American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

Biology is seen not merely as a privileged oppressor of women but as a co-victim of masculinist social assumptions. We see feminist critique as one of the normative controls that any scientist must perform whenever analyzing data, and we seek to demonstrate what has happened when this control has not been utilized. Narratives of fertilization and sex determination traditionally have been modeled on the cultural patterns of male/female interaction, leading to gender associations being placed on cells and their components. We (...) also find that when gender biases are controlled, new perceptions of these intracellular and extracellular relationships emerge. (shrink)

Since Darwin, the idea of psychological continuity between humans and other animals has dominated theory and research in investigating the minds of other species. Indeed, the field of comparative psychology was founded on two assumptions. First, it was assumed that introspection could provide humans with reliable knowledge about the causal connection between specific mental states and specific behaviors. Second, it was assumed that in those cases in which other species exhibited behaviors similar to our own, similar psychological causes were at (...) work. In this paper. we show how this argument by analogy is flowed with respect to the case of second-order mental states. As a test case, we focus on the question of how other species conceive of visual attention, and in particular whether chimpanzees interpret seeing as a mentalistic event involving internal states of perception, attention, and belief. We conclude that chimpanzees do not reason about seeing in this manner, and indeed, there is considerable reason to suppose that they do not harbor representations of mental states in general. We propose a reinterpretation model in which the majority of the rich social behaviors that humans and other primates share in common emerged long before the human lineage evolved the psychological means of interpreting those behaviors in mentalistic terms. Although humans, chimpanzees, and most other species may be said to possess mental states, humans alone may have evolved a cognitive specialization for reasoning about such states. (shrink)

The prospect of using genome technologies to modify the human germline has raised profound moral disagreement but also emphasizes the need for wide-ranging discussion and a well-informed policy response. The Hinxton Group brought together scientists, ethicists, policymakers, and journal editors for an international, interdisciplinary meeting on this subject. This consensus statement formulated by the group calls for support of genome editing research and the development of a scientific roadmap for safety and efficacy; recognizes the ethical challenges involved in clinical reproductive (...) applications of genome editing but, importantly, rejects the idea that human reproductive germline modification is necessarily morally unacceptable; and highlights the importance of meaningful engagement in discussions of genome editing and the development of regulation and oversight mechanisms to govern future uses of such technologies. (shrink)

Malm and colleagues (2008) consider (and reject) five arguments putatively justifying the idea that healthcare workers (HCWs) have a duty to treat (DTT) during a pandemic. We do not have sufficient...

A twenty‐person working group convened to discuss the ethical and policy considerations of the controversial intervention called “growth attenuation,” and if possible to develop practical guidance for health professionals. A consensus proved elusive, but most of the members did reach a compromise.

We would like to open some questions here about the institutional and cultural conditions of anything that might be called cultural studies or multiculturalism. By introducing cultural studies and multiculturalism many intellectuals aim at a more democratic culture. We share this aim. In this essay, however, we would like to argue that the projects of cultural studies and multiculturalism require: a more international model of cultural studies than the dominant Anglo-American versions; renewed attention to the institutional environments of cultural studies; (...) and a questioning of the relations between multiculturalism and identity politics. We seek less to “fix” these problems than to provide a critical analysis of the languages, the methods of criticism, and the assumptions about identity, culture, and politics that present the problems to us. Because the thickets entangling what our group calls cultural studies are so deeply rooted in Western academia, which to a large degree constitutes our own group, the counterexample of cultural criticism in other contexts can be more than usually instructive. We begin by considering the position of cultural studies in China, since our group includes a number of Chinese intellectuals, on whose experience the following section is largely based. The Chicago Cultural Studies Group began meeting in June 1990. It includes Lauren Berlant, David Bunn, Vinay Dharwadker, Norma Field, Dilip Gaonkar, Marilyn Ivy, Benjamin Lee, Leo Ou-fan Lee, Xinmin Liu, Mathew Roberts, Sharon Stephens, Katie Trumpener, Greg Urban, Michael Warner, Jianyang Zha, and Jueliang Zhou. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

This composition text focuses on argument and persuasion using examples, exercises, readings, and writing assignments. The text guides students through developing a thesis, finding and organizing evidence, and writing and revising several different types of argumentative papers. The second edition de-emphasizes the language of formal logic, and all the readings, examples, and exercises have been updated. Additional coverage has been given to refutation. Widely used in both advanced composition and second semester freshman courses.

This book starts from the premise that methodology has always dominated archaeology to the detriment of broader social theory.

We concur with Baum and colleagues (2009) on the importance of pandemic planners taking explicit steps to employ public engagement methodologies. Thus far, as Baum and colleagues note, there have b...

Originally published between 1925 and 1931 the volumes in this mini-set cover education, from early years to further education, as well as the role parents and society have in the moral education of children and young people. Among others the authors included are: C E M Joad, W J K Diplock, M Chaning Pearce and J F Roxburgh.

The focus of the titles in this mini-set, originally published between 1926 and 1928 is on the challenges of feeding an increasing global population, technological changes in the home, the evolutionary role of clothes and the dangers and benefits of alcohol.

Originally published between 1924 and 1929 discuss the future of psychology and the break-throughs it could provide for modern medicine. Authors included are E N Bennett, H F Carlill,D F Fraser Harris, M Jaeger and C J Patten.

_Routledge Library Editions: Psychoanalysis_ brings together as one set, or individual volumes, a series of 8 previously out-of-print titles, originally published between 1923 and 1993. Written by international authors from a variety of backgrounds, this set looks at psychoanalysis in a number of different areas including, culture, religion, sociology, postmodernism, literary criticism and others.

This set collects together a vital selection of works on Existentialism, including the key Introduction to the New Existentialism by Colin Wilson. Some of the titles were early works written as this new philosophy spread into the English language, while others are more recent examinations.

Originally published between 1982 and 1991 the 3 volumes in this set Reflect the diversity in Hegelianism and every branch of philosophy which he contributed to. Examine Hegel's work in relation to Marx and Wittgenstein Discuss Hegel's social theory Examine British Hegelian thinking and the lines of its development Offer an interpretation of Hegelian theory that is relevant for the understanding of modern republican constitutions.

Reissuing works originally published between 1949 and ‘79, this set presents a rich selection of renowned scholarship across the subject, touching also on ethics, religion, and psychology and other behavioural science. Classic previously out-of-print works are brought back into print here in this set of important discourse and theory.

This 20 volume Routledge Revivals collection brings together a selection of groundbreaking Philosophy titles, from the rich and diverse Routledge backlist. With titles published between 1933 and 1991, this is a truly wide-ranging selection, encompassing works by distinguished authors such as: Simone Weil, Hilary Putnam, Franz Brentano, Anthony Kenny, Karl Jaspers and Israel Scheffler. Dealing with everything from the notion of freewill, to concepts of time and space, to theories of morality, this set offers a collection of the best of (...) Routledge publishing in the field of Philosophy from across the Twentieth Century. Please note that all titles have been previously available for sale individually through the Routledge Revivals programme. (shrink)

The thirteen titles in this mini-set include works by some of the most well-known scientists and medical professionals of the twentieth century: Daedalus by J B S Haldane, Eos, or the Wider Aspects of Cosmogony by J H Jeans, Archimedes, or the Future of Physics by L L Whyte and the The Conquest of Cancer by H W S Wright to name but a few. Ground breaking in their day, some of the works remain controversial nearly 100 years after their (...) original publication. (shrink)

Originally published between 1926 and 1931 the titles in this mini-set discuss the role of women in both domestic and professional areas, contraception, sexual relationships and the changing nature of the family within society.