Familial clustering of a disease is defined as the occurrence of the disease within some families in excess of what would be expected from the occurrence in the population. It has been demonstrated for several cancer types, ranging from rare cancers as the adenomatosis-coli-associated colon cancer or the Li-Fraumeni syndrome to more common cancers as breast cancer and colon cancer. Familial clustering, however, is merely an epidemiological pattern, and it does not tell whether genetic or environmental causes or both in (...) combination are responsible for the familial clustering. Familial clustering may be due to genetic predisposition to the disease, but exposure to environmental factors — shared by members of some families, but not by members of other families — may also cause familial clustering and hence mimic genetic inheritance in the study of nuclear families. Based on assumptions regarding the individual steps in the biological process starting with exposure to carcinogens and ending with death from disseminated cancer we suggest that genetic and environmental factors may both be involved in most of these steps. The present paper focuses on research methodologies necessary to discriminate between the effect of genes and family environment in the development of cancer. (shrink)
In Euripides' Hippolytus , Phaedra, wife of Theseus, king of Athens, falls in love with the unsuspecting Hippolytus, Theseus' son by the amazon Antiope. Phaedra's passion is the work of the goddess Aphrodite, who wants to revenge herself on Hippolytus because he has rejected her and devoted himself to the chaste Artemis. Through Paedra's nurse Hippolytus is made aware of her love and invited to her bed. He emphatically rejects her offer and violently abuses Phaedra and her nurse. To save (...) her honour Phaedra commits suicide and leaves a note accusing Hippolytus of raping her. Theseus, confronted on his return from an expedition with the suicide and the note, banishes Hippolytus and prays to his father, the seagod Poseidon, to fulfil one of the three wishes he has granted him and kill Hippolytus. Leaving Troezen, Hippolytus is killed when his horses are frightened by a monster thrown on shore by Poseidon from a giant wave. Theseus is brought to realize his mistake by the goddess Artemis who appears to him and reveals the truth. The play ends with the reconciliation of Theseus and the dying Hippolytus. This, in bare outline, is what happens in the play. It is what might be called its subject. The play is about these events and characters. Now it is also possible to give another type of description of Euripides' play. For the play does not merely have a subject but also a theme. While it is straightforward and unproblematic to give a description of the subject of the play a statement of its theme presents difficulties. The subject is, in an obvious sense, given for any competent speaker of the language in which the work is written. The theme, on the other hand, emerges from the subject in conjunction with other features of the work, and it emerges through the reader's constructive labour. There is no theme for the reader who is unwilling or unable to engage in this constructive labour. (shrink)
Søren Kierkegaard published an extraordinary number of works during his lifetime, but he left behind nearly as much unpublished writing, most of which consists of what are called his "journals and notebooks." Volume 3 of this 11-volume edition of Kierkegaard's Journals and Notebooks includes Kierkegaard's extensive notes on lectures by the Danish theologian H. N. Clausen and by the German philosopher Schelling, as well as a great many other entries on philosophical, theological, and literary topics. In addition, the volume includes (...) many personal reflections by Kierkegaard, notably those in which he provides an account of his love affair with Regine Olsen, his onetime fiancée. (shrink)
An intricate, long, and occasionally heated debate surrounds Boltzmann’s H-theorem (1872) and his combinatorial interpretation of the second law (1877). After almost a century of devoted and knowledgeable scholarship, there is still no agreement as to whether Boltzmann changed his view of the second law after Loschmidt’s 1876 reversibility argument or whether he had already been holding a probabilistic conception for some years at that point. In this paper, I argue that there was no abrupt statistical turn. In the first (...) part, I discuss the development of Boltzmann’s research from 1868 to the formulation of the H-theorem. This reconstruction shows that Boltzmann adopted a pluralistic strategy based on the interplay between a kinetic and a combinatorial approach. Moreover, it shows that the extensive use of asymptotic conditions allowed Boltzmann to bracket the problem of exceptions. In the second part I suggest that both Loschmidt’s challenge and Boltzmann’s response to it did not concern the H-theorem. The close relation between the theorem and the reversibility argument is a consequence of later investigations on the subject. (shrink)
George H. Mead and Alfred Schutz proposed foundations for an interpretative sociology from opposite standpoints. Mead accepted the objective meaning structure a priori. His problem became therefore the explanation of the individuality and creativity of human actors in his social behavioristic approach. In contrast, Schutz started from the subjective consciousness of an isolated actor as a result of a phenomenological reduction. He was concerned with the problem of explaining the possibility of this isolated actor’s perceiving other actors in their existence, (...) their concreteness, and the motives for their behavior. I treat these two approaches and their associated problems as equally relevant. My evaluation is based on their success in solving their specific problems. The aim is to decide which of the two approaches provides the more adequate foundation for an interpretative sociology. (shrink)
Ernst H. Gombrich criticized abstract painting with several remarks scattered around his wide oeuvre. I argue that his view of abstract paintings is coherent with the account of pictorial representation he put forward in Art and Illusion, show some limits of such view, and maintain that, although several of Gombrich’s criticisms of abstract painting should be rejected, some of his remarks are insightful and worth of consideration.
