BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford (...) and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures. (shrink)

Personalized medicine aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. Semi-structured telephone interviews were conducted among leading representatives of 13 PIOs located in Europe and North-America. The data collected were analysed using a conventional content analysis approach. The PIO representatives supported (...) the realization of PM but feared that many financial, structural and organizational challenges may delay its realization. They encouraged strategies to modernize drug licencing mechanisms, develop research and data sharing infrastructures, and educate patients and health care professionals in PM. Notably, they emphasized the importance of developing PM in an equitable way and taking into consideration the patients’ needs, values and personal situation. Despite varying levels of awareness regarding PM, the PIO representatives expressed willingness to engage in the PM agenda and recommended that PIOs work closely with policy-makers to design PM in a way that truly addresses the needs and concerns of patients. PIOs have the potential to become central drivers of the PM agenda. Collaborations should be further developed between PIOs, researchers, drug developers and health care authorities. (shrink)

Individual research results from population-based genetic and genomic research are traditionally not disclosed to research participants. Current practices of non-disclosure are, however, being challenged by an increasing number of scientists, ethicists and policy-makers who make arguments in favour of disclosing at least individual results of potential health or lifestyle significance to research participants. Simultaneously, research participants are expressing greater interest in accessing their results. This article first provides an overview of main arguments for and against the disclosure of individual research (...) results to research participants. Next, it discusses the need for a move from the current ethical framework under which researchers operate, which is rather protective of research participants and does not encourage disclosure, to a new ethical framework that would better cope with current developments within the field. Comparative analysis of existing and potential ethical frameworks favours implementation of an ethical framework aimed at enhancing the autonomy of research participants through the disclosure of individual research results. Finally, this article explores practical models of disclosure that could be used under such a new framework. A model of disclosure that takes into account the two key criteria of communicability of research results and the research participant’s preferences to determine which results to disclose is found to comply best with the selected ethical framework. (shrink)

An increasing number of European research projects return, or plan to return, individual genomic research results (IRR) to participants. While data access is a data subject’s right under the General Data Protection Regulation (GDPR), and many legal and ethical guidelines allow or require participants to receive personal data generated in research, the practice of returning results is not straightforward and raises several practical and ethical issues. Existing guidelines focusing on return of IRR are mostly project-specific, only discuss which results to (...) return, or were developed outside Europe. To address this gap, we analysed existing normative documents identified online using inductive content analysis. We used this analysis to develop a checklist of steps to assist European researchers considering whether to return IRR to participants. We then sought feedback on the checklist from an interdisciplinary panel of European experts (clinicians, clinical researchers, population-based researchers, biobank managers, ethicists, lawyers and policy makers) to refine the checklist. The checklist outlines seven major components researchers should consider when determining whether, and how, to return results to adult research participants: 1) Decide which results to return; 2) Develop a plan for return of results; 3) Obtain participant informed consent; 4) Collect and analyse data; 5) Confirm results; 6) Disclose research results; 7) Follow-up and monitor. Our checklist provides a clear outline of the steps European researchers can follow to develop ethical and sustainable result return pathways within their own research projects. Further legal analysis is required to ensure this checklist complies with relevant domestic laws. (shrink)

After years of the welfare state, the rise of technology, combined with neoliberal governmental apparatuses, has established a new society of the precarious. In this new way of the world, productivity is not just connected to labor in the traditional sense of work hours, but more totally, to the formation of the self: work becomes performative and affective, and personal identities seep more and more into working ones. This new mode of being has another side, however: it can lead to (...) new forms of self-organization, resistance and exodus. In it we see the emergence of a new and disobedient self-government of the precarious. (shrink)

Prenatal and preimplantation testing technologies have offered unprecedented access to information about the genetic and congenital makeup of our prospective progeny. Future developments such as preconception testing, non-intrusive prenatal testing and more extensive preimplantation testing promise to increase that access further still. The result may be greater reproductive choice, but it also increases the burden on women and men to avail themselves of these technologies in order to avoid having a child with a disability. The overwhelming question for legislators has (...) been whether and, if so, how to regulate the use of these technologies in the face of compelling but seemingly contradictory claims about the advancement of reproductive choice and the dangers of eugenic or discriminatory effects. This book examines the evolution of this legislative oversight across a number of jurisdictions and explores the tensions and ambiguities that inform these laws. (shrink)

