Interaction between sciences has always been an optimum. Within this frame of interdisciplinary approach, an attempt is made to apply a method, a mathematical model, used in the Hyperstructure Theory, in teaching and research procedure. More specifically, when dealing with a great amount of data arranged in a ‘linear’ disposal, it is quite difficult to teach. This is the case when the Helix Model is suggested to be used. With the Helix Model, every single piece of data is (...) present and every element maintains its independence. (shrink)

One of our most brilliant evolutionary biologists, Richard Lewontin has also been a leading critic of those--scientists and non-scientists alike--who would misuse the science to which he has contributed so much. In The Triple Helix, Lewontin the scientist and Lewontin the critic come together to provide a concise, accessible account of what his work has taught him about biology and about its relevance to human affairs. In the process, he exposes some of the common and troubling misconceptions that misdirect (...) and stall our understanding of biology and evolution.The central message of this book is that we will never fully understand living things if we continue to think of genes, organisms, and environments as separate entities, each with its distinct role to play in the history and operation of organic processes. Here Lewontin shows that an organism is a unique consequence of both genes and environment, of both internal and external features. Rejecting the notion that genes determine the organism, which then adapts to the environment, he explains that organisms, influenced in their development by their circumstances, in turn create, modify, and choose the environment in which they live.The Triple Helix is vintage Lewontin: brilliant, eloquent, passionate, and deeply critical. But it is neither a manifesto for a radical new methodology nor a brief for a new theory. It is instead a primer on the complexity of biological processes, a reminder to all of us that living things are never as simple as they may seem. (shrink)

사용-참신성 예측주의에 따르면, 가설 구성에 사용된 자료는 증거가 되기 어렵다. DNA 이중 나선 구조의 발견에 대한 사례 연구는 이에 대한 반례를 제공한다. 로잘린드 프랭클린의 DNA X선 회절 사진은 이중 나선 가설의 구성에 사용된 동시에 증거로도 사용되었다. 이 사례에서 증거는 제약에 의한 대안가설의 명시적 제거에 의존하는 증거와 제약들 사이의 정합성 확인에 의존하는 증거로 구분되며, 두 증거 모두 ‘사용-참신한 예측’이라는 조건에는 의존하지 않는다.

The author discusses B.G. Yudin's image technoscience as having two contours, the external one dealing with science, business and society, and the internal one represented by laboratories. Together these two contours present a multidimensional net of relations between science and technology in conducting experiments, development of instruments (e.g. visualization tools), etc. The author argues that, in such a system, coordinated activity of the internal and the external contours is provided by a synergy of regulatory principles of truth, good and usefulness. (...) He discusses a case of synthetic biology which, as he argues, demonstrates that the internal and external contours of technoscience undergo a process of technologization. Technologization is understood as a transition from research techniques to systematic use of technologies. Biotechnologies are claimed to have a double socio-biological helix network structure. Each network is formed as a kind of ad hoc "factory" and is aimed at solving specific research problems. (shrink)

While the Triple Helix and Quadruple Helix models are popular in innovation studies, the relations between them have not been addressed extensively in the literature. There are diverse interpretations of helix models in empirical studies that apply them, but these sometimes deviate from the original theses of the models. Such a situation can confuse newcomers to the field in terms of which helix model to apply in their empirical research. We discern that the cause of this (...) research challenge is a lack of systematic comparison of the two models. To bridge the research gap, this paper compares the models from the perspectives of how they were introduced and discussed in the literature and improved and how useful they are in addressing the innovation processes in contemporary society. Our major findings are as follows: First, reviewing the extant literature applying the two helix models for identifying research gaps, we discover that these studies were influenced by three views on the relations between the two models that were located on a continuum between two extreme ends—namely, isolation versus integration of the two models. Second, we provide a systematic comparison of both the advantages and weaknesses of the two models, and this may help researchers choose suitable helix models as conceptual/analytical tools in their empirical innovation studies. Third, our comparison of the two models shows that they are largely supplementary to each other when analysing innovation processes in contemporary society, providing a ground for potential synergy building between the two helix models. (shrink)

