recent decades there has been a growing interest in the question of whether computer programs are capable of genuinely creative activity. Although this notion can be explored as a purely philosophical debate, an alternative perspective is to consider what aspects of the behaviour of a program might be noted or measured in order to arrive at an empirically supported judgement that creativity has occurred. We sketch out, in general abstract terms, what goes on when a potentially creative program is (...) constructed and run, and list some of the relationships (for example, between input and output) which might contribute to a decision about creativity. Specifically, we list a number of criteria which might indicate interesting properties of a program’s behaviour, from the perspective of possible creativity. We go on to review some ways in which these criteria have been applied to actual implementations, and some possible improvements to this way of assessing creativity. (shrink)

We analyse aspects of the Big Bang program in modern cosmology, with special focus on the strategies employed by its adherents both in defending the theory against anomalous data and in dismissing rival accounts. We illustrate this by critically examining four aspects of Big Bang cosmology: the interpretation of the cosmic red-shift, the explanation of the cosmic background radiation, the inflation hypothesis and the search for dark matter. We conclude that the Big Bang's dominance of contemporary cosmology is not justified (...) by the degree of experimental support it receives relative to rival theories. (shrink)

Although research into the biosemiotic mechanisms underlying the purposeful behavior of brainless living systems is extensive, researchers have not adequately described biosemiosis among neurons. As the conscious use of signs is well-covered by the various fields of semiotics, we focus on subconscious sign action. Subconscious semiotic habits, both functional and dysfunctional, may be created and reinforced in the brain not necessarily in a logical manner and not necessarily through repeated reinforcement. We review literature that suggests hypnosis may be effective in (...) changing subconscious dysfunctional habits, and we offer a biosemiotic framework for understanding these results. If it has been difficult to evaluate any psychological approach, including hypnosis, this may be because contemporary neuroscience lacks a theory of the sign. We argue that understanding the fluid nature of representation in biological organisms is prerequisite to understanding the nature of the subconscious and may lead to more effective of treatments for dysfunctional habits developed through personal experience or culture. (shrink)

The meanings of words seem to change over time. But while there is a growing body of literature in linguistics and philosophy about meaning change, there has been little discussion about the metaphysical underpinnings of meaning change. The central aim of this paper is to push this discussion forward by surveying the terrain and advocating for a particular metaphysical picture. In so doing, we hope to clarify various aspects of the nature of meaning change, as well as prompt future philosophical (...) investigation into this topic. More specifically, this paper has two parts. The first, broadly exploratory, part surveys various metaphysical accounts of meaning change. The goal here is to lay out the terrain, thereby highlighting some key choice points. Then, in the second part, after critiquing Prosser’s (Philosophy Phenomenol Res 100(3):657–676, 2020) exdurantism about ‘mental files’, we sketch and defend the enduring senses view of meaning change. (shrink)

Analytic philosophy has recently demonstrated a revived interest in metaphysical problems about possibility and necessity. Graeme Forbes here provides a careful description of the logical background of recent work in this area for those who may be unfamiliar with it, moving on to d discuss the distinction between modality de re and modality de dicto and the ontological commitments of possible worlds semantics. In addition, Forbes offers a unified theory of the essential properties of sets, organisms, artefacts, substances, and (...) events, based on the doctrine that identity facts must be intrinsically grounded, and analyzes and rejects apparent counterexamples to this doctrine. (shrink)

What is a physical object according to the theory of quantum mechanics? The first answer to be considered is that given by Bohr in terms of the concept of complementarity. This interpretation is illustrated by way of an example, the two slit experiment, which highlights some of the associated problems of ontology. One such problem is the so-called problem of measurement or observation. Various interpretations of measurement in Quantum Theory, including those of Heisenberg, von Neumann, Everett and Bohr, are compared (...) and contrasted. A second problem concerns whether or not QT can be considered complete and therefore satisfactory as a basis for physics. Various attempts to complete QT by means of the addition of ‘hidden variables’ to the quantum mechanical state function are considered and their aims and achievements assessed. Finally, we investigate some of the characteristic ontological problems for the orthodox interpretation of Relativistic Quantum Theory. -/- . (shrink)

