Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

The decision to undertake this volume was made in 1971 at Lake Como during the Varenna summer school ofthe Italian Physical Society, where Professor Leon Rosenfeld was lecturing on the history of quantum theory. We had long been struck by the unique blend of epistemological, histori cal and social concerns in his work on the foundations and development of physics, and decided to approach him there with the idea of publishing a collection of his papers. He responded enthusiastically, and agreed (...) to help us select the papers; furthermore, he also agreed to write a lengthy introduction and to comment separately on those papers that he felt needed critical re-evaluation in the light of his current views. For he was still vigorously engaged in both theoretical investigations of, and critical not reflections on the foundations of theoretical physics. We certainly did conceive of the volume as a memorial to a 'living saint', but rather more practically, as a useful tool to place in the hands of fellow workers and students engaged in wrestling with these difficult problems. All too sadly, fate has added a memorial aspect to our labors. We agreed that in order to make this book most useful for the con temporary community of physicists and philosophers, we should trans late all non-English items into English. (shrink)

Using an explicit task cuing paradigm, we tested whether masked cues can trigger task-set activation, which would suggest that unconsciously presented stimuli can impact cognitive control processes. Based on a critical assessment of previous findings on the priming of task-set activation, we present two experiments with a new method to approach this subject. Instead of using a prime, we varied the visibility of the cue. These cues either directly signaled particular tasks in Experiment 1, or certain task transitions in Experiment (...) 2. While both masked task and transition cues affected task choice, only task cues affected the speed of task performance. This observation suggests that task-specific stimulus–response rules can be activated only by masked cues that are uniquely associated with a particular task. Taken together, these results demonstrate that unconsciously presented stimuli have the power to activate corresponding task sets. (shrink)

Der Aufsatz fragt am Beispiel von Tucholskys Pyrenäenbuch von 1927 nach den Möglichkeiten disziplinärer Zuständigkeiten und methodisch gesteuerter Interpretationen im Feld der Kulturwissenschaft. Gibt im Falle des Pyrenäenbuchs die aus Sicht der Medienwissenschaft avancierte Kombinatorik von Text und Photographie die Auslegung vor oder lässt sich jenseits dieser etablierten medienwissenschaftlichen Theorie-Topik dem Text selbst noch ein anderer konkurrenzfähiger Auslegungshorizont abgewinnen? Gelesen im Umfeld von Arnold Gehlens Reflexionen über Gewohnheit (1927) und Walter Benjamins Kunstwerk-Aufsatz wird Tucholskys Reisebuch lesbar als aktualisierte Kierkegaard-Lektüre und (...) damit als systematische Abhandlung über mediale Gebrauchsweisen und Praktiken im Zeichen der Wiederholung. Drawing upon the example of Tucholsky's 1927 [Book of the Pyrenees], the paper inquires into the possibilities of disciplinary competences and methodology-driven interpretations in the field of cultural studies. It asks whether in the case of the, the combination strategies of text and photography necessarily predetermine the interpretation, or whether there are other competitive horizons of interpretation beyond this wellestablished theoretical topos of media studies. If it is read in the context of Arnold Gehlen's 1927 [Reflections on habit] and Walter Benjamin's, Tucholsky's [Book/journal of voyages] presents itself as an contemporary reading of Kierkegaard and thus as a systematic discussion of medial usages and practices under the sign of repetition. (shrink)

This conceptual paper analyses the arguments which have been made in favour of a transition towards humanistic management. In order to reconcile economic as well as moral arguments an integrative model of humanistic management is presented. This model outlines prospective lines of empirical research especially in the area where business conduct is profitable but not humanistic.

