The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co‐evolution of polypeptides and their receptors.

John Searle (1932-) is one of the most famous living American philosophers. A pupil of J. L. Austin at Oxford in the 1950s, he is currently Mills Professor of the Philosophy of Mind and Language at the University of California, Berkeley. In 1995 John Searle published "The Construction of Social Reality", a text which not only promises to disclose the institutional backdrop against which speech takes place, but initiate a new 'philosophy of society'. Since then "The Construction of Social Reality" (...) has been subject to a flurry of criticism. While many of Searle's interlocutors share the sense that the text marks an important breakthrough, he has time and again accused critics of misunderstanding his claims. Despite Searle's characteristic crispness and clarity there remains some confusion, among both philosophers and sociologists, regarding the significance of his proposals. This book traces some of the high points of this dialogue, leveraging Searle's own clarifications to propose a new way of understanding the text. In particular, Joshua Rust looks to Max Weber in suggesting that Searle has articulated an ideal type. In locating The Construction of Social Reality under the umbrella of one of sociology's founding fathers, this book not only makes Searle's text more accessible to the readers in the social sciences, but presents Max Weber as a thinker worthy of philosophical reconsideration. Moreover, the recharacterization of Searle's claims in terms of the ideal type helps facilitate a comparison between Searle and other social theorists such as Talcott Parsons. (shrink)

Unlike nonhuman primates, thousands of bird species have articulatory capabilities that equal or surpass those of humans, and they develop their vocalizations through vocal imitation in a way that is very similar to how human infants learn to speak. An understanding of how speech mechanisms have evolved is therefore unlikely to yield key insights into how the human brain is special.

The aim of this essay is to understand the relationship between knowledge and society and to reflect on the links between science and political decision making. The text evolved from a number of reflections the author made while president of the European Astronomical Society, president of the Swiss Academy of Sciences and vice-president of the European Academies Science Advisory Council (EASAC). The book starts by using astronomy as a showcase for what science brings to society in terms of intellectual enrichment, (...) of practical tools and of societal inputs. It then turns to looking generally at science as a human endeavour for which pleasure is a prime motivation and it describes the efforts made by researchers to rationalise their findings, thus making them universally acceptable. The author also describes the role of science in shaping our environment and discusses resulting responsibility of the scientists with respect to the evolution of the world. As part of an analysis of the relationship between science and policy the author describes the way in which scientists can (and must) bring knowledge in the political decision making process. The argument is closed with considerations on global governance, while the conclusion puts evidence based decision making processes in relation with the more emotional aspects of our behaviour. The readership of the book is intended to be all scientists involved in "science for policy" activities, as well as those who should become more active in this domain. This includes, but is not limited to, all members of science academies. Astronomers will find specific elements to help them think about their science. The intended readers of the book also include civil servants and policy makers who develop legislation and societal action in domains in which a solid knowledge base is important. The book should furthermore be of interest to citizens following public life and all those worried by the "post evidence" trends in policy. (shrink)

Lewis proposes a solution for bridging the gap between cognitive-psychological and neurobiological theories of emotion in terms of dynamic systems modeling. However, an important brain network is absent in his account: the neuroendocrine system. In this commentary, the dynamic features of the cross-talk between the hypothalamic-pituitary-adrenal (HPA) and gonadal (HPG) axes are discussed within a triple-balance model of emotion.

Durante los últimos años ha habido un creciente interés por parte de físicos y matemáticos en el estudio de problemas que surgen al tratar de comprender cuestiones de biología. Por otra parte los avances en las técnicas experimentales están permitiendo obtener una gran cantidad de información sobre los mecanismos que emplean las células en su funcionamiento. En este artículo se describen algunas líneas de investigación en matemáticas cuyo estudio ha sido motivado por el estudio de problemas biológicos.

Christian philosophers have engaged naturalism in three main ways: direct refutation; systematic comparison; and sustained development of compelling alternative accounts. While all of these options have value, I argue that it is, and especially, that are most likely to win converts, and that we are witnessing an encouraging strategic shift in that direction. Options and bring Christian philosophers into closer dialogue with their naturalistic counterparts, building mutual respect and a greater opportunity for Christian philosophers to gain a full and fair (...) hearing. This points to a bright future for Christian philosophy. (shrink)

Genealogía y lógica de la ratio imperial romana -- Racionalización ética judía y religión de salvación cristiana -- La revolución teológica de Pablo y sus consecuencias -- Teología política imperial y militancia cristiana -- La teología trinitaria y el destino de la teología imperial -- Hilario, Ambrosio y el camino del catolicismo en Occidente -- Mal y salvación: Augstín de Hipona.

Quizá la "dialéctica de la Ilustración" no sea sino el equívoco de una Ilustración que no es consciente de sus dificultades. Quizá si esas dificultades hubieran sido mejor conocidas, no se hubiera culpabilizado a una "razón" cuyo peor defecto fue mostrarse ufana acerca de sus ilusorias seguridades. Este libro quiere alegar en favor de una tesis: una ilustración consciente de su propia improbabilidad no debiera sentirse decepcionada por la escasez de sus prestaciones. Acaso alrededor de los textos kantianos podamos todavía (...) hallar el ámbito en el que, más allá de la limitada lectura de Foucault, sea perceptible el sentido clásico de la Ilustración, fortalecida por su anclaje en la historia de la razón occidental, siempre con la voluntad de distanciarse de Platón y de hacer pie en las playas epicúreas y estoicas. (shrink)

What are the responsibilities of a business towards the city in which it operates? The Professor of Business Ethics at Nijenrode University, the Netherlands Business School suggests three practical ways of identifying them. This article is the substance of a paper which he delivered as Chairman of the European Business Ethics Network at its 1992 Conference in Paris.

v. 1. Del sistema de la libertad en Fichte al primado de la teología en Schelling -- v. 2. La hegemonía del pensamiento de Hegel.