16 found
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  1.  12
    In Vitro Gametogenesis and the Creation of ‘Designer Babies’.Seppe Segers, Guido Pennings, Wybo Dondorp, Guido de Wert & Heidi Mertes - 2019 - Cambridge Quarterly of Healthcare Ethics 28 (3):499-508.
    :Research into the development of stem cell-derived gametes in humans, otherwise known as in vitro gametogenesis, is largely motivated by reproductive aims. Especially, the goal of establishing genetic parenthood by means of SCD-gametes is considered an important aim. However, like other applications in the field of assisted reproduction, this technology evokes worries about the possibility of creating so-called ‘designer babies.’ In this paper, we investigate various ways in which SCD-gametes could be used to create such preference-matched offspring, and what this (...)
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  2.  11
    UTx With Deceased Donors Also Places Risks and Burdens on Third Parties.Heidi Mertes & Kristof Van Assche - 2018 - American Journal of Bioethics 18 (7):22-24.
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  3.  8
    Using Stem Cell-Derived Gametes for Same-Sex Reproduction: An Alternative Scenario.Seppe Segers, Heidi Mertes, Guido Pennings, Guido de Wert & Wybo Dondorp - 2017 - Journal of Medical Ethics 43 (10):688-691.
    It has been suggested that future application of stem-cell derived gametes might lead to the possibility for same-sex couples to have genetically related children. Still, for this to become possible, the technique of gamete derivation and techniques of reprogramming somatic cells to a pluripotent state would have to be perfected. Moreover, egg cells would have to be derived from male cells and sperm cells from female cells, which is believed to be particularly difficult, if not impossible. We suggest a more (...)
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  4.  15
    Getting What You Desire: The Normative Significance of Genetic Relatedness in Parent–Child Relationships.Seppe Segers, Guido Pennings & Heidi Mertes - 2019 - Medicine, Health Care and Philosophy 22 (3):487-495.
    People who are involuntarily childless need to use assisted reproductive technologies if they want to have a genetically related child. Yet, from an ethical point of view it is unclear to what extent assistance to satisfy this specific desire should be warranted. We first show that the subjectively felt harm due to the inability to satisfy this reproductive desire does not in itself entail the normative conclusion that it has to be met. In response, we evaluate the alternative view according (...)
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  5.  64
    Embryonic Stem Cell–Derived Gametes and Genetic Parenthood: A Problematic Relationship.Heidi Mertes & Guido Pennings - 2008 - Cambridge Quarterly of Healthcare Ethics 17 (1):7-14.
    The recent success in generating live offspring from embryonic stem cell –derived gametes in mice sparked visions of growing tailor-made sperm for men faced with infertility. However, although this development will almost certainly lead to new insights into the processes underlying spermatogenesis and thus in the possible causes of male infertility, it is less certain if deriving sperm from ES cells, which are in turn derived from a sterile man, can make someone a genetic parent. As the gap between newly (...)
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  6.  12
    In Vitro Gametogenesis and Reproductive Cloning: Can We Allow One While Banning the Other?Seppe Segers, Guido Pennings, Wybo Dondorp, Guido de Wert & Heidi Mertes - 2019 - Bioethics 33 (1):68-75.
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  7.  26
    Does Human Genome Editing Reinforce or Violate Human Dignity?Seppe Segers & Heidi Mertes - 2020 - Bioethics 34 (1):33-40.
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  8.  40
    The Force of Dissimilar Analogies in Bioethics.Heidi Mertes & Guido Pennings - 2011 - Theoretical Medicine and Bioethics 32 (2):117-128.
    Although analogical reasoning has long been a popular method of reasoning in bioethics, current literature does not sufficiently grasp its variety. We assert that the main shortcoming is the fact that an analogy's value is often judged on the extent of similarity between the source situation and the target situation, while in (bio)ethics, analogies are often used because of certain dissimilarities rather than in spite of them. We make a clear distinction between dissimilarities that aim to reinforce a similar approach (...)
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  9.  4
    Ethical values supporting the disclosure of incidental and secondary findings in clinical genomic testing: a qualitative study.Marlies Saelaert, Heidi Mertes, Tania Moerenhout, Elfride De Baere & Ignaas Devisch - 2020 - BMC Medical Ethics 21 (1):1-12.
    Incidental findings and secondary findings, being results that are unrelated to the diagnostic question, are the subject of an important debate in the practice of clinical genomic medicine. Arguments for reporting these results or not doing so typically relate to the principles of autonomy, non-maleficence and beneficence. However, these principles frequently conflict and are insufficient by themselves to come to a conclusion. This study investigates empirically how ethical principles are considered when actually reporting IFs or SFs and how value conflicts (...)
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  10.  8
    Modification of the Embryo's Genome: More Useful in Research Than in the Clinic.Heidi Mertes & Guido Pennings - 2015 - American Journal of Bioethics 15 (12):52-53.
  11.  3
    The Ethics of Ectogenesis‐Aided Foetal Treatment.Seppe Segers, Guido Pennings & Heidi Mertes - forthcoming - Bioethics.
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  12.  14
    Ethical Aspects of the Use of Stem Cell Derived Gametes for Reproduction.Heidi Mertes & Guido Pennings - 2010 - Health Care Analysis 18 (3):267-278.
    A lot of interest has been generated by the possibility of deriving gametes from embryonic stem cells and bone marrow stem cells. These stem cell derived gametes may become useful for research and for the treatment of infertility. In this article we consider prospectively the ethical issues that will arise if stem cell derived gametes are used in the clinic, making a distinction between concerns that only apply to embryonic stem cell derived gametes and concerns that are also relevant for (...)
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  13.  13
    Ethical Concerns Eliminated: Safer Stimulation Protocols and Egg Banking.Heidi Mertes & Guido Pennings - 2011 - American Journal of Bioethics 11 (9):33-35.
    The American Journal of Bioethics, Volume 11, Issue 9, Page 33-35, September 2011.
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  14.  15
    Balancing Animal Welfare and Assisted Reproduction: Ethics of Preclinical Animal Research for Testing New Reproductive Technologies.Verna Jans, Wybo Dondorp, Ellen Goossens, Heidi Mertes, Guido Pennings & Guido de Wert - 2018 - Medicine, Health Care and Philosophy 21 (4):537-545.
    In the field of medically assisted reproduction, there is a growing emphasis on the importance of introducing new assisted reproductive technologies only after thorough preclinical safety research, including the use of animal models. At the same time, there is international support for the three R’s, and the European Union even aims at the full replacement of animals for research. The apparent tension between these two trends underlines the urgency of an explicit justification of the use of animals for the development (...)
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  15.  21
    The Diversity of Genetic Perfection.Heidi Mertes & Kristien Hens - 2015 - American Journal of Bioethics 15 (6):34-36.
  16.  12
    Testicular Tissue Cryopreservation: Combining Access With Safeguards.Heidi Mertes & Guido Pennings - 2013 - American Journal of Bioethics 13 (3):46 - 48.
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