Hexa-Sabbath. Foreign Matter and Vital Substances, Experts and the Critical Consumer in the FRG during the 1950s and 1960sIn the late Fifties and early Sixties the regulation of food additives represented a remarkable turning point in German consumer politics, establishing a debate about decision making and policy advice, altering the discourse of purity and contamination, and inaugurating a new political actor, the organized critical consumer. The amendment of the Food Law in December 1958 functioned as a negotiation process between representatives (...) of science, industry and the state, which was institutionalized in the Senate Commissions of the German Research Foundation. While these Commissions for preservatives, foreign matter and colorants worked behind closed doors, a public discourse about the “toxic condition” of modern life and the negative role of the pharmaceutical and chemical industry gained strength.The debate about the admission of hexamethylenetetramine (hexa) took part at a crucial moment. Hexa was used as a preservative in the fish industry. But its anti microbial effectiveness was caused by the decomposition of hexa to formaldehyde. Despite the commission’s verdict against hexa, the lobbying activities of the industry granted it a reprieve. In the media, the case of hexa was seen as a touchstone for the capacity of negotiated decision making and the ability of rational scientists to resist the demands of industry. Finally, in 1963 it was the new political actor of the organized critical consumer, heir and successor to the housewife federations as well as to “purists” advocating life reform, who, supported by the media, enforced the prohibition of hexa as a preservative. (shrink)

chapter Introduction Poststructuralist perspectives on language, gender and sexual identity Since the inception of the field of language and gender in the, ...

Kritik: Formbildung und Formbegriff. Das Formdenken der Moderne, hrsg. von Ralph Ubl. Malika Maskarinec, Rahel Villinger und Markus Klammer, Paderborn: Fink 2019.

Empirical research on the perception of physical events is rarely designed to test a particular theory. The research often fails to be embedded in a larger theoretical context or it is carried out with the implicit goal to support a particular theoretical approach. I argue that this is not very productive. While three theories are relevant for our understanding of events, their limits have rarely been addressed. I expose these limits. The three theories or approaches are direct or ecological perception, (...) inference theory, and the concept of internalization. I demonstrate that all three fail empirically and/or theoretically with respect to explaining the perception of events. They fail because they adhere to simplistic stationary views or because they remain too vague. An adequate theory of event perception has to include three factors at the level of the explanans, namely the stimulus, the purpose of the action to which the percept belongs, and the appraisal of this action's success. Examples from the domains of arrival-time judgment and perception of events involving classical mechanics are used to support the claims. I suggest that a new pragmatic theory of event perception ought to modify and to incorporate the three concepts of affordances, thought-like processes, and evolutionary principles. (shrink)

Implicit and explicit filling-in phenomena should be distinguished. Blind spot phenomena and mechanisms of boundary completion can be accounted for by implicit filling-in. Surface regions are “painted” with perceptual quantities, such as brightness, by explicit filling-in. “Filling-in” and “finding-out” relate to different computational tasks. Mechanisms of purposive computation (e.g., for navigation) evaluate local measurements, thus “finding out”; whereas mechanisms for grasping might require passive reconstruction, thus “filling in.”.

Immanuel Kant is, famously, not only the major philosopher of European enlightenment, but also one of the first philosophers to develop a philosophical theory of “human races”. How do these two sides of Kant relate to each other? What is the significance of race in Kant’s philosophy? In this article, we aim to discuss these questions by taking a close look into the conceptual and philosophical presuppositions underlying Kant’s understanding of race; relating them to the concept of teleology as developed (...) by Kant in the Critique of Judgement and to the idea of natural history that can be derived from there. In the last two chapters, we intertwine both perspectives in such a way that, on the one hand, we can determine the philosophical significance of race for Kant, and, on the other hand, show how a race-sensible perspective gives new and critical insight into Kant’s concept of reason. (shrink)

The article critically engages Menachem Fisch’s account of normative frameworks, in particular of (rational) transitions between them. I argue, first, that exposure to the normative criticism leveled at us by other human beings is indeed “capable of destabilizing normative commitment” to one’s own underlying framework beliefs and standards, as Fisch holds; however, closer scrutiny reveals that such exposure is neither sufficient nor necessary but rather accidental in this respect. Second, I will try to show that Søren Kierkegaard’s account of how (...) people fundamentally change their mind provides resources for both a substantial critique of Fisch and a more adequate understanding of the transitions in question. The article argues, third, that Fisch’s framework model – though meaningful, in fact heuristically indispensable in and as of itself – has robust transcendental implications which as such are being ignored, if not directly denied by Fisch and, precisely by being ignored or denied, unnecessarily weaken the overall plausibility of his account. Finally, and ex post, I will address an important objection raised by some commentators. (shrink)

