Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are well documented and modelled, a simple enough virtual cell taking into account the mechano-chemical coupling between calcium oscillations and cell mechanical properties is still lacking. Considering the spontaneous periodic contraction of isolated cardiac myocytes, we propose here a virtual cardiac cell model in which the cellular contraction is modelled using an hyperelastic description of the cell (...) mechanical behaviour. According to the experimental data, the oscillating cytosolic calcium concentrations trigger the spatio-temporal variation of the anisotropic intracellular stresses. The finite element simulations of the virtual cell deformations are compared to the self-sustained contractions of isolated rat cardiomyocytes recorded by time-lapse video-microscopy. (shrink)

How environmental mechanical forces affect cellular functions is a central problem in cell biology. Theoretical models of cellular biomechanics provide relevant tools for understanding how the contributions of deformable intracellular components and specific adhesion conditions at the cell interface are integrated for determining the overall balance of mechanical forces within the cell. We investigate here the spatial distributions of intracellular stresses when adherent cells are probed by magnetic twisting cytometry. The influence of the cell nucleus stiffness on the simulated nonlinear (...) torque-bead rotation response is analyzed by considering a finite element multi-component cell model in which the cell and its nucleus are considered as different hyperelastic materials. We additionally take into account the mechanical properties of the basal cell cortex, which can be affected by the interaction of the basal cell membrane with the extracellular substrate. In agreement with data obtained on epithelial cells, the simulated behaviour of the cell model relates the hyperelastic response observed at the entire cell scale to the distribution of stresses and strains within the nucleus and the cytoskeleton, up to cell adhesion areas. These results, which indicate how mechanical forces are transmitted at distant points through the cytoskeleton, are compared to recent data imaging the highly localized distribution of intracellular stresses. (shrink)

Is knowledge the epistemic norm of action and assertion? Gettier and justified-false-belief cases have been raised as counterexamples to the necessity direction of that claim. Most knowledge normers reply by distinguishing permissibility from excusability. An important objection to this move, however, is that it requires a still lacking view of epistemic excuses sufficiently general to cover all the cases, correctly relating the supposed excuse to the subject's cognitive life, and not collapsing into an account of the fundamental normative standard (see (...) Gerken 2017). In this paper, I rely on independent work in epistemology and cognitive science to suggest a novel account of epistemic excuses in terms of epistemic feelings. In contrast to other existing accounts, this account is immune from the above objection and can thus be used to rescue the knowledge norm. (shrink)

Professor Dreze is a highly respected mathematical economist and econometrician. This book brings together some of his major contributions to the economic theory of decision making under uncertainty, and also several essays. These include an important essay on 'Decision theory under moral hazard and state dependent preferences' that significantly extends modern theory, and which provides rigorous foundations for subsequent chapters. Topics covered within the theory include decision theory, market allocation and prices, consumer decisions, theory of the firm, labour contracts, and (...) public decisions. (shrink)

An introduction to Derrida's contribution to literary studies, comprising much of Derrida's work on writers such as Shakespeare, Mallarme, Joyce and Kafka, with an introductory essay on deconstruction.

The traditional view in epistemology has it that knowledge is insensitive to the practical stakes. More recently, some philosophers have argued that knowledge is sufficient for rational action: if you know p, then p is a reason you have (epistemically speaking). Many epistemologists contend that these two claims stand in tension with one another. In support of this, they ask us to start with a low stakes case where, intuitively, a subject knows that p and appropriately acts on p. Then, (...) they ask us to consider a high stakes version of the case where, intuitively, this subject does not know that p and could not appropriately act on p without double-checking. Finally, they suggest that the best explanation for our shifty intuitions is that p is a reason the subject has in the low stakes case but not in the high stakes case. In short, according to this explanation, having a reason (in the epistemic sense) is sensitive to the stakes. If so, either knowledge is sensitive to the stakes or else you can know that p even if p is not a reason you have (in the epistemic sense). In this paper, I consider more closely the relation between having a reason (in the epistemic sense) and having a reason to check. I argue that the supposition that if one has p as a reason (in the epistemic sense) then one has a reason not to check whether p, or no reason to check whether p, is highly doubtful. On the contrary, I suggest, it is plausible that, given our fallibility, one always has an epistemic reason to check whether p, whether or not p is a reason one has (in the epistemic sense). On the basis of this observation, I show that one can offer a new way of explaining the cases in question, allowing us to reconcile the traditional view about knowledge and the sufficiency of knowledge for rational action. (shrink)

Martial Gueroult (1891–1976) and Victor Goldschmidt (1914–1981) are two major figures in French history of philosophy during the second half of the last century. The latter has often been described as one of the former's “disciples”, on the basis of their common opposition to the “geneticist” approach in the study of past philosophers, and their common support for a “structuralist” one, which was an influential paradigm in various fields of French thought at the time of their activity. A detailed study (...) of their methodological principles and their concrete practice shows that their relationship was much more complicated. (shrink)

(1994). Young people and life in the city. The lessons of political sociology and of the patterns of socialization of young people. World Futures: Vol. 41, No. 1-3, pp. 110-114.

