Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)
Legal responses to battered women who kill have long animated scholarly debate and law reform activity. In September 2012 after 47 years of alleged abuse, Frenchwoman Jacqueline Sauvage fatally shot her abusive husband three times in the back. The subsequent contested trial, conviction for murder, unsuccessful appeal and later presidential pardon of Sauvage thrust the French law of self-defence into the spotlight. The Sauvage case raises important questions surrounding the adequacy of the French criminal law in this area, the (...) ongoing proliferation of gendered stereotypes in law and the need for reform. In the wake of the Sauvage case, this article provides a timely analysis of the gendered law of self-defence in France. Drawing from an in-depth analysis of the judgments imposed in the Sauvage case, this article examines the adequacy of French legal responses to battered women who kill and ignites an argument for further law reform. (shrink)
In this entry to David Hume scholarship, Jacqueline Taylor brings together a line of interpretation she has been developing over several years, connecting Hume's theory of the passions to what she calls Hume's "social theory." Through a concise, well-organized argument, the book offers insights into how one of the Enlightenment's most famous and gifted thinkers conceptualized social roles and institutions, the ways we navigate these roles and institutions, and how all this connects to the kind of creature we are. (...) It is a rewarding read for anyone interested in Hume's moral project.The book begins with a lively, historicized defense of Hume's "experimental" method against readers who have thought his approach fails... (shrink)
Ont contribué au volume : David Allen, Gabriel Bergounioux, Claude Blanckaert, Jacqueline Carroy, Jean François Chiantarretto, Françoise Couchard, Gérard Lagneau, Sophie-Anne Leterrier, Laurent Muchielli, Jean Yves Pautrat, Paule Petitier, Jacques Postel, Jacques Rancière, Marc Renneville, Nathalie Richard et Geneviève Vermès. A priori, loin de la problématique des relations entre les sexes, ce recueil de textes issu d'un colloque organisé par la Société française pour l'histoire des s..
This anthology offers a comprehensive introduction to Pliny the Younger's Epistulae for intermediate and advanced Latin students, with the grammatical, lexical, and historical support to enable them to read quickly and fluidly. As the only selection of the letters with extensive commentary, it provides instructors with a unique and complete resource for students.ABOUT THE SERIESThe Oxford Greek and Latin College Commentaries is designed for students in intermediate or advanced Greek or Latin. Each volume includes a comprehensive introduction. The placement, on (...) the same page, of the ancient text, a running vocabulary, and succinct notes focusing on grammar, syntax, and distinctive features of style provides students with essential learning aids.Series Editors: Barbara Weiden Boyd, Bowdoin College, Stephen Esposito, Boston University, and Mary Lefkowitz, Wellesley CollegeAlso Available Ovid: Ars Amatoria, Book 3, Christopher M. Brunelle, St. Olaf CollegeForthcoming Latin VolumesSuetonius's Life of AugustusDarryl Phillips, Connecticut CollegeLucan's De Bello Civile, Book 5Jonathan Tracy, Massey University, New Zealand. (shrink)
This book, comprised of thirteen essays and an introduction by the editors, is an exploration of the concept of liberty—moral and political, theological and metaphysical —in the seventeenth and eighteenth centuries. The topic in itself is interesting, raising the question of the extent to which moral and political liberty are related to metaphysical liberty. With the possible exception of Catherine Cockburn, these types of liberty seem harder to separate in the centuries under discussion than they would be now. This could (...) be because moral and political liberty were more of an omnipresent concern to philosophers generally then than they are now, but it is also relevant that all but one... (shrink)
The giving up of the body or suicide for spiritual reasons has been dealt with by James Benn and D Max Moermane. The relationships of the dead and the living are discussed by Bryan J Cuevas, John Cliff ord Holt, and Matthew T Kapstein, while Hank Glassman, Mark Rowe, and Jason A Carbine talk about different funeral practices. With glossaries for Chinese, Japanese, and Korean characters and an elaborate index, this book is a unique peek into Buddhist practices regarding the (...) dead and deserves attention by researchers, students, and admirers of this religion. (shrink)