The present study evaluates the cognitive representation of a kicking movement performed by a human and a humanoid robot, and how they are represented in experts and novices of soccer and robotics, respectively. To learn about the expertise-dependent development of memory structures, we compared the representation structures of soccer experts and robot experts concerning a human and humanoid robot kicking movement. We found different cognitive representation structures for both expertise groups under two different motor performance conditions . In general, the (...) expertise relies on the perceptual-motor knowledge of the human motor system. Thus, the soccer experts’ cognitive representation of the humanoid robot movement is dominated by their representation of the corresponding human movement. Additionally, our results suggest that robot experts, in contrast to soccer experts, access functional features of the technical system of the humanoid robot in addition to their perceptual-motor knowledge about the human motor system. Thus, their perceptual-motor and neuro-functional machine representation are integrated into a cognitive representation of the humanoid robot movement. (shrink)

Prispevek predstavi sklop evholoških besedil na čast svetemu Hieronimu: od prvih omemb v Gelazijevem zakramentarju do prenovljenega rimskega misala Pavla vi. Orisan je potek kompozicije temeljnih zakramentarjev in misalov rimskega obreda, ki so vir, iz katerega se je bogato razširil obstoječ misal. Predstavljeni so vidiki, ki bi jih za zvest prenos misli, izraženih v latinski evhologiji, v drug jezik, lahko upoštevali. Razširjeni konteksti umeščenega besedila namreč v bogoslužju omogočajo liturgičnemu besedilu, da lahko postane učinkovit dogodek vere. Njihovo neupoštevanje pa učinkovitost (...) besedila omejuje. Zaradi pretežno filološke metode prevedeno evhološko besedilo uporabnika lahko doseže šele s katehezo, homilijo ali komentarjem. Tak pristop je neprimerljivo hitrejši in zaradi še neizdelanih študij za vsak posamezni formular se ohranja vtis, da je zahtevni proces inkulturacije rimskega obreda nujno potrebno centralno nadzorovati. Predstavljena so tudi obvezujoča navodila, s katerimi Cerkev že desetletja usmerja prevajanje in iz katerih postaja še bolj očitna teža in preroškost odločitev, ki jih je v korist vernikov naredila na drugem vatikanskem koncilu. (shrink)

Performance on working memory (WM) tasks may partially be supported by long-term memory (LTM) processing. Hence, brain activation recently being implicated in WM may actually have been driven by (incidental) LTM formation. We examined which brain regions actually support successful WM processing, rather than being confounded by LTM processes, during the maintenance and probe phase of a WM task. We administered a four-pair (faces and houses) associative delayed-match-to-sample (WM) task using event-related fMRI and a subsequent associative recognition LTM task, using (...) the same stimuli. This enabled us to analyze subsequent memory effects for both the WM and the LTM test by contrasting correctly recognized pairs with incorrect pairs for either task. Critically, with respect to the subsequent WM effect, we computed this analysis exclusively for trials that were forgotten in the subsequent LTM recognition task. Hence, brain activity associated with successful WM processing was less likely to be confounded by incidental LTM formation. The subsequent LTM effect, in contrast, was analyzed exclusively for pairs that previously had been correctly recognized in the WM task, disclosing brain regions involved in successful LTM formation after successful WM processing. Results for the subsequent WM effect showed no significantly activated brain areas for WM maintenance, possibly due to an insensitivity of fMRI to mechanisms underlying active WM maintenance. In contrast, a correct decision at WM probe was linked to activation in the “retrieval success network” (anterior and posterior midline brain structures). The subsequent LTM analyses revealed greater activation in left dorsolateral prefrontal cortex and posterior parietal cortex in the early phase of the maintenance stage. No supra-threshold activation was found during the WM probe. Together, we obtained clearer insights in which brain regions support successful WM and LTM without the potential confound of the respective memory system. (shrink)

Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...) to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localized tumors or systemic treatment of advanced cancers, respectively. Although radiation is widely used as treatment, most scheduling is based on empirical knowledge and less on the predictions of sophisticated growth dynamical models of treatment response. Part of the failure to translate modeling research to the clinic may stem from language barriers, exacerbated by often esoteric model renderings with inaccessible parameterization. Here we discuss some ideas for combining tractable dynamical tumor growth models with radiation response models using biologically accessible parameters to provide a more intuitive and exploitable framework for understanding the complexity of radiotherapy treatment and failure. (shrink)

The notion of internalization put forth by Roger Shepard continues to be appealing and challenging. He suggests that we have internalized, during our evolutionary development, environmental regularities, or constraints. Internalization solves one of the hardest problems of perceptual psychology: the underspecification problem. That is the problem of how well-defined perceptual experience is generated from the often ambiguous and incomplete sensory stimulation. Yet, the notion of internalization creates new problems that may outweigh the solution of the underspecification problem. To support this (...) claim, I first examine the concept of internalization, breaking it down into several distinct interpretations. These range from well-resolved dynamic regularities to ill-resolved statistical regularities. As a function of the interpretation the researcher selects, an empirical test of the internalization hypothesis may be straightforward or it may become virtually impossible. I then attempt to cover the range of interpretations by drawing on examples from different domains of visual event perception. Unfortunately, the experimental tests regarding most candidate regularities, such as gravitational acceleration, fail to support the concept of internalization. This suggests that narrow interpretations of the concept should be given up in favor of more abstract interpretations. However, the latter are not easily amenable to empirical testing. There is nonetheless a way to test these abstract interpretations by contrasting internalization with the opposite concept: externalization of body dynamics. I summarize evidence for such a projection of body constraints onto external objects. Based on the combined evidence of well-resolved and ill- resolved regularities, the value of the notion of internalization has to be reassessed. Key Words: event perception; evolution; internalization. (shrink)

Zusammenfassung Sportvereine reagieren auf einen Veränderungsdruck ihrer Umwelt selten einheitlich und keinesfalls immer so, wie es die damit verbundenen Forderungen nahe legen. Was steckt hinter diesem Phänomen? Weshalb ist es anscheinend so irrelevant für die Entwicklung der Sportvereine, wenn externe Experten die Notwendigkeit von Strukturveränderungen einfordern? Bedeutet dies, dass Sportvereine ausschließlich nach dem Gutdünken ihrer Funktionäre operieren, oder dass sie gar unfähig sind, sich von Ereignissen in ihrer Umwelt zu Lernprozessen anregen zu lassen? Der vorliegende Beitrag beschäftigt sich mit der (...) Lernfähigkeit von Sportorganisationen. Dabei zeigt sich der Sportverein als besonders lernfähig im Hinblick auf eine Abwehr von Irritationen. Die Notwendigkeit dieser Abwehr ergibt sich aus den sportvereinsspezifischen Organisationsstrukturen. (shrink)

This study presents a contrastive corpus linguistic analysis of language use before and after Stonewall. It uses theoretical insights on normativity from the field of language and sexuality to investigate how the shifting normativities associated with the Stonewall Riots – widely considered the central event of gay liberation in the Western world – have shaped our conceptualization of sexuality as it surfaces in language use. Drawing on two corpora of gay men’s pre-Stonewall narratives dating from two time periods, the analysis (...) combines quantitative and qualitative corpus linguistic methods to examine discursive shifts as evident from narrators’ language use. The study identifies the terms homosexual and normal as central contrastive labels in PRE, and gay and straight as corresponding terms in POST. Other discursive shifts detected are from sexual desire/practices to identity, from an individualistic to a community-based conceptualization of sexuality, and from unquestioned heteronormativity and gender binarism to a weakening of such dominant discourses. The findings are discussed in relation to the desire-identity shift, which is traditionally assumed to have taken place at the end of the 19th century, and shed new light on Stonewall as a central event for the development of an identity-based conceptualization of sexuality as we know it today. (shrink)