To better understand the multiple individual factors that contribute to college cheating, we undertook a multivariate analysis of a national sample of 2,503 college students. Our findings indicated that demographic characteristics, character qualities, college experience, and student perceptions and attitudes are all significantly associated with academic cheating.

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Academic cheating has remained prevalent on college campuses over the past half century (e.g., Bolin, 2004; Haines et al., 1986; McCabe et al., 2001; H. Yu, Glanzer, Johnson et al., 2017). One rece...

Background: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling of terminal illness and the role of nurses thus is not explicit when encountering this issue. Objectives: The intention of this paper is to provide ethical guidelines or strategies with regards to decision-making on truth-telling of terminal illness for Chinese nurses. Methods: This paper initially present a case (...) scenario and then critically discuss the ethical issue in association with ethical principles and philosophical theories. Instead of focusing on attitudes toward truth disclosure, it aims to provide strategies regarding this issue for nurses. It highlights and discusses some of the relevant ethical assumptions around the perceived role of nurses in healthcare settings by focusing on nursing ethical virtues, nursing codes of ethics, and philosophical perspectives. And Confucian culture is discussed to explicate that deontology does not consider family-oriented care in China. Conclusion: Treating each family individually to explore the family’s beliefs and values on this issue is essential in healthcare practice and nurses should tailor their own approach to individual needs regarding truth-telling in different situations. Moreover, the Chinese Code of Ethics should be modified to be more specific and applicable. Finally, a narrative ethics approach should be applied and teamwork between nurses, physicians and families should be established to support cancer patients and to ensure their autonomy and hope. Ethical considerations: This paper was approved by the Ethics Committee of The Second Affiliated Hospital of Guangzhou Medical University. The authors have obtained consent to use the case study and it has been anonymised to preserve the patient's confidentiality. (shrink)

Ontologies, as the term is used in informatics, are structured vocabularies comprised of human- and computer-interpretable terms and relations that represent entities and relationships. Within informatics fields, ontologies play an important role in knowledge and data standardization, representation, integra- tion, sharing and analysis. They have also become a foundation of artificial intelligence (AI) research. In what follows, we outline the Coronavirus Infectious Disease Ontology (CIDO), which covers multiple areas in the domain of coronavirus diseases, including etiology, transmission, epidemiology, pathogenesis, diagnosis, (...) prevention, and treatment. We emphasize CIDO development relevant to COVID-19. (shrink)

We study the degree structure of the ω-c.e., n-c.e., and Π10 equivalence relations under the computable many-one reducibility. In particular, we investigate for each of these classes of degrees the most basic questions about the structure of the partial order. We prove the existence of the greatest element for the ω-c.e. and n-computably enumerable equivalence relations. We provide computable enumerations of the degrees of ω-c.e., n-c.e., and Π10 equivalence relations. We prove that for all the degree classes considered, upward density (...) holds and downward density fails. (shrink)

Objective: Work stress is one of the urgent public health problems, which has aroused wide attention. In addition, work stress also has a negative impact on the development of enterprises. This study has three purposes: to understand the current status of working stress among couriers, to examine the association between work stress, job satisfaction and sleep quality of Chinese couriers, and to verify the mediating role of psychological capital.Methods: A cross-sectional survey was conducted among 3000 couriers in Beijing of China (...) from January to December 2019 using cluster stratified random sampling. Descriptive statistical analysis was used to describe demographic characteristics of respondents. Pearson correlation analysis was used to analyze the correlation among work stress, job satisfaction, sleep quality, and psychological capital. The mediating analysis was calculated role of psychological capital.Results: A total of 2831 participants were included in this study. The average score of work stress was 2.49 ± 0.76. Work stress was negatively correlated with job satisfaction, sleep quality, and psychological capital, respectively. The direct effect of work stress on job satisfaction is –0.223, and the total effect of work stress on job satisfaction is –0.267. The a*b*c’ is positive, indicating the mediating role psychological capital has in explaining the relationship between couriers’ work stress and job satisfaction. Moreover, psychological capital plays a mediating role between work stress and sleep quality among couriers.Conclusion: Couriers face certain work stress and should be paid attention to and psychological capital can effectively alleviate the work stress of couriers, so measures can be taken to improve it, promoting healthy development of employees and organizations. (shrink)

The authors explore the interfaces between different dimensions of moral cognition, bridging economic, Bayesian and reinforcement learning perspectives. The human aversion to harming others cuts across these different interfaces, influencing decisions, judgments, and inferences about morality.