Dans cet essai qui privilégie la joie d'une pensée insoumise plutôt que la dénonciation, Isabelle Stengers prend le relais d'Alfred North Whitehead lorsque, diagnostiquant le "déclin de la civilisation moderne", celui-ci assigna à la philosophie la tâche de "souder le sens commun avec l'imagination". Face aux prétentions à déterminer ce que nous avons le droit de savoir, elle cherche à donner force à ce que nous savons. Face aux oppositions doctrinales prédatrices qui démembrent le sens commun, elle affirme la philosophie (...) comme puissance de problématisation. Prolongeant et renouvelant les ressources proposées par Whitehead, elle fait exister tant la possibilité d'une science "civilisée" que celle, politique, de dispositifs susceptibles d'habiliter les "gens du commun" à faire valoir les questions qui les concernent. Au déclin de la civilisation a aujourd'hui succédé la débâcle : "Nous entendons déjà les grincements et les craquements sourds marquant la rupture des plaques de glace, démantibulant le sol que nous avions défini comme assuré." II s'agit désormais d'apprendre à vivre dans un monde devenu lui-même intrinsèquement problématique. D'autres voix, et notamment celles, contemporaines, de Donna Haraway, Bruno Latour, David Abram ou Anna Tsing, viendront dès lors s'associer à celle de Whitehead dans l'exploration des manières de "faire commun" que demande notre époque. (shrink)

Un spectre hante l'Université française : celui de la déconstruction. Créé par Jacques Derrida à la fin des années 1960, ce concept est devenu, dans l'esprit des réactionnaires de tout poil, le mot-valise désignant tout ce qu'ils haïssent dans la pensée, lorsque celle-ci cherche à émanciper davantage qu'à ordonner. Dégénérescence de la culture, mépris pour les grandes œuvres, délire interprétatif, amphigouri linguistique, danger politique, confusion sexuelle, licence morale : à en croire les ennemis de la déconstruction, tout ce qui va' (...) mal dans le monde lui est imputable. Que signifie la fixation frénétique d'une frange d'intellectuels sur tout ce qui peut ressembler à une pensée différente, inventive et fondamentalement démocratique? Que cela signifie-t-il, si ce n'est la volonté de policer la pensée et ses institutions, pour mieux, ensuite, policer les corps? Telle est l'interrogation qui a présidé au colloque "Qui a peur de la déconstruction?", qui s'est tenu à l'École normale supérieure et à la Sorbonne en janvier 2023. En voici les actes."--Cover page 4. (shrink)

Comment penser l'effort aujourd'hui? Le thème peut sembler à la fois banal et faussement suranné. Banal, d'une part, parce que l'effort est, pour paraphraser Descartes, "la chose du monde la mieux partagée". Depuis toujours, nous sommes enjoints à "faire des efforts", dans des domaines très variés de l'existence, pour apprendre à marcher ou faire du vélo, à l'école, dans nos relations avec autrui puis, plus tard, pour mener à bien des études et une vie professionnelle, trouver le bonheur dans notre (...) vie privée et surmonter les "coups durs" qui sont le lot de chacun. Banal aussi, parce que, tel un marronnier des propos de comptoir, le thème est dans l'actualité, lorsqu'il s'agit de déplorer le "manque d'efforts" des "jeunes générations" ou la perte du "goût de l'effort", à l'école notamment. Ainsi, l'effort serait requis partout, et pourtant perdu, omniprésent dans les discours et si difficile à définir, si difficile à saisir aussi dans les actes. De quoi parle-t-on, de l'effort physique, démonstratif, ou de l'effort intellectuel, intériorisé, impalpable, mais dont les neurosciences visent à montrer la teneur somatique? (shrink)

Stengers recovers the idea of 'common sense' as a meeting place-a commons-where opposed ideas of science and humanistic inquiry can engage one another and help to move society forward. Her reconciliation of science and philosophy is especially urgent today-when climate disaster looms all around us, when the values of what we thought of as civilization and modernity are discredited, and when expertise of any kind is under attack.