Changes in knowledge production, increasing interaction between government, universities and industry, and changes in labor markets for doctoral degree holders are forces that have spurred a debate about the organization of doctoral education and the competencies graduates need to master to work as scientists and researchers in a triple helix research context. Recent policy also has supported a redefinition of researcher training with increasing focus on broader skills and relevance for careers outside the university sector. Consequently, it is pertinent (...) to investigate current changes in doctoral education and researcher training. Particularly further knowledge about university–industry collaboration as a context for researcher training is required. With this in mind, this study provides empirical illustrations of how research training carried out in collaborative research contexts is experienced by doctoral students, and offers some insight into antecedent and process factors that are central in shaping PhD students’ research and training experience in collaborative research contexts. Based on the empirical data and a review of existing literature, suggestions for further research are made. (shrink)

Three apparently unrelated developmental processes – mammalian myogenesis, the choice of neural fate and sex determination in Drosophila – are controlled by a common mechanism. Most of the genes governing these processes encode transcriptional factors that contain the helix‐loop‐helix (HLH) motif. This domain mediates the formation of homo‐ or heterodimers that specifically bind to DNA through a conserved basic region adjacent to the HLH motif. Dimers differ in their affinity for DNA and in their ability to activate transcription (...) from HLH binding‐site containing promoters. In addition, the activity of HLH proteins is inhibited by dimerization with another class of HLH proteins that lack a basic domain entirely or have an altered one. These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways. (shrink)

The author discusses B.G. Yudin's image technoscience as having two contours, the external one dealing with science, business and society, and the internal one represented by laboratories. Together these two contours present a multidimensional net of relations between science and technology in conducting experiments, development of instruments (e.g. visualization tools), etc. The author argues that, in such a system, coordinated activity of the internal and the external contours is provided by a synergy of regulatory principles of truth, good and usefulness. (...) He discusses a case of synthetic biology which, as he argues, demonstrates that the internal and external contours of technoscience undergo a process of technologization. Technologization is understood as a transition from research techniques to systematic use of technologies. Biotechnologies are claimed to have a double socio-biological helix network structure. Each network is formed as a kind of ad hoc "factory" and is aimed at solving specific research problems. (shrink)

In this article, we propose four modifications to the standard Triple Helix innovation model, which consists of the three strands: university, government, industry. First, in view of recent economic, cultural, organizational and ideological changes in many countries, it is now important to introduce a fourth strand to the standard model, namely society. Second, we observe that strands occur in doublets which we refer to as binomials. Examples of doublets include university/society, university/industry, industry/society, etc. Third, the binomials are organized in (...) a hierarchic mode; for example in the university/society binomial, university may be dominant and the society secondary. The hierarchy arrangement proves decisive. Fourth, Helix-driven innovation processes take the form of temporary segmented phases. Using the case study of Dip-Pen nanolithography, we identify four phases where each phase is characterised by specific binomials accompanied by a hierarchy: academic instrument research (university/society); from instrument to tool; company start-up (university/industry); the mature firm and commercialization (industry/society); confirming the societal strand nanofication (society/industry). The government strand operates as a recessive component in phases one and four. (shrink)

We consider iterations of general elementary embeddings and, using this notion, point out helices of consistency-wise implications between large large cardinals.Up to now, large cardinal properties have been considered as properties which cannot be accessed by any weaker properties and it has been known that, with respect to this relation, they form a proper hierarchy. The helices we point out significantly change this situation: the same sequence of large cardinal properties occurs repeatedly, changing only the parameters.As results of our investigation (...) of this helical structure, we have new characterizations of extendible cardinals and of Vopěnkan cardinals in terms of elementary embeddings from the universe V, a new large large cardinal property which looks like Shelahness properly between Vopěnkaness and almost hugeness, and a more direct relation between Vopěnkaness and Woodinness than already known.We also consider limits of the helices and relations with the axioms I1–I3. (shrink)

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During (...) the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During (...) the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

The Triple Helix is a global model originating in developed economies but less developed countries have also made attempts to implement it into their national contexts. Meanwhile, the national context can be characterised by means-ends decoupling at the state level which implies that policies and practices of the state are disconnected from its core goal of creating public welfare. It refers to the oligarchic economies in which the state is captured by exploitative, rent-seeking oligarchies in business and politics. Ukraine (...) is an example of such a country. Thus, the research question is: how did means-ends decoupling at the state level affect the implementation of the Triple Helix model in Ukraine? To answer this question, we employed both rational choice institutionalism and sociological institutionalism. The data emanate from interviews with the senior managers of four universities and science parks established within them. The findings reveal that means-ends decoupling at the state level, caused by the rent-seeking behaviour of business and political oligarchies, led to the implementation of the Triple Helix model in Ukraine also reflecting a case of means-ends decoupling. The greater the institutional complexity experienced by the science park and the more the senior managers of the university and the science park maintain a logic of confidence in practices that deviate from the Triple Helix model, the greater rent-seeking and means-ends decoupling at the organisational level. Both rent-seeking and means-ends decoupling were found to not only hinder economic growth but also result in a diversion of human intellectual capital. (shrink)

