Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Using the corpus of JSTOR articles, we investigate the role of gender in collaboration patterns across the scholarly landscape by analyzing gender-based homophily--the tendency for researchers to co-author with individuals of the same gender. For a nuanced analysis of gender homophily, we develop methodology necessitated by the fact that the data comprises heterogeneous sub-disciplines and that not all authorships are exchangeable. In particular, we distinguish three components of gender homophily in collaborations: a structural component that is due to demographics and (...) non-gendered authorship norms of a scholarly community, a compositional component which is driven by varying gender representation across sub-disciplines, and a behavioral component which we define as the remainder of observed homophily after its structural and compositional components have been taken into account. Using minimal modeling assumptions, we measure and test for behavioral homophily. We find that significant behavioral homophily can be detected across the JSTOR corpus and show that this finding is robust to missing gender indicators in our data. In a secondary analysis, we show that the proportion of female representation in a field is positively associated with significant behavioral homophily. (shrink)

Objective: The objectives of this study are to understand the current functions, structure and operation of hospital ethics committees (HECs) in Shanghai and to facilitate their improvement. Methods: (1) A questionnaire survey, (2) interviews with secretaries and (3) on-site document reviews of HECs in Shanghai were used in the study, which surveyed 33 hospitals. Results: In Shanghai, 57.56% of the surveyed hospitals established HECs from 1998 to 2005. Most HECs used bioethical review of research involving human subjects as well as (...) bioethical review or consultation regarding medical care services and administrative decision- making. Of the surveyed HECs, 14.3% did not provide any formal bioethical training to the HECs’ members and many HECs had no standard operating procedures. Some HECs had no clear definition of what was “conflict of interest” that should be considered by the HECs, while 44.4% of the HECs did not perform continuing review. Discussion: After the issues of related national regulations, more and more hospitals established HECs in Shanghai, but the functions of HECs need to be further developed and formal training on bioethics should be provided to HEC members. To assure the independence and good performance of HECs, the conflict of interest procedure, the standard operating procedures and bioethical review should be improved. Conclusion: HECs in Shanghai had developed in the preceding 10 years and they played great roles in protecting the rights and welfare of human subjects and patients; some areas need improvement. (shrink)

Survival after solid-organ transplantation has improved significantly, and many contemporary transplant recipients are of childbearing potential. There are limited data to guide decision-making surrounding pregnancy after transplantation, variations in clinical practice, and significant knowledge gaps, all of which raise significant ethical issues. Post-transplant pregnancy is associated with an increased risk of maternal and fetal complications. Shared decision-making is a central aspect of patient counselling but is complicated by significant knowledge gaps. Stakeholder interests can be in conflict; exploring these tensions can (...) help patients to evaluate their options and inform their deliberations. We argue that uniform, evidence-based recommendations for pregnancy after solid organ transplantation are needed. Conducting research, including patient-engaged studies, in this area should be priority for the transplant community. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Great Synthesis of Wang Yang Ming Neo-Confucianism in Korea: The Chonŏn (Testament) by Chŏng Chedu (Hagok) by Edward Y.J. ChungMaria Hasfeldt Long (bio)The Great Synthesis of Wang Yang Ming Neo-Confucianism in Korea: The Chonŏn (Testament) by Chŏng Chedu (Hagok). By Edward Y.J. Chung. Landham: Lexington Books, 2020. Pp. vii+ 351. Hardcover $137.00, isbn 978-1-7936-1469-8. The Korean Neo-Confucian tradition during the Chosŏn dynasty (1392–1910) was dominated (...) by the orthodox Sŏngnihak (School of Human Nature and Principle), which is also known as the Chŏngjuhak (Cheng–Zhu School). This school of Neo-Confucianism followed the doctrines and teachings of the Great Synthesizer Zhu Xi (1130–1200) to such a point that other Neo-Confucian schools were labeled as wrong and even persecuted until the late nineteenth century. One of these schools was Simhak (School of the Mind/Heart) established by the Chinese scholar Wang Yangming (1472–1529), which during the Ming dynasty (1382–1644) had grown to rival the Cheng–Zhu school. However, the academic-political power of the Cheng–Zhu school in Korea managed to suppress Yangming scholarship and maintain dominance throughout the dynasty. Despite that, a few scholars did take up the scholarship of Simhak in Korea, with the most influential being Chŏng Chedu, also known as Hagok (1649–1736) (p. 4). In his book, The Great Synthesis of Wang Yang Ming Neo-Confucianism in Korea: The Chonŏn (Testament) by Chŏng Chedu (Hagok), Edward Y.J. Chung presents not only an annotated translation of Hagok's main writings but also a look into intellectual scholarship that opposed the orthodoxy of the Cheng–Zhu school of Korea. This in-depth study and translation of Hagok into English was motivated by the lack of attention in Western scholarship on Korean Neo-Confucianism. It presents a study that goes beyond the three most famous scholars, Yi Hwang T'oegye (1501–1570), Yi I Yulgok (1536–1584), and Chŏng Yagyong Tasan (1762–1836), who founded the three mainstream schools of the Chosŏn dynasty. According to Chung, Hagok's writing not only represents important aspects of intellectual history but also serves as a fourth and lesser-known school of Korean Neo-Confucian thinking that should be placed on the same level as the other three. Unlike other Korean scholars who tried to take up the Yangming doctrine, Hagok did not care that the doctrine was prohibited. This set him apart from other scholars. Despite the Cheng–Zhu school being the "right learning," Hagok did not agree with the majority of it and based his theories on the Yangming doctrine. Although Hagok openly followed the Yangming doctrine, he did not do so blindly. [End Page 1] Hagok was aware that Yangming's theories had their flaws and he agreed with some theories of the Cheng–Zhu school (p. 7–8). This resulted in him trying to synthesize the two schools into one harmonious doctrine, which is why Chung believes Hagok to be important and has undertaken the task of bringing attention to this Korean scholar. Consisting of two distinct parts, Chung gives the reader a solid introduction to Hagok and his main theories via the selected translations from his most influential text, Chonŏn, which can be translated into "testament" or "living words." The first part of the book is divided into notes on the translation itself, such as transliteration, citation style, abbreviations, and, more importantly, how and why Chung selected the sections of the Chonŏn that have been translated. Through the selection, translation, annotation, and discussion of forty-one important essays from Chonŏn's three parts, Chung wishes to show the heart of Hagok's Neo-Confucian thought (p. x). The Chonŏn is not organized according to any thematic system and consists of different paragraphs, notes, and comments. Chung has, therefore, chosen which parts to translate in order to best portray Hagok's interpretation of the key concepts, the theories found in the Yangming Neo-Confucianism, and Hagok's criticism of Zhu Xi and T'oegye. All of this is properly introduced and explained in... (shrink)

