The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)
With respect to the ethical debate about the treatment of animals in biomedical and behavioral research, Harry F. Harlow represents a paradox. On the one hand, his work on monkey cognition and social development fostered a view of the animals as having rich subjective lives filled with intention and emotion. On the other, he has been criticized for the conduct of research that seemed to ignore the ethical implications of his own discoveries. The basis of this contradiction is discussed (...) and propositions for current research practice are presented. (shrink)
Harry Harlow is credited with the discovery of learning set, a process whereby problem solving becomes essentially complete in a single trial of training. Harlow described that process as one that freed his primates from arduous trial-and-error learning. The capacity of the learner to acquire learning sets was in positive association with the complexity and maturation of their brains. It is here argued that Harlow's successful conveyance of learning-set phenomena is of historic significance to the philosophy of psychology. Learning (...) set is said to reflect the affirmation or rejection of hypotheses. Hypotheses are generated by the learner's brain, not its muscles. Thus, learning-set research served to advance the perspective that even nonhuman primates think and that their thinking reflects the active processing of information accrued from efforts to solve problems. Their learning processes are not simply the strengthening of some motor responses over others. Hence, learning-set research served to advance studies of animals as rational agents. This trend is serving to supplant the radical-behavioristic models, formulated earlier this century, with models predicated on rational processes for animals' complex learning and behavior. (shrink)
In this paper I argue that Harry Frankfurt's work (both on volitional necessity and on Descartes) can help us to understand the argument that is at the heart of P. F. Strawson's classic article, "Freedom and Resentment". Strawson seems to say that it is both idle and irrelevant to ask whether the participant attitude (the framework within which we see others as morally responsible agents) is justified, but many have been puzzled by these remarks. In this paper I contend (...) that we can better understand Strawson's argument by taking him to be saying that the participant attitude is volitionally necessary. (shrink)
In his article, “Equality as a Moral Ideal”, Harry Frankfurt argues against economic egalitarianism and presents what he calls the “doctrine of sufficiency.” According to the doctrine of sufficiency, what is morally important is not relative economic equality, but rather, whether somebody has enough, where “having enough” is a non-comparative standard of reasonable contentment that may differ from person to person given his/her aims and circumstances. The purpose of this paper is to show that Frankfurt’s original arguments in support (...) for his doctrine of sufficiency have critical problems that Frankfurt himself does not properly recognize. In the end, I will argue that in order to solve these problems the doctrine of sufficiency cannot help but to incorporate certain prioritarian commitments – commitments which many would view as implying economic egalitarianism. This is embarrassing for a doctrine whose raison d’être was mainly to defeat economic egalitarianism. (shrink)
Harry Stack Sullivan has been described as 'the most original figure in American psychiatry'. Challenging Freud's psychosexual theory, Sullivan founded the interpersonal theory of psychiatry, which emphasized the role of interpersonal relations, society and culture as the primary determinants of personality development and psychopathology. This concise and coherent account of Sullivan's work and life invites the modern audience to rediscover the provocative, groundbreaking ideas embodied in Sullivan's interpersonal theory and psychotherapy.
Most philosophical explorations of responsibility discuss the topic solely in terms of metaphysics and the "free will" problem. By contrast, these essays by leading philosophers view responsibility from a variety of perspectives -- metaphysics, ethics, action theory, and the philosophy of law. After a broad, framing introduction by the volume's editors, the contributors consider such subjects as responsibility as it relates to the "free will" problem; the relation between responsibility and knowledge or ignorance; the relation between causal and moral responsibility; (...) the difference, if any, between responsibility for actions and responsibility for omissions; the metaphysical requirements for making sense of "collective" responsibility; and the relation between moral and legal responsibility. The contributors include such distinguished authors as Alfred R. Mele, John Martin Fischer, George Sher, and Frances Kamm, as well as important rising scholars. Taken together, the essays in _Action, Ethics, and Responsibility_ offer a breadth of perspectives that is unmatched by other treatments of the topic. Contributors: Joseph Keim Campbell, David Chan, Randolph Clarke, E.J. Coffman, John Martin Fischer, Helen Frowe, Todd Jones, Frances Kamm, Antti Kauppinen, Alfred R. Mele, Michael O'Rourke, Paul Russell, Robert F. Schopp, George Sher, Harry S. Silverstein, Saul Smilansky, Donald Smith, Charles T. Wolfe The hardcover edition does not include a dust jacket. (shrink)
For Weberian Marxists, the social theories of Max Weber and Karl Marx are complementary contributions to the analysis of modern capitalist society. Combining Weber's theory of rationalization with Marx's critique of commodity fetishism to develop his own critique of reification, Georg Lukacs contended that the combination of Marx's and Weber's social theories is essential to envisioning socially transformative modes of praxis in advanced capitalist society. By comparing Lukacs's theory of reification with Habermas's theory of communicative action as two theories in (...) the tradition of Weberian Marxism, I show how the prevailing mode of "doing theory" has shifted from Marx's critique of economic determinism to Weber's idea of the inner logic of social value spheres. Today, Weberian Marxism can make an important contribution to theoretical sociology by reconstituting itself as a framework for critically examining prevailing societal definitions of the rationalization imperatives specific to purposive-rational social value spheres (the economy, the administrative state, etc.). In a second step, Weberian Marxists would explore how these value spheres relate to each other and to value spheres that are open to the type of communicative rationalization characteristic of the lifeworld level of social organization. (shrink)