The first attempt to represent the Periodic system graphically was the Telluric Helix presented in 1862 by Alexandre-Emile Béguyer de Chancourtois, in which the sequence of elements was wound round a cylinder. This has hardly been attempted since, because the intervals between periodic returns vary in length from 2 to 32 elements, but Charles Janet presented a model wound round four nested cylinders. The rows in Janet’s table are defined by a constant sum of the first two quantum numbers, (...) n and l, so that they end with the s-block, headed by hydrogen and helium. By combining Janet’s table, Edward Mazurs’ version, in which each row represents an electron shell and Valery Tsimmerman’s use of a half square for each element, I have produced a representation that can be printed out and wound round to make a cylinder with manageable dimensions. In the unwound version, I have placed the s-block in the middle, to emphasise its pivotal nature, since it both ends each row and contributes electrons to the valence of elements in the next row; it thus does not necessarily belong either on the left or the right side of a table. The downward arrows that link subshells within each series graphically illustrate the Janet Effect. To acknowledge my debt to Chancourtois, Janet, Mazurs and Tsimmerman, I call my design the ‘Telluric Remix’. (shrink)

Teleological theories are often dismissed in the study of animal behaviour, because of both the anthropomorphic element, and the paradox of retro-causation. Instead, emergent properties of animal systems, such as those which drive behaviour and decision making, are generally deemed to be non-purposeful. Nonetheless, organisms’ interactions with the environment, including sensory processing, have long been subject to biological study, and the resulting models include Jakob von Uexküll’s functional circle (part of his ‘Umwelt Theory’). The functional circle is modelled on an (...) assumption of three- dimensional space containing matter and energy, and one-dimensional, linear time. Moreover, the function of such models relies upon feedback within biological systems, and generally assume that the functional feedback loops close. I argue that this is impossible, because a feedback loop cannot go back intime to close itself, and so whilst it may approximate closure in space, it does not close in the dimension of time. To address this problem, I propose a conceptual model where time is treated as having a three- dimensional structure, and is measured in terms of past, future, and subjective present, termed the ‘period,’ ‘present’ and ‘phase,’ respectively. Space and matter, meanwhile, occur as a two- dimensional intersect, in which three-dimensional emergent properties which occur ion time are embedded. The model relies on functional helices rather than circles, and the loops of each helix (unlike circular loops) never achieve closure. I explain how this therefore results in a biological system, based on both feedback and anticipatory probabilities, which is both autopoietic and teleological. I also provide examples of how the concept can be applied, using foraging behaviour as an example. I further propose the theoretical origin of such a system is ‘timing’ and ‘rhythm,’ both of which I argue have their origins in single cellular organisms’ chemotaxis and the associated gradient descent search. (shrink)