~Et moi,.... si j'avait su comment en revenir, One service mathematics has rendered the je n'y serais point alle.' human race. It has put common sense back Jules Verne where it belongs, on the topmost shelf next to the dusty canister labelled 'discarded non· The series is divergent; therefore we may be sense'. Eric T. Bell able to do something with it. O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and (...) non­ linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One service topology has rendered mathematical physics...'; 'One service logic has rendered com­ puter science...'; 'One service category theory has rendered mathematics...'. All arguably true. And all statements obtainable this way form part of the raison d'etre of this series. (shrink)

This paper is aimed at a critical assessment of the moral framework of the current Chinese health system from a Confucian perspective, by focusing on the debate between the individual directed approach and the family-oriented approach to a health care system. Concerned with the nature and status of the family in communal life, the paper deals with the following questions: to cope with the frailties of material life (including susceptibility to disease), what good is presupposed by human existence and flourishing; (...) why it is the family that serves as the primary locus of bearing and realizing this unique good; and what kind of society might possess the structures necessary to achieve the good thus conceived. All these questions lead to a revision of the theory of justice required in health care, in favor of family health saving accounts as an important institutional guarantee. (shrink)

Using an international sample of banks, we study how differences in religiosity across countries affect earnings management. Given that religiosity is a major source of morality and ethical behavior, it may reduce excessive risk taking and act as deterrence for earnings manipulations. Therefore, we predict lower earnings management in societies that have higher religiosity. Consistent with expectations, our cross-country analysis indicates that religiosity is negatively related to income-increasing earnings management for loss-avoidance and just-meeting-or-beating prior year’s earnings. We also find that (...) religiosity reduces income-increasing earnings management through abnormal loan loss provisions. In additional tests, we document that religiosity increases the information value of bank earnings, with both earnings persistence and cash flow predictability being enhanced by higher religiosity. For the crisis period analysis, our evidence shows that banks in countries with higher religiosity exhibit lower probability of reporting asset deterioration and lower probability of having poor performance. (shrink)

It was natural and inevitable that his two Aethiopias, in the eastern and western extremities of the world, should be identified with the countries of the two dark-skinned peoples in the Far East and the Far West of the Ancient World: India and Mauretania. There was the difficulty that the real Aethiopia was in Africa, neither in the Far East nor in the Far West. Serious writers on geography tried to reconcile Homer and the geographical facts. I wish to excerpt (...) from Strabo three theories concerning Aethiopia and the Aethiopians which will then be used to elucidate passages in Latin literature. (shrink)

This classic edition presents the correspondence of one of the great thinkers of the 18th century, and offers a rich picture of the man and his age. This first volume contains David Hume's letters from 1727 to 1765. Hume's correspondents include such famous public figures as Jean-Jacques Rousseau, Adam Smith, James Boswell, and Benjamin Franklin.