Epithelial stem cells have been identified in integumental structures such as hairs and continuously growing teeth of various rodents, and in the gut. Here we propose the involvement of epithelial stem cells in the continuous tooth replacement that characterizes non‐mammalian vertebrates, as exemplified by the zebrafish. Arguments are based on morphological observations of tooth renewal in the zebrafish and on the similarities between molecular control of hair and tooth formation. Dissection of the molecular cascades underlying the regulation of the epithelial (...) stem cell niche might open perspectives for new regenerative treatment strategies in clinical dentistry. BioEssays 26:665–671, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Social theory has paid little attention to air, despite its centrality to bodily existence and air pollution being named the world’s biggest public health crisis. Where attention to air is found, the body is largely absent. On the other hand, conceptualizing the body without life-sustaining breath fails to highlight breathing as the ongoing metabolic bodily act in which the materiality of human and more-than-human intermingle and transmute one another. Political ecology studies how unequal power structures and knowledge production reproduce human–environment (...) relations, including a nascent focus on the body and air – but as separate issues. This article argues that a political ecology of air would productively fuse with a political ecology of the body to bring the visceral realm into intersectional analysis of air’s contemporary materialities. A feminist political ecology situates explicitly air-and-breathing-bodies, their intimately posthuman, relational, elemental and corpomaterial intra-action, at the heart of such analysis. (shrink)

La relación médico-paciente (RMP) es una relación profesional-interpersonal base para la gestión de la salud. Nuestro objetivo fue desarrollar un instrumento que permitiera evaluar la presencia de los principios bioéticos en la atención médica recibida en la consulta externa de una institución hospitalaria. El instrumento quedó constituido por 21 reactivos para evaluar su confiabilidad y consistencia. El coeficiente de correlación intraclase fue de 0,81 (_p_.

BackgroundFor many decades, the debate on children’s competence to give informed consent in medical settings concentrated on ethical and legal aspects, with little empirical underpinnings. Recently, data from empirical research became available to advance the discussion. It was shown that children’s competence to consent to clinical research could be accurately assessed by the modified MacArthur Competence Assessment Tool for Clinical Research. Age limits for children to be deemed competent to decide on research participation have been studied: generally children of 11.2 (...) years and above were decision-making competent, while children of 9.6 years and younger were not. Age was pointed out to be the key determining factor in children’s competence. In this article we reflect on policy implications of these findings, considering legal, ethical, developmental and clinical perspectives.DiscussionAlthough assessment of children’s competence has a normative character, ethics, law and clinical practice can benefit from research data. The findings may help to do justice to the capacities children possess and challenges they may face when deciding about treatment and research options. We discuss advantages and drawbacks of standardized competence assessment in children on a case-by-case basis compared to application of a fixed age limit, and conclude that a selective implementation of case-by-case competence assessment in specific populations is preferable. We recommend the implementation of age limits based on empirical evidence. Furthermore, we elaborate on a suitable model for informed consent involving children and parents that would do justice to developmental aspects of children and the specific characteristics of the parent-child dyad.SummaryPrevious research outcomes showed that children’s medical decision-making capacities could be operationalized into a standardized assessment instrument. Recommendations for policies include a dual consent procedure, including both child as well as parents, for children from the age of 12 until they reach majority. For children between 10 and 12 years of age, and in case of children older than 12 years in special research populations of mentally compromised patients, we suggest a case-by-case assessment of children’s competence to consent. Since such a dual consent procedure is fundamentally different from a procedure of parental permission and child assent, and would imply a considerable shift regarding some current legislations, practical implications are elaborated. (shrink)

For decades, the discussion on children’s competence to consent to medical issues has concentrated around normative concerns, with little progress in clinical practices. Decision-making competence is an important condition in the informed consent model. In pediatrics, clinicians need to strike a proper balance in order to both protect children’s interests when they are not fully able to do so themselves and to respect their autonomy when they are. Children’s competence to consent, however, is currently not assessed in a standardized way. (...) Moreover, the correlation between competence to give informed consent and age in children has never been systematically investigated, nor do we know which factors exactly contribute to children’s competence. (shrink)

Although law is established on a strong presumption that persons younger than a certain age are not competent to consent, statutory age limits for asking children’s consent to clinical research differ widely internationally. From a clinical perspective, competence is assumed to involve many factors including the developmental stage, the influence of parents and peers, and life experience. We examined potential determining factors for children’s competence to consent to clinical research and to what extent they explain the variation in competence judgments.