The hardest part of replicating a genome is the beginning. The first step of DNA replication (called “initiation”) mobilizes a large number of specialized proteins (“initiators”) that recognize specific sequences or structural motifs in the DNA, unwind the double helix, protect the exposed ssDNA, and recruit the enzymatic activities required for DNA synthesis, such as helicases, primases and polymerases. All of these components are orderly assembled before the first nucleotide can be incorporated. On the occasion of the 50th anniversary (...) of the discovery of the DNA structure, we review our current knowledge of the molecular mechanisms that control initiation of DNA replication in eukaryotic cells, with particular emphasis on the recent identification of novel initiator proteins. We speculate how these initiators assemble molecular machines capable of performing specific biochemical tasks, such as loading a ring‐shaped helicase onto the DNA double helix. BioEssays 25:1158–1167, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In correspondence with Mersenne in 1629, Descartes discusses a construction involving a cylinder and what Descartes calls a “helice.” Mancosu has argued that by “helice” Descartes was referring to a cylindrical helix. The editors of Mersenne’s correspondence (Vol. II), and Henk Bos, have independently argued that, on the con- trary, by “helice” Descartes was referring to the Archimedean spiral. We argue that identifying the helice with the cylindrical helix makes better sense of the text. In the process we (...) take a careful look at constructions of the cylindrical helix available to Descartes and relate them to his criteria for excluding mechanical curves from geometry. Résumé Dans sa correspondance avec Mersenne en 1629, Descartes discute d’une construction qui fait intervenir un cylindre et ce que Descartes appelle une “hélice”. Mancosu a argumenté que Descartes faisait référence à une hélice cylindrique. Les éditeurs de la Correspondance de Mersenne (vol. 2), et Henk Bos, ont indépendamment affirmé que, au contraire, par “hélice” Descartes faisait référence à la spirale d’Archimède. Nous affirmons qu’identifier l’hélice avec l’hélice cylindrique est plus cohérent avec le texte. Dans le même temps nous examinons soigneusement les constructions de l’hélice cylindrique que Descartes avait à disposition et nous les mettons en relation avec son critère d’exclusion des courbes mécaniques de la géométrie. (shrink)

Certain sequences of double‐helical DNA can be recognized and tightly bound by oligonucleotides. The effects of such triple‐helical structures on DNA binding proteins have been studied. Stabilities of DNA triple‐helices at or near physiological conditions are sufficient to inhibit DNA binding proteins directed to overlapping sites. Such proteins include restriction endonucleases, methylases, transcription factors, and RNA polymerases. These and Other results suggest that oligonucleotide‐directed triple‐helix formation could provide the basis for designing artificial gene repressors. The general question of whether (...) biological systems employ RNA molecules for recognition and regulation of double‐helical DNA is discussed. (shrink)

Quadruple Helix Collaborations (QHCs) is a cooperation model in which industry, government, academia, and the public interact to innovate. This paper analyses the impact of a training intervention to provide specific knowledge, skills, and attitudes to deal with barriers commonly found in the progress of QHCs. We designed, implemented, and evaluated three training programs in Austrian, Colombian, Danish, and Spanish institutions. We analysed trainees’ (n = 66) and trainers’ (n = 9) perceptions to identify the competencies acquired with the (...) intervention and the approach’s limitations. We used online questionnaires (35 trainees; 9 trainers), semi-structured interviews (10 trainees), and a focus group (6 trainers). Trainees answered positively regarding their self-perception about the impact of the course and highlighted the acquisition of inspiration for their practice (score 4.1 out of 5.0) and knowledge (3.7). In contrast, they perceived that a deeper interaction with other participants (2.7) was challenging. After the courses, 74% of respondents indicated that they know more about how QHCs work in practice, and 86% about collaboration or engagement methods. Moreover, participants plan to be more sensitive towards setting common goals (71%) and power imbalances (63%). Trainers’ perceptions align with those expressed by participants, except that they considered that the interaction amongst participants during the course was higher. Qualitative analysis of interviews with participants and the focus group with trainers provides more detail about the strengths and weaknesses of the intervention. Our study shows that the collaborative design and implementation of training impact the participant’s learning competencies, with potential implications in their medium- to long-term practice. (shrink)

For the past three decades or so, the field of Science and Technology Studies (STS) has shed light on the interrelationship between modern science and technology, on one side, and contemporary society, on the other. A majority of this knowledge and insights are situated in the context of Western societies, or more precisely, in economically and technologically advanced societies in Western Europe and North America. However, STS has much to offer to the discourse of science and technology in the Global (...) South, a territory characterized by developmental processes. Insights from different schools of thoughts in STS are arguably not only relevant but also applicable to unveil the root cause of problems that many developing societies are facing today. To make this possible, an STS-informed framework is developed to replace the Triple Helix model, which is currently a dominant perspective that prompts how science, technology, and innovation are structurally organized in the developing world. Two steps are taken in this agenda. First, limitations of the Triple Helix are exposed, and second, a new approach drawing on STS concepts is offered as an alternative model that takes into account structural, cultural, and epistemological features of technoscience. (shrink)

The rapidly changing field of genetics affects society through advances in health-care and through implications of genetic research. This study addresses the impacts of new genetic discoveries and technologies on different segments of today's society. The book begins with a chapter on genetic complexity, and subsequent chapters discuss moral and ethical questions arising from today's genetics from the perspectives of health care professionals, the media, the general public, special interest groups and commercial interests.