This book has been written for eighteen year olds (or anyone who will listen) as an honest attempt to face their justified questionings and to offer them a metaphysical framework with which to confront the twenty-first century. It is vitally important that certain modes of thought are uprooted and new modes put in their place if mankind and planet Earth are not soon to suffer an historic global catastrophe. Apart from the continuing world-wide proliferation of conventional, chemical, biological and nuclear (...) weaponry, the temperature of the planet has risen more rapidly in the last twenty-five years than it has since the year 900AD, which confirms global warming by some cause or other. These and the many intensifying human conflicts and natural disasters demand that some fundamental changes to our thinking are made as soon as possible. These 120 pages begin with an original examination of the quantum-theoretical understanding of reason (logic) and reality (existence) and find both to be at odds with common sense. A theory of everything is a reduction to a single grand idea! A quantum theory of everything is a mathematical theory of a consciousness realizing this grand idea! That is what this book tries to comprehend by means of five indisputable propositions. (shrink)

This article argues for the importance of conceptual clarity in the debate about the so-called right not to know. This is vital both at the theoretical and the practical level. It is suggested that, unlike many formulations and attempts to give effect to this right, what is at stake is not merely an aspect of personal autonomy and therefore cannot and should not be reduced only to a question of individual choice. Rather, it is argued that the core interests that (...) can be protected by the right not to know are better conceived of as privacy interests rather than autonomy interests. This not only helps us to understand what is in play but also informs regulatory, professional, and legal responses to handling information and taking decisions about whether or not to disclose information to persons about themselves. The practical implications of this conceptualization are explored in the context of feedback policies in health-related research. (shrink)

The right not to know is a contested matter. This can be because the inversion of the normal framing of entitlement to information about one's own health is thought to be illogical and inconsistent with self-authorship and/or because the very idea of claiming a right not to know information is an inappropriate appeal to the discourse of rights that places impossible responsibilities on others. Notwithstanding, there has been a sustained increase in this kind of appeal in recent years fueled in (...) large part by the rise and rise of the importance of personal autonomy in health care ethics, and by domestic and international health law. The right not to know has been acknowledged in at least two important international legal instruments. For example, the UNESCO Universal Declaration on the Human Genome and Human Rights, Article 5c provides: “The right of every individual to decide whether or not to be informed of the results of genetic examination and the resulting consequences should be respected.”. (shrink)

Two challenges facing Archbishop John Bede Polding after arriving in Sydney in 1835 were providing for the spiritual needs of Catholics in the colony and managing their affairs in a way that attempted to guarantee a good working relationship with the government. It became apparent to Polding that education was fundamental in developing both these areas. Polding regarded education as a means of social advancement, beneficial to those 'on the lower steps of the social scale'. He wanted a 'native race (...) of priests and statesmen, of lawyers and physicians, of solicitors, and sailors, and artists'. He sought to emulate Downside Abbey's approach to education in Australia; specifically in the field of secondary education that would 'transcend the mere bread-and-butter preoccupations of the masses and prepare an 'elite' from among whom the offices of Church and state could eventually be filled'. Polding's goal was to create schools that would provide a Catholic education for its students founded on the principles of Benedictine ideals. But, as Francesca Fitz-Walter argues, it was the colonial conditions of the time that placed obstacles on Polding's expression of the Benedictine ideal in education. Given that the colonial conditions of the time imposed restrictions on the expression of the Benedictine ideal, Polding still maintained that a lifelong education was significant in developing in the student the ability to make an informed Christian response to whatever circumstance might emerge in the life of that person. (shrink)

In this article I will examine the purchase and opening of Lyndhurst College in 1852 and its contribution to early Catholic education in Sydney. In a previous article, I discussed the establishment of St Mary's Seminary by Archbishop John Bede Polding in 1836. Lyndhurst College was another Benedictine school set up by Polding in Sydney that gave students of wealthier Catholics the opportunity to prepare for the church, university and the civil service.