In this paper we discuss expected and reported effects on care provider-patient relations of the introduction of electronic patient records (EPRs) in consultation settings by reviewing exemplary studies and literature on the subject from the past decade. We argue that in order for such assessments to be meaningful, talk of effects of “the” EPR needs to be replaced by an “unpacking” of EPR systems into their constituent parts and functionalities, the effects of which need to be assessed individually. Following from (...) this principle, the paper discusses EPR systems ranging from simple data entry and retrieval systems to more sophisticated multi-user and multifunctional on-line systems. On a second level, our analysis of the literature is informed by the question which model of ideal patienthood underlies the assessment of effects of EPRs. To this end, we identify three “models of patienthood” implicit in writing about benefits and drawbacks of EPRs for patients: the autonomy, the consumer, and the holistic models, and argue that assumptions concerning these models need to be reflected upon more critically to improve understanding of what exactly EPR use does to the doctor-patient relationship. (shrink)

Platonic Patterns is a reprint collection of many of Holger Thesleff's studies in Plato—spanning from 1967 to 2003. It includes three books, four articles and a new introduction by the author, which sets the general outline of his interpretation of Plato. Whereas much of the scholarship on Plato has tended to operate within the frame of one language and/or a single school of thought, Thesleff constructively combines several discoveries and theories of various scholars with his own research, focusing (...) on how Plato can be understood in his own context. The work represents small but significant breakthroughs in research on Plato from an internationally inclusive standpoint. Having previously been published mainly in Finland by scholarly societies, availability outside the Nordic countries has, up until now, been minimal. Thesleff employs his singular expertise of Greek language and literature to make innovative contributions to the study and interpretation of Plato. He thematically stresses the significance of the less overt elements found in Plato's dialogues, such as Plato's use of humor and his linguistic expression, while taking into account the chronology and/or the intended audience. (shrink)

Revisión del libro Violencia, espionaje y represión estatal. Seis estudios de caso sobre el pasado reciente argentino por D. D´Antonio (comp.).

Las feministas han reconocido la importancia de defender la capacidad de pensar de las mujeres y de pensarse a sí mismas; es necesario ir más allá: sólo logramos devolver el respeto a las dominadas duraderas producidas por el machismo patriarcal en el que aún vivimos, al establecer que su facultad de juzgar radica en el uso del diálogo que comparte con los hombres, además de su diferencia de sexo y que sólo podemos disipar todas las presuntas dudas planteadas por violadores (...) e intelectuales que se han mantenido machistas respecto a su facultad femenina de juzgar mostrando su origen en una segunda naturaleza común del lenguaje así como su eficacia. Apoyaremos nuestro análisis con un caso que fue noticia en los medios televisivos de Francia. (shrink)

In the article, I examine Hélène Cixous's play La Ville parjure ou le Réveil des Erinyes as a political contribution to the debate over memory and justice. The focus is on the question of how the telling of a story of atrocities may be therapeutic to both the victim and to society. I stress Cixous's alternative way of addressing justice: through forgiveness instead of criminal prosecution or other forms of retribution or reconciliation. Referring to Jacques Derrida's work, the main argument (...) revolves around the question of whether forgiveness for unspeakable crimes should be unconditional or conditional. Instead of seeing Cixous's play as an unequivocal stance on restorative justice in general, and on conditional forgiveness in particular, I stress that the main protagonist, the Mother, is not willing to forgive the crime itself because of its unforgivable nature. (shrink)

Diese Situation wird als eine Kumulation aller Ungleichheiten beschrieben, die einen Menschen treffen können: soziale Klassenungleichheit, sexuelle Ungleichheit und Ungleichheit aufgrund der Rasse. Durch die Zuspitzung dieser Ungleichheiten lässt sich die große Zahl afrikanischer Migrantinnen erklären. Die Suche nach sozialer, ziviler und bürgerlicher Gleichheit, die nach dem Modell der von Männern propagierten und zur Schau gestellten Selbstbeherrschung gedacht ist, kann in dem Maße nicht erfolgreich sein, wie sie versucht, sich einem Macho-Modell zu unterwerfen, das der Natur des Menschen widerspricht. Weil (...) die zeitgenössische Anthropologie uns lehrt, dass dieser die Sprache erfinden musste, um sich das Leben zu ermöglichen und es jedes Mal neu zu harmonisieren, wenn er in eine Sackgasse gerät, weil die dialogische Vorstellungskraft, die den Dialog der Seele mit sich selbst antreibt, den Platon entdeckt hatte, durch das Gesetz der Wahrheit geregelt wird, müssen afrikanische Frauen erkennen, dass sie die Objektivität der ihnen auferlegten und der von ihnen selbst erfundenen Lebensbedingungen beurteilen müssen, um ihre Wahrheitsurteile mit ihren männlichen Partnern teilen zu können und um sich von jeglicher Herrschaft zu emanzipieren, unabhängig von ihrer Geschlechtszugehörigkeit. (shrink)