Bioethics should update its conception of the geneThe 25th of April marks the 50th anniversary of the publication in Nature of the letter by James Watson and Francis Crick announcing their solution to the structure of deoxyribose nucleic acid .1 By that time, much was known about the role of chromosomes in inheritance, the contribution of DNA to chromosome structure, and the chemistry of DNA.2 The gene concept itself was also well established by then; the principal scientific problem became to (...) specify what genes were in molecular terms and how they functioned in the cell during ordinary function and cell division.The importance of the solution of the structure of DNA was twofold. First, it gave insight into finding a mechanism for DNA replication, as the authors recognised in this famous sentence:"It has not escaped our notice that the specific pairing we have postulated immediately suggests a copying mechanism for the genetic material.3 … ". (shrink)

Genetic testing reveals information about a patient's health status and predictions about the patient's future wellness, while also potentially disclosing health information relevant to other family members. With the increasing availability and affordability of genetic testing and the integration of genetics into mainstream medicine, the importance of clarifying the scope of confidentiality and the rules regarding disclosure of genetic findings to genetic relatives is prime. The United Nations International Declaration on Human Genetic Data urges an appreciation for principles of equality, (...) justice, solidarity and responsibility in the context of genetic testing, including a commitment to honoring the privacy and security of the person tested. Considering this global mandate and recent professional statements in the context of a legal amendment to patient privacy policies in Australia, a fresh scrutiny of the legal history of a physician's duty to warn is warranted. This article inquiries whether there may be anything ethically or socially amiss with a potential future recommendation for health professionals or patients to universally disclose particular cancer predisposition genetic diagnosis to genetic family members. While much of the discussion remains applicable to all genetic diagnosis, the article focuses on the practice of disclosure within the context of BRCA1/2 diagnosis. An ‘ethic of care’ interpretation of legal tradition and current practice will serve to reconcile law and medical policy on the issue of physician disclosure of genetic results to family members without patient consent. (shrink)

Based upon the quintuple helix model (QHM), this study explores whether the differences in firms' emission reduction effectiveness can be attributed to the five institutional helices related to educational system, economic development, political–legal system, cultural orientation, and the natural capital. Using a set of listed European firms for the 2015–2020 period, we show that firms with better emission reduction effectiveness operate in nations with more public educational expenditure and scientific production, more extensive economic development, and better institutional and governance (...) quality. Moreover, emission reduction strategies are more pronounced in firms located in countries characterized by less masculinity, individualism, power distance, and uncertainty avoidance, and more long-term orientation and indulgence. In addition, we find that companies with better emission reduction effectiveness are found in countries with more natural capital, characterized by a life in harmony with nature and employing the finite resources available in a sustainable and environmentally conscious manner. Moreover, employing a two-stage model to identify the most relevant helix, we find that the political–legal system helix is the most pivotal in promoting firms' commitment to reducing environmental emissions. (shrink)

R&D collaborations between industry, government, civil society, and research ) have recently gained attention from R&D theorists and practitioners. In aiming to come to grips with their complexity, past models have generally taken a stakeholder-analytical approach based on stakeholder types. Yet stakeholder types are difficult to operationalise. We therefore argue that a processual model is more suited for studying the interaction in QHCs because it eschews matters of titles and identities. We develop such a model in which the QHC is (...) represented as a process of generating four types of value: research value, market value, political value, and societal value. We then apply this processual model in analysing real-life cases of friction in QHCs. Friction is seen, not as an interpersonal clash, but as a discrepancy between two or more value-creation processes that compete for limited resources. (shrink)

Lisa Bellantoni argues that contemporary bioethics divides into two logically incommensurable positions: a cult of rights, which identifies the worth of human life with our autonomy, and a cult of life, which identifies human worth with the possession of a soul, and thereby, of human dignity.