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

We study the relationship between effective domination properties and the bounded jump. We answer two open questions about the bounded jump: We prove that the analogue of Sacks jump inversion fails for the bounded jump and the wtt-reducibility. We prove that no c.e. bounded high set can be low by showing that they all have to be Turing complete. We characterize the class of c.e. bounded high sets as being those sets computing the Halting problem via a reduction with use (...) bounded by an ω-c.e. function. We define several notions of a c.e. set being effectively dominant, and show that together with the bounded high sets they form a proper hierarchy. (shrink)

Host-microbiome interactions (HMIs) are critical for the modulation of biological processes and are associated with several diseases, and extensive HMI studies have generated large amounts of data. We propose that the logical representation of the knowledge derived from these data and the standardized representation of experimental variables and processes can foster integration of data and reproducibility of experiments and thereby further HMI knowledge discovery. A community-based Ontology of Host-Microbiome Interactions (OHMI) was developed following the OBO Foundry principles. OHMI leverages established (...) ontologies to create logically structured representations of microbiomes, microbial taxonomy, host species, host anatomical entities, and HMIs under different conditions and associated study protocols and types of data analysis and experimental results. (shrink)

The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open (...) this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

Journal Name: Semiotica Issue: Ahead of print.

Stroke and other neurological disorders have an effect on mobility which has a significant impact on independence and quality of life. The core rehabilitation requirements for patients with lower limb motor dysfunction are gait training, restand, and mobility. In this work, we introduce a newly developed multifunctional wheelchair that we call “ReChair” and evaluated its performance preliminarily. ReChair seamlessly integrates the mobility, gait training, and multiposture transformation. ReChair driving and multiposture transformation are done using the voice, button, and mobile terminal (...) control. This work describes the functional requirements, mechanical structure, and control system and the overall evaluation of ReChair including the kinematic simulation of the multiposture transformation and passive lower limb rehabilitation training to quantitatively verify the motion capability of ReChair, the voice control system evaluation that shows how the voice recognition system is suitable for home environment, the sensorless speed detection test results that indicate how the wheel speeds measured by sensorless method are appropriate for travelling control, and the passive and balance training test results that show how the lower limb rehabilitation training in daily life by ReChair is convenient. Finally, the experimental results show that ReChair meets the patients’ requirements and has practical significance. It is cost-effective, easy to use, and supports multiple control modes to adapt to different rehabilitation phases. (shrink)

ObjectiveWe wished to explore Parkinson's disease subtypes by clustering analysis based on the multimodal magnetic resonance imaging indices amplitude of low-frequency fluctuation and gray matter volume. Then, we analyzed the differences between PD subtypes.MethodsEighty-six PD patients and 44 healthy controls were recruited. We extracted ALFF and GMV according to the Anatomical Automatic Labeling partition using Data Processing and Analysis for Brain Imaging software. The Ward linkage method was used for hierarchical clustering analysis. DPABI was employed to compare differences in ALFF (...) and GMV between groups.ResultsTwo subtypes of PD were identified. The “diffuse malignant subtype” was characterized by reduced ALFF in the visual-related cortex and extensive reduction of GMV with severe impairment in motor function and cognitive function. The “mild subtype” was characterized by increased ALFF in the frontal lobe, temporal lobe, and sensorimotor cortex, and a slight decrease in GMV with mild impairment of motor function and cognitive function.ConclusionHierarchical clustering analysis based on multimodal MRI indices could be employed to identify two PD subtypes. These two PD subtypes showed different neurodegenerative patterns upon imaging. (shrink)