The aim of this study was to describe how patients’ participation in the care they received was documented in their health care records during the last three months of their lives. Two hundred and twenty-nine deceased adult persons were randomly identified from 12 municipalities in a Swedish county and their records were selected from different health care units. Content analysis was used to analyse the text. Four categories of patient participation were described: refusing offered care and treatments; appealing for relief; (...) desire for everyday life; and making personal decisions. The most common way for these patients to be involved in their care at the end of their life was by refusal of the treatment and care offered. Characteristic of the different ways of participation were the diverse activities represented. The description of patients’ involvement in their life situation at this time indicated their dissociation from the health care offered more than consenting to it. (shrink)

Classical verse work expounding early Vedantic approach in Hindu philosophy.

El objetivo del trabajo de investigación fue evaluar la relación entre el uso de una red social y el rendimiento académico en la materia de matemáticas. Para el método de investigación se trabajó con una muestra de 570 alumnos inscritos en la materia de matemáticas, la cual se dividió en estratos. Se llevó a cabo en una universidad pública del norte de México. La investigación fue longitudinal y correlacional. Los principales resultados indican que a mayor interacción académica en una red (...) social, mejor rendimiento académico en matemáticas. Lo cual puede ser aplicable para ciencias exactas en Instituciones de Educación Superior. (shrink)

The COVID-19 pandemic has posed significant burden across different industrial sectors. Generally, an increase in psychological stress experiences has been reported, while the stress and coping responses of specific, potentially burdened populations have received less attention thus far. Thus, the present study investigated relations between individual and organizational factors, indicators of psychological health, and possible mediating effects of four broad coping dimensions in a specific sample of soldier students who engage in a double-role being military affiliates and students of non-military (...) subjects. To this end, we assessed data of soldier students at two measurement points shortly after the second national lockdown in Germany during the COVID-19 pandemic. Personality traits showed expected associations with indicators of psychological health, i.e., positive relations between neuroticism and social loneliness, between extraversion and COVID-19 stress, and negative relations between neuroticism and life satisfaction. Remarkably, organizational variables showed effects above and beyond personality traits on loneliness and life satisfaction. Neither individual, nor organizational factors could predict change in psychological health over time. We found evidence for mediation effects through active coping, avoidant coping, and the use of social support, but not through positive cognitive restructuring. Findings highlight the relative importance of organizational factors besides personality traits for psychological health in a military student sample, holding important implications for designing efficient support systems in the military. (shrink)

The COVID-19 pandemic has impacted medical care in many ways; previously, a patient would enter a hospital and had an approximate idea of what would happen upon his admission, the physician informed them about it, but in the last two years this scenario has changed. Therefore, our aim was to identify if bioethical principles are present in the physician–patient relationship and the effect of these in the health care provided, through an observational and descriptive study where patients answered the validated (...) ReMePaB questionnaire that measures the presence of bioethical principles in the physician–patient relationship, on the seventh day of their hospital stay and 24 h after discharge, during the period from 1 August to 5 November 2020. In autonomy, an improvement in the score was observed in the second application compared to the first measurement; in the principle of non-vulnerability, the same scenario was observed for the first and second measurements, respectively. In the principles of beneficence, dignity, and justice, no statistically significant differences were observed. Considering the presence or absence of bioethical aspects in health care in this pandemic creates an area of opportunity to know the feelings of the patient during the care received and to maintain what is done well and improve those aspects that can be improved. (shrink)

La philosophie du langage s'est développée au XXe siècle comme prima philosophia. L'auteure entend montrer que le vivant humain ne peut se réaliser qu'en forgeant sa faculté philosophique de juger à l'aide du dialogue. Mais il ne peut affirmer ses vérités qu'en jaugeant celles-ci aux effets de bonheur qu'elles transmettent. Cette régulation de l'usage du langage par l'esthétique inhérente à l'usage du jugement de vérité est en effet autant une condition de vie qu'une condition de son bonheur. Le tournant esthétique (...) qu'opère la conception de la philosophie comme esthétique culturelle prétend, quant à elle, que l'usage du langage n'est condition de vie de l'être humain qu'en déployant la dynamique d'harmonisation du monde, de soi-même et d'autrui à l'aide de l'imagination dialogique et du jugement de vérité. Seul l'exercice de ce jugement permet de juger si l'harmonie de vie exprimée dans la pensée et la parole rend aussi heureux les interlocuteurs que celle-ci leur fait partager sa vérité"--Page 4 of cover. (shrink)

