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  1.  18
    A Mechanical Model for the Formation of Vascular Networks in Vitro.D. Manoussaki, S. R. Lubkin, R. B. Vemon & J. D. Murray - 1996 - Acta Biotheoretica 44 (3-4):271-282.
    Endothelial cells, when cultured on gelled basement membrane matrix exert forces of tension through which they deform the matrix and at the same time they aggregate into clusters. The cells eventually form a network of cord-like structures connecting cell aggregates. In this network, almost all of the matrix has been pulled underneath the cell cords and cell clusters. This phenomenon has been proposed as a possible model for the growth and development of planar vascular systems in vitro. Our hypothesis is (...)
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  2.  25
    Modelling the Spatial Patterning of Teeth Primordia in the Alligator.P. M. Kulesa, G. C. Cruywagen, S. R. Lubkin, M. W. J. Ferguson & J. D. Murray - 1996 - Acta Biotheoretica 44 (2):153-164.
    We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator, Alligator mississippiensis. Detailed embryological studies by Westergaard and Ferguson have shown that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a dynamic patterning mechanism, which crucially includes domain growth. The mechanism can reproduce the spatial pattern development of the first seven teeth primordia in each half jaw of A. mississippiensis. The (...)
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  3.  14
    Quantifying Efficacy of Chemotherapy of Brain Tumors with Homogeneous and Heterogeneous Drug Delivery.Kristin R. Swanson, Ellsworth C. Alvord & J. D. Murray - 2002 - Acta Biotheoretica 50 (4):223-237.
    Gliomas are diffuse and invasive brain tumors with the nefarious ability to evade even seemingly draconian treatment measures. Here we introduce a simple mathematical model for drug delivery of chemotherapeutic agents to treat such a tumor. The model predicts that heterogeneity in drug delivery related to variability in vascular density throughout the brain results in an apparent tumor reduction based on imaging studies despite continual spread beyond the resolution of the imaging modality. We discuss a clinical example for which the (...)
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  4. Forward Inferences About Specific Events During Reading.J. D. Murray, C. M. Klin & J. L. Myers - 1991 - Bulletin of the Psychonomic Society 29 (6):506-506.
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