Disons que, pour m'en tenir au cadre, à la limite, j'écris ici quatre fois autour de la peinture. Quatre fois, dira-t-on autour de la peinture, donc dans les parages qu'on s'autorise, c'est toute l'histoire, à contenir comme les entours ou les abords de l'œuvre : cadre, passe-partout, titre, signature, musée, archive, discours, marché, bref partout où on légifère en marquant la limite, celle de la couleur même. Du droit à la peinture, voilà le titre ambitieux auquel j'aurais voulu accorder ce (...) livre, son trajet autant que son objet, leur trait commun, qui n'est autre, ni un ni indivible, que le trait lui-même. JD. (shrink)

El tema de la verdad está tratado en este artículo tanto desde el punto de vista filosófico como del antropobiológico. Si el hombre no puede pensar un pensamiento antes de reflexionarlo, el condicionamiento de ese pensamiento a un juicio de objetividad del hombre sobre el mundo que lo rodea no puede ser apartado. En efecto, para que la realidad mental sea tan real como el mundo de los sentidos, es preciso que el hombre considere como verdadero lo que piensa para (...) poder pensarlo. Esta ley de verdad acompaña la construcción de la vida mental del hombre y el juicio de objetividad que debe tener sobre el mundo para ser libre. (shrink)

Quelqu'un sait quelque chose, voila la situation de depart de toute problematique cognitive. Dans toute situation cognitive, un sujet connaissant se trouve en relation cognitive avec un objet connu. Contrairement a l'approche analytique suivie par les disciplines cognitives classiques - logique, epistemologie, psychologie cognitive, et aujourd'hui l'intelligence artificielle - qui detachent l'objet de leur recherche de son contexte d'origine, la demarche de ce livre est integrante. Elle entend ne pas couper la problematique cognitive des situations cognitives effectives dans lesquelles cette (...) problematique prend corps et se deploie. (shrink)

1. Descartes continue d’ordonner Yopus philosophicum à Yesse. Mais conçoit l’intelligence elle-même d’une façon platonicienne, comme ordonnée aux seules essences. 2. De là la nécessité pour lui de compenser — sans arriver à l’équilibre — une tendance idéaliste par une tendance volontariste. Contrastes qui s’ensuivent. 3. De là aussi la nécessité de procéder à des « coups de force existentiels ». Il semble que l’idéalisme moderne ne puisse pas se passer de coups de force de cette nature.

La vie la mort est l'un des séminaires les plus féconds de Jacques Derrida. En jeu : penser la vie et la mort en vertu d'une logique qui ne poserait pas la mort comme l'opposé de la vie. La pureté de la vie n'est-elle pas, par essence, contaminée par la possibilité même de la mort, puisque seul un vivant peut mourir? interroge d'emblée le philosophe. En renversant la perspective classique, Derrida entreprend d'enseigner à ses étudiants que c'est la mort, (...) au contraire, qui rend la vie possible. En quatorze séances érudites et palpitantes délivrées au cours de l'année 1975-1976, Derrida déconstruit l'opposition traditionnelle entre la vie et la mort à travers des lectures multiples et délibérément pluridisciplinaires, élaborant sa pensée aussi bien au contact de la philosophie (Hegel, Nietzsche, Heidegger) et de l'épistémologie des sciences (Georges Canguilhem) que dans la confrontation à la génétique contemporaine (François Jacob) et à la psychanalyse (catégories freudiennes de pulsions de vie et de mort)."--Page 4 of cover. (shrink)

Catholic philosopher's attempt to show the traditional ways by which the reality of God has been demonstrated.

"What is the purpose and meaning of life if death is, as it appears to an ever-broadening segment of modern secularized humanity, total annihilation of the conscious personality?" This is the profound question asked by Jacques Choron in his new book, Modern Man and Mortality. And in his investigation of man's confrontation with the fact of death, he offers the most comprehensive, most objective study ever published on this subject.