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Jason Karlawish [12]Jason H. T. Karlawish [4]
  1.  14
    Alive Inside.Andrew Peterson, Adrian M. Owen & Jason Karlawish - 2020 - Bioethics 34 (3):295-305.
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  2.  9
    Supported Decision Making With People at the Margins of Autonomy.Andrew Peterson, Jason Karlawish & Emily Largent - 2020 - American Journal of Bioethics 21 (11):4-18.
    This article argues that supported decision making is ideal for people with dynamic cognitive and functional impairments that place them at the margins of autonomy. First, we argue that guardianship and similar surrogate decision-making frameworks may be inappropriate for people with dynamic impairments. Second, we provide a conceptual foundation for supported decision making for individuals with dynamic impairments, which integrates the social model of disability with relational accounts of autonomy. Third, we propose a three-step model that specifies the necessary conditions (...)
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  3.  35
    Community Equipoise and the Architecture of Clinical Research.Jason H. T. Karlawish & John Lantos - 1997 - Cambridge Quarterly of Healthcare Ethics 6 (4):385-.
    Equipoise is an essential condition to justify a clinical trial. The term, describes a state of uncertainty: the data suggest but do not prove a drug's safety and efficacy The only way to resolve this uncertainty is further study In many cases, a clinical trial seems to be the most efficient way to prove safety and efficacy Equipoise is therefore not an esoteric philosophic construct applied to research ethics. Rather, since it is vital for the justification of clinical trials, it (...)
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  4.  6
    Where Do You End, and I Begin? How Relationships Confound Advance Directives in the Care of Persons Living with Dementia.David M. Lyreskog, Jason Karlawish & Saskia K. Nagel - 2020 - American Journal of Bioethics 20 (8):83-85.
    Volume 20, Issue 8, August 2020, Page 83-85.
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  5.  11
    The Proactive Patient: Long-Term Care Insurance Discrimination Risks of Alzheimer's Disease Biomarkers.Jalayne J. Arias, Ana M. Tyler, Benjamin J. Oster & Jason Karlawish - 2018 - Journal of Law, Medicine and Ethics 46 (2):485-498.
    Previously diagnosed by symptoms alone, Alzheimer's disease is now also defined by measures of amyloid and tau, referred to as “biomarkers.” Biomarkers are detectible up to twenty years before symptoms present and open the door to predicting the risk of Alzheimer's disease. While these biomarkers provide information that can help individuals and families plan for long-term care services and supports, insurers could also use this information to discriminate against those who are more likely to need such services. In this article, (...)
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  6.  12
    Community Equipoise and the Architecture of Clinical Research.Jason H. T. Karlawish & John Lantos - 1997 - Cambridge Quarterly of Healthcare Ethics 6 (4):385-396.
    Equipoise is an essential condition to justify a clinical trial. The term, describes a state of uncertainty: the data suggest but do not prove a drug's safety and efficacy The only way to resolve this uncertainty is further study In many cases, a clinical trial seems to be the most efficient way to prove safety and efficacy Equipoise is therefore not an esoteric philosophic construct applied to research ethics. Rather, since it is vital for the justification of clinical trials, it (...)
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  7. A Taxonomy of Value in Clinical Research.David J. Casarett, Jason H. T. Karlawish & Jonathan D. Moreno - 2002 - IRB: Ethics & Human Research 24 (6):1.
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  8.  43
    Patient and Physician Views About Protocolized Dialysis Treatment in Randomized Trials and Clinical Care.Ashley Kraybill, Laura M. Dember, Steven Joffe, Jason Karlawish, Susan S. Ellenberg, Vanessa Madden & Scott D. Halpern - 2016 - Ajob Empirical Bioethics 7 (2):106-115.
  9. Open Label Extension Studies & the Ethical Design of Clinical Trials.David Casarett, Jason Karlawish, Pamela Sankar, Karen B. Hirschman & David A. Asch - 2001 - IRB: Ethics & Human Research 23 (4):1.
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  10.  4
    Supported Decision Making with People at the Margins of Autonomy: Response to Commentaries.Emily A. Largent, Jason Karlawish & Andrew Peterson - 2021 - American Journal of Bioethics 22 (1):W1-W4.
    Supported decision making is a model of decision making in which an adult with impaired capacity enters freely into an agreement with a closely trusted person or persons (the “s...
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  11. Creating the Truth with Persons Living with Advanced Dementia.Jason Karlawish - 2021 - Journal of Law, Medicine and Ethics 49 (2):266-268.
    Truth telling to persons living with dementia is a nuanced problem that demands negotiating between the hazards of principlism and the loving deceiver’s demand to lie as needed. To ban deception, as we do restraints, would be misguided and cruel. So too to demand we always tell the truth. We ought to adopt a practice called “creative care.” It begins with the premise that person’s living with dementia are capable of creativity. Creative care breaks down the mysterious fourth wall we (...)
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  12.  2
    Please, Don’T Fly Me to the Moon.Jason Karlawish - 2021 - American Journal of Bioethics 21 (12):20-22.
    Years after the publication of “Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Disease?” I hope it continues to animate and...
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  13.  7
    Decision-Making Capacity Will Have a Limited Effect on Civil Commitment Practices.Jason Karlawish, Dominic A. Sisti & Rocksheng Zhong - 2019 - American Journal of Bioethics 19 (10):86-88.
    Volume 19, Issue 10, October 2019, Page 86-88.
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  14.  7
    Amyloid in the Brain, Alzheimer's on the Mind.Jason Karlawish - 2018 - Hastings Center Report 48 (5).
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  15.  4
    Research on Cognitively Impaired Adults.Jason Karlawish - 2009 - In Bonnie Steinbock (ed.), The Oxford Handbook of Bioethics. Oxford University Press.
    The preeminence of informed consent in human subjects protections reflects Western democratic societies' ethical and political commitments to secure each citizen against both coercive and paternalistic influences of other people. Society permits adults extensive personal discretion in choices such as where to live, what to eat, how to dress, and whether to be in research. In short, individuals are afforded extensive discretion in choosing what to do and what is in their own best interests. Informed consent to enroll in research (...)
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  16.  1
    Informed Consent for Alzheimer's Disease Clinical Trials: A Survey of Clinical Investigators.Jason H. T. Karlawish, David Knopman, Christopher M. Clark, John C. Morris, Daniel Marson, Peter J. Whitehouse & Claudia H. Kawas - 2002 - IRB: Ethics & Human Research 24 (5):1.