I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

Wie verhalten sich Ideen zu der materiellen Wirklichkeit, die sie abbilden wollen? In der Strukturanalyse der Platonschen Spiegel-Metapher findet der Autor den Schlüssel, um den Zusammenhang der materiellen Vielheit als universelles Reflexionssystem darstellen zu können und das menschliche In-der-Welt-sein als Moment des Naturverhältnisses zu begründen.

Rorty’s Philosophy and the Mirror of Nature presents the most thorough and sustained critique of Western epistemology and foundationalism in the second half of the twentieth Century. The work deconstructs philosophy as an autonomous discipline generating a “neutral matrix” to assess knowledge, truth, and rationality, offering philosophical analyses of the mind-body distinction, representation, reference, and truth, and ultimately the concept of knowledge as a “mirror of nature.” The deconstruction of Cartesian dualism undermines the mind as the immaterial ground of absolute (...) certainty; the deconstruction of the Kantian empirical-transcendental distinction destroys the transcendental realm as philosophy’s uniquely accessible and founding domain. Instead, Rorty invites us to reconceive philosophy as an edifying voice in the “conversation of mankind.”. (shrink)

Bei Nietzsches Texten handelt es sich häufig um Reaktionen auf seine breitgestreuten Lektüren. Sein Lesen ist zugleich ein Schreiben, und es verläuft ebenso selektiv und assoziativ wie aneignend: So werden unter Nietzsches Hand etwa Lesefrüchte aus naturwissenschaftlichen Lexika ästhetischen Überlegungen einverleibt oder ethno-anthropologische Fachbücher im Kontext philosophiegeschichtlicher Einordnungsversuche zitiert. Die Interpretation von Nietzsches Schriften ist daher stets auf eine philologisch-differenzierte Quellenarbeit angewiesen, die zugleich auch philosophisch-hermeneutischen Ansprüchen genügt. Nur so findet die spezifische Gemengelage aus Eigenem und Fremdem in Nietzsches Texten (...) ebenso adäquate Berücksichtigung wie die Vielzahl der handschriftlichen Lesespuren in den bis heute erhaltenen Büchern aus seiner persönlichen Bibliothek. In einer Reihe von Überblicksdarstellungen und exemplarischen Fallstudien unternimmt es der Band, Nietzsche im Spiegel seiner Lektüren als äußerst produktiven wie kreativen Leser zu charakterisieren, dessen Voraussetzungsreichtum nicht überschätzt werden kann. (shrink)

Dit boek is een hommage aan de filosoof Hubert Dethier (°21 juli 1933), die we zeker in de rij kunnen plaatsen van denkers als Jaap Kruithof, Hans Achterhuis en Etienne Vermeersch. Deze hommage is geen chronologische biografie. Het is daarentegen wel een verhaal waarin het leven van Hubert Dethier verweven wordt met de geschiedenis van zijn denken. Een denken dat zich situeert in de tweede helft van de vorige eeuw en het begin van de huidige eeuw en zich moeiteloos (...) projecteert naar de toekomst. Ontegensprekelijk een woelige en gewelddadige periode, maar ook een tijdgewricht van hoop en verwachting van het “nieuwe”.0. (shrink)

