The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme‐responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is (...) rhythmically expressed independently of the sleep‐wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian‐ and sleep‐dependent molecules. (shrink)

This is an attempt to outline the range of problems that should be taken into account when studying the ethos of scholars. The author sets forth from an uncommon starting point. He does not construct “an ideal model of the ethos of the scholar”, neither is he concerned with the “pathology of academic life”. Such approaches are dubbed “normative-functional” by the author, and without implicating that they are methodologically implausible he refrains from using them due to the simple consideration that (...) they are unable to accommodate the “tragic component of the role” involved. He sets out to show that the scholars cannot avoid finding themselves in a conflict of values and norms that cannot be ordered using criteria commonly accepted in the academic circles or derived from the concept of the role or the ethos of the scholar. Scholars are exposed to a conflict between the norms accepted by the academic community and the norms accepted by other communities to which they belong. The article discusses the influence of contemporary changes in the organization of science – its dependence on the state, its subservience to the national goals or to the exigencies of other social groups. The author is not satisfied with the treatment of these problems by R. K. Merton, and he reviews various philosophical conceptions with the hope of finding a better answer. He seeks to conceptualize the role of the scholar in terms of the theories proposed by L. Petrażycki, A. Kępiński, I. Kant, M. Weber, K. Mannheim, P. Bourdieu, and others, but has to conclude that in none of these theories is it possible to remove the tragic element from the picture of ethically relevant decision-making. The author ends by saying that the possession of “social and moral competences” that overstep the boundaries of the scholar’s responsibility defined by his role and ethos is a necessary condition of the social fulfilment of that role. (shrink)

Germany since 1990 has one of the strictest human embryo protection laws, yet according to the Stem Cell Act of 2002 allows, under strict conditions, the import and use of human embryonic stem cells (hESC) for high priority research goals. The author tries to show how this is taken to be coherent by the parliamentary majority (though not necessarily by the general public) in Germany. In doing so, he firstly looks into the chronicle of the debate in Germany showing its (...) different stages since 1999, then dwells upon the relation between the law and the role of ethics in this issue, and thirdly presents the two fundamentally different positions of the German debate, that is, that the human embryo created for IVF purposes is a human being and stands from its very beginnings under the constitutional principles of respect for, and protection of, human life versus the position that before being implanted the human embryo may become a human being and therefore belongs to the human species only potentially, so that its right to life protection may be assessable over against other high priority goals, such as research aiming at possible help for patients with life-endangering diseases. In spite of the Stem Cell Act of 2002, the debate of the German general public goes on, especially due to the recent EU 6th Research Framework Program which plans to also fund hESC research. (shrink)

Aktuelle bioethische Debatten werden vor allem von zwei Schwierigkeiten überschattet: zum einen von der Unklarheit des Begriffes menschlicher Autonomie. Hier geht es um individualethische Fragen, vor allem um Beginn und Ende menschlichen Lebens. Zum anderen bedroht die Verschiebung individueller Wissensträgerschaft zum anonymen Kollektivsubjekt angesichts einer zunehmenden Ökonomisierung des Gesundheitswesens das ärztliche Ethos des Helfens und Heilens. Diese und weitere konfliktgeladene Problemstellungen diskutiert Jan P. Beckmann in seinem neuen Buch.

Uniwersytet jako biurokratycznie i rynkowo zarządzane przedsiębiorstwo był obiektem krytyki od lat 80. minionego wieku — w Stanach Zjednoczonych Allan Bloom nazwał go wtedy multiwersytetem, a trochę później Bill Readings pisał już o „uniwersytecie w ruinie” (in ruins), który ukrywa się za szyldem „doskonałości”. Polski uniwersytet przejął ekonomiczne kryteria ewaluacji nauki — wymierne w liczbach grantów i punktów. Merkantylizacja wiedzy stwarza szereg problemów także natury etycznej — prowadzi do zaniżenia lub porzucenia wszelkich standardów akademickich, do degradacji autorytetu w nauce, krytyki (...) naukowej, faktycznej jakości badań i nauczania. Czy na współczesnym uniwersytecie jest w ogóle miejsce na zachowania podlegające ocenie moralnej? Jakie są umiejętności wymagane do — i warunki możliwości — stosowania norm moralnych w życiu akademickim? (shrink)