ObjectiveThis study aimed to investigate the morphometric alterations in the cortical and subcortical structures in multiple system atrophy patients with mild cognitive impairment, and to explore the association with cognitive deficits.MethodsA total of 45 MSA patients and 29 healthy controls were recruited. FreeSurfer software was used to analyze cortical thickness, and voxel-based morphometry was used to analyze the gray matter volumes. Cortical thickness and gray matter volume changes were correlated with cognitive scores.ResultsCompared to healthy controls, both MSA subgroups exhibited widespread (...) morphology alterations of brain structures in the fronto-temporal regions. Direct comparison of MSA-MCI and MSA-only patients showed volume reduction in the left superior and middle temporal gyrus, while cortical thinning was found in the left middle and inferior temporal gyrus in MSA-MCI patients. Cortical thinning in the left middle temporal gyrus correlated with cognitive assessment and disease duration.ConclusionStructural changes in the brain occur in MSA-MCI patients. The alteration of brain structure in the left temporal regions might be a biomarker of cognitive decline in MSA-MCI patients. (shrink)

Due to the NP-hard nature, the permutation flowshop scheduling problem is a fundamental issue for Industry 4.0, especially under higher productivity, efficiency, and self-managing systems. This paper proposes an improved genetic-shuffled frog-leaping algorithm to solve the permutation flowshop scheduling problem. In the proposed IGSFLA, the optimal initial frog in the initialized group is generated according to the heuristic optimal-insert method with fitness constrain. The crossover mechanism is applied to both the subgroup and the global group to avoid the local optimal (...) solutions and accelerate the evolution. To evolve the frogs with the same optimal fitness more outstanding, the disturbance mechanism is applied to obtain the optimal frog of the whole group at the initialization step and the optimal frog of the subgroup at the searching step. The mathematical model of PFSSP is established with the minimum production cycle as the objective function, the fitness of frog is given, and the IGSFLA-based PFSSP is proposed. Experimental results have been given and analyzed, showing that IGSFLA not only provides the optimal scheduling performance but also converges effectively. (shrink)

We examine the association between benevolent leadership and team creative performance in scientific research teams. Moreover, the mediating effects of creative self-efficacy and the moderating effects of openness to experience on the relationship were also analyzed. The study sample comprised 251 postgraduates from 58 scientific research teams in Chinese universities. Results revealed that benevolent leadership was positively related to team creative performance, and creative self-efficacy partially mediated this positive relationship. When team personality composition had a high average team level of (...) or a low level of variance on openness to experience, the relationship between creative self-efficacy and team creative performance was stronger. The same situation also occurred as an indirect effect of benevolent leadership on team creative performance through creative self-efficacy. This study suggests that while people may pay focus on benevolent leadership and creative self-efficacy, team personality composition should also be considered in scientific research team practices. (shrink)

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2013 Issue: 197 Pages: 141-152.

This paper affords a Lotmanian cultural semiotic analysis of the inner workings of ritual embodying the mechanism of cultural memory. In this intersectional study, we propose treating ritual as an integral semiotic system in which the community follows a prescribed collective process to create religious or social meanings and to regulate the mechanism of cultural memory through concrete symbols in the forms of behavior, speech, gestures, objects, spatial structures, and so on. Three semiotic properties of ritual in relation to cultural (...) memory are identified, namely, continuity, concreteness, and integrity, which are jointly responsible for the efficacy of ritual in cultural memory making, or to be specific, in the preservation, retrieval, and even reproduction of cultural memory. With these properties, ritual helps construct and maintain socio-cultural order and group identity in the community, by repeating itself and thus creating a sense of continuity through the preservation and retrieval of cultural memory. The key components in ritual are its diverse and polysemous symbols, which are seldom confined to a specific context, although they are indeed subject to the dominant symbol and the dominant meaning in a ritual when necessary. With an extraordinary degree of autonomy and not bound to any fixed context, ritual symbols can enter a ritual situation as its components but retain the freedom of leaving the ritual context at any time, like an unchained “spectator,” and permeating multiple contexts as self-contained units. It is precisely through these transferrable ritual symbols that the fragments of cultural memory are randomly dispersed in the semiosphere and carried to unexpected socio-cultural contexts, bridging the past, the present, and the future and creating new cultural memory. (shrink)

In order to solve the shortcomings of particle swarm optimization in solving multiobjective optimization problems, an improved multiobjective particle swarm optimization algorithm is proposed. In this study, the competitive strategy was introduced into the construction process of Pareto external archives to speed up the search process of nondominated solutions, thereby increasing the speed of the establishment of Pareto external archives. In addition, the descending order of crowding distance method is used to limit the size of external archives and dynamically adjust (...) particle parameters; in order to solve the problem of insufficient population diversity in the later stage of algorithm iteration, time-varying Gaussian mutation strategy is used to mutate the particles in external archives to improve diversity. The simulation experiment results show that the improved algorithm has better convergence and stability than the other compared algorithms. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2016 Heft: 210 Seiten: 151-166.

This paper affords a critical and historical reappraisal of Bakhtin’s theory of polyphony. It addresses the issue of the subjectivity of interpretation in the reception and formulation of this highly influential theory in literary semiotics. Following a revaluation of three major patterns of interpretation of polyphony that have emerged in the global field of literary theory since 1929, as well as Bakhtin’s shift in emphasis in 1963, we find that Bakhtin’s theorizing of polyphony, based on his seemingly inconsistent interpretation of (...) Dostoevsky’s novels, was defined by his own subjectivity as well. An obvious consequence of such subjective predispositions in both the reception of Bakhtin’s theory and his own treatment of Dostoevsky’s polyphonic novels is that they have instigated a type of perpetuating availability bias in approaching the theory of polyphony. This revelation is key to understanding the wholeness of the theory of polyphony from a diachronic perspective. By tracing the cultural and intellectual sources of Dostoevsky’s polyphonic creation, this paper attempts to reframe and restore the Bakhtinian idea of polyphony to its fullness, which we believe can be encapsulated in one phrase: harmony without uniformity. (shrink)

In light of current findings under the culture-driven view, the present article proposes a co-shaping interactive relation between the human brain and culture, and a further notion that semiosis actually serves as the central link that connects external models and internal models, initiating what is known as unlimited semiosis, which coincides with the neurological process of cognition. Empirical studies on the differences of neural activities pertaining to distinct cultural modeling systems, such as the Chinese orthography, the English and the French (...) alphabets, have also provided clear evidence that the human brain exists in an adaptive relation to the corresponding culture, in which semiosis proves to be one of the fundamental mechanisms of how culture exerts its influence. Besides the cultural specificity of semiosis and brain functions, this paper also proposes that it is essential to pay constant attention to semiosic individuality, as this will secure a comprehensive unbiased perspective of semiotic and cognitive studies. (shrink)

Through a simple model of autogenic interpreting system featuring molecular constraint-work dynamics, Deacon critically tackles the issue of the nature of information in living systems and proposes that interpretation of a molecule as information about something else is more important than molecular replication. Two aspects of the target article are highlighted in this commentary. First, Deacon’s illustrations nicely resonate with and instantiate the wisdom in the doctrine of yin-yang in Chinese philosophy. Second, his theorizing demonstrates a bold intellectual innovation with (...) regard to Peircean semiotics. In short, the article exemplifies what highly relevant, and succinct, semiotic modeling looks like. (shrink)

By means of a theoretical analysis from the point of view of phenomenology of the body, this essay tries to explain the views of Taizhou School on the body so as to apprehend the essence of Confucian thought, which is a philosophy that seeks to “establish oneself” and “cultivate oneself” rather than a “philosophy of consciousness.”.

By focusing on three different yet correlated disciplines in China in which the Sebeok’s Chinese connection has been found, this article elaborates on his personal contact with the Chinese semiotic community and extant constructive academic responses from Chinese semioticians. It provides a detailed description of the reasons for the uniqueness of Sebeok’s Chinese connection and proceeds to demonstrate the three major Chinese figures that used to know Sebeok and the interactions between them. Against the common belief that influence of Sebeok (...) the semiotician, rather than Sebeok the convener, is quite minimal in China, I have proven that he did have a direct impact upon the Chinese semiotic literati, which is evident not only in the form of the work exclusively on Sebeok the person but also in the form of the writings in recognition of both his contributions to semiotics as a global cause and his status as the mid-wife of contemporary semiotics. As a projection into the future, I put forward a vision in which Sebeok’s work and achievements should be duly appreciated in their full extent by the new Eastern stronghold of semiotics. (shrink)