In der deutschen Geistesgeschichte wurde seit Hegel und Hölderlin die Geschichte als tragischer Prozess verstanden. Ein Drama wie die Antigone des Sophokles sollte als das vollkommenste Werk der Kunst die griechische Deutung des Miteinanders der Menschen und der Götter zeigen. Hegel legte aber dar, dass die Antigone mit den Reigen ihrer Chöre auf einer modernen Bühne nicht aufführbar sei. Doch zehn Jahre nach seinem Tod dirigierte sein Hörer Felix Mendelssohn-Bartholdy in Potsdam und Berlin seine Vertonung der Antigone. Hölderlins Sophokles-Übertragungen erhielten (...) eine harte Kritik; im Zeitalter des Expressionismus griff man aber auf ihre ausdrucksvolle Sprache zurück. Als nach den Zerstörungen des Zweiten Weltkriegs gleich ein weiterer Krieg drohte, brachte Carl Orff seine Vertonung von Hölderlins Antigonä auf die Bühne. Martin Heidegger, der selber das erste Standlied der Antigone übersetzt und ausgelegt hatte, gratulierte Orff bei einer Münchener Aufführung zur 'Wiedererweckung der antiken Tragödie'. Bertolt Brecht stellte seine Bearbeitung der Antigone gegen Orffs Mythisierung. Als man diese Bearbeitung im Oktober 1989 in Ost-Berlin spielte, bejubelte das Publikum Antigones Wort an Kreon: 'Weniger (Menschen) sind es (in der DDR) geworden, seit du herrschst'. Auch in den Ruinen von Kabul wurde Antigone gezeigt. John Cranco brachte ein Antigone-Ballett ein, als er das Stuttgarter Ballett zum Weltruhm führte. Ein Maler wie Werner Scholz, einst durch die Brücke beeinflusst, zeigte Antigone auf Ölbildern. Dabei ging es, wie Hans-Georg Gadamer formulierte, nicht mehr um die überlebensgroßen Erscheinungen der Götter Homers. Schon die tragische Bühne und dann das gemalte Bild zeigten den Geschlagenen und Leidenden als den ganz menschlichen Menschen. So führt Antigones Tragödie die Menschen vor ihr Schicksal und zeigt, was Geschichte ist. (shrink)

In March 2020, the rapid increase in severe COVID‐19 cases overwhelmed the healthcare systems in several European countries. The capacities for artificial ventilation in intensive care units were too scarce to care for patients with acute respiratory disorder connected to the disease. Several professional associations published COVID‐19 triage recommendations in an extremely short time: in 21 days between March 6 and March 27. In this article, we compare recommendations from five European countries, which combine medical and ethical reflections on this (...) situation in some detail. Our aim is to provide a detailed overview on the ethical elements of the recommendations, the differences between them and their coherence. In more general terms we want to identify shortcomings in regard to a common European response to the current situation. (shrink)

Current radical democratic politics is characterized by new participatory spaces for citizens’ engagement, which aim at facilitating the democratic ideals of freedom and equality. These spaces are, however, situated in the context of deep societal inequalities. Modes of discrimination are carried over into participatory interaction. The democratic subject is judged by its physically embodied appearance, which replicates external hierarchies and impedes the freedom of self-expression. To tackle this problem, this article seeks to identify ways to increase the freedom of the (...) subject to explore its multiple self. Understanding the self as inherently fugitive, the article investigates participatory, deliberative and agonistic concepts of self-transformation. As all of them appear limited, it introduces a transformative perspective in democratic thought. Enriching the transformative perspective with queer and gender theory, the article generates the concept of a politics of becoming, which, through radical democratic practices of disidentification, advances the freedom of the subject to change. (shrink)

This article compares situated cognition to contemporary Neo-Aristotelian approaches to the mind. The article distinguishes two components in this paradigm: an Aristotelian essentialism which is alien to situated cognition and a Wittgensteinian “capacity approach” to the mind which is not just congenial to it but provides important conceptual and argumentative resources in defending social cognition against orthodox cognitive science. It focuses on a central tenet of that orthodoxy. According to what I call “encephalocentrism,” cognition is primarily or even exclusively a (...) computational process occurring inside the brain. Neo-Aristotelians accuse this claim of committing a “homuncular” or “mereological fallacy”. The article explains why the label “fallacy” is misleading, reconstructs the argument to the effect that encephalocentric applications of psychological predicates to the brain and its parts amount to a category mistake, and defends this argument against objections by Dennett, Searle, and Figdor. At the same time it criticizes the Neo-Aristotelian denial that the brain is the organ of cognition. It ends by suggesting ways in which the capacity approach and situated cognition might be combined to provide a realistic and ecologically sound picture of cognition as a suite of powers that flesh-and-blood animals exercise within their physical and social environments. (shrink)

In this major work, Blumenberg takes issue with Karl Lowith's well-known thesis that the idea of progress is a secularized version of Christian eschatology, which promises a dramatic intervention that will consummate the history of the ...