The author inquires into the relation between the production of genetic knowledge on the one hand, and human autonomy and self-determination on the other. He does so by specifying the notions of “genetic test” and “human autonomy”; by discussing the epistemic status of genetic knowledge, given its importance for the clarification of its anthropological and ethical implications; and by inquiring into some ethical implications by investigating the conditions under which genetic knowledge of the individual may justifiably be established. This discussion (...) shows that the autonomy-based right to self-determination as far as gene in formation is concerned, is fundamental. This has major implications, which the author identifies with regard to the difficult problem of the moral legitimacy of the use of genetic knowledge in the context of insurance policies. S. Afr. J. Philos. Vol.23(1) 2004: 69-81. (shrink)

This paper deals with the exact constructions of the regular heptagon in Greek and Arabic geometry, which are preserved in a number of mainly unpublished Arabic manuscripts. Appended are editions of the Arabic texts and English translations of Propositions 17 and 18 of the “Book of the Construction of the Circle, Divided into Seven Equal Parts”, attributed to Archimedes, and of the “Book on the Construction of the Heptagon in the Circle and the Division of the Rectilineal Angle into Three (...) Equal Parts” by the 10th century geometer Al-Sijzi. (shrink)

This collection of essays reflects the wide range of David Pingree's expertise in the scientific texts of Ancient Mesopotamia, Greece, India, Persia, and the medieval Arabic, Hebrew and Latin traditions. Both theoretical aspects and the practical applications of the exact sciences-in time keeping, prediction of the future, and the operation of magic-are dealt with. The book includes several critical editions and translations of hitherto unknown or understudied texts, and a particular emphasis is on the diffusion of scientific learning from one (...) culture to another, and through time. Above all, the essays show the variety and sophistication of the exact sciences in non-Western societies in pre-modern times. (shrink)

Much has been done on the publication of original sources in Arabic during the past 30 years, but much more remains to be done. Some of the recent multiple editions are unnecessary duplication of work and therefore waste of energy. This energy could be better spent on the publication of unpublished sources, and on studies involving the contextualization of Islamic sciences. Furthermore, historians of pre-modern science should work on the popularization of their wonderful subject. This exoteric work is as important (...) as esoteric research, because the survival of the field depends on its image among various audiences outside the community of historians of science. (shrink)

The question of bodylines of the memory in the eschatological perspective During last decades the cognitive sciences have progressed a lot in analysing the link between mind and body on the field of philosophy of mind. The results of the body-mind investigations influence largely also theology. The classical theological thought considers the will, the reason and the memory as faculties of the soul. However, contemporary neuroscience attempts, with some success, to discover physical substrates of these faculties, which impacts also philosophy (...) of the mind. In this perspective, mutability and fragility of human body that is, according to psychologists, the memory’s ground, as well as human identity taken in its theological understanding, determined by the memory but transcending the temporal life, require some re-analysis of the spiritual dimension of the memory and some connection between the spiritual and the bodily sphere in the perspective of relation of the man with God. Though, theology must respect the scientific solutions of the body-mind question. In order to undertake it, the very object of theology and neuroscience has to be analysed to ascertain whether the memory examined by both sciences constitutes the same phenomenon. Then, one should analyse the philosophical assumptions of their discourses. Only these preliminary inquiries will allow to determine the philosophical area to build an integral reflexion. In turn, only this area may constitute the basis for such an anthropological-theological system that could retain its integrity vis-à-vis the discoveries of neuroscience. (shrink)

Le premier volume du Corpus of Mycenaean Inscriptions from Knossos est sorti de presse en 1986 ; le second sort cette année : trente-sept raccords de fragments ont été effectués dan· le premier volume depuis la fin de 1984 et le second contient soixante-dix raccords inédits ; le· auteurs les présentent et les commentent, comme ils l'avaient déjà fait pour les quarante-troi· raccords inédits de CoMIK I (BCH 110 [1986], p. 21-39).

The tradeoff hypothesis in the speech–gesture relationship claims that (a) when gesturing gets harder, speakers will rely relatively more on speech, and (b) when speaking gets harder, speakers will rely relatively more on gestures. We tested the second part of this hypothesis in an experimental collaborative referring paradigm where pairs of participants (directors and matchers) identified targets to each other from an array visible to both of them. We manipulated two factors known to affect the difficulty of speaking to assess (...) their effects on the gesture rate per 100 words. The first factor, codability, is the ease with which targets can be described. The second factor, repetition, is whether the targets are old or new (having been already described once or twice). We also manipulated a third factor, mutual visibility, because it is known to affect the rate and type of gesture produced. None of the manipulations systematically affected the gesture rate. Our data are thus mostly inconsistent with the tradeoff hypothesis. However, the gesture rate was sensitive to concurrent features of referring expressions, suggesting that gesture parallels aspects of speech. We argue that the redundancy between speech and gesture is communicatively motivated. (shrink)