20 found
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  1. Clarifying the Ethics and Oversight of Chimeric Research.Josephine Johnston, Insoo Hyun, Carolyn P. Neuhaus, Karen J. Maschke, Patricia Marshall, Kaitlynn P. Craig, Margaret M. Matthews, Kara Drolet, Henry T. Greely, Lori R. Hill, Amy Hinterberger, Elisa A. Hurley, Robert Kesterson, Jonathan Kimmelman, Nancy M. P. King, Melissa J. Lopes, P. Pearl O'Rourke, Brendan Parent, Steven Peckman, Monika Piotrowska, May Schwarz, Jeff Sebo, Chris Stodgell, Robert Streiffer & Amy Wilkerson - 2022 - Hastings Center Report 52 (S2):2-23.
    This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...)
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  2.  88
    Authentic values and individual autonomy.Insoo Hyun - 2001 - Journal of Value Inquiry 35 (2):195-208.
  3.  28
    Allowing Innovative Stem Cell-Based Therapies outside of Clinical Trials: Ethical and Policy Challenges.Insoo Hyun - 2010 - Journal of Law, Medicine and Ethics 38 (2):277-285.
    Armed with expanded federal funding for human embryonic stem cell research and new methods for deriving pluripotent stem cells, stem cell researchers in the U.S. are poised to proceed with unprecedented speed toward the development of new clinical therapies. Staring into the new dawn of regenerative medicine, many observers may assume that the only responsible route to the clinic, both scientifically and ethically, is through FDA-approved clinical trials processes. Conventional wisdom dictates that, like pharmaceutical drugs and the use of biological (...)
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  4.  49
    Allowing Innovative Stem Cell-Based Therapies Outside of Clinical Trials: Ethical and Policy Challenges.Insoo Hyun - 2010 - Journal of Law, Medicine and Ethics 38 (2):277-285.
    This paper discusses exceptional circumstances under which patients outside of clinical trials are likely to receive innovative stem cell-based interventions. These circumstances involve: (1) stem cell interventions not initially amenable to a clinical trials approach; (2) expanded access to investigational stem cell products (“compassionate use”); and (3) off-label uses of FDA approved stem cell products. This paper proposes a new approach to regulating these exceptional cases.
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  5.  38
    Waiver of Informed Consent, Cultural Sensitivity, and the Problems of Unjust Families and Traditions.Insoo Hyun - 2002 - Hastings Center Report 32 (5):14-22.
    To be autonomous, a person must also have authentic moral values. She must act on her own values, not on values that were improperly pressed upon her. To respect a patient's autonomy, then, a caregiver must do more than carry out her requests. The caregiver must honor the patient's authentic requests. But how to do that?
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  6.  97
    Clinical Cultural Competence and the Threat of Ethical Relativism.Insoo Hyun - 2008 - Cambridge Quarterly of Healthcare Ethics 17 (2):154-163.
    Taking seriously the value of cultural competence in healthcare requires at least three general commitments. First, it involves accepting the view that patients' health beliefs and behaviors are influenced to a significant degree by their own social and cultural practices. Second, it requires careful attention to how health professionals typically respond to patients' different social and cultural standards at various levels of the healthcare delivery system. And third, it calls for developing interventions that are sensitive to these first two issues (...)
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  7.  25
    Magic eggs and the frontier of stem cell science.Insoo Hyun - 2006 - Hastings Center Report 36 (2):16-19.
  8.  61
    When adolescents "mismanage" their chronic medical conditions: An ethical exploration.Insoo Hyun - 2000 - Kennedy Institute of Ethics Journal 10 (2):147-163.
    : Many adolescent patients with chronic medical conditions do not manage their illnesses very closely and often put themselves at risk for serious health complications. Setting aside cases of nonadherence that are due to practical difficulties involving the implementation of a management plan, a deeply problematic question remains. How should health care providers respond to adolescent patients who express a conscious and value-driven decision to pursue other goals and interests that are incompatible with their doctors' recommended directives? Using two guiding (...)
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  9.  49
    Conceptions of Family-Centered Medical Decisionmaking and Their Difficulties.Insoo Hyun - 2003 - Cambridge Quarterly of Healthcare Ethics 12 (2):196-200.