Since the late 1980s, the neglect of experiment by philosophers and historians of science has been replaced by a keen interest in the subject. In this volume, a number of prominent philosophers of experiment directly address basic theoretical questions, develop existing philosophical accounts, and offer novel perspectives on the subject, rather than rely exclusively on historical cases of experimental practice. Each essay examines one or more of six interconnected themes that run throughout the collection: the philosophical implications of actively and (...) intentionally interfering with the material world while conducting experiments; issues of interpretation regarding causality; the link between science and technology; the role of theory in experimentation involving material and causal intervention; the impact of modeling and computer simulation on experimentation; and the philosophical implications of the design, operation, and use of scientific instruments. (shrink)

This collection of original essays by preeminent interpreters of continental philosophy explores the question of whether Western thought and culture have been dominated by a vision-centered paradigm of knowledge, ethics, and power. It focuses on the character of vision in modern philosophy and on arguments for and against the view that contemporary life and thought are distinctively "ocularcentric." The authors examine these ideas in the context of the history of philosophy and consider the character of visual discourse in the writings (...) of Plato, Descartes, Hegel, Nietzsche, Husserl, Heidegger, Benjamin, Sartre, Merleau-Ponty, Levinas, Derrida, Foucault, Gadamer, Wittgenstein, and Habermas. With essays on television, the visual arts, and feminism, the book will interest readers in cultural studies, gender studies, and art history as well as philosophers. (shrink)

Inhaltsverzeichnis - Einleitung; Lebenswelt und Technisierung unter Aspekten der Phänomenologie; 'Nachahmung der Natur'. Zur Vorgeschichte der Idee des schöpferischen Menschen; Anthropologische Annäherung an die Aktualität der Rhetorik; Sprachsituation und immanente Poetik; Paradigma, grammatisch; Ernst Cassirers gedenkend bei Entgegennahme des Kuno-Fischer-Preises der Universität Heidelberg.

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

The paper aims at a perspicuous representation of Isaac Levi's pragmatist epistemology, spanning from the 1967 classic "Gambling with Truth" to his 2004 book on "Mild Contraction". Based on a formal framework for Levi's notion of inquiry, I analyse his decision-theoretic approach with truth and information as basic cognitive values, and with Shackle measures as emerging structures. Both cognitive values figure prominently in Levi's model of inductive belief expansion, but only the value of information is employed in his model of (...) belief contraction. I argue that the former model is more successful than the latter. (shrink)

Technik bestimmt auf die mannigfaltigste Weise unser Leben und Zusammenleben. Obgleich sie von Platon und Aristoteles bis in das zwanzigste Jahrhundert in Einzelaspekten betrachtet worden ist, wurde sie erst in den letzten Jahrzehnten zu einem eigenständigen Gegenstand der Philosophie. Dennoch werden ihre philosophischen Probleme immer noch eher beiläufig behandelt. So geht es um die Klärung ganz zentraler und herausfordernder Aufgaben – von der menschlichen Schöpferkraft über eine Klärung, was ein technisches Artefakt ist, zum technischen Wissen, in all diesen Elementen verknüpft (...) mit dem Verantwortungsproblem. Das Ziel ist eine Darstellung dieser faszinierenden philosophischen Fragen vor dem Hintergrund der Tradition. (shrink)

In this accessible collection of short meditations on various topics, Blumenberg works as a detective of ideas scouring the periphery of intellectual and philosophical history for clues—metaphors, gestures, anecdotes—essential to grasping human finitude.