In den Mittelpunkt der Schrift stellt Nicolaus Cusanus die Figur eines Laien (idiota), der – als Gegenpol zum universitär ausgebildeten Philosophen – den einfachen Ungebildeten und damit die wahre Weisheit repräsentiert, die dem Geist des Menschen und seinen Potentialen entspricht. Statt auf Bücherwissen und Autoritäten setzt er auf das eigene Philosophieren, das immer neu nach der Wahrheit fragt. Der Laie verkörpert die cusanische Philosophie in besonderem Maße: Fundamentale anthropologische, erkenntnistheoretische und metaphysische Bestimmungen des Cusanus finden sich hier in einer Gestalt (...) vereint. Aus dem Wissen heraus, dass menschliches Erkennen immer nur mutmaßend sein kann, geht es um das rechte kritische Verhältnis zu den eigenen Erkenntnismöglichkeiten. An der Figur des Laien macht Cusanus deutlich, dass dies keineswegs in einen erkenntnistheoretischen Skeptizismus führt, der die Möglichkeit sicheren Wissens von vornherein für nicht erreichbar und infolgedessen alle Erkenntnisbemühungen für überflüssig hält, sondern dass darin das unendliche und dynamische Potential des Menschen zum Ausdruck kommt, sich unermüdlich an die Wahrheit anzunähern. In der Geschichte der Erkenntnistheorie vor Kant spielt "Der Laie über den Geist" somit eine fundamentale Rolle. (shrink)

Providing a compelling scholarly statement about the interrelation and pliability of values in the life sciences, medicine and health care, this volume aims to aid our understanding of the roles of power, knowledge production and economic action in the heavily scientised and economised areas of life science and medicine.

This article looks at the current state of sacred prostitution studies in both ancient Near Eastern and Classical Studies through the review of two books published in 2019. Both books reveal that the current trend is to dismiss the existence of sacred prostitution in antiquity, one by attempting (not entirely successfully) to agree with that assessment, and one by condemning that dismissal altogether. All things considered, it does now appear that there has been a marked change of opinion in the (...) academy, and that Aphrodite’s and Ištar’s cult brothels are making their way to the dustpan of historiography. (shrink)

Women in the Ancient Near East: A Sourcebook. Edited by Mark W. Chavalas. Routledge Sourcebooks for the Ancient World. London: Routledge, 2014. Pp. xii + 319. $43.95.

This book details how quantification can serve both as evidence and as an instrument of government, whether when dealing with statistics on employment, occupational health and economic governance, or when developing public management or target-driven policies. In the process, it presents a thought-provoking homage to Alain Desrosières, who pioneered ways to study large numbers and the politics underlying them. It opens with a summary of Desrosières's contributions to the field in which several generations of researchers detail how this statistician and (...) historian profoundly influenced them. This tribute, based on personal testimonies, bears witness to the vitality of the school of thought and analytical framework Desrosières initiated. Next, a collection of essays explores the statistical argument in the neoliberal era, examining issues such as counting the homeless in Europe, measuring the performance of public services, and quantifying the effects of public action on the unemployed in France. The third part details the uses of quantification. It reveals that although statistics are frequently used to the advantage of those in power, they can also play a vital role in challenging and resisting both the conventions underlying the measurements as well as the measurements themselves.Featuring the work of economists, historians, political scientists, sociologists, and statisticians, this title provides readers with a thoughtful look at an influential figure in the history of statistics. It also shows how statistics are used to direct public policy, the degree of conflict that is possible in their production, and the disputes that can develop around their uses. (shrink)