From 2012 to 2015 I was the first Eugene H. Fram Chair in Applied Critical Thinking at Rochester Institute of Technology, in Rochester, NY. To the best of my knowledge it is the only such endowed position devoted solely to this at a major North American university. It was made possible by a generous 3 million dollar gift from an anonymous alumnus who wished to honor a retired faculty member who had taught for 51 years. The honoree was revered for (...) his devotion to Bloom’s taxonomy and his academic rigor, which infused case studies and the Socratic method. A primary motivation for the chair was a belief that an alarming number of college graduates lack the necessary critical thinking skills in order to advance successfully in their careers. My responsibilities included collaborative leadership, advocacy and oversight for critical thinking across the entire campus. It provided a unique opportunity to reflect on the current state of critical thinking instruction–very broadly construed, as well as to examine its specific role at RIT, an institution with its own unique history, mission, and character. (shrink)
This article is an investigation of parallel themes in Heinrich Hertz's philosophy science and Kant's theory of schemata, symbols and regulative ideas. It is argued that Hertz's "pictures" bears close similarities to Kantian "schemata", that is, they are rules linking concepts to intuitions and provide them with their meaning. Kant's distinction between symbols and schemata is discussed and related to Hertz's three pictures of mechanics. It is argued that Hertz considered his own picture of mechanics (the "hidden mass" picture) as (...) symbolic in a different way than the force and energy pictures. In the final part of the article it is described how Harald Høffding soon after the publication of Hertz's Principles of Mechanics developed a general theory of analogical reasoning, relying on the ideas of Hertz and Kant. (shrink)
W. H. Auden and Hannah Arendt belonged to a generation that experienced the catastrophic events of the mid-twentieth century, and they both sought to respond to the enormity of the novel phenomena they witnessed.
T. H. Morgan (1866–1945), the founder of the Drosophila research group in genetics that established the chromosome theory of Mendelian inheritance, has been described as a radical empiricist in the historical literature. His empiricism, furthermore, is supposed to have prejudiced him against certain scientific conclusions. This paper aims to show two things: first, that the sense in which the term empiricism has been used by scholars is too weak to be illuminating. It is necessary to distinguish between empiricism as an (...) epistemological position and the so-called methodological empiricism. I will argue that the way the latter has been presented cannot distinguish an empiricist methodology from a non-empiricist one. Second, I will show that T. H. Morgan was not an epistemological empiricist as this term is usually defined in philosophy. The reason is that he believed in the existence of genes as material entities when they were unobservable entities when they were unobservable entities introduced to account for the phenotypic ratios found in breeding experiments. These two points, of course, are interrelated. If we were to water down the meaning of empiricis, perhaps we could call Morgan an empiricist. But then we would also fail to distinguish empiricism from realism. (shrink)
J. H. Lambert proved important results of what we now think of as non-Euclidean geometries, and gave examples of surfaces satisfying their theorems. I use his philosophical views to explain why he did not think the certainty of Euclidean geometry was threatened by the development of what we regard as alternatives to it. Lambert holds that theories other than Euclid’s fall prey to skeptical doubt. So despite their satisfiability, for him these theories are not equal to Euclid’s in justification. Contrary (...) to recent interpretations, then, Lambert does not conceive of mathematical justification as semantic. According to Lambert, Euclid overcomes doubt by means of postulates. Euclid’s theory thus owes its justification not to the existence of the surfaces that satisfy it, but to the postulates according to which these “models” are constructed. To understand Lambert’s view of postulates and the doubt they answer, I examine his criticism of Christian Wolff’s views. I argue that Lambert’s view reflects insight into traditional mathematical practice and has value as a foil for contemporary, model-theoretic, views of justification. (shrink)
Let h : ℕ → ℚ be a computable function. A real number x is called h-monotonically computable if there is a computable sequence of rational numbers which converges to x h-monotonically in the sense that h|x – xn| ≥ |x – xm| for all n andm > n. In this paper we investigate classes h-MC of h-mc real numbers for different computable functions h. Especially, for computable functions h : ℕ → ℚ, we show that the class h-MC coincides (...) with the classes of computable and semi-computable real numbers if and only if Σi∈ℕ) = ∞and the sum Σi∈ℕ) is a computable real number, respectively. On the other hand, if h ≥ 1 and h converges to 1, then h-MC = SC no matter how fast h converges to 1. Furthermore, for any constant c > 1, if h is increasing and converges to c, then h-MC = c-MC. Finally, if h is monotone and unbounded, then h-MC contains all ω-mc real numbers which are g-mc for some computable function g. (shrink)
