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  1.  10
    Lessons From a BACE1 Inhibitor Trial: Off-Site but Not Off Base.D. K. Lahiri, B. Maloney, J. M. Long & N. H. Greig - 2014 - Alzheimers Dement 10:S411-9.
    Alzheimer's disease is characterized by formation of neuritic plaque primarily composed of a small filamentous protein called amyloid-beta peptide . The rate-limiting step in the production of Abeta is the processing of Abeta precursor protein by beta-site APP-cleaving enzyme . Hence, BACE1 activity plausibly plays a rate-limiting role in the generation of potentially toxic Abeta within brain and the development of AD, thereby making it an interesting drug target. A phase II trial of the promising LY2886721 inhibitor of BACE1 was (...)
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  2.  5
    Autism, Alzheimer Disease, and Fragile X: APP, FMRP, and mGluR5 Are Molecular Links.D. K. Sokol, B. Maloney, J. M. Long, B. Ray & D. K. Lahiri - 2011 - Neurology 76:1344-52.
    The present review highlights an association between autism, Alzheimer disease , and fragile X syndrome . We propose a conceptual framework involving the amyloid-beta peptide , Abeta precursor protein , and fragile X mental retardation protein based on experimental evidence. The anabolic effect of the secreted alpha form of the amyloid-beta precursor protein may contribute to the state of brain overgrowth implicated in autism and FXS. Our previous report demonstrated that higher plasma sAPPalpha levels associate with more severe symptoms of (...)
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    Classification of the Mathematical Sciences.J. M. Long - 1886 - Journal of Speculative Philosophy 20 (4):417 - 425.
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