This is a proposal for rethinking the main lines of Plato’s philosophy, including some of the conceptual tools he uses for building and maintaining it. Drawing on a new interpretive paradigm for Plato’s overall vision, the central focus is on the so-called Forms. Regarding the guiding paradigm, we propose replacing the dualism of a world of Forms separated from a world of particulars, with the monistic model of a hierarchically structured universe comprising interdependent levels of reality. Regarding the tools of (...) the trade, we distinguish between three constructs that have come, one and all, and largely indiscriminately, to be regarded as Forms: Ideal Forms, Conceptual Forms, and Relational Forms. This recalibration of what we know of Plato’s outlook, tools, and methods, together with a realignment of these with his general aims, will also help restore the philosopher’s emphasis on that which is good, a perspective often blurred in the structure of two worlds. (shrink)

The purpose of this study is to analyse the teachings of religious moderation contained in the Wawacan Babad Walangsungsang script. This research employs a qualitative method with philology as the main analysis of the data, namely manuscript inventory, script description, script transfer, and language translation. The script shows the story of Prince Walangsungsang’s journey in search of spirituality, specifically Islam. Interestingly, he learned his spirituality through many non-Muslim teachers until he finally met Sheik Datuk Kahfi in Bukit Amparan Jati. The (...) result of this study shows that upon his spiritual journey while gaining knowledge he experienced magical scenery. The conclusion is the willingness of prince Walangsungsang to learn knowledge and ajimat from Budhaprawa teachers, the openness and support of Budhaprawa teachers about the Prophet’s shari’a and the explanation of Sheikh Datuk Kahfi (Muslim) for the religious search conducted by Prince Walangsungsang shows the beauty of speech that is rich with nuances of religious moderation. Contribution: This research is important as a basic reference for religious moderation, which is rooted in the local wisdom of the Sundanese culture and tradition and can be adopted to spread those in our interaction with other religions. (shrink)

Lietuvai atkūrus nepriklausomybę ir įstojus į Europos Sąjungą suaktyvėjo Lietuvos gyventojų judumas, kuris sudarė prielaidas naujoms veikloms, karjeros galimybėms ir šeiminio gyvenimo formoms. 1980–2000 m. gimusiųjų asmeninio gyvenimo planavimas vyko aplinkoje, kuri labai skyrėsi nuo jų tėvų asmeninį gyvenimą formavusios sovietmečio aplinkos. Dalyvavimas migraciniuose procesuose per tėvų, artimųjų arba asmenines patirtis formavo asmeninio gyvenimo lūkesčius ir elgseną, keliančius visuomenės nerimą dėl jaunų žmonių išvykimo iš Lietuvos ir šeiminių ryšių transformacijos mobilumo sąlygomis. Pasitelkiant Carol Smart (2007) asmeninio gyvenimo koncepcijoje pasiūlytas teorines (...) idėjas apie socialinės aplinkos, kasdienių praktikų ir asmeninių projektų sąryšį, straipsnyje analizuojama, kaip globali migracija formuoja 1980–2000 m. gimusių ir nepriklausomoje Lietuvoje augusių asmenų migracinius ketinimus, susisaistymo su Lietuva ir šeiminio gyvenimo vaizdinius. Remiantis dviejų Lietuvos gyventojų reprezentatyvių apklausų bei migracinės patirties turinčių asmenų kvotinės apklausos duomenimis, surinktais įgyvendinant Lietuvos mokslo tarybos (LMT) finansuotus mokslininkų grupių projektus, statistinės analizės rezultatais, autorės nagrinėja, kaip jaunimas kuria ateities planus, kokia dalis jų svarsto išvykti iš šalies, kaip migracinės praktikos koreguoja šeiminio gyvenimo įsivaizdavimą. Straipsnyje atskleidžiama, kaip nepriklausomybės laikotarpiu susiformavusi atvira visuomenė ir mobili socialinė aplinka sukūrė prielaidas lanksčiam susisaistymui su savo kilmės šalimi ir savitam jaunų žmonių supratimui apie šeiminį gyvenimą. (shrink)

Perspectives of Islamic philosophy; articles.