This article is an investigation of parallel themes in Heinrich Hertz's philosophy science and Kant's theory of schemata, symbols and regulative ideas. It is argued that Hertz's "pictures" bears close similarities to Kantian "schemata", that is, they are rules linking concepts to intuitions and provide them with their meaning. Kant's distinction between symbols and schemata is discussed and related to Hertz's three pictures of mechanics. It is argued that Hertz considered his own picture of mechanics as symbolic in a different (...) way than the force and energy pictures. In the final part of the article it is described how Harald Høffding soon after the publication of Hertz's Principles of Mechanics developed a general theory of analogical reasoning, relying on the ideas of Hertz and Kant. (shrink)
New Waves in Philosophy, a book collection that stands out for giving a snapshot of research in all areas of philosophy is a successful editorial project addressed by Vincent F. Hendricks and Duncan Pritchard. New Waves in Philosophy of Action is one of its last titles, edited by Jesús H. Aguilar, Andrei A. Buckareff and Keith Frankish. -/- The book is aimed at the researchers of all fields and readers in general interested in this sub-discipline of philosophy very difficult to (...) localize (is it part of a sub-discipline such as metaphysics or maybe part of the philosophy of mind?). What is and how can we know the nature of intentions and its role in action? (shrink)
La obra del filósofo estadounidense David H. Finkelstein, Expression and the Inner, publicada originariamente en 2003 por Harvard University Press (2ª ed. 2008) puede ahora leerse en la versión española de Lino San Juan, editada por la ovetense KRK Ediciones con el título: La expresión y lo interno. Finkelstein propone en La expresión y lo interno un análisis expresivista del autoconocimiento. Podría parecer cuando menos sorprendente y aún más admirable que con tan sólo dos capítulos (“Detectivismo y constitutivismo” y “Expresión”) (...) y un Epílogo (“Deliberación y transparencia”), Finkelstein haya conseguido presentar en esta obra un planteamiento calificado por muchos como una auténtica renovación de la discusión analítica en torno al tema del autoconocimiento, o sea, acerca del problema de qué clase de autoridad quepa atribuir a las expresiones sobre nuestros propios estados de ánimo y/o nuestros estados mentales sin más. (shrink)
During the British socialist revival of the 1880s competing theories of evolution were central to disagreements about strategy for social change. In News from Nowhere (1891), William Morris had portrayed socialism as the result of Lamarckian processes, and imagined a non-Malthusian future. H.G. Wells, an enthusiastic admirer of Morris in the early days of the movement, became disillusioned as a result of the Malthusianism he learnt from Huxley and his subsequent rejection of Lamarckism in light of Weismann's experiments on mice. (...) This brought him into conflict with his fellow Fabian, George Bernard Shaw, who rejected neo-Darwinism in favour of a Lamarckian conception of change he called "creative evolution.". (shrink)
Using a result of H. Hanche-Olsen, we show that (subject to fairly natural constraints on what constitutes a system, and on what constitutes a composite system), orthodox finite-dimensional complex quantum mechanics with superselection rules is the only non-signaling probabilistic theory in which (i) individual systems are Jordan algebras (equivalently, their cones of unnormalized states are homogeneous and self-dual), (ii) composites are locally tomographic (meaning that states are determined by the joint probabilities they assign to measurement outcomes on the component (...) systems) and (iii) at least one system has the structure of a qubit. Using this result, we also characterize finite dimensional quantum theory among probabilistic theories having the structure of a dagger-monoidal category. (shrink)
In this essay, I reconstruct H. Richard Niebuhr's interpretation of George Herbert Mead's account of the social constitution of the self. Specifically, I correct Niebuhr's interpretation, because it mischaracterizes Mead's understanding of social constitution as more dialogical than ecological. I also argue that Niebuhr's interpretation needs completing because it fails to engage one of Mead's more significant notions, the I/me distinction within the self. By reconstructing Niebuhr's account of faith and responsibility as theologically self-constitutive through Mead's I/me distinction, I demonstrate (...) Niebuhr's deep yet unacknowledged agreement with Mead: the self is constituted by its participation in multiple communities, but responds to them creatively by enduring the moral perplexity of competing communal claims. I conclude by initiating a constructive account of conscience that follows from this agreement. Conscience is more ecological than dialogical because it regards our creative participation in multiple ecologies of social roles oriented by patterns of responsive relations. (shrink)
This article traces Kurt H. Wolff’s involvement with Italy, from his first sojourn in the 1930s as a German Jewish intellectual in exile to the end of his life. Wolff developed profound ties with the country that hosted him, and that he was forced to abandon once racial laws were introduced there on the eve of World War II. Nonetheless, throughout his life he regarded Italy as an elective homeland of sorts. Wolff’s Italian experience is revisited through a detailed examination (...) of the places where he resided, his activities as a student, teacher, and scholar, and the many individuals with whom he associated, many of whom became his lifelong friends and collaborators. The documentary evidence collected here includes unpublished conversations with some of Wolff’s Italian connections and serves for a consideration of how his ties to Italy had an impact on the development of his sociological and esthetic theories. (shrink)
T. S. Eliot left Harvard during his third year of study in the department of philosophy and went to England. Forty-six years later he authorized the publication of his doctoral dissertation. Here we have a reprint of his sympathetic but not entirely uncritical study of the English idealist philosopher F. H. Bradley.