This article will explore the musicianship of Bishop Charles Henry Davis, osb, coadjutor to Australia's first Catholic Archbishop, John Bede Polding, osb. It will focus on his musical contribution to the early Australian Catholic Church-his ability to improvise, compose, conduct and perform during his short time as bishop at St Mary's, Sydney.

Approximately 1 in 30 people develop cancer due to an underlying familial predisposition. Genetic counselling and testing for people with (and at risk of) familial cancer are becoming more widely available, but service providers need to address challenging issues in relation to privacy and property. As in any counselling situation, a genetic counsellor seeks to ensure that the principles of autonomy, confidentiality, beneficence, and equity operate in favour of the client. But in dealing with a familial disorder, the application of (...) these principles to the individual must be balanced with the potential for these principles to apply to other family members. This paper summarises the recent experience of a familial cancer service in seeking to avoid situations in which these principles, operating for both individual clients and their relatives, can come into conflict. (shrink)

This paper examines the legal conception of political parties. It does so by unearthing the history and ontology of the common law relating to political parties in international perspective. The flexibility of the unincorporated association, in which parties are understood through the private law of contract as networks of internal rules or agreements, rather than as legal entities, has proven to be a mask. In the common laws imagination, the ideal party is a ground-up organization animated by its membership. But (...) the law mandates no such thing, and in its statutory and constitutional conception intra-party democracy may be sublimated as parties need be no more than an electoral persona or brand. (shrink)

ABSTRACTMy critics and I agree that ideology is understudied, though I think it is the most important factor while they reserve a lesser role for it. Hertog’s analysis of personality traits is suggestive and valuable, though it illuminates a path that leads to the Islamic State's ideology rather than to its violence. Owen correctly identifies the challenge the Islamic State – and other forms of revivalist religion – pose for Lockean toleration. Fadel's swerve toward an “ideology” of Arab despotism is (...) a diversion. Juergensmeyer rightly notes parallel forms of violence in other traditions, and his analysis of the role of social conditions is partly shared by ISIS supporters themselves. (shrink)

This article interrogates Andrew Feenberg’s thesis that modern technology is in need of ‘re-aestheticization’. The notion that modern technology requires aesthetic critique connects his political analysis of micro-contexts of social shaping to his wider concern with civilization change. The former involves a modified constructionism, in which the motives, values and beliefs of proximal agents are understood in terms of their wider sociological significance. This remedies a widely acknowledged blind-spot of conventional constructionism, enabling Feenberg to identify democratic potential in progressive agency (...) at the scene of technology design. Feenberg argues that the aesthetics of naturalistic modernism may serve as a bridge between such interventions and cultural transformation. Referring to developments in design culture, especially as this relates to the human-machine interface on digital artefacts, the article suggests that this part of Feenberg’s argument has been falsified. This kind of aesthetic modernism is hegemonic in contemporary design and it has not brought about significant progressive advance. In conclusion, the article suggests a different approach to aesthetic critique that is based on difference rather than wholeness, and on the principle that there is no inherent correspondence of aesthetic standards and ethics in technology design. (shrink)

First published in 1973, this was the first detailed comparative analysis of the writings of Karl Marx and John Stuart Mill. it contains a full, careful and sympathetic account of their respective social doctrines, and concludes with a critical comparative evaluation of the two thinkers.

The programme of work -- Towards a theory of jokes -- The process of joke comprehension -- Text comprehension -- Processing and prediction -- Logic in jokes -- Incongruity and resolution -- Surprise -- The role of language -- Impropriety -- Superiority and aggression -- What's in a joke? -- Applying the framework -- The way forward.