La critique s'est longuement intéressée à l'hétérogénéité comme une caractéristique de certaines formes d'expression littéraires ou artistiques, plus particulièrement dans une modernité vouée au composite. Privilégiant par le titre proposé le concept d'"hétérogène", les articles réunis dans cet ouvrage interrogent sa pertinence pour l'étude des littératures de langue française, en prenant en compte son articulation avec ce qui est supposé ou donné comme homogène. Le mot "hétérogène" est ainsi moins entendu en ce qu'il qualifie les différents éléments d'un ensemble aptes (...) à produire des formes hybrides qu'en ce qu'il donne à voir une relation dynamique avec ce que la langue et la société instituent comme homogène. Ainsi, les approches proposées dans cet ouvrage permettent de rendre compte de la façon dont le texte littéraire participe d'une pensée critique qui met en question les discours dominants, tant au niveau des représentations sociales que des formes esthétiques, et qui interroge de ce fait nos propres outils d'analyse. (shrink)

Les derniers travaux de Michel Foucault peuvent être appréhendés comme une nouvelle grille de lecture pour l'analyse des pratiques d'écriture personnelle dont peut se saisir la théorie littéraire. Dans ses cours au Collège de France sur les pratiques de soi antiques, Michel Foucault ébauche une généalogie de l'écriture de soi : celle-ci ne vise pas à découvrir ce qui est "intus et in cute" comme l'annonçait Rousseau en exergue des Confessions, mais à élaborer un sujet éthique par l'ascèse, par l'exercice (...) de l'écriture. La pratique de l'écriture personnelle, dès lors qu'elle renonce au psychologique, à une "histoire de la personnalité" (Philippe Lejeune) et s'ouvre à une altérité, devient une "pratique de liberté" (Michel Foucault). Face à une épreuve existentielle (le deuil, la maladie), face aux agressions de l'histoire, face à un contexte sociopolitique répressif, le récit de soi en tant que pratique éthique de subjectivation offre un cheminement vers une émancipation que la littérature peut aussi aider à interpréter. Le récit de soi requiert dès lors une lecture éthique et convoque, nécessairement, pour son analyse, la littérature et la philosophie. (shrink)

Should emotions play a role in our decisions, even if they are "just feelings" and not necessarily "imbued with reason" or cognitively penetrated? The author shows that such basic feelings as aversion and attraction can be important normative guides by disrupting engrained habits and beliefs, enabling us to reconsider our ways, which is important due to the ever-changing nature of ethical demands on us. Therefore, these feelings should guide our decisions, even if they are not cognitive. This book fi lls (...) a gap in the philosophy of emotions, ethics, and virtue epistemology. (shrink)

Habermas est un des philosophes contemporains vivants les plus célèbres. Cet héritier de l'Ecole de Francfort a participé aux grandes controverses du XXe siècle, celle opposant Adorno à Popper, mais aussi à la querelle des historiens allemands. L'oeuvre abondante d'Habermas croise morale, sociologie, politique et épistémologie. Isabelle Aubert en découvre la profonde unité dans l'intersubjectivité, cette notion que l'on trouve chez Fichte et Husserl mais qu'Habermas s'est efforcé de détourner. Il ne s'agit pas d'éliminer toute forme de subjectivité mais de (...) déplacer la perspective sur le social en mettant au centre une notion qui appréhende la réalité de sujets situés et en relation. Ce modèle alternatif d'intelligibilité s'effectue sur le mode de la participation au dialogue, de l'échange de paroles et non selon le mode de l'observation entre un pôle de représentation et un environnement extérieur. Ainsi naît une nouvelle anthropologie sociale fonctionnelle, à l'écart du mouvement post-moderne. (shrink)

In Virgin Mary and the Neutrino, first published in French in 2006 and appearing here in English for the first time, Isabelle Stengers experiments with the possibility of addressing modern practices not as a block but through the way they diverge from each other. Drawing on thinkers ranging from Dewey to Deleuze, she develops what she calls an "ecology of practices" into a capacious and heterogeneous perspective that is inclusive of cultural and political forces but not reducible to them. Stengers (...) first advocates for an approach to sciences that would emphasize the way each should be situated by the kind of relationship demanded by what it attempts to address. This approach turns away from the disabling scientific/nonscientific binary-like the opposition between the neutrino and Virgin Mary. An ecology of practices stimulates instead an appetite for thinking reality not as an arbiter but as what we can relate with through the generation of diverging concerns and obligations. (shrink)

