Humberto Figueroa [3]H. Figueroa [1]
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    Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.Y. Wen, W. H. Yu, B. Maloney, J. Bailey, J. Ma, I. Marie, T. Maurin, L. Wang, H. Figueroa, M. Herman, P. Krishnamurthy, L. Liu, E. Planel, L. F. Lau, D. K. Lahiri & K. Duff - 2008 - Neuron 57:680-90.
    Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...)
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