This book is the first monograph in German dealing exclusively with F.C.S. Schiller, until now and even given today‘s "Renaissance of Pragmatism" the most neglected of the classical pragmatists. It tries for the first time to analyse aspects of his oeuvre as a "twofold Humanism": consisting of a more descriptive "methodical humanism" on the one side and a more normative "prophetic humanism" on the other side. These two and irreducible perspectives of Schiller's writing allow him to take into account the (...) human condition not, as most of the interpreters suggest, in a radical but in a holistic manner: man existing as an individual and as a member of society, as an I in relation to God, as a biological fact and as a still not yet realized ideal in the light of multiple forms of criticism and reform. Thus it becomes clear that Schiller's complex thought - logical, ethical, social, educational and metaphysical - cannot be confined to individual aspects, particularly not to the topos of the "theory of truth" as the common "reading" of his writing stereotypically insinuates. Rather, it revolves around the most fundamental question of philosophy as such: concerned with the meaning of life in its entirety, especially in the light of the modern threat of nihilism and pessimism. -/- Table of Contents (translated) -/- 1. Oversight 2. The Philosophically Designated Path into the Abyss 2.1. Agnosticism 2.2. Scepticism 2.3. Pessimism 3. The Methodical Humanism as Possibilism – The Conversion of Thought from Destinity to Possibility 3.1. In the Antechamber of Practice 3.2. Excursion: William James' Concept of the "Will to Believe" 3.3. "All that has become has History" 3.4. The Ethical Unmasking of Knowledge 3.5. Bertrand Russell's Critique of Pragmatism – Ennobling the Human by Degrading him 3.6. "Problems of Belief" – The Complexity of the Person 3.7. The Bilocal Fixation of Philosophy – as Public Office and Private Poetry 3.8. On the Half-Way – Retrospect and Prospect 4. The Prophetic Humanism Consisting in Personalistic Speculation and Genetic Manipulation 4.1. The Speculative Humanism 4.1.1. Naturalizing the Human as Humanizing the Nature 4.1.2. Excursion: The "Personal Idealism" of George Holmes Howison 4.1.3. Schiller's Theatrum Mundi – The World as a Pedagogical Play between God and Man 4.2. The Eugenical Humanism 4.2.1. Putting it on its Feet – Schiller's Political Diagnosis 4.2.2. The Eugenically Reformist March Through the Institutions 4.2.3. Excursion: The Humanistic Mobilization of Religious Reserves in John Dewey's "A Common Faith" 5. Follow-up. (shrink)

PurposeThis study aims to develop and validate a stigma scale for Chinese patients with breast cancer.MethodsPatients admitted to the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, for breast cancer treatment participated in this study. Development of the Breast Cancer Stigma Scale involved the following procedures: literature review, interview, and applying a theoretical model to generate items; the Breast Cancer Stigma Scale’s content validity was assessed by a Delphi study and feedback from patients with breast cancer ; (...) exploratory factor analysis was used to assess the construct validity; convergent validity was assessed with the Social Impact Scale ; internal consistency Cronbach’s α, split-half reliability, and test–retest reliability were used to identify the reliability of the scale.ResultsThe final version of the Breast Cancer Stigma Scale consisted of 15 items and showed positive correlations with the Social Impact Scale. Exploratory factor analysis revealed four components of the Breast Cancer Stigma Scale: self-image impairment, social isolation, discrimination, and internalized stigma, which were strongly related to our perceived breast cancer stigma model and accounted for 69.443% of the total variance. Cronbach’s α for the total scale was 0.86, and each subscale was 0.75–0.882. The test–retest reliability with intra-class correlation coefficients of the total scale was 0.947, and split-half reliability with intra-class correlation coefficients of the total scale was 0.911. The content validity index was 0.73–1.0.ConclusionThe newly developed Breast Cancer Stigma Scale offers a valid and reliable instrument for assessing the perceived stigma of patients with breast cancer in clinical and research settings. It may be helpful for stigma prevention in China. (shrink)

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)