In the wake of the 2008 global financial crisis, an important conceptual battleground for democratic theorists ought to be, it would seem, the capitalist firm. We are now painfully aware that the typical model of government in so-called investor-owned companies remains profoundly oligarchic, hierarchical, and unequal. Renewing with the literature of the 1970s and 1980s on workplace democracy, a few political theorists have started to advocate democratic reforms of the workplace by relying on an analogy between firm and state. To (...) the extent that a firm is an organization comparable to the state, it too ought to be ruled along democratic lines. Our paper tests the robustness of the analogy between firm and state by considering six major objections to it: the objection from a difference in ends, the objection from shareholders’ property rights, the objection from worker’s consent, the objection from workers’ exit opportunities, the objection from workers’ expertise, and the objection from the fragility of firms. We find all of these objections wanting. While the paper does not ambition to settle the issue of workplace democracy at once, our goal is to pave the way for a more in-depth study of the ways in which firms and states can be compared and the possible implications this may have for our understanding of the nature of managerial authority and the governance of firms. (shrink)

This study explores how in science fiction’s novels myths are intimately linked to their ideological dimension and criticism. It begins with a mythocritical analysis that leads to a mythoanalysis in order to understand how those myths and the big issues of the accelerating technoscientific progress in the 20th and 21th centuries are linked. My approach is based on the restricted example of Dan Simmons’ science fiction novels: by studying the myths he rewrites, I will show that those myths are representing (...) how technoscience can have an influence on history, on the development of humanity and on the issue of ethics. (shrink)

Le scepticisme de Montaigne -- Perturbations dans le genre -- Bouleversement des catégories du masculin et du féminin dans "Par divers moyens on arrive à pareille fin" -- L'identité en question -- L'homme insoluble -- Les Indiennes, les Indiens et nous -- Le sexe indécis -- Renversement -- Critique sceptique de la rhétorique adressée aux femmes -- Féminité et savoir du corps -- Parodie de la discipline conjugale -- Au sujet de la femme insatiable -- Déplacement et/ou réhabilitation inattendue -- (...) Malheur et bonheur du mariage ou la vie selon son mouvement -- Solitude ou mariage -- Grandeur de la relation conjugale -- Examen sceptique de la gynécocratie -- Satire du patriarcat -- Abandon et transmission du pouvoir -- Restauration de la légitimité du gouvernement féminin -- Réduction à l'absurde -- Réquisitoire contre la chasse aux sorcières -- Vanité de la recherche des causes -- Justice sceptique et clémence -- Vénus, les boiteux et les boiteuses -- Apologie paradoxale -- L'amour de préférence à la guerre -- Trivialité et danger de l'amour -- Éloge de l'amour -- Dernières accolades -- Construction d'une communauté autre -- Un lectorat féminin estimé -- Les femmes dédicataires dans les Essais -- Marie de Gournay, une philosophe féministe autonome, mais fidèle. (shrink)

Con el apoyo de su querida familia Chicanx, una niña llamada Chabelita descubre que está bien que le gusten las niñas.

The Corpus of English Philosophy Texts (CEPhiT) is part of the Coruña Corpus of English Scientific Writing (CC) following CETA (Corpus of English Texts on Astronomy). In accordance with the rest of the Corpus, CEPhiT has been compiled for the description of philosophical texts written in English in the eighteenth and nineteenth centuries. The sampling method employed requires the collection of extracts of 10,000 words. This method has been followed in CETA and CEPhiT, with samples from 40 different authors in (...) the latter, both from Europe and North America. Text selection is based on some extralinguistic criteria, such as year of publication, sex, geographical provenance and text-types/genres. The corpus contains samples belonging to six different genre categories. This taxonomy, as well as some other extralinguistic information, can be used to search the corpus. CEPhiT, like CETA, is released on CD-Rom with Coruña Corpus Tool (CCT), purpose-designed software by IrLab. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)