R&D collaborations between industry, government, civil society, and research (also known as ‘quadruple helix collaborations’ (QHCs)) have recently gained attention from R&D theorists and practitioners. In aiming to come to grips with their complexity, past models have generally taken a stakeholder-analytical approach based on stakeholder types. Yet stakeholder types are difficult to operationalise. We therefore argue that a processual model is more suited for studying the interaction in QHCs because it eschews matters of titles and identities. We develop such (...) a model in which the QHC is represented as a process of generating four types of value: research value, market value, political value, and societal value. We then apply this processual model in analysing reallife cases of friction in QHCs. Friction is seen, not as an interpersonal clash, but as a discrepancy between two or more value-creation processes that compete for limited resources (some overperforming while others under-performing). (shrink)

Biological order provided by α-helical secondary protein structures is an important resource exploitable by living organisms for increasing the efficiency of energy transport. In particular, self-trapping of amide I energy quanta by the induced phonon deformation of the hydrogen-bonded lattice of peptide groups is capable of generating either pinned or moving solitary waves following the Davydov quasiparticle/soliton model. The effect of applied in-phase Gaussian pulses of amide I energy, however, was found to be strongly dependent on the site of application. (...) Moving solitons were only launched when the amide I energy was applied at one of the α-helix ends, whereas pinned solitons were produced in the α-helix interior. In this paper, we describe a general mechanism that launches moving solitons in the interior of the α-helix through phase-modulated Gaussian pulses of amide I energy. We also compare the predicted soliton velocity based on effective soliton mass and the observed soliton velocity in computer simulations for different parameter values of the isotropy of the exciton-phonon interaction. The presented results demonstrate the capacity for explicit control of soliton velocity in protein α-helices, and further support the plausibility of gradual optimization of quantum dynamics for achieving specialized protein functions through natural selection. (shrink)

Through the case of the Helix_T wind turbine project, this article sets out to argue two points: first, on a theoretical level, that Commons-based peer production, in conjunction with the emerging technological capabilities of three-dimensional printing, can also produce promising hardware, globally designed and locally produced. Second, the Commons-oriented wind turbine examined here is also meant to practically contribute to the quest for novel solutions to the timely problem of the need for renewable sources of energy, more in the sense (...) of a development process than as a ready-to-apply solution. We demonstrate that it is possible for someone with partial initial knowledge to initiate a similar, complex project based on an interesting idea, and to succeed in implementing it through collaboration with Commons-oriented communities, while using peer-produced products and tools. Given the trends and trajectories both of the current information-based paradigm and the problems of the predominant industrial modes of production with all the collateral damage they entail, this may be considered a positive message indeed. (shrink)

The specific nature and dynamic of the emerging triple helix of state-industry-university relations in Japan and Singapore is analyzed in this article. The impact of globalization and the emergence of trans-disciplinary scientific fields on this institutional reconstitution are examined. Overall, the implications of these transformations for the debates over the knowledge society are discussed.

The discovery of conserved protein domains found in many Drosophila and mammalian developmental gene products suggests that fundamental developmental processes are conserved throughout evolution. Our understanding of development has been enhanced by the discovery of the widespread role of the homeodomain (HD). The action of HD‐containing proteins as transcriptional regulators is mediated through a helix‐turn‐helix motif which confers sequence specific DNA binding. Unexpectedly, the well conserved structural homology between the HD and the prokaryotic helix‐turn‐helix proteins contrasts (...) with their divergent types of physical interaction with DNA. A C‐terminal extension of the HD recognition helix has assumed the role that the N‐terminus of the prokaryotic helix plays for specification of DNA binding preference. However, the HD appears also capable of recognizing DNA in an alternative way and its specificity in vivo may be modified by regions outside the helix‐turn‐helix motif. We propose that this intrinsic complexity of the HD, as well as its frequent association with other DNA binding domains, explains the functional specificity achieved by genes encoding highly related HDs. (shrink)

The object of this paper is two-fold: first, to show that contrary to what seem to have become a widely accepted view among historians of biology, the famous 1953 first Nature paper of Watson and Crick on the structure of DNA was widely cited — as compared to the average paper of the time — on a continuous basis from the very year of its publication and over the period 1953–1970 and that the citations came from a wide array of (...) scientific journals. A systematic analysis of the bibliometric data thus shows that Watson's and Crick's paper did in fact have immediate and long term impact if we define "impact" in terms of comparative citations with other papers of the time. In this precise sense it did not fall into "relative oblivion" in the scientific community. The second aim of this paper is to show, using the case of the reception of the Watson—Crick and Jacob—Monod papers as concrete examples, how large scale bibliometric data can be used in a sophisticated manner to provide information about the dynamic of the scientific field as a whole instead of limiting the analysis to a few major actors and generalizing the result to the whole community without further ado. (shrink)