    Over the past decade or so, the predominant patient-centered ethos in American bioethics has come under attack by critics who claim that it is morally deficient in certain respects, particularly when viewed in the context of acute-care decisionmaking. One line of criticism has been that the current ethic of patient autonomy gives an individual competent patient far too much decisional authority over the terms of his own treatment so that the patient is at complete liberty to neglect the ways in (...)
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  10.  35
    The Embryo Potentiality Argument Revisited: “Once More Unto the Breach, Dear Friends”.Insoo Hyun - 2013 - American Journal of Bioethics 13 (1):28-29.
  11.  31
    Oocyte and Somatic Cell Procurement for Stem Cell Research: The South Korean Experience.Kyu Won Jung & Insoo Hyun - 2006 - American Journal of Bioethics 6 (1):W19-W22.
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  12.  72
    Stem cells from skin cells: The ethical questions.Insoo Hyun - 2008 - Hastings Center Report 38 (1):20-22.
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  13.  16
    Moral Status and the Oversight of Research Involving Chimeric Animals.Patricia Marshall, Kaitlynn P. Craig & Insoo Hyun - 2022 - Hastings Center Report 52 (S2):41-45.
    The use of nonhuman animals in research has long been a source of bioethical and scientific debate. We consider the oversight and use of nonhuman animals in chimeric research. We conducted interviews with twelve members of embryonic stem cell research oversight committees, nine members of institutional animal care and use committees, and fourteen scientists involved in human–nonhuman‐animal chimeric research in different areas of the United States. Interviews addressed animal welfare and conceptual issues associated with moral status and humanization of nonhuman (...)
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  14.  59
    Multi-cellular engineered living systems: building a community around responsible research on emergence.Matthew Sample, Marion Boulicault, Caley Allen, Rashid Bashir, Insoo Hyun, Megan Levis, Caroline Lowenthal, David Mertz & Nuria Montserrat - 2019 - Biofabrication 11 (4).
    Ranging from miniaturized biological robots to organoids, multi-cellular engineered living systems (M-CELS) pose complex ethical and societal challenges. Some of these challenges, such as how to best distribute risks and benefits, are likely to arise in the development of any new technology. Other challenges arise specifically because of the particular characteristics of M-CELS. For example, as an engineered living system becomes increasingly complex, it may provoke societal debate about its moral considerability, perhaps necessitating protection from harm or recognition of positive (...)
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  15.  39
    David U. Himmelstein practices medi.Daniel Callahan, R. Alta Charo, Guang-Shing Cheng, Frank A. Chervenak, Robert P. George, Susan Dorr Goold, Lawrence O. Gostin, Markus Grompe, William B. Hurlbut & Insoo Hyun - forthcoming - Hastings Center Report.
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  16.  14
    ANT vs. SCNT.Insoo Hyun & Kyu Won Jung - 2006 - Hastings Center Report 36 (6):6 - author.
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  17.  50
    Human Research Cloning, Embryos, and Embryo-Like Artifacts.Insoo Hyun & Kyu Won Jung - 2006 - Hastings Center Report 36 (5):34-41.
    Research suggests that cloning is incapable of producing a viable embryo when it is used on primate eggs. In fact, the entity created may not qualify as an embryo at all. If the results stand, cloning avoids the moral objections typically lodged against it, and cloning is itself an “alternative source” of stem cells.
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  18.  5
    Moonshots and Other Metaphors: The BRAIN Initiative.Insoo Hyun - 2020 - American Journal of Bioethics Neuroscience 11 (3):198-200.
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  19.  66
    Big Bang Theory: More Reason to Scrap Bush's Stem Cell Policy.John A. Robertson, Cynthia B. Cohen & Insoo Hyun - 2008 - Hastings Center Report 38 (6):4-6.
  20.  37
    Review of K. R. Monroe, R. B. Miller, and J. Tobis. Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical and Political Issues.1 Review of C. B. Cohen. Renewing the Stuff of Life: Stem Cells, Ethics, and Public Policy.2 Review of R. Korobkin with S. R. Munzer. Stem Cell Century: Law and Policy for a Breakthrough Technology.3. [REVIEW]Insoo Hyun - 2008 - American Journal of Bioethics 8 (6):57-59.