8 found
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  1.  98
    The Empirical Nonequivalence of Genic and Genotypic Models of Selection: A (Decisive) Refutation of Genic Selectionism and Pluralistic Genic Selectionism.Robert N. Brandon & H. Frederik Nijhout - 2006 - Philosophy of Science 73 (3):277-297.
    Genic selectionists (Williams 1966; Dawkins 1976) defend the view that genes are the (unique) units of selection and that all evolutionary events can be adequately represented at the genic level. Pluralistic genic selectionists (Sterelny and Kitcher 1988; Waters 1991; Dawkins 1982) defend the weaker view that in many cases there are multiple equally adequate accounts of evolutionary events, but that always among the set of equally adequate representations will be one at the genic level. We describe a range of cases (...)
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  2.  34
    The Biological Significance of Substrate Inhibition: A Mechanism with Diverse Functions.Michael C. Reed, Anna Lieb & H. Frederik Nijhout - 2010 - Bioessays 32 (5):422-429.
  3.  21
    Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes.Richard Gawne, Kenneth Z. McKenna & H. Frederik Nijhout - 2018 - Bioessays 40 (1):1600265.
    The question of whether the modern evolutionary synthesis requires an extension has recently become a topic of discussion, and a source of controversy. We suggest that this debate is, for the most part, not about the modern synthesis at all. Rather, it is about the extent to which genetic mechanisms can be regarded as the primary determinants of phenotypic characters. The modern synthesis has been associated with the idea that phenotypes are the result of gene products, while supporters of the (...)
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  4. Causal Realism and the Laws of Nature.Richard Corry, Robert N. Brandon, H. Frederik Nijhout, Richard Dawid, Ron Mallon, Jonathan M. Weinberg & Hong Yu Wong - 2006 - In Borchert (ed.), Philosophy of Science. Macmillan. pp. 261-276.
    This paper proposes a revision of our understanding of causation that is designed to address what Hartry Field has suggested is the central problem in the metaphysics of causation today: reconciling Bertrand Russell’s arguments that the concept of causation can play no role in the advanced sciences with Nancy Cartwright’s arguments that causal concepts are essential to a scientific understanding of the world. The paper shows that Russell’s main argument is, ironically, very similar to an argument that Cartwright has put (...)
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  5.  9
    Size and Shape: The Developmental Regulation of Static Allometry in Insects.Alexander W. Shingleton, W. Anthony Frankino, Thomas Flatt, H. Frederik Nijhout & Douglas J. Emlen - 2007 - Bioessays 29 (6):536-548.
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  6.  2
    The Robustness of the Transcriptional Response to Alterations in Morphogenetic Gradients.Reiner A. Veitia & H. Frederik Nijhout - 2006 - Bioessays 28 (3):282-289.
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  7.  29
    A Day in the Life of Cell Metabolism.H. Frederik Nijhout, Michael C. Reed & Cornelia M. Ulrich - 2007 - Biological Theory 2 (2):124-127.
  8.  20
    Environment and Genetic Accommodation.H. Frederik Nijhout & Yuichiro Suzuki - 2008 - Biological Theory 3 (3):204-212.
    Waddington’s experiments on genetic assimilation showed that selection on environmentally induced phenotypic variants can cause inherited evolutionary changes in the phenotype. We have recently extended this work by demonstrating that it is possible to select for a polyphenism in a monophenic species . We found that a mutation in the juvenile hormone regulatory pathway in Manduca sexta enabled heat stress to reveal a hidden reaction norm of larval coloration. Artificial selection for increased color change in response to heat-shock resulted in (...)
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