Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...) Hydra raises the question of whether, in early metazoan evolution, cell–cell communication was based mainly on these small molecules rather than on the growth‐factor‐like cytokines that control differentiation and development in higher animals. BioEssays 23:420–427, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

It has been convincingly shown that peptides play important roles in the regulation and maintenance of a variety of tissues and organs in living animals. However, little is known concerning the potential role of peptides as signaling molecules in developmental processes. In Hydra, there is circumstantial evidence that small diffusible molecules act as morphogens in the regulation of patterning processes. In order to view the entire spectrum of peptide signaling molecules, we initiated a project aiming at the systematic identification of (...) peptide signaling molecules in Hydra. In this review, we describe three peptide signaling molecules and one family of peptides that function as signaling molecules in the processes of axial pattern formation and neuron differentiation in Hydra. These peptides are produced by epithelial cells and are therefore termed “epitheliopeptides”. We discuss the importance of epitheliopeptides in developmental processes within a subset of hydrozoans. (shrink)

How do the Japanese about their native philosophy, Shinto, a decade and a half after its abolishment as a state religion by the Western Allies? // What is its relationship to Buddhism, and particularly to Zen? // How modern can this very ancient creed ever be? // These are some of the questions considered in this study by Dr. Chikao Fujisawa, who specialized in the study of traditional Japanese philosophy and its effect on modern society. // Zen and Shinto (...) is a strong plea to rectify the steps taken to eradicate Shinto, the very substance of Japanese life and thought. At the same time, it offers new insight into the amazing adaptability of the Japanese psyche--its depth, vitality and universality--and its remarkable capacity to assimilate foreign thought and ideas, and thus contribute to the world's hope for permanent peace. // Dr. Chikao Fujisawa was a Japanese philosopher and historian, and he lectured on the topics at Nihon University. He believed in preserving Japanese customs, and as such he was a strong supporter of reintroducing Shinto and Zen traditions to Japan's youth. (shrink)

Three multifunctional protein kinases, cyclic AMP‐dependent protein kinase, protein kinase C, and calmodulin‐dependent protein kinase II, are involved in signal transduction in response to their respective second messengers, cyclic AMP, diacylglycerol, and Ca2+. This review will summarize the key findings on calmodulin‐dependent protein kinase II.

Fujisawa in his plea for Shinto cosmic vitalism may indeed be right in thinking that Japanese thought has much to contribute to Western philosophy. But this has to be supported by a far more searching and self-critical